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The map label for this gene is livM [H]

Identifier: 146339849

GI number: 146339849

Start: 3053145

End: 3054485

Strand: Reverse

Name: livM [H]

Synonym: BRADO2851

Alternate gene names: 146339849

Gene position: 3054485-3053145 (Counterclockwise)

Preceding gene: 146339850

Following gene: 146339848

Centisome position: 40.96

GC content: 66.67

Gene sequence:

>1341_bases
GTGAGCGCGTCCCTTCCACCCTCTTCGCCTGTCCCATCGAATGGCTCCGAGCCCGTCGGAGCCGCCTTCATCCTCAGGAA
GGCTGTCCTCAGCGCGCTGGTCGCGCTCGGCCTGTTCTCGCTGATGGTCGGCGTCCGCACCGAGGCCGGCCAGAGCGGCC
AGCTCGAATACTGGACCCGCTTCGGCGAGCTCGCCAGCCTCGTCGGCGCGGTGTTCGTTGGCTCGATCGTGGTCGAGCTG
TTGCGGCTCTGGCTCGGCCCGCGCGGCGGCCTCGGCAGCTTCGTTCCCGCGTCGGTGCAGAGCGGCCTGTCCGTTGCGGG
GCGCTATCTCGCACCGGCGCTACTGATCTTCACCTTTCTCGTGCCGGTGATCTTCTACAATCAGCGCTACATTCTCGACC
TCGGCATCCTCGTCCTCACCTATGTGATGCTGGGCTGGGGCCTCAACGTCGTGGTCGGCCTCGCCGGCCTGCTCGATCTC
GGCTACGTCGCGTTCTACGCGGTCGGCGCCTATTCCTACGGTTTGCTGTCGACAACCTTCGGCCTGTCGTTCTGGATCTG
CCTGCCGCTCGCCGGCATCCTTGCCGCGTTCTGGGGCGTGCTGCTCGGCTTCCCCGTGCTGCGGCTGCGCGGCGATTACC
TCGCCATCGTCACGCTCGCCTTCGGCGAAATCATCCGTCTGGTGCTGATCAACTGGCAGGAGGTGACGGGCGGCCCCAAT
GGCGTCTCCGGCATTCCGCGCCCGACCCTGTTCGGCATCCCGTTGACTCCCGGCGAAGGCGGCCTTGCGTCGATGCTCGG
CATTCCGTTCTCGCCGACGCATCGCATCGTGTTCCTGTTCTACTTGATCCTGGCGCTGGCGCTGCTGACCAACTGGGTGA
CGATCAGGCTGCGCCGGCTGCCGATCGGCCGCGCCTGGGAAGCGCTGCGCGAGGATGAGGTCGCCTGCCGCGCGCTCGGC
ATCAACATCACCACGACCAAGCTGACGGCGTTCGCCACCGGCGCGATGTTTGGCGGCTTCGCCGGCGCCTTCTTCGCCAC
GCGGCAGGGCTTCATCAGCCCCGAGTCCTTCACGTTCCAAGAGTCAGCGCTGGTGCTGGCGATCGTCGTGCTCGGCGGCA
TGGGCTCGCAGCTCGGTGTGGCGCTGGCCGCGCTCGCCATGATCGGTGGCTTCGAGCTGTTCCGAAGCCTCGAGGTCTAC
CGCATGCTGGTGTTCGGTCTCGCCATGGTGCTGGTGATGATCTGGCGCCCGCGCGGCATCGTCGGCCATCGCGCGCCGAC
CGTGTTCCTGGAAAAATCCAAGAGCATCTCCTCGGACCTCGTCAAGGAAGGCCACGGATGA

Upstream 100 bases:

>100_bases
GACGTCGCGGCGTTCTCGATCCTGATCGTGGTGCTGATCTTCCTGCCGACCGGCCTCCTGGGCCGTCCCGAAGTCGAAAA
AGTCTGACGACGGAGCCCGT

Downstream 100 bases:

>100_bases
GCTCCGCTCCCATCCTCGCGCTCGAGAATCTCACCATGCGTTTCGGCGGCATCGTCGCCGTCAACGCGCTGTCGTTCACC
GCCCAGCGCAAGCAGATCAC

Product: high-affinity branched-chain amino acid ABC transporter permease

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 446; Mature: 445

Protein sequence:

>446_residues
MSASLPPSSPVPSNGSEPVGAAFILRKAVLSALVALGLFSLMVGVRTEAGQSGQLEYWTRFGELASLVGAVFVGSIVVEL
LRLWLGPRGGLGSFVPASVQSGLSVAGRYLAPALLIFTFLVPVIFYNQRYILDLGILVLTYVMLGWGLNVVVGLAGLLDL
GYVAFYAVGAYSYGLLSTTFGLSFWICLPLAGILAAFWGVLLGFPVLRLRGDYLAIVTLAFGEIIRLVLINWQEVTGGPN
GVSGIPRPTLFGIPLTPGEGGLASMLGIPFSPTHRIVFLFYLILALALLTNWVTIRLRRLPIGRAWEALREDEVACRALG
INITTTKLTAFATGAMFGGFAGAFFATRQGFISPESFTFQESALVLAIVVLGGMGSQLGVALAALAMIGGFELFRSLEVY
RMLVFGLAMVLVMIWRPRGIVGHRAPTVFLEKSKSISSDLVKEGHG

Sequences:

>Translated_446_residues
MSASLPPSSPVPSNGSEPVGAAFILRKAVLSALVALGLFSLMVGVRTEAGQSGQLEYWTRFGELASLVGAVFVGSIVVEL
LRLWLGPRGGLGSFVPASVQSGLSVAGRYLAPALLIFTFLVPVIFYNQRYILDLGILVLTYVMLGWGLNVVVGLAGLLDL
GYVAFYAVGAYSYGLLSTTFGLSFWICLPLAGILAAFWGVLLGFPVLRLRGDYLAIVTLAFGEIIRLVLINWQEVTGGPN
GVSGIPRPTLFGIPLTPGEGGLASMLGIPFSPTHRIVFLFYLILALALLTNWVTIRLRRLPIGRAWEALREDEVACRALG
INITTTKLTAFATGAMFGGFAGAFFATRQGFISPESFTFQESALVLAIVVLGGMGSQLGVALAALAMIGGFELFRSLEVY
RMLVFGLAMVLVMIWRPRGIVGHRAPTVFLEKSKSISSDLVKEGHG
>Mature_445_residues
SASLPPSSPVPSNGSEPVGAAFILRKAVLSALVALGLFSLMVGVRTEAGQSGQLEYWTRFGELASLVGAVFVGSIVVELL
RLWLGPRGGLGSFVPASVQSGLSVAGRYLAPALLIFTFLVPVIFYNQRYILDLGILVLTYVMLGWGLNVVVGLAGLLDLG
YVAFYAVGAYSYGLLSTTFGLSFWICLPLAGILAAFWGVLLGFPVLRLRGDYLAIVTLAFGEIIRLVLINWQEVTGGPNG
VSGIPRPTLFGIPLTPGEGGLASMLGIPFSPTHRIVFLFYLILALALLTNWVTIRLRRLPIGRAWEALREDEVACRALGI
NITTTKLTAFATGAMFGGFAGAFFATRQGFISPESFTFQESALVLAIVVLGGMGSQLGVALAALAMIGGFELFRSLEVYR
MLVFGLAMVLVMIWRPRGIVGHRAPTVFLEKSKSISSDLVKEGHG

Specific function: Component of the high affinity leucine, isoleucine, valine, transport system (LIV-I), which is operative without Na(+) and is specific for alanine and threonine, in addition to branched-chain amino acids [H]

COG id: COG4177

COG function: function code E; ABC-type branched-chain amino acid transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789865, Length=313, Percent_Identity=56.5495207667732, Blast_Score=329, Evalue=2e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851
- InterPro:   IPR021807 [H]

Pfam domain/function: PF02653 BPD_transp_2; PF11862 DUF3382 [H]

EC number: NA

Molecular weight: Translated: 47570; Mature: 47439

Theoretical pI: Translated: 9.75; Mature: 9.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCEEEEECCCCHHHHHHHCCCC
>Mature Secondary Structure 
SASLPPSSPVPSNGSEPVGAAFILRKAVLSALVALGLFSLMVGVRTEAGQSGQLEYWTR
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
FGELASLVGAVFVGSIVVELLRLWLGPRGGLGSFVPASVQSGLSVAGRYLAPALLIFTFL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VPVIFYNQRYILDLGILVLTYVMLGWGLNVVVGLAGLLDLGYVAFYAVGAYSYGLLSTTF
HHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLSFWICLPLAGILAAFWGVLLGFPVLRLRGDYLAIVTLAFGEIIRLVLINWQEVTGGPN
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GVSGIPRPTLFGIPLTPGEGGLASMLGIPFSPTHRIVFLFYLILALALLTNWVTIRLRRL
CCCCCCCCCEEECCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PIGRAWEALREDEVACRALGINITTTKLTAFATGAMFGGFAGAFFATRQGFISPESFTFQ
CCHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHH
ESALVLAIVVLGGMGSQLGVALAALAMIGGFELFRSLEVYRMLVFGLAMVLVMIWRPRGI
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VGHRAPTVFLEKSKSISSDLVKEGHG
CCCCCCEEEEECCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2120183; 10984043 [H]