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The map label for this gene is iorA [H]

Identifier: 146342333

GI number: 146342333

Start: 5670036

End: 5670488

Strand: Direct

Name: iorA [H]

Synonym: BRADO5488

Alternate gene names: 146342333

Gene position: 5670036-5670488 (Clockwise)

Preceding gene: 146342332

Following gene: 146342334

Centisome position: 76.04

GC content: 64.46

Gene sequence:

>453_bases
ATGATCAAGGTGAAAATCAACGGACAGGAGCAGAGCTGGGATGGCGATCCGAGCCTGCCGCTGTTGTGGTATCTGCGCGA
TGAACTGGGGCTCACCGGCTCGAAATATGGCTGCGGCCAGGCGTTGTGCGGCGCCTGCACCGTCATGGTCGACAAGGAGG
CCGCGCGCTCCTGCATCACGGCGATCTCGGATGTCGCGGGTCGTGAGGTCACGACCATCGAGGGCCTGCATCCGACCGGC
GACCACCCGGTGCAGAAGGCGTGGCGGCAGGTCAACGTGCCGCAATGCGGCTTCTGCCAGGCCGGGCAGATCATGCAGGC
GGCCGCGCTGCTGAACGAAAATCCCAAGCCGTCGCATGACCAGATCCGGGACGCGATGTCCGGCAATATCTGCCGCTGCG
GCTGCTATCAGCGCATCGAGAATGCGGTCCATCTGGCCTCGACGGGGGTGTGA

Upstream 100 bases:

>100_bases
TCTCAATTGATCCGGCGCGTGCATCCGGGACTTGTGGTCCCGCGCGCGTCCACCAGCGATCAGAACCAACGACCATTGGT
CCGACAGAGCGAGGGCGATC

Downstream 100 bases:

>100_bases
TCATGACCATCATCGCAAATCCGGACATCGCGAGTTCCAACTCGCGCCGCGGCTTCGAGCGGCATCTCAAGGTCGAGAAC
GTCTCGCGCCGCGCCATCTT

Product: isoquinoline 1-oxidoreductase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 150; Mature: 150

Protein sequence:

>150_residues
MIKVKINGQEQSWDGDPSLPLLWYLRDELGLTGSKYGCGQALCGACTVMVDKEAARSCITAISDVAGREVTTIEGLHPTG
DHPVQKAWRQVNVPQCGFCQAGQIMQAAALLNENPKPSHDQIRDAMSGNICRCGCYQRIENAVHLASTGV

Sequences:

>Translated_150_residues
MIKVKINGQEQSWDGDPSLPLLWYLRDELGLTGSKYGCGQALCGACTVMVDKEAARSCITAISDVAGREVTTIEGLHPTG
DHPVQKAWRQVNVPQCGFCQAGQIMQAAALLNENPKPSHDQIRDAMSGNICRCGCYQRIENAVHLASTGV
>Mature_150_residues
MIKVKINGQEQSWDGDPSLPLLWYLRDELGLTGSKYGCGQALCGACTVMVDKEAARSCITAISDVAGREVTTIEGLHPTG
DHPVQKAWRQVNVPQCGFCQAGQIMQAAALLNENPKPSHDQIRDAMSGNICRCGCYQRIENAVHLASTGV

Specific function: Specific towards N-containing N-heterocyclic substrates, including isoquinoline, isoquinolin-5-ol, phthalazine and quinazoline [H]

COG id: COG2080

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 2Fe-2S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=147, Percent_Identity=39.4557823129252, Blast_Score=87, Evalue=6e-18,
Organism=Homo sapiens, GI71773480, Length=139, Percent_Identity=43.1654676258993, Blast_Score=81, Evalue=3e-16,
Organism=Escherichia coli, GI1786480, Length=162, Percent_Identity=38.8888888888889, Blast_Score=111, Evalue=2e-26,
Organism=Escherichia coli, GI1789232, Length=145, Percent_Identity=40, Blast_Score=91, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17540638, Length=151, Percent_Identity=39.0728476821192, Blast_Score=110, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17539860, Length=151, Percent_Identity=35.7615894039735, Blast_Score=103, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI32566215, Length=159, Percent_Identity=34.5911949685535, Blast_Score=100, Evalue=2e-22,
Organism=Drosophila melanogaster, GI17737937, Length=147, Percent_Identity=38.0952380952381, Blast_Score=96, Evalue=9e-21,
Organism=Drosophila melanogaster, GI24647197, Length=158, Percent_Identity=36.7088607594937, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24647195, Length=158, Percent_Identity=36.7088607594937, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24647199, Length=134, Percent_Identity=35.0746268656716, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24647201, Length=148, Percent_Identity=33.1081081081081, Blast_Score=80, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24647193, Length=157, Percent_Identity=32.484076433121, Blast_Score=77, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002888
- InterPro:   IPR006058
- InterPro:   IPR012675
- InterPro:   IPR001041 [H]

Pfam domain/function: PF00111 Fer2; PF01799 Fer2_2 [H]

EC number: =1.3.99.16 [H]

Molecular weight: Translated: 16186; Mature: 16186

Theoretical pI: Translated: 6.48; Mature: 6.48

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

6.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
8.7 %Cys+Met (Translated Protein)
6.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
8.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKVKINGQEQSWDGDPSLPLLWYLRDELGLTGSKYGCGQALCGACTVMVDKEAARSCIT
CEEEEECCCCCCCCCCCCCCEEEEEHHHHCCCCCCCCCHHHHHHHHHHEECHHHHHHHHH
AISDVAGREVTTIEGLHPTGDHPVQKAWRQVNVPQCGFCQAGQIMQAAALLNENPKPSHD
HHHHHCCCCEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCHH
QIRDAMSGNICRCGCYQRIENAVHLASTGV
HHHHHHCCCEEEHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIKVKINGQEQSWDGDPSLPLLWYLRDELGLTGSKYGCGQALCGACTVMVDKEAARSCIT
CEEEEECCCCCCCCCCCCCCEEEEEHHHHCCCCCCCCCHHHHHHHHHHEECHHHHHHHHH
AISDVAGREVTTIEGLHPTGDHPVQKAWRQVNVPQCGFCQAGQIMQAAALLNENPKPSHD
HHHHHCCCCEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCHH
QIRDAMSGNICRCGCYQRIENAVHLASTGV
HHHHHHCCCEEEHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7782304; 8157655 [H]