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The map label for this gene is parC [H]

Identifier: 146341364

GI number: 146341364

Start: 4649696

End: 4651948

Strand: Reverse

Name: parC [H]

Synonym: BRADO4448

Alternate gene names: 146341364

Gene position: 4651948-4649696 (Counterclockwise)

Preceding gene: 146341368

Following gene: 146341363

Centisome position: 62.39

GC content: 65.29

Gene sequence:

>2253_bases
ATGGGAAAATCACTGATTCCGCCGGAGCCTGCGGAGATTCACGAGGTCGCGCTGCGCGACGCGCTGGAGGAGCGCTATCT
CGCCTATGCGCTGTCGACCATCATGCACCGGGCGCTGCCGGATGCCCGCGACGGCCTCAAGCCCGTGCACCGGCGCATCC
TCTACGGCATGCGGCTCTTGCGGCTCGATCCCGGCACCGCGTTCAAGAAGTCGGCGAAGATCGTCGGCGACGTGATGGGC
TCGTTCCATCCGCATGGCGACCAGGCGATCTACGACGCGATGGTGCGCCTCGCGCAGGACTTCTCGTCGCGCTATCCGCT
GGTCGACGGCCAGGGCAATTTCGGCAACATCGACGGCGATAACCCGGCCGCCTACCGCTACACGGAAGCGCGCATGACCG
ATGTCGCGCGCCTCCTGCTCGAGGGCATCGACGAGGACGGCGTCGAGTTCCGGCCGAACTATGACGGCCAGTCGAAGGAG
CCGGTGGTGCTGCCCGGCGGCTTCCCGAACCTGCTCGCCAACGGCGCGCAGGGCATCGCGGTTGGCATGGCGACCTCGAT
CCCGCCGCACAACGCTGCCGAACTGTGCGACGCCGCACTGCATCTGATCGAAAAGCCCGACGCCAAGTCGCGCGCGCTAC
TGCGCTGGGTGAAGGGTCCGGACTTCCCGACCGGCGGCACCGTGATCGACTCCAAGGAGTCGATCATCGAGGCCTACACC
ACCGGCCGCGGCTCGTTCCGCGTCCGCGCCAAGTGGAAGCAGGAAGAGGGTAATCGCGGCACCTGGGTGGTCGTGATCAC
CGAGATTCCGTTTCTCGTGCAGAAGTCGCGGCTGGTCGAGAAGATCGCCGAGCTCTTGAACGAGAAGAAGCTGCCGCTGG
TCGGCGACGTCCGCGACGAATCCGCCGAGGACGTGCGGCTCGTGATCGAGCCGAAGTCGAAGAACGTCGATCCCGCCCTG
ATGATGGAGTCGCTGTTCCGGCTGACGGATCTCGAGAGCAAGATTCCGCTGAACCTCAACGTGCTGATCAAGGGCAAGAT
TCCCAAGGTGGTCGGCCTCGCCGAGTGCCTGCGCGAATGGCTCGATCATCTGCGCGACGTGCTGCTGCGCCGCTCGAACT
ACCGCAAGAAGCAGATCGAGAACCGGCTCGAGATTCTCGGCGGCTATCTGATCGCCTATCTCAACATCGACGAGGTGATC
CGGATCATCCGCACCGAGGACGAGCCGAAGCCGGTCCTGATGAAGACCTTCAAGCTCACCGAGGTGCAGGCTGAGGCCAT
CCTCAACATGCGCCTGCGCTCTCTGCGCAAGCTCGAGGAAATGGAGATCCGCACCGAGGACAAGAACCTGCGCGGCGAGC
TCAAGGGCATCAACGAGCTGCTCGGCTCCGAGCCGTTGCAGTGGGCCAAGGTCGGCGAGCAGGTCAAGACCGTGCGCGAC
ATGTTCGGGCCGAAGACCCCGCTCGGCAAGCGTCGCACCAATTTCGCCGACGCGCCGGAGCACGATCTCGCCGCCATCGA
GGAGGCCTTCATCGAGCGCGAGCCGGTCACGGTGGTCGTCTCCGAGAAGGGCTGGGTGCGGACGCTGAAGGGGCACGTCG
CCGATCTGTCGAACCTGCAGTTCAAGACCGACGACCAGCTCGGCCAATCGTTCTTTGCCGAGAACACCTCGAAGGTGCTG
CTGTTCGCGACCAACGGCAAGTTCTACTCGCTCGATGTCGGCAAGCTGCCCGGCGGCCGCGGCCATGGCGAGCCGATCCG
CATGTTCATCGATCTCGACCAGGACGCCTCGATCGTGTCGATGTTCGTCACCAAGGGCGAGCGCAAGTTCCTGGTGGCGG
CCTCCGACGGCCAGGGCTTCGTGGTCAAGGAAGAGGATTGCGTCAGCAACACCCGCAAGGGCAAGCAGGTGCTGAACGTG
ACGGCCCCCGCCGAGGCGCGCGCGATCTGCACGGTCACCGGCGATCAGGTCGCGGTCATCGGCACCAACCACAAGATGGT
GGTGTTCGGCCTCGACCAGGTGCCGGAGATGGCGCGGGGCCGCGGCGTCCGCCTGCAGAAATACACCAGCGCCCAGCTCT
CCGACGTCACCACGTTCGAGCAGAAGCAGGGCTTGGCCTGGAAGGATTCCGCCGGCCGCGACCAGGGCCTGAGCTGGAAG
GAGCTCGCCGACTACCGCGGCAACCGCGCCGACGCCGGCCGTATCGCGCAGGGCCTGCCAAAGTCGAACAAGTTCAACCG
GCCGATCGAGTGA

