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The map label for this gene is pepQ [H]

Identifier: 146342486

GI number: 146342486

Start: 5833921

End: 5835744

Strand: Direct

Name: pepQ [H]

Synonym: BRADO5647

Alternate gene names: 146342486

Gene position: 5833921-5835744 (Clockwise)

Preceding gene: 146342484

Following gene: 146342487

Centisome position: 78.24

GC content: 68.42

Gene sequence:

>1824_bases
ATGTTCGAAGCCCTGTTCCAGACGTTCGAAGAACCCGAAACCGGTGTCGCGCTGACGGCACGACTCGCCGCGCTCCGCGA
GGAGCTGGCGCGGCGCCAGCTCACCGGCTTCATCGTGCCGCGCGCGGACCAGCAGCAGAACGAGTATGTGCCGCCGTCCG
AGGAGAGGCTGGCGTGGCTGACCGGGTTCACCGGCTCGGCCGGTCTCGCGATCGTTCTGCTGCACGAGGCCGCGATCTTC
GTCGACGGCCGCTACACATTGCAGGCGGGCAAGCAGGTCGATGGGAAGGCCTGGGCCGTGGAATCGCTGATCGAGCCGCC
GCCCGAAAGCTGGCTGACGGGGCATCTGCAGCGCGGCGACCGTATCGGCTTCGATCCCTGGCTGCAGACGACGGCCGCTG
CCGAACGCTTCGCGGCGGCCTGCGCCAAGGCAGGTGCCGAGCTGGTGCCAGTGGAGACCAATCCGGTCGACAGCATCTGG
ACCGAGCGCCCTCAGCCGCCGCTCGGCGCGGTCTCGATCCATGGCGCGGAATTGTCCGGCGAGGTCGAGGCCGAGAAGCT
CGAACGCATCCGCCGGGAGATCGAGAGGCTCGGCGTCGAGGCGCTGGTGCTGTCCGATTCCCACAATGTGGCCTGGACGT
TCAACATCCGTGGCGCCGACGTGTCGCACACGCCGCTGCCGATCTCCTACGCCTTGGTGCCAAAGACCGGACGGCCGACG
ATCTTCATCGATTCCCGCAAGCTCTCGAACCTGACACGCGATCACCTCGAGCAGAGCGCTGACGTGGCGGAGCCGGACGC
GATGGCGCCGCGCCTGACGGAGCTCGCGCGGTCGGGCGCAGCCATCGCGCTCGACAGCGCCACCGCGGCGGACGCGCTGA
CGCGGCTGATCCAGGGCGCGGGCGGCAAGCCGGTGCGTGGTGCCGATCCCGTGAGCCTGCTCAAGGCCGCGAAAAATGCG
GTCGAGATCGAGGGCACGCGACGCGCACACCGGCGCGACGCCGTCGCCCTGGCGCGCTTTCTCGCCTTCATCGATCGCGA
GGCGCCGAAGGGGACATTGACCGAGATCGACGCCGTCGAGGCGCTGGAGAGCTTTCGCCGCGACACCGGCGCGCTGAAGG
ACGTGTCGTTTCCGACCATCTCCGGGACCGGCCCGAACGGTGCCATCGTGCATTATCGCGTCACTCGCAAGAGCAACCGG
CGCATCATGACCGGCGATCTGCTGCTGATCGATTCCGGCGCGCAATACCAGGACGGTACGACCGACGTCACGCGCACCAT
CGCGGTGGGCGCGCCGACCACGGAGATGCGCGACCGCTTCACGCGCGTGCTGCGCGGCCATCTGGCGATCGCGCGCGCGC
TGTTTCCCGACGGCACCACCGGCGCCCAGCTCGACACCTTGGCACGGCAGTTCCTGTGGCAGGCCGGGATCGACTTCGAG
CACGGCACCGGACATGGCGTCGGCAGCTATCTGTCGGTGCACGAAGGACCGGCGCGGATTTCCAAGCTCGGCACGACGCC
GCTGAAGCGCGGCATGATCCTGTCCAACGAGCCCGGCTACTACAAGACCGATGCCTTCGGCATCCGCATCGAGAATCTCG
AGCTGGTCGTGGCGAAGGACATTGCGGGCGGGGAGAAGCCGATGAACGGCTTCGAGGCGCTGACGCTCGCGCCGATCGAT
CGCCGGCTGATCGACGTGGCGATGCTGAGCAGCGAGGAGCGCAGCTGGCTCGACGTCTATCACGCCCGCGTCAGGGAGGC
CGTGCACGCGGCCCTCAACGAGCCCGACCAGCTGTGGCTCGATCAGGCGACAGCGCCACTCTGA

