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The map label for this gene is galE [C]

Identifier: 146339115

GI number: 146339115

Start: 2206404

End: 2207513

Strand: Reverse

Name: galE [C]

Synonym: BRADO2069

Alternate gene names: 146339115

Gene position: 2207513-2206404 (Counterclockwise)

Preceding gene: 146339116

Following gene: 146339114

Centisome position: 29.6

GC content: 64.14

Gene sequence:

>1110_bases
ATGACACGTGTCCTGATCACCGGAGGCGCAGGGTTCATCGGCTCGCATACCGCCGATGCGCTAATCTCCGCAGGCTACGA
GGTCCGGCTGCTCGACACGCTCGCTCCACAGGTCCACGGCTCGCAGCGGCAGCGTCCATCTTATCTGCACGCCGATGCCG
AACTGCTGATCGGCGATGTCACCGATCCGATCGCCGTCGAACGCGCGCTGCGCGGCGTCGACAAGGTGCTGCATCTTGCC
TCCAGTGTCGGTGTCGGCCAGAGTATGTACGACATCGAATCCTATGTGCGCACCAACGAGCTCGGCACAGCCGTGCTGCT
GCAGGCCTTGGTCAACCGGCCCGTCGCACGCCTGGTCGTTGCATCCTCGATGAGCGTCTATGGCGAGGGCGCTTGCCGCG
CCGGCGACGCTTCGGTCGTCGCGCCGGAGGAGCGTACGCTCGATCAGCTGAAACGCGGCGAGTGGGAGTTGGCCGGCGCA
GGCGGCGCGCTCGAACCGATACCGACCCCCGAGACCAAGCAGCCGACTCTAAGCTCGATCTACGCGCTTAACAAATATGC
GCAGGAGCGGATGTGCCTGATCACCGGAAAGGCGTACGGCATTCCCACTCTCGCACTGCGCTTCTTCAACGTGTTCGGCC
CGCGCCAGGCCTTGTCCAATCCCTATACCGGCGTGCTCGCGATCTTCGCCGCACGGCTTCTCAACGACCGTTCGCCACTG
GTGTTCGAGGATGGCCTGCAGCGCCGCGACTTCGTCCATGTCCATGATGTTGCCCGTGCCTGCGTGCTCGCGCTCGAGAG
CGATCGTGTTGACGACGTGTTCAATGTCGGTTCGGGCCAGAGCCGCAGCATCGTCTCCGTTGCCGAGGATCTCGCGCGCG
TGATGGGGCGCTCGCAGATGACGCCGACGATCACAGGCAAGTATCGCGCCGGCGACATCCGGCATTGTTTCGCCGATATC
TCGAAGACCGAGCGTCTGCTCGGGTTCAAGCCCGCGGTGCGATTTGAGGATGGGCTGGACGAGCTGGCACATTACCTCGC
CGACCAGATCGCCGACGACCAGGCGGAGAAGGCGACCGAAGAGCTGTCGCAACGCGGGCTGGTTGCATGA

Upstream 100 bases:

>100_bases
GAGAAATTATTGTTTGTACGTGACGTAGGAACCAACATTCATTGCGCCGCTTCTCACACGGAGACGTCGTTCCAAATTCA
CTTAGAGGGAGTAGCGCGGC

Downstream 100 bases:

>100_bases
TGGAAGCGACCTCGACTCAGGCTCCGATCGTGATCACCGGGGGCTGCGGCTTCATCGGCTGCAACCTTGCCGACCGGCTC
GCGACGCGTGGCGACCATGT

Product: putative NAD-dependent epimerase/dehydratasen UDP-glucose 4-epimerase

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 369; Mature: 368

Protein sequence:

