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The map label for this gene is sir [H]

Identifier: 148242368

GI number: 148242368

Start: 1125189

End: 1126925

Strand: Direct

Name: sir [H]

Synonym: SynRCC307_1269

Alternate gene names: 148242368

Gene position: 1125189-1126925 (Clockwise)

Preceding gene: 148242366

Following gene: 148242384

Centisome position: 50.57

GC content: 60.39

Gene sequence:

>1737_bases
GTGACGATTGCGCCCGAAGGGAAGAAAACGACTGAGCGCAGCAAGTTCGAACAGCTCAAGGTCAATAGCGCCTACTTGCG
CGAGCCTCTGGCCACGGAGCTGGAAAACGATCTGCCGTATTTCACCGACGATGCGGTTCAGATCCTGAAGTTTCACGGCA
GCTATCAACAGGACAACCGCGACAACAGGCGCAAAGGCGAGTCCAAGGATTGGGGAATGATGCTGCGCCTGCGCAGCCCG
GGAGGACGGATCCCAGCCCAGCTCTACTTAGCGCTCGACGATCTCTCCAATCAATACGGCAACGGCAGCATCCGGGCCAC
GACGCGCCAAGCCTTCCAACTCCACGGCATCCCCAAAGACGATCTACGCACCGTGGTGGGCACCATCGTGCGCAACATGG
GCTCCACCCTGGCGGCCTGCGGTGACATCAACCGCAACGTGATGGCACCGGCGGCGCCCTTCCAGCAGCACGGCTACCCC
GTGGCCCGGCGGCTGGCTGATGACATTGCCGATCTGCTGGCACCCAAAGCCGCTGCAGGGGTCTATCTCGAGCTCTGGGT
GGATGGCGAGAAGCGCTACAAAATTCGCCCCTCCGTGCTGGCGAGCCGCATCAAAAAACAACAGCAACACGGTGAGGTAT
TCAGCGGCGACAGCGATGAGCCGCTTTACGGCGACACGTTCATGCCACGCAAATTCAAGGTGGCTGTCACGGTCCCGGGC
GATAACTCCGTCGATCTGCTCACCCAAGACGTGGGCCTGGTGGCCTTCACCGATATGGGTGGTCGGCTTCGGGGCTGCAA
CGTCTATGTCGGTGGCGGCATGGGGCGCACCCACAACAAAGAAGAAACCTTCGCCCGCACGGCTGATTGCCTCGGCTACA
TCAAAGGCACCGACGTGCTGCCGTTGGTTCAAGCCGTGGTGGCCCTGCAGCGCGACCATGGCGACCGCAAGGTGCGGCGT
CATTCCCGCATGAAATATCTCTTGCACGACAAAGGAATTGAGTGGTTCAGCAAGGAGATCAGCCGTTATTTCAGCGGTGA
GATCAAGCCAGCCCGCACCGAACAAAAGCCCGAGCTGCTGGATTACCTCGGCTGGCACCAGCAGGGTGATGGGCTGTGGT
TTGTGGGCCTGCCCTTGCTCTGCGGGCGCCTCGAAGGCGATCTCAAAGGGCAGATGCGCCAGCTGGTTGAGACCTACAAA
CCCGAGATCCGCCTCACACCCAATCAGGACCTGTTGCTCTGCAACATCGCCAAAAACCAAAAGCAAGAGATCACAGAACA
GCTCGATGCCATGGGCTGGGCCGATCCATCGCATACCTCCCTGCTCAGCCGCCACGCCATCGCTTGCCCGGCGCTGCCCA
CCTGCGGGTTAGCGGTGACTGAATCGGAGCGCATCTTTCCCCATGTTTTGGGGCGCCTGGAAACGCTGTTGGAAGAACTC
AAGATCGACTCACCGATCCTTGTGCGTATGACCGGCTGCCCCAACGGCTGCGCCCGTCCCTACATGGCTGAACTCGCCAT
GGTGGGAAGTGGGGTTGAGCAATACCAGCTCTGGCTCGGCGGCAGTCCTGGATTAACCCGTTTGGCACGGCCAGTGCTGC
AAAAAATGCCGCTGGCTGAGATGGAATCGACCCTGCGCCCGCTGTTGAAGCAGTGGCAGGAGCAGGCTCCCACGCAAAGC
TTTGGCGACTACTGCCATTCACTCGGCGATCAACTTGAGGCGACGCTTCAAGCCTGA

Upstream 100 bases:

>100_bases
GCCACAGAAGCTTTACGAGCAGGTTGTGACTTTATGAATCCGCCGAACCCCTCCATTGCCTAGGGTCGAAGCATCTCTGT
CCGCCGCTGCTGCATCAATC

Downstream 100 bases:

>100_bases
GCACTGCGGCCGTAATGGGCGCAAGGGGCCTCGCTGCTCCAAGCCCAGAGCTGATCGCCCCAGCTGAAATGCCACCACTC
CGTGGGGTGCCTAACGAATC

Product: sulfite reductase subunit beta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 578; Mature: 577

Protein sequence:

>578_residues
MTIAPEGKKTTERSKFEQLKVNSAYLREPLATELENDLPYFTDDAVQILKFHGSYQQDNRDNRRKGESKDWGMMLRLRSP
GGRIPAQLYLALDDLSNQYGNGSIRATTRQAFQLHGIPKDDLRTVVGTIVRNMGSTLAACGDINRNVMAPAAPFQQHGYP
VARRLADDIADLLAPKAAAGVYLELWVDGEKRYKIRPSVLASRIKKQQQHGEVFSGDSDEPLYGDTFMPRKFKVAVTVPG
DNSVDLLTQDVGLVAFTDMGGRLRGCNVYVGGGMGRTHNKEETFARTADCLGYIKGTDVLPLVQAVVALQRDHGDRKVRR
HSRMKYLLHDKGIEWFSKEISRYFSGEIKPARTEQKPELLDYLGWHQQGDGLWFVGLPLLCGRLEGDLKGQMRQLVETYK
PEIRLTPNQDLLLCNIAKNQKQEITEQLDAMGWADPSHTSLLSRHAIACPALPTCGLAVTESERIFPHVLGRLETLLEEL
KIDSPILVRMTGCPNGCARPYMAELAMVGSGVEQYQLWLGGSPGLTRLARPVLQKMPLAEMESTLRPLLKQWQEQAPTQS
FGDYCHSLGDQLEATLQA

Sequences:

>Translated_578_residues
MTIAPEGKKTTERSKFEQLKVNSAYLREPLATELENDLPYFTDDAVQILKFHGSYQQDNRDNRRKGESKDWGMMLRLRSP
GGRIPAQLYLALDDLSNQYGNGSIRATTRQAFQLHGIPKDDLRTVVGTIVRNMGSTLAACGDINRNVMAPAAPFQQHGYP
VARRLADDIADLLAPKAAAGVYLELWVDGEKRYKIRPSVLASRIKKQQQHGEVFSGDSDEPLYGDTFMPRKFKVAVTVPG
DNSVDLLTQDVGLVAFTDMGGRLRGCNVYVGGGMGRTHNKEETFARTADCLGYIKGTDVLPLVQAVVALQRDHGDRKVRR
HSRMKYLLHDKGIEWFSKEISRYFSGEIKPARTEQKPELLDYLGWHQQGDGLWFVGLPLLCGRLEGDLKGQMRQLVETYK
PEIRLTPNQDLLLCNIAKNQKQEITEQLDAMGWADPSHTSLLSRHAIACPALPTCGLAVTESERIFPHVLGRLETLLEEL
KIDSPILVRMTGCPNGCARPYMAELAMVGSGVEQYQLWLGGSPGLTRLARPVLQKMPLAEMESTLRPLLKQWQEQAPTQS
FGDYCHSLGDQLEATLQA
>Mature_577_residues
TIAPEGKKTTERSKFEQLKVNSAYLREPLATELENDLPYFTDDAVQILKFHGSYQQDNRDNRRKGESKDWGMMLRLRSPG
GRIPAQLYLALDDLSNQYGNGSIRATTRQAFQLHGIPKDDLRTVVGTIVRNMGSTLAACGDINRNVMAPAAPFQQHGYPV
ARRLADDIADLLAPKAAAGVYLELWVDGEKRYKIRPSVLASRIKKQQQHGEVFSGDSDEPLYGDTFMPRKFKVAVTVPGD
NSVDLLTQDVGLVAFTDMGGRLRGCNVYVGGGMGRTHNKEETFARTADCLGYIKGTDVLPLVQAVVALQRDHGDRKVRRH
SRMKYLLHDKGIEWFSKEISRYFSGEIKPARTEQKPELLDYLGWHQQGDGLWFVGLPLLCGRLEGDLKGQMRQLVETYKP
EIRLTPNQDLLLCNIAKNQKQEITEQLDAMGWADPSHTSLLSRHAIACPALPTCGLAVTESERIFPHVLGRLETLLEELK
IDSPILVRMTGCPNGCARPYMAELAMVGSGVEQYQLWLGGSPGLTRLARPVLQKMPLAEMESTLRPLLKQWQEQAPTQSF
GDYCHSLGDQLEATLQA

Specific function: This Enzyme Catalyzes The 6-Electron Reduction Of Sulfite To Sulfide. This Is One Of Several Activities Required For The Biosynthesis Of L-Cysteine From Sulfate. [C]

COG id: COG0155

COG function: function code P; Sulfite reductase, beta subunit (hemoprotein)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nitrite and sulfite reductase 4Fe-4S domain family [H]

Homologues:

Organism=Escherichia coli, GI1789122, Length=565, Percent_Identity=32.3893805309734, Blast_Score=295, Evalue=7e-81,
Organism=Saccharomyces cerevisiae, GI6322597, Length=576, Percent_Identity=37.8472222222222, Blast_Score=361, Evalue=1e-100,

