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The map label for this gene is ttuC [H]

Identifier: 148259202

GI number: 148259202

Start: 206484

End: 207557

Strand: Reverse

Name: ttuC [H]

Synonym: Acry_0182

Alternate gene names: 148259202

Gene position: 207557-206484 (Counterclockwise)

Preceding gene: 148259206

Following gene: 148259201

Centisome position: 6.12

GC content: 70.39

Gene sequence:

>1074_bases
ATGAAGACCTACCGGATCGCCTCGATTCCCGGCGACGGCATCGGCCCCGAAGTGATCGGTGCCGGGCTCGACGTGCTCGA
CGCCCTCGCCCGCCGCGACAGCGGCTTCGCGCTCGACGTCACGGCGTTCGACTACGGCTCGGATTACTACCGCCGCCACG
GGGTGATGATGCCGGACGGCGCGCTGGAACGGCTGAAGGCCTTCGACGCAATCTATTTCGGCGCGGTCGGCGCGCCGGAC
ATCCCCGACCATGTCACCCTCTGGGGTCTGCGCCTCGCGATCTGCCAGGGGTTCGACCAGTATGCCAATGTCCGCCCGAC
CCGGGTGCTGCGCGGCCTCGACTCGCCGCTGCGCGCCTGCGCCCCGGCGGATCTCGACTGGGTGATCGTGCGCGAGAACA
GCGAGGGCGAATATGCCGGCCAGGGCGGCCGCTCGCATCGCGGCCACGCCGAGGAGGTCGCGACCGAGGTGGCGATCTTC
ACGCGCGCCGGCGTCGCGCGGATCATGCGCTTCGCCTTCGCCCTCGCCGCGTCGCGCCCGCGCAGGCACCTCACCGTCGT
CACCAAGTCGAACGCGCAGCGCCACGGCATGGTGCTGTGGGACGAGGTCGCCGCCGAGACAGCGCGCGATTTCCCGGAGG
TGACGTGGGACAAGATGCTGGTCGATGCGATGACCGTCCGCATGGTGCACGCCCCGGCGAGCATCGACACGGTGGTGGCG
ACCAACCTGCACGCCGACATCCTCTCCGACCTCGCCGCCGCACTCGCCGGCTCGATCGGCATTGCACCGACGGCGAACGT
CAACCCGGAGCGGAACTACCCCTCGATGTTCGAGCCGATCCACGGCTCCGCCTTCGACATCACCGGCAAGGGCATCGCCA
ATCCGGTCGGCGCGTTCTGGACGGCGTCGCAGATGCTGGAGCATCTCGGCGAGGCGGATGCGGCGCGGCGGCTGATGGCG
GCGGTGGAACGGGTGACGGCGGCCGGCATCCGCACCCGCGATCTCGGCGGCGATGCCACCACGGCCGAGGTAACGGCGGC
GGTGATCGACGCGATCGAGGGCGGCAACGCATAG

Upstream 100 bases:

>100_bases
GCGAGACATGTTACCGCAGCCGACGATGCGCCGCGCCCGCCCTTCGGGCAAGCCGGCCCGGCGCGCAACGGTTCACCCAC
GGGCAGAGGAGCAAGCGCCC

Downstream 100 bases:

>100_bases
GCGCAGCGCAGCCTGCGCCCCTTGCGCCGGCCCCTTCCATGCGCAATTCGACTAGGTGTGTAACGAGCACGAGGAGCAGC
AATGATCACCGGCAGCTTTC

Product: tartrate dehydrogenase

Products: NA

Alternate protein names: TDH; D-malate dehydrogenase [decarboxylating] [H]

