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The map label for this gene is czcD [H]

Identifier: 146341363

GI number: 146341363

Start: 4648472

End: 4649446

Strand: Reverse

Name: czcD [H]

Synonym: BRADO4447

Alternate gene names: 146341363

Gene position: 4649446-4648472 (Counterclockwise)

Preceding gene: 146341364

Following gene: 146341360

Centisome position: 62.35

GC content: 68.31

Gene sequence:

>975_bases
ATGGCGCAGTCGCATTCCGATCACGACGACCACGACCATGATCATTCCCGCGATCACGCCCACGCGCATTCTCATTCCCA
CTCCCACGCCGGCCACAGCCACGCGCCCACGAGCTTCGGCGCGGCCTTCGCGATCGGCGTTGCGCTGAACACGGCCTTTG
TCATCGCCGAGCTGATCTTCGGCTATGCCGCGAACTCGCTGGCGCTGATCTCCGACGCGATCCACAATCTCTCCGACGTG
ATGTCGCTGCTGCTGGCCTGGGGCGCGCTGTGGCTGTCCGGGCGGCGGCCGACCGACCGCCACACCTACGGCTATCGCCG
CGCGTCCATCCTTGCCGCGCTGATCAATGCCGGCCTGCTGCTGCTCGTGGTCGGCGGCATCGCGGTCGAAGCGTTCGACC
GGCTGCGCAATCCCGGCGATGTCGCCGGCGTCACCGTGCTGTGGGTCGCGGCGCTCGGCATCGCCATCAATGGCGCCACC
GCGATGCTGTTCATGCGCGGCCGCGACACCGACCTCAACATCCGCGGCGCCTATCTGCACATGGCGGCGGATGCCGCCGT
GTCGTTCGGCGTCGTCGTTGCCGCGCTGGTGACGATCTGGACCGGCTGGCTGTGGGTCGATCCGGTCGTCAGCCTCGTTA
TCGCGCTCGTCGTGCTGCTCAGCGGCTGGGATCTCGCCCGCGACAGCGTCAACCTCGCGCTCGATGCGGTGCCGCGCGAC
ATCGCGCTGCCGCAGGTGCGCGACTATCTCGCCTCGCTCGAGGGCGTCAGCGAGGTGCACGACCTCCACATCTGGGCGAT
GAGTACCAACGAGACCGCGCTGACCGCACATCTGGTGCGGCCGGGCGGCACCGACGACGCCTTCCTGCATCGCGTCTGCG
CCGAGCTGTCCCAGCGCTTCAACATCCAGCATCCGACCTTGCAGATCGAGGCCGACGGCAAGCCGTGCAAGCTGGCGCCC
GCCGACGTGGTGTGA

Upstream 100 bases:

>100_bases
GAACGACGCGCATGCCAATTAATTGCCGCCGGTGGCTATGGGTCCCGGCGTTCGCCGGGACGACATCGAGGCTGGTCTTG
AGCAGCGGGTGTTAGGTCGC

Downstream 100 bases:

>100_bases
GCCGATGCCTCAGCTCCAACCCGCCAGCCTGATCAGCACGCCGGCGGCGCAGGACGCTCCGAGCACGGTCAGCATGCCCA
GCCTGAAGCGGAGGATGGCG

Product: CDF family cation efflux system protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 324; Mature: 323

Protein sequence:

>324_residues
MAQSHSDHDDHDHDHSRDHAHAHSHSHSHAGHSHAPTSFGAAFAIGVALNTAFVIAELIFGYAANSLALISDAIHNLSDV
MSLLLAWGALWLSGRRPTDRHTYGYRRASILAALINAGLLLLVVGGIAVEAFDRLRNPGDVAGVTVLWVAALGIAINGAT
AMLFMRGRDTDLNIRGAYLHMAADAAVSFGVVVAALVTIWTGWLWVDPVVSLVIALVVLLSGWDLARDSVNLALDAVPRD
IALPQVRDYLASLEGVSEVHDLHIWAMSTNETALTAHLVRPGGTDDAFLHRVCAELSQRFNIQHPTLQIEADGKPCKLAP
ADVV

Sequences:

>Translated_324_residues
MAQSHSDHDDHDHDHSRDHAHAHSHSHSHAGHSHAPTSFGAAFAIGVALNTAFVIAELIFGYAANSLALISDAIHNLSDV
MSLLLAWGALWLSGRRPTDRHTYGYRRASILAALINAGLLLLVVGGIAVEAFDRLRNPGDVAGVTVLWVAALGIAINGAT
AMLFMRGRDTDLNIRGAYLHMAADAAVSFGVVVAALVTIWTGWLWVDPVVSLVIALVVLLSGWDLARDSVNLALDAVPRD
IALPQVRDYLASLEGVSEVHDLHIWAMSTNETALTAHLVRPGGTDDAFLHRVCAELSQRFNIQHPTLQIEADGKPCKLAP
ADVV
>Mature_323_residues
AQSHSDHDDHDHDHSRDHAHAHSHSHSHAGHSHAPTSFGAAFAIGVALNTAFVIAELIFGYAANSLALISDAIHNLSDVM
SLLLAWGALWLSGRRPTDRHTYGYRRASILAALINAGLLLLVVGGIAVEAFDRLRNPGDVAGVTVLWVAALGIAINGATA
MLFMRGRDTDLNIRGAYLHMAADAAVSFGVVVAALVTIWTGWLWVDPVVSLVIALVVLLSGWDLARDSVNLALDAVPRDI
ALPQVRDYLASLEGVSEVHDLHIWAMSTNETALTAHLVRPGGTDDAFLHRVCAELSQRFNIQHPTLQIEADGKPCKLAPA
DVV