Upstream 100 bases:

>100_bases
AGCCCATCGTTGCGCCGCGGCCCGCGATCGCATAAAGCCTGTTCCCAAATCGTTCACGTCAGCCCCTGATTTGGGCTAAC
CCACTGAAAGCTCTACGCGA

Downstream 100 bases:

>100_bases
GGCGGGCAGAGTGACGATCGAACACCTCTTCGGTCTGCCACTCACCGCGACGACAGAAAAGGTCGTCGTCCCGGGCAAGC
CCCGCGCGCATAGCGCGTGG

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 750; Mature: 749

Protein sequence:

>750_residues
MGKSLIPPEPAEIHEVALRDALEERYLAYALSTIMHRALPDARDGLKPVHRRILYGMRLLRLDPGTAFKKSAKIVGDVMG
SFHPHGDQAIYDAMVRLAQDFSSRYPLVDGQGNFGNIDGDNPAAYRYTEARMTDVARLLLEGIDEDGVEFRPNYDGQSKE
PVVLPGGFPNLLANGAQGIAVGMATSIPPHNAAELCDAALHLIEKPDAKSRALLRWVKGPDFPTGGTVIDSKESIIEAYT
TGRGSFRVRAKWKQEEGNRGTWVVVITEIPFLVQKSRLVEKIAELLNEKKLPLVGDVRDESAEDVRLVIEPKSKNVDPAL
MMESLFRLTDLESKIPLNLNVLIKGKIPKVVGLAECLREWLDHLRDVLLRRSNYRKKQIENRLEILGGYLIAYLNIDEVI
RIIRTEDEPKPVLMKTFKLTEVQAEAILNMRLRSLRKLEEMEIRTEDKNLRGELKGINELLGSEPLQWAKVGEQVKTVRD
MFGPKTPLGKRRTNFADAPEHDLAAIEEAFIEREPVTVVVSEKGWVRTLKGHVADLSNLQFKTDDQLGQSFFAENTSKVL
LFATNGKFYSLDVGKLPGGRGHGEPIRMFIDLDQDASIVSMFVTKGERKFLVAASDGQGFVVKEEDCVSNTRKGKQVLNV
TAPAEARAICTVTGDQVAVIGTNHKMVVFGLDQVPEMARGRGVRLQKYTSAQLSDVTTFEQKQGLAWKDSAGRDQGLSWK
ELADYRGNRADAGRIAQGLPKSNKFNRPIE

Sequences:

>Translated_750_residues
MGKSLIPPEPAEIHEVALRDALEERYLAYALSTIMHRALPDARDGLKPVHRRILYGMRLLRLDPGTAFKKSAKIVGDVMG
SFHPHGDQAIYDAMVRLAQDFSSRYPLVDGQGNFGNIDGDNPAAYRYTEARMTDVARLLLEGIDEDGVEFRPNYDGQSKE
PVVLPGGFPNLLANGAQGIAVGMATSIPPHNAAELCDAALHLIEKPDAKSRALLRWVKGPDFPTGGTVIDSKESIIEAYT
TGRGSFRVRAKWKQEEGNRGTWVVVITEIPFLVQKSRLVEKIAELLNEKKLPLVGDVRDESAEDVRLVIEPKSKNVDPAL
MMESLFRLTDLESKIPLNLNVLIKGKIPKVVGLAECLREWLDHLRDVLLRRSNYRKKQIENRLEILGGYLIAYLNIDEVI
RIIRTEDEPKPVLMKTFKLTEVQAEAILNMRLRSLRKLEEMEIRTEDKNLRGELKGINELLGSEPLQWAKVGEQVKTVRD
MFGPKTPLGKRRTNFADAPEHDLAAIEEAFIEREPVTVVVSEKGWVRTLKGHVADLSNLQFKTDDQLGQSFFAENTSKVL
LFATNGKFYSLDVGKLPGGRGHGEPIRMFIDLDQDASIVSMFVTKGERKFLVAASDGQGFVVKEEDCVSNTRKGKQVLNV
TAPAEARAICTVTGDQVAVIGTNHKMVVFGLDQVPEMARGRGVRLQKYTSAQLSDVTTFEQKQGLAWKDSAGRDQGLSWK
ELADYRGNRADAGRIAQGLPKSNKFNRPIE
>Mature_749_residues
GKSLIPPEPAEIHEVALRDALEERYLAYALSTIMHRALPDARDGLKPVHRRILYGMRLLRLDPGTAFKKSAKIVGDVMGS
FHPHGDQAIYDAMVRLAQDFSSRYPLVDGQGNFGNIDGDNPAAYRYTEARMTDVARLLLEGIDEDGVEFRPNYDGQSKEP
VVLPGGFPNLLANGAQGIAVGMATSIPPHNAAELCDAALHLIEKPDAKSRALLRWVKGPDFPTGGTVIDSKESIIEAYTT
GRGSFRVRAKWKQEEGNRGTWVVVITEIPFLVQKSRLVEKIAELLNEKKLPLVGDVRDESAEDVRLVIEPKSKNVDPALM
MESLFRLTDLESKIPLNLNVLIKGKIPKVVGLAECLREWLDHLRDVLLRRSNYRKKQIENRLEILGGYLIAYLNIDEVIR
IIRTEDEPKPVLMKTFKLTEVQAEAILNMRLRSLRKLEEMEIRTEDKNLRGELKGINELLGSEPLQWAKVGEQVKTVRDM
FGPKTPLGKRRTNFADAPEHDLAAIEEAFIEREPVTVVVSEKGWVRTLKGHVADLSNLQFKTDDQLGQSFFAENTSKVLL
FATNGKFYSLDVGKLPGGRGHGEPIRMFIDLDQDASIVSMFVTKGERKFLVAASDGQGFVVKEEDCVSNTRKGKQVLNVT
APAEARAICTVTGDQVAVIGTNHKMVVFGLDQVPEMARGRGVRLQKYTSAQLSDVTTFEQKQGLAWKDSAGRDQGLSWKE
LADYRGNRADAGRIAQGLPKSNKFNRPIE

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=181, Percent_Identity=31.4917127071823, Blast_Score=79, Evalue=2e-14,
Organism=Homo sapiens, GI19913406, Length=409, Percent_Identity=26.161369193154, Blast_Score=77, Evalue=7e-14,
Organism=Escherichia coli, GI1789396, Length=686, Percent_Identity=42.7113702623907, Blast_Score=518, Evalue=1e-148,
Organism=Escherichia coli, GI1788562, Length=734, Percent_Identity=36.6485013623978, Blast_Score=405, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI212645845, Length=389, Percent_Identity=23.3933161953728, Blast_Score=82, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17535065, Length=439, Percent_Identity=25.7403189066059, Blast_Score=77, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI212645657, Length=188, Percent_Identity=31.9148936170213, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=384, Percent_Identity=25, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17136538, Length=172, Percent_Identity=30.8139534883721, Blast_Score=74, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013760
- InterPro:   IPR005742 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 83589; Mature: 83458