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MKTYRIASIPGDGIGPEVIGAGLDVLDALARRDSGFALDVTAFDYGSDYYRRHGVMMPDGALERLKAFDAIYFGAVGAPD
IPDHVTLWGLRLAICQGFDQYANVRPTRVLRGLDSPLRACAPADLDWVIVRENSEGEYAGQGGRSHRGHAEEVATEVAIF
TRAGVARIMRFAFALAASRPRRHLTVVTKSNAQRHGMVLWDEVAAETARDFPEVTWDKMLVDAMTVRMVHAPASIDTVVA
TNLHADILSDLAAALAGSIGIAPTANVNPERNYPSMFEPIHGSAFDITGKGIANPVGAFWTASQMLEHLGEADAARRLMA
AVERVTAAGIRTRDLGGDATTAEVTAAVIDAIEGGNA

Sequences:

>Translated_357_residues
MKTYRIASIPGDGIGPEVIGAGLDVLDALARRDSGFALDVTAFDYGSDYYRRHGVMMPDGALERLKAFDAIYFGAVGAPD
IPDHVTLWGLRLAICQGFDQYANVRPTRVLRGLDSPLRACAPADLDWVIVRENSEGEYAGQGGRSHRGHAEEVATEVAIF
TRAGVARIMRFAFALAASRPRRHLTVVTKSNAQRHGMVLWDEVAAETARDFPEVTWDKMLVDAMTVRMVHAPASIDTVVA
TNLHADILSDLAAALAGSIGIAPTANVNPERNYPSMFEPIHGSAFDITGKGIANPVGAFWTASQMLEHLGEADAARRLMA
AVERVTAAGIRTRDLGGDATTAEVTAAVIDAIEGGNA
>Mature_357_residues
MKTYRIASIPGDGIGPEVIGAGLDVLDALARRDSGFALDVTAFDYGSDYYRRHGVMMPDGALERLKAFDAIYFGAVGAPD
IPDHVTLWGLRLAICQGFDQYANVRPTRVLRGLDSPLRACAPADLDWVIVRENSEGEYAGQGGRSHRGHAEEVATEVAIF
TRAGVARIMRFAFALAASRPRRHLTVVTKSNAQRHGMVLWDEVAAETARDFPEVTWDKMLVDAMTVRMVHAPASIDTVVA
TNLHADILSDLAAALAGSIGIAPTANVNPERNYPSMFEPIHGSAFDITGKGIANPVGAFWTASQMLEHLGEADAARRLMA
AVERVTAAGIRTRDLGGDATTAEVTAAVIDAIEGGNA

Specific function: Unknown

COG id: COG0473

COG function: function code CE; Isocitrate/isopropylmalate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=344, Percent_Identity=32.5581395348837, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI28178821, Length=358, Percent_Identity=28.4916201117318, Blast_Score=135, Evalue=7e-32,
Organism=Homo sapiens, GI28178816, Length=357, Percent_Identity=29.1316526610644, Blast_Score=135, Evalue=8e-32,
Organism=Homo sapiens, GI4758582, Length=355, Percent_Identity=29.5774647887324, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI28178838, Length=324, Percent_Identity=29.320987654321, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI28178819, Length=199, Percent_Identity=31.6582914572864, Blast_Score=103, Evalue=2e-22,
Organism=Escherichia coli, GI1788101, Length=359, Percent_Identity=50.974930362117, Blast_Score=360, Evalue=1e-100,
Organism=Escherichia coli, GI87081683, Length=346, Percent_Identity=37.2832369942197, Blast_Score=196, Evalue=1e-51,
Organism=Escherichia coli, GI1787381, Length=373, Percent_Identity=26.8096514745308, Blast_Score=105, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI71986051, Length=345, Percent_Identity=31.8840579710145, Blast_Score=155, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17550882, Length=353, Percent_Identity=30.3116147308782, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI25144293, Length=360, Percent_Identity=27.2222222222222, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI17505779, Length=352, Percent_Identity=25.2840909090909, Blast_Score=113, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6322097, Length=362, Percent_Identity=34.5303867403315, Blast_Score=171, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6324709, Length=351, Percent_Identity=33.6182336182336, Blast_Score=161, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6319830, Length=367, Percent_Identity=31.3351498637602, Blast_Score=142, Evalue=6e-35,
Organism=Saccharomyces cerevisiae, GI6324291, Length=354, Percent_Identity=29.0960451977401, Blast_Score=141, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24643268, Length=347, Percent_Identity=32.8530259365994, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24643270, Length=347, Percent_Identity=32.8530259365994, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24661184, Length=356, Percent_Identity=29.7752808988764, Blast_Score=145, Evalue=3e-35,
Organism=Drosophila melanogaster, GI281362242, Length=343, Percent_Identity=29.4460641399417, Blast_Score=135, Evalue=5e-32,
Organism=Drosophila melanogaster, GI24648872, Length=343, Percent_Identity=29.4460641399417, Blast_Score=135, Evalue=5e-32,
Organism=Drosophila melanogaster, GI161078633, Length=361, Percent_Identity=25.7617728531856, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24650122, Length=361, Percent_Identity=25.7617728531856, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI161078635, Length=361, Percent_Identity=26.0387811634349, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI161078637, Length=361, Percent_Identity=25.7617728531856, Blast_Score=121, Evalue=7e-28,
Organism=Drosophila melanogaster, GI161078639, Length=358, Percent_Identity=25.9776536312849, Blast_Score=121, Evalue=7e-28,
Organism=Drosophila melanogaster, GI20130355, Length=354, Percent_Identity=27.683615819209, Blast_Score=113, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR011829 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.93; =4.1.1.73; =1.1.1.83 [H]