>369_residues
MTRVLITGGAGFIGSHTADALISAGYEVRLLDTLAPQVHGSQRQRPSYLHADAELLIGDVTDPIAVERALRGVDKVLHLA
SSVGVGQSMYDIESYVRTNELGTAVLLQALVNRPVARLVVASSMSVYGEGACRAGDASVVAPEERTLDQLKRGEWELAGA
GGALEPIPTPETKQPTLSSIYALNKYAQERMCLITGKAYGIPTLALRFFNVFGPRQALSNPYTGVLAIFAARLLNDRSPL
VFEDGLQRRDFVHVHDVARACVLALESDRVDDVFNVGSGQSRSIVSVAEDLARVMGRSQMTPTITGKYRAGDIRHCFADI
SKTERLLGFKPAVRFEDGLDELAHYLADQIADDQAEKATEELSQRGLVA

Sequences:

>Translated_369_residues
MTRVLITGGAGFIGSHTADALISAGYEVRLLDTLAPQVHGSQRQRPSYLHADAELLIGDVTDPIAVERALRGVDKVLHLA
SSVGVGQSMYDIESYVRTNELGTAVLLQALVNRPVARLVVASSMSVYGEGACRAGDASVVAPEERTLDQLKRGEWELAGA
GGALEPIPTPETKQPTLSSIYALNKYAQERMCLITGKAYGIPTLALRFFNVFGPRQALSNPYTGVLAIFAARLLNDRSPL
VFEDGLQRRDFVHVHDVARACVLALESDRVDDVFNVGSGQSRSIVSVAEDLARVMGRSQMTPTITGKYRAGDIRHCFADI
SKTERLLGFKPAVRFEDGLDELAHYLADQIADDQAEKATEELSQRGLVA
>Mature_368_residues
TRVLITGGAGFIGSHTADALISAGYEVRLLDTLAPQVHGSQRQRPSYLHADAELLIGDVTDPIAVERALRGVDKVLHLAS
SVGVGQSMYDIESYVRTNELGTAVLLQALVNRPVARLVVASSMSVYGEGACRAGDASVVAPEERTLDQLKRGEWELAGAG
GALEPIPTPETKQPTLSSIYALNKYAQERMCLITGKAYGIPTLALRFFNVFGPRQALSNPYTGVLAIFAARLLNDRSPLV
FEDGLQRRDFVHVHDVARACVLALESDRVDDVFNVGSGQSRSIVSVAEDLARVMGRSQMTPTITGKYRAGDIRHCFADIS
KTERLLGFKPAVRFEDGLDELAHYLADQIADDQAEKATEELSQRGLVA

Specific function: Galactose metabolism; third step. [C]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI42516563, Length=349, Percent_Identity=29.2263610315186, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI56237023, Length=371, Percent_Identity=27.4932614555256, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI56118217, Length=371, Percent_Identity=27.4932614555256, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI189083684, Length=371, Percent_Identity=27.4932614555256, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI193211614, Length=265, Percent_Identity=26.4150943396226, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI8393516, Length=265, Percent_Identity=26.4150943396226, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI1786974, Length=372, Percent_Identity=26.8817204301075, Blast_Score=89, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17539532, Length=354, Percent_Identity=26.8361581920904, Blast_Score=107, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6319493, Length=371, Percent_Identity=25.8760107816712, Blast_Score=97, Evalue=4e-21,
Organism=Drosophila melanogaster, GI21356223, Length=352, Percent_Identity=27.2727272727273, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI19923002, Length=372, Percent_Identity=26.8817204301075, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 39936; Mature: 39805

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRVLITGGAGFIGSHTADALISAGYEVRLLDTLAPQVHGSQRQRPSYLHADAELLIGDV
CCEEEEECCCCCCCCHHHHHHHHCCCEEEEHHHHCHHHCCCCCCCCCEECCCHHEEEECC
TDPIAVERALRGVDKVLHLASSVGVGQSMYDIESYVRTNELGTAVLLQALVNRPVARLVV
CCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
ASSMSVYGEGACRAGDASVVAPEERTLDQLKRGEWELAGAGGALEPIPTPETKQPTLSