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The map label for this gene is livH [H]

Identifier: 146339850

GI number: 146339850

Start: 3054499

End: 3055416

Strand: Reverse

Name: livH [H]

Synonym: BRADO2852

Alternate gene names: 146339850

Gene position: 3055416-3054499 (Counterclockwise)

Preceding gene: 146339853

Following gene: 146339849

Centisome position: 40.98

GC content: 62.85

Gene sequence:

>918_bases
ATGGATTATTTCGCGCAGCAGCTCATCAACGGCCTCGTGCTCGGCTCGATCTACGGCCTGATCGCCATCGGCTACACCAT
GGTCTACGGCATCGTCGGCATGATCAATTTTGCCCATGGCGACGTCTTCATGATCGGCGGCTTCATCGCGCTGATCTCGT
TCCTGGTGCTGGTGTCCATCGGACTGACCGCGGTTCCGGTAATCCTGCTGATCGTGCTGCTGGTGTCGATGGCGATCACC
GCGCTGTATGGCTGGACCATCGAGCGGATCGCCTATCGTCCGCTGCGCCATTCCTTCCGCCTGGCGCCGATGCTGTCGGC
GATCGGCATGTCATTCGTGCTGACCAACTTCTCGCAGGTGTCGCAGGGCGCGCGCGTCAAGCCGGTCCCGCCGATCATCA
CCGGCGGCTATACGCTGCATGAGGGCGACAGTGGCTTCGTCGTGCAGCTCTCCAACATCCAGATCGTCGTCGTGGTCACC
ACGATCGTGCTCCTCGGCCTGTTCACCTGGCTGGTGTCACGCACCCGGCTTGGGCGCGATATGCGCGCCTGCGAGCAGGA
CCAGACGATGGCGGCGCTGCTCGGCGTCGACGTCGATCGTACGATCTCGATGACCTTTGTGATCGGCGCGGCGCTCGCCG
CCGTCGCCGGGATGATGTACCTGCTCTATTACGGCCTGGTCGATTTCTTCATGGGCTTCGTTGCCGGCATCAAGGCGTTC
ACCGCGGCCGTGCTCGGCGGCATCGGCTCGCTGCCTGGCGCGATGCTTGGCGGCCTCGCGATCGGCTTGATCGAGACATT
CTGGTCGGCCTACTTCTCGGTCGAGTACAAGGACGTCGCGGCGTTCTCGATCCTGATCGTGGTGCTGATCTTCCTGCCGA
CCGGCCTCCTGGGCCGTCCCGAAGTCGAAAAAGTCTGA

Upstream 100 bases:

>100_bases
ACGCGCCGTCTGCGGCCGCGGGTGCCGGAAGATACCGCCCCCGTCCGCCAGGCCCCCGCCGCGTTGCGAACGAGTATCGA
CAGTCTCGAAACGGCAGTTC

Downstream 100 bases:

>100_bases
CGACGGAGCCCGTGTGAGCGCGTCCCTTCCACCCTCTTCGCCTGTCCCATCGAATGGCTCCGAGCCCGTCGGAGCCGCCT
TCATCCTCAGGAAGGCTGTC

Product: high-affinity branched-chain amino acid ABC transporter permease

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MDYFAQQLINGLVLGSIYGLIAIGYTMVYGIVGMINFAHGDVFMIGGFIALISFLVLVSIGLTAVPVILLIVLLVSMAIT
ALYGWTIERIAYRPLRHSFRLAPMLSAIGMSFVLTNFSQVSQGARVKPVPPIITGGYTLHEGDSGFVVQLSNIQIVVVVT
TIVLLGLFTWLVSRTRLGRDMRACEQDQTMAALLGVDVDRTISMTFVIGAALAAVAGMMYLLYYGLVDFFMGFVAGIKAF
TAAVLGGIGSLPGAMLGGLAIGLIETFWSAYFSVEYKDVAAFSILIVVLIFLPTGLLGRPEVEKV

Sequences:

>Translated_305_residues
MDYFAQQLINGLVLGSIYGLIAIGYTMVYGIVGMINFAHGDVFMIGGFIALISFLVLVSIGLTAVPVILLIVLLVSMAIT
ALYGWTIERIAYRPLRHSFRLAPMLSAIGMSFVLTNFSQVSQGARVKPVPPIITGGYTLHEGDSGFVVQLSNIQIVVVVT
TIVLLGLFTWLVSRTRLGRDMRACEQDQTMAALLGVDVDRTISMTFVIGAALAAVAGMMYLLYYGLVDFFMGFVAGIKAF
TAAVLGGIGSLPGAMLGGLAIGLIETFWSAYFSVEYKDVAAFSILIVVLIFLPTGLLGRPEVEKV
>Mature_305_residues
MDYFAQQLINGLVLGSIYGLIAIGYTMVYGIVGMINFAHGDVFMIGGFIALISFLVLVSIGLTAVPVILLIVLLVSMAIT
ALYGWTIERIAYRPLRHSFRLAPMLSAIGMSFVLTNFSQVSQGARVKPVPPIITGGYTLHEGDSGFVVQLSNIQIVVVVT
TIVLLGLFTWLVSRTRLGRDMRACEQDQTMAALLGVDVDRTISMTFVIGAALAAVAGMMYLLYYGLVDFFMGFVAGIKAF
TAAVLGGIGSLPGAMLGGLAIGLIETFWSAYFSVEYKDVAAFSILIVVLIFLPTGLLGRPEVEKV

Specific function: Component of the high affinity leucine, isoleucine, valine, transport system (LIV-I), which is operative without Na(+) and is specific for alanine and threonine, in addition to branched-chain amino acids [H]

COG id: COG0559

COG function: function code E; Branched-chain amino acid ABC-type transport system, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789866, Length=303, Percent_Identity=49.1749174917492, Blast_Score=286, Evalue=1e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851 [H]

Pfam domain/function: PF02653 BPD_transp_2 [H]

EC number: NA

Molecular weight: Translated: 32729; Mature: 32729

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYFAQQLINGLVLGSIYGLIAIGYTMVYGIVGMINFAHGDVFMIGGFIALISFLVLVSI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
GLTAVPVILLIVLLVSMAITALYGWTIERIAYRPLRHSFRLAPMLSAIGMSFVLTNFSQV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SQGARVKPVPPIITGGYTLHEGDSGFVVQLSNIQIVVVVTTIVLLGLFTWLVSRTRLGRD
HCCCCCCCCCCEEECCEEEEECCCCEEEEECCEEHHHHHHHHHHHHHHHHHHHHHHHCHH
MRACEQDQTMAALLGVDVDRTISMTFVIGAALAAVAGMMYLLYYGLVDFFMGFVAGIKAF
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TAAVLGGIGSLPGAMLGGLAIGLIETFWSAYFSVEYKDVAAFSILIVVLIFLPTGLLGRP
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCC
EVEKV
CCCCC
>Mature Secondary Structure
MDYFAQQLINGLVLGSIYGLIAIGYTMVYGIVGMINFAHGDVFMIGGFIALISFLVLVSI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
GLTAVPVILLIVLLVSMAITALYGWTIERIAYRPLRHSFRLAPMLSAIGMSFVLTNFSQV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SQGARVKPVPPIITGGYTLHEGDSGFVVQLSNIQIVVVVTTIVLLGLFTWLVSRTRLGRD
HCCCCCCCCCCEEECCEEEEECCCCEEEEECCEEHHHHHHHHHHHHHHHHHHHHHHHCHH
MRACEQDQTMAALLGVDVDRTISMTFVIGAALAAVAGMMYLLYYGLVDFFMGFVAGIKAF
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TAAVLGGIGSLPGAMLGGLAIGLIETFWSAYFSVEYKDVAAFSILIVVLIFLPTGLLGRP
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCC
EVEKV
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2120183; 10984043; 2509433 [H]