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI52352805, Length=327, Percent_Identity=30.2752293577982, Blast_Score=146, Evalue=2e-35,
Organism=Homo sapiens, GI21359890, Length=272, Percent_Identity=29.4117647058824, Blast_Score=128, Evalue=9e-30,
Organism=Homo sapiens, GI289803013, Length=304, Percent_Identity=29.9342105263158, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI289803009, Length=304, Percent_Identity=29.9342105263158, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI289803007, Length=304, Percent_Identity=29.9342105263158, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI289803003, Length=304, Percent_Identity=29.9342105263158, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI64762489, Length=304, Percent_Identity=29.9342105263158, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI21361112, Length=291, Percent_Identity=29.553264604811, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI20070323, Length=314, Percent_Identity=25.4777070063694, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI14210520, Length=234, Percent_Identity=28.2051282051282, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI52351208, Length=121, Percent_Identity=40.495867768595, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI222080086, Length=111, Percent_Identity=35.1351351351351, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI40255009, Length=111, Percent_Identity=35.1351351351351, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI1786966, Length=277, Percent_Identity=36.101083032491, Blast_Score=133, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI193210990, Length=333, Percent_Identity=29.1291291291291, Blast_Score=144, Evalue=6e-35,
Organism=Caenorhabditis elegans, GI17555794, Length=326, Percent_Identity=29.4478527607362, Blast_Score=131, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI17555796, Length=285, Percent_Identity=30.1754385964912, Blast_Score=124, Evalue=8e-29,
Organism=Caenorhabditis elegans, GI32564488, Length=292, Percent_Identity=26.7123287671233, Blast_Score=103, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6320411, Length=168, Percent_Identity=33.3333333333333, Blast_Score=86, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6323899, Length=120, Percent_Identity=40, Blast_Score=85, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6324892, Length=118, Percent_Identity=38.9830508474576, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24583858, Length=307, Percent_Identity=30.2931596091205, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24585900, Length=146, Percent_Identity=31.5068493150685, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24585898, Length=146, Percent_Identity=31.5068493150685, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24585896, Length=146, Percent_Identity=31.5068493150685, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI19921672, Length=146, Percent_Identity=31.5068493150685, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24584409, Length=147, Percent_Identity=31.2925170068027, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI28574430, Length=147, Percent_Identity=31.2925170068027, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24645863, Length=106, Percent_Identity=34.9056603773585, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24656728, Length=110, Percent_Identity=32.7272727272727, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24656724, Length=110, Percent_Identity=32.7272727272727, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24656720, Length=110, Percent_Identity=32.7272727272727, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24656715, Length=110, Percent_Identity=32.7272727272727, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI21357035, Length=110, Percent_Identity=32.7272727272727, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 34702; Mature: 34571

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQSHSDHDDHDHDHSRDHAHAHSHSHSHAGHSHAPTSFGAAFAIGVALNTAFVIAELIF
CCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
GYAANSLALISDAIHNLSDVMSLLLAWGALWLSGRRPTDRHTYGYRRASILAALINAGLL
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHH
LLVVGGIAVEAFDRLRNPGDVAGVTVLWVAALGIAINGATAMLFMRGRDTDLNIRGAYLH
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCEEEEHEEE
MAADAAVSFGVVVAALVTIWTGWLWVDPVVSLVIALVVLLSGWDLARDSVNLALDAVPRD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCC
IALPQVRDYLASLEGVSEVHDLHIWAMSTNETALTAHLVRPGGTDDAFLHRVCAELSQRF
CCCHHHHHHHHHHHHHHHHHHEEEEEEECCCCEEEEEEECCCCCCHHHHHHHHHHHHHHC
NIQHPTLQIEADGKPCKLAPADVV
CCCCCEEEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
AQSHSDHDDHDHDHSRDHAHAHSHSHSHAGHSHAPTSFGAAFAIGVALNTAFVIAELIF
CCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
GYAANSLALISDAIHNLSDVMSLLLAWGALWLSGRRPTDRHTYGYRRASILAALINAGLL
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHH
LLVVGGIAVEAFDRLRNPGDVAGVTVLWVAALGIAINGATAMLFMRGRDTDLNIRGAYLH
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCEEEEHEEE
MAADAAVSFGVVVAALVTIWTGWLWVDPVVSLVIALVVLLSGWDLARDSVNLALDAVPRD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCC
IALPQVRDYLASLEGVSEVHDLHIWAMSTNETALTAHLVRPGGTDDAFLHRVCAELSQRF
CCCHHHHHHHHHHHHHHHHHHEEEEEEECCCCEEEEEEECCCCCCHHHHHHHHHHHHHHC
NIQHPTLQIEADGKPCKLAPADVV
CCCCCEEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377; 9099864 [H]