Paralogues:

None

Copy number: 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005117
- InterPro:   IPR006067
- InterPro:   IPR006066
- InterPro:   IPR011787 [H]

Pfam domain/function: PF01077 NIR_SIR; PF03460 NIR_SIR_ferr [H]

EC number: =1.8.7.1 [H]

Molecular weight: Translated: 64560; Mature: 64429

Theoretical pI: Translated: 7.74; Mature: 7.74

Prosite motif: PS00365 NIR_SIR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIAPEGKKTTERSKFEQLKVNSAYLREPLATELENDLPYFTDDAVQILKFHGSYQQDNR
CCCCCCCCCCHHHHHHHHHCCCHHHHHCHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCC
DNRRKGESKDWGMMLRLRSPGGRIPAQLYLALDDLSNQYGNGSIRATTRQAFQLHGIPKD
CHHHCCCCCCCEEEEEECCCCCCCCHHHEEEHHHHHCCCCCCCEEEHHHHHHHCCCCCHH
DLRTVVGTIVRNMGSTLAACGDINRNVMAPAAPFQQHGYPVARRLADDIADLLAPKAAAG
HHHHHHHHHHHHHCHHHHHHCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHCCHHHCC
VYLELWVDGEKRYKIRPSVLASRIKKQQQHGEVFSGDSDEPLYGDTFMPRKFKVAVTVPG
EEEEEEECCCCCEEECHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEECCC
DNSVDLLTQDVGLVAFTDMGGRLRGCNVYVGGGMGRTHNKEETFARTADCLGYIKGTDVL
CCCHHHHECCCCEEEEECCCCEEECCEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCHH
PLVQAVVALQRDHGDRKVRRHSRMKYLLHDKGIEWFSKEISRYFSGEIKPARTEQKPELL
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCHHHH
DYLGWHQQGDGLWFVGLPLLCGRLEGDLKGQMRQLVETYKPEIRLTPNQDLLLCNIAKNQ
HHHCCCCCCCCEEEECHHHHHHHCCCHHHHHHHHHHHHHCCCEEECCCCCEEEEECCCCH
KQEITEQLDAMGWADPSHTSLLSRHAIACPALPTCGLAVTESERIFPHVLGRLETLLEEL
HHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHH
KIDSPILVRMTGCPNGCARPYMAELAMVGSGVEQYQLWLGGSPGLTRLARPVLQKMPLAE
CCCCCEEEEECCCCCCCCCHHHHHHHHHHCCHHHEEEEECCCCCHHHHHHHHHHHCCHHH
MESTLRPLLKQWQEQAPTQSFGDYCHSLGDQLEATLQA
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TIAPEGKKTTERSKFEQLKVNSAYLREPLATELENDLPYFTDDAVQILKFHGSYQQDNR
CCCCCCCCCHHHHHHHHHCCCHHHHHCHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCC
DNRRKGESKDWGMMLRLRSPGGRIPAQLYLALDDLSNQYGNGSIRATTRQAFQLHGIPKD
CHHHCCCCCCCEEEEEECCCCCCCCHHHEEEHHHHHCCCCCCCEEEHHHHHHHCCCCCHH
DLRTVVGTIVRNMGSTLAACGDINRNVMAPAAPFQQHGYPVARRLADDIADLLAPKAAAG
HHHHHHHHHHHHHCHHHHHHCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHCCHHHCC
VYLELWVDGEKRYKIRPSVLASRIKKQQQHGEVFSGDSDEPLYGDTFMPRKFKVAVTVPG
EEEEEEECCCCCEEECHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEECCC
DNSVDLLTQDVGLVAFTDMGGRLRGCNVYVGGGMGRTHNKEETFARTADCLGYIKGTDVL
CCCHHHHECCCCEEEEECCCCEEECCEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCHH
PLVQAVVALQRDHGDRKVRRHSRMKYLLHDKGIEWFSKEISRYFSGEIKPARTEQKPELL
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCHHHH
DYLGWHQQGDGLWFVGLPLLCGRLEGDLKGQMRQLVETYKPEIRLTPNQDLLLCNIAKNQ
HHHCCCCCCCCEEEECHHHHHHHCCCHHHHHHHHHHHHHCCCEEECCCCCEEEEECCCCH
KQEITEQLDAMGWADPSHTSLLSRHAIACPALPTCGLAVTESERIFPHVLGRLETLLEEL
HHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHH
KIDSPILVRMTGCPNGCARPYMAELAMVGSGVEQYQLWLGGSPGLTRLARPVLQKMPLAE
CCCCCEEEEECCCCCCCCCHHHHHHHHHHCCHHHEEEEECCCCCHHHHHHHHHHHCCHHH
MESTLRPLLKQWQEQAPTQSFGDYCHSLGDQLEATLQA
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8347657 [H]