Molecular weight: Translated: 38180; Mature: 38180

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTYRIASIPGDGIGPEVIGAGLDVLDALARRDSGFALDVTAFDYGSDYYRRHGVMMPDG
CCCEEEECCCCCCCCHHHHHCCHHHHHHHHHCCCCCEEEEEEECCCCHHHHHCCCCCCCH
ALERLKAFDAIYFGAVGAPDIPDHVTLWGLRLAICQGFDQYANVRPTRVLRGLDSPLRAC
HHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCHHHHHCCCHHHHHHHCCCHHHHC
APADLDWVIVRENSEGEYAGQGGRSHRGHAEEVATEVAIFTRAGVARIMRFAFALAASRP
CCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RRHLTVVTKSNAQRHGMVLWDEVAAETARDFPEVTWDKMLVDAMTVRMVHAPASIDTVVA
CCEEEEEECCCCCCCCCEEHHHHHHHHHHHCCCHHHHHHHHHHHHHHHEECCCCCHHHHH
TNLHADILSDLAAALAGSIGIAPTANVNPERNYPSMFEPIHGSAFDITGKGIANPVGAFW
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCCCCCEEEECCCCCCCHHHHHH
TASQMLEHLGEADAARRLMAAVERVTAAGIRTRDLGGDATTAEVTAAVIDAIEGGNA
HHHHHHHHHCCHHHHHHHHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKTYRIASIPGDGIGPEVIGAGLDVLDALARRDSGFALDVTAFDYGSDYYRRHGVMMPDG
CCCEEEECCCCCCCCHHHHHCCHHHHHHHHHCCCCCEEEEEEECCCCHHHHHCCCCCCCH
ALERLKAFDAIYFGAVGAPDIPDHVTLWGLRLAICQGFDQYANVRPTRVLRGLDSPLRAC
HHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCHHHHHCCCHHHHHHHCCCHHHHC
APADLDWVIVRENSEGEYAGQGGRSHRGHAEEVATEVAIFTRAGVARIMRFAFALAASRP
CCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RRHLTVVTKSNAQRHGMVLWDEVAAETARDFPEVTWDKMLVDAMTVRMVHAPASIDTVVA
CCEEEEEECCCCCCCCCEEHHHHHHHHHHHCCCHHHHHHHHHHHHHHHEECCCCCHHHHH
TNLHADILSDLAAALAGSIGIAPTANVNPERNYPSMFEPIHGSAFDITGKGIANPVGAFW
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCCCCCEEEECCCCCCCHHHHHH
TASQMLEHLGEADAARRLMAAVERVTAAGIRTRDLGGDATTAEVTAAVIDAIEGGNA
HHHHHHHHHCCHHHHHHHHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7592429 [H]