Theoretical pI: Translated: 8.00; Mature: 8.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKSLIPPEPAEIHEVALRDALEERYLAYALSTIMHRALPDARDGLKPVHRRILYGMRLL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHEE
RLDPGTAFKKSAKIVGDVMGSFHPHGDQAIYDAMVRLAQDFSSRYPLVDGQGNFGNIDGD
EECCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCC
NPAAYRYTEARMTDVARLLLEGIDEDGVEFRPNYDGQSKEPVVLPGGFPNLLANGAQGIA
CCCEEEEHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCCEEECCCCHHHHCCCCCCEE
VGMATSIPPHNAAELCDAALHLIEKPDAKSRALLRWVKGPDFPTGGTVIDSKESIIEAYT
EEEECCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCEECCHHHHHHHHH
TGRGSFRVRAKWKQEEGNRGTWVVVITEIPFLVQKSRLVEKIAELLNEKKLPLVGDVRDE
CCCCCEEEEEEECCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCEEECCCCC
SAEDVRLVIEPKSKNVDPALMMESLFRLTDLESKIPLNLNVLIKGKIPKVVGLAECLREW
CCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHHHHH
LDHLRDVLLRRSNYRKKQIENRLEILGGYLIAYLNIDEVIRIIRTEDEPKPVLMKTFKLT
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHEEECHHHHHHHHHCCCCCCCHHHHHHHHH
EVQAEAILNMRLRSLRKLEEMEIRTEDKNLRGELKGINELLGSEPLQWAKVGEQVKTVRD
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
MFGPKTPLGKRRTNFADAPEHDLAAIEEAFIEREPVTVVVSEKGWVRTLKGHVADLSNLQ
HCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHCCE
FKTDDQLGQSFFAENTSKVLLFATNGKFYSLDVGKLPGGRGHGEPIRMFIDLDQDASIVS
ECCHHHHHHHHHHCCCCEEEEEEECCEEEEEECCCCCCCCCCCCCEEEEEECCCCCHHHH
MFVTKGERKFLVAASDGQGFVVKEEDCVSNTRKGKQVLNVTAPAEARAICTVTGDQVAVI
HHHHCCCEEEEEEECCCCEEEEECHHHHHHHHCCCEEEEEECCCCCCEEEEEECCEEEEE
GTNHKMVVFGLDQVPEMARGRGVRLQKYTSAQLSDVTTFEQKQGLAWKDSAGRDQGLSWK
ECCCEEEEEECHHCHHHHCCCCCEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHH
ELADYRGNRADAGRIAQGLPKSNKFNRPIE
HHHHHCCCCCCHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
GKSLIPPEPAEIHEVALRDALEERYLAYALSTIMHRALPDARDGLKPVHRRILYGMRLL
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHEE
RLDPGTAFKKSAKIVGDVMGSFHPHGDQAIYDAMVRLAQDFSSRYPLVDGQGNFGNIDGD
EECCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCC
NPAAYRYTEARMTDVARLLLEGIDEDGVEFRPNYDGQSKEPVVLPGGFPNLLANGAQGIA
CCCEEEEHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCCEEECCCCHHHHCCCCCCEE
VGMATSIPPHNAAELCDAALHLIEKPDAKSRALLRWVKGPDFPTGGTVIDSKESIIEAYT
EEEECCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCEECCHHHHHHHHH
TGRGSFRVRAKWKQEEGNRGTWVVVITEIPFLVQKSRLVEKIAELLNEKKLPLVGDVRDE
CCCCCEEEEEEECCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCEEECCCCC
SAEDVRLVIEPKSKNVDPALMMESLFRLTDLESKIPLNLNVLIKGKIPKVVGLAECLREW
CCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHHHHH
LDHLRDVLLRRSNYRKKQIENRLEILGGYLIAYLNIDEVIRIIRTEDEPKPVLMKTFKLT
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHEEECHHHHHHHHHCCCCCCCHHHHHHHHH
EVQAEAILNMRLRSLRKLEEMEIRTEDKNLRGELKGINELLGSEPLQWAKVGEQVKTVRD
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
MFGPKTPLGKRRTNFADAPEHDLAAIEEAFIEREPVTVVVSEKGWVRTLKGHVADLSNLQ
HCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHCCE
FKTDDQLGQSFFAENTSKVLLFATNGKFYSLDVGKLPGGRGHGEPIRMFIDLDQDASIVS
ECCHHHHHHHHHHCCCCEEEEEEECCEEEEEECCCCCCCCCCCCCEEEEEECCCCCHHHH
MFVTKGERKFLVAASDGQGFVVKEEDCVSNTRKGKQVLNVTAPAEARAICTVTGDQVAVI
HHHHCCCEEEEEEECCCCEEEEECHHHHHHHHCCCEEEEEECCCCCCEEEEEECCEEEEE
GTNHKMVVFGLDQVPEMARGRGVRLQKYTSAQLSDVTTFEQKQGLAWKDSAGRDQGLSWK
ECCCEEEEEECHHCHHHHCCCCCEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHH
ELADYRGNRADAGRIAQGLPKSNKFNRPIE
HHHHHCCCCCCHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]