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The map label for this gene is merR [H]

Identifier: 148242726

GI number: 148242726

Start: 1426634

End: 1427044

Strand: Direct

Name: merR [H]

Synonym: SynRCC307_1627

Alternate gene names: 148242726

Gene position: 1426634-1427044 (Clockwise)

Preceding gene: 148242722

Following gene: 148242727

Centisome position: 64.12

GC content: 55.23

Gene sequence:

>411_bases
GTGGAGAGTCAAGCCGTGGACGACTCCAGCGAATGCATCCGCATTGGCGCTGTGGCTCAGCAGGCTGGAATGAGCATTAA
AACGATTCGCTTCTACAGCGACGAGGGCCTTGTTCCCGTAGCTGGCCGAACCCAAGGGGGATACAGGCTTTATCACCAGC
ACGTGGTTGAGGAACTCCAGCTCATCCAAAACCTGAAAGGTCTCGGGCTTCCGCTAGGCACCATTCGCAGTTATTTGGCT
GCGAAACGCGAGGGGGCTTGCCACTGCGAGCAGCTGAAGCAATCCATGCGTGAACAGAAACAGGCCATTCATCAAAGAAT
TGCTGTTCTGCAGAACCTTCAGCAAGAACTCAGCGAAACAATGGAGGGCTGGGTGAACTGCGGCGGCCGTTTAGACGCCA
CACTGATGTGA

Upstream 100 bases:

>100_bases
TGCGCCGACGCTGGCACCACAGCGGCCAGCACAAGCAATGCCAACAGCAGCTTCGGCATCTTTTTTGCTGAGAATATTTA
TATGATCAGGTCTCCAGTAA

Downstream 100 bases:

>100_bases
GAACCGTTCTCGGTGACCTTGACTTCGACTCACAGCCATAGCCCTGTTCCTGTCACGATCCTGACGGGATTTCTAGGGGC
AGGTAAAACGACCCTCTTGA

Product: transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 136; Mature: 136

Protein sequence:

>136_residues
MESQAVDDSSECIRIGAVAQQAGMSIKTIRFYSDEGLVPVAGRTQGGYRLYHQHVVEELQLIQNLKGLGLPLGTIRSYLA
AKREGACHCEQLKQSMREQKQAIHQRIAVLQNLQQELSETMEGWVNCGGRLDATLM

Sequences:

>Translated_136_residues
MESQAVDDSSECIRIGAVAQQAGMSIKTIRFYSDEGLVPVAGRTQGGYRLYHQHVVEELQLIQNLKGLGLPLGTIRSYLA
AKREGACHCEQLKQSMREQKQAIHQRIAVLQNLQQELSETMEGWVNCGGRLDATLM
>Mature_136_residues
MESQAVDDSSECIRIGAVAQQAGMSIKTIRFYSDEGLVPVAGRTQGGYRLYHQHVVEELQLIQNLKGLGLPLGTIRSYLA
AKREGACHCEQLKQSMREQKQAIHQRIAVLQNLQQELSETMEGWVNCGGRLDATLM

Specific function: Mediates the mercuric-dependent induction of mercury resistance operon. In the absence of mercury merR represses transcription by binding tightly to the mer operator region; when mercury is present the dimeric complex binds a single ion and becomes a pote

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789687, Length=105, Percent_Identity=34.2857142857143, Blast_Score=65, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 15129; Mature: 15129

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESQAVDDSSECIRIGAVAQQAGMSIKTIRFYSDEGLVPVAGRTQGGYRLYHQHVVEELQ
CCCCCCCCHHHHHHHHHHHHHHCCEEEEEEEECCCCCEECCCCCCCCHHHHHHHHHHHHH
LIQNLKGLGLPLGTIRSYLAAKREGACHCEQLKQSMREQKQAIHQRIAVLQNLQQELSET
HHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MEGWVNCGGRLDATLM
HHHHHCCCCCCCCCCC
>Mature Secondary Structure
MESQAVDDSSECIRIGAVAQQAGMSIKTIRFYSDEGLVPVAGRTQGGYRLYHQHVVEELQ
CCCCCCCCHHHHHHHHHHHHHHCCEEEEEEEECCCCCEECCCCCCCCHHHHHHHHHHHHH
LIQNLKGLGLPLGTIRSYLAAKREGACHCEQLKQSMREQKQAIHQRIAVLQNLQQELSET
HHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MEGWVNCGGRLDATLM
HHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1400173 [H]