Upstream 100 bases:

>100_bases
CTTTTTGCACAGGCGAATGCAAGGAGATTCTTCGTGCACCGCACGCCCAACTGGATGAGTATCGATCGCGGTGAAGATCC
ACGCCCAAAGTATGAGACCG

Downstream 100 bases:

>100_bases
CCATGAAGCCGTAGGGTGGGCAAAGCGGCCGCCGCAGGCGGCAGCGTGCCCACCGCGTCTCAGTGCGTTCATCCGCGCAG
CGGTGGGCACGGCGCGCGAT

Product: putative aminopeptidase P

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 607; Mature: 607

Protein sequence:

>607_residues
MFEALFQTFEEPETGVALTARLAALREELARRQLTGFIVPRADQQQNEYVPPSEERLAWLTGFTGSAGLAIVLLHEAAIF
VDGRYTLQAGKQVDGKAWAVESLIEPPPESWLTGHLQRGDRIGFDPWLQTTAAAERFAAACAKAGAELVPVETNPVDSIW
TERPQPPLGAVSIHGAELSGEVEAEKLERIRREIERLGVEALVLSDSHNVAWTFNIRGADVSHTPLPISYALVPKTGRPT
IFIDSRKLSNLTRDHLEQSADVAEPDAMAPRLTELARSGAAIALDSATAADALTRLIQGAGGKPVRGADPVSLLKAAKNA
VEIEGTRRAHRRDAVALARFLAFIDREAPKGTLTEIDAVEALESFRRDTGALKDVSFPTISGTGPNGAIVHYRVTRKSNR
RIMTGDLLLIDSGAQYQDGTTDVTRTIAVGAPTTEMRDRFTRVLRGHLAIARALFPDGTTGAQLDTLARQFLWQAGIDFE
HGTGHGVGSYLSVHEGPARISKLGTTPLKRGMILSNEPGYYKTDAFGIRIENLELVVAKDIAGGEKPMNGFEALTLAPID
RRLIDVAMLSSEERSWLDVYHARVREAVHAALNEPDQLWLDQATAPL

Sequences:

>Translated_607_residues
MFEALFQTFEEPETGVALTARLAALREELARRQLTGFIVPRADQQQNEYVPPSEERLAWLTGFTGSAGLAIVLLHEAAIF
VDGRYTLQAGKQVDGKAWAVESLIEPPPESWLTGHLQRGDRIGFDPWLQTTAAAERFAAACAKAGAELVPVETNPVDSIW
TERPQPPLGAVSIHGAELSGEVEAEKLERIRREIERLGVEALVLSDSHNVAWTFNIRGADVSHTPLPISYALVPKTGRPT
IFIDSRKLSNLTRDHLEQSADVAEPDAMAPRLTELARSGAAIALDSATAADALTRLIQGAGGKPVRGADPVSLLKAAKNA
VEIEGTRRAHRRDAVALARFLAFIDREAPKGTLTEIDAVEALESFRRDTGALKDVSFPTISGTGPNGAIVHYRVTRKSNR
RIMTGDLLLIDSGAQYQDGTTDVTRTIAVGAPTTEMRDRFTRVLRGHLAIARALFPDGTTGAQLDTLARQFLWQAGIDFE
HGTGHGVGSYLSVHEGPARISKLGTTPLKRGMILSNEPGYYKTDAFGIRIENLELVVAKDIAGGEKPMNGFEALTLAPID
RRLIDVAMLSSEERSWLDVYHARVREAVHAALNEPDQLWLDQATAPL
>Mature_607_residues
MFEALFQTFEEPETGVALTARLAALREELARRQLTGFIVPRADQQQNEYVPPSEERLAWLTGFTGSAGLAIVLLHEAAIF
VDGRYTLQAGKQVDGKAWAVESLIEPPPESWLTGHLQRGDRIGFDPWLQTTAAAERFAAACAKAGAELVPVETNPVDSIW
TERPQPPLGAVSIHGAELSGEVEAEKLERIRREIERLGVEALVLSDSHNVAWTFNIRGADVSHTPLPISYALVPKTGRPT
IFIDSRKLSNLTRDHLEQSADVAEPDAMAPRLTELARSGAAIALDSATAADALTRLIQGAGGKPVRGADPVSLLKAAKNA
VEIEGTRRAHRRDAVALARFLAFIDREAPKGTLTEIDAVEALESFRRDTGALKDVSFPTISGTGPNGAIVHYRVTRKSNR
RIMTGDLLLIDSGAQYQDGTTDVTRTIAVGAPTTEMRDRFTRVLRGHLAIARALFPDGTTGAQLDTLARQFLWQAGIDFE
HGTGHGVGSYLSVHEGPARISKLGTTPLKRGMILSNEPGYYKTDAFGIRIENLELVVAKDIAGGEKPMNGFEALTLAPID
RRLIDVAMLSSEERSWLDVYHARVREAVHAALNEPDQLWLDQATAPL

Specific function: Splits dipeptides with a prolyl in the C-terminal position and a nonpolar amino acid at the N-terminal position [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Archaeal-type prolidase subfamily [H]

Homologues:

Organism=Homo sapiens, GI264681563, Length=613, Percent_Identity=39.6411092985318, Blast_Score=424, Evalue=1e-118,
Organism=Homo sapiens, GI264681565, Length=613, Percent_Identity=38.0097879282219, Blast_Score=391, Evalue=1e-109,
Organism=Homo sapiens, GI93141226, Length=612, Percent_Identity=34.8039215686275, Blast_Score=369, Evalue=1e-102,
Organism=Escherichia coli, GI1788728, Length=234, Percent_Identity=34.1880341880342, Blast_Score=96, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17509539, Length=599, Percent_Identity=35.0584307178631, Blast_Score=347, Evalue=7e-96,
Organism=Caenorhabditis elegans, GI25149105, Length=626, Percent_Identity=29.2332268370607, Blast_Score=272, Evalue=3e-73,
Organism=Saccharomyces cerevisiae, GI6322999, Length=655, Percent_Identity=32.5190839694656, Blast_Score=317, Evalue=3e-87,
Organism=Drosophila melanogaster, GI17137632, Length=612, Percent_Identity=34.8039215686275, Blast_Score=334, Evalue=1e-91,
Organism=Drosophila melanogaster, GI161078230, Length=590, Percent_Identity=31.3559322033898, Blast_Score=279, Evalue=4e-75,
Organism=Drosophila melanogaster, GI21357287, Length=590, Percent_Identity=31.3559322033898, Blast_Score=279, Evalue=4e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 65999; Mature: 65999

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFEALFQTFEEPETGVALTARLAALREELARRQLTGFIVPRADQQQNEYVPPSEERLAWL
CHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCHHHEEEE
TGFTGSAGLAIVLLHEAAIFVDGRYTLQAGKQVDGKAWAVESLIEPPPESWLTGHLQRGD
ECCCCCCCEEEEEEEEEEEEECCEEEEECCCCCCCHHHHHHHHCCCCCHHHHHHHHCCCC
RIGFDPWLQTTAAAERFAAACAKAGAELVPVETNPVDSIWTERPQPPLGAVSIHGAELSG
CCCCCHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHCCCCCCCCCEEEEECCCCCC
EVEAEKLERIRREIERLGVEALVLSDSHNVAWTFNIRGADVSHTPLPISYALVPKTGRPT
CCCHHHHHHHHHHHHHCCCEEEEEECCCCEEEEEEECCCCCCCCCCCEEEEEECCCCCCE
IFIDSRKLSNLTRDHLEQSADVAEPDAMAPRLTELARSGAAIALDSATAADALTRLIQGA
EEECCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCEEEECCHHHHHHHHHHHHCC
GGKPVRGADPVSLLKAAKNAVEIEGTRRAHRRDAVALARFLAFIDREAPKGTLTEIDAVE
CCCCCCCCCHHHHHHHHHHCEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
ALESFRRDTGALKDVSFPTISGTGPNGAIVHYRVTRKSNRRIMTGDLLLIDSGAQYQDGT
HHHHHHHHCCCCCCCCCCEECCCCCCCCEEEEEEECCCCCEEEECCEEEEECCCCCCCCC
TDVTRTIAVGAPTTEMRDRFTRVLRGHLAIARALFPDGTTGAQLDTLARQFLWQAGIDFE
CHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCC
HGTGHGVGSYLSVHEGPARISKLGTTPLKRGMILSNEPGYYKTDAFGIRIENLELVVAKD
CCCCCCCCCCEEECCCHHHHHHCCCCHHHCCEEECCCCCCEECCEEEEEEECEEEEEEEC
IAGGEKPMNGFEALTLAPIDRRLIDVAMLSSEERSWLDVYHARVREAVHAALNEPDQLWL
CCCCCCCCCCCCEEEECHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHH
DQATAPL
HHCCCCC
>Mature Secondary Structure
MFEALFQTFEEPETGVALTARLAALREELARRQLTGFIVPRADQQQNEYVPPSEERLAWL
CHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCHHHEEEE
TGFTGSAGLAIVLLHEAAIFVDGRYTLQAGKQVDGKAWAVESLIEPPPESWLTGHLQRGD
ECCCCCCCEEEEEEEEEEEEECCEEEEECCCCCCCHHHHHHHHCCCCCHHHHHHHHCCCC
RIGFDPWLQTTAAAERFAAACAKAGAELVPVETNPVDSIWTERPQPPLGAVSIHGAELSG
CCCCCHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHCCCCCCCCCEEEEECCCCCC
EVEAEKLERIRREIERLGVEALVLSDSHNVAWTFNIRGADVSHTPLPISYALVPKTGRPT
CCCHHHHHHHHHHHHHCCCEEEEEECCCCEEEEEEECCCCCCCCCCCEEEEEECCCCCCE
IFIDSRKLSNLTRDHLEQSADVAEPDAMAPRLTELARSGAAIALDSATAADALTRLIQGA
EEECCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCEEEECCHHHHHHHHHHHHCC
GGKPVRGADPVSLLKAAKNAVEIEGTRRAHRRDAVALARFLAFIDREAPKGTLTEIDAVE
CCCCCCCCCHHHHHHHHHHCEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
ALESFRRDTGALKDVSFPTISGTGPNGAIVHYRVTRKSNRRIMTGDLLLIDSGAQYQDGT
HHHHHHHHCCCCCCCCCCEECCCCCCCCEEEEEEECCCCCEEEECCEEEEECCCCCCCCC
TDVTRTIAVGAPTTEMRDRFTRVLRGHLAIARALFPDGTTGAQLDTLARQFLWQAGIDFE
CHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCC
HGTGHGVGSYLSVHEGPARISKLGTTPLKRGMILSNEPGYYKTDAFGIRIENLELVVAKD
CCCCCCCCCCEEECCCHHHHHHCCCCHHHCCEEECCCCCCEECCEEEEEEECEEEEEEEC
IAGGEKPMNGFEALTLAPIDRRLIDVAMLSSEERSWLDVYHARVREAVHAALNEPDQLWL
CCCCCCCCCCCCEEEECHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHH
DQATAPL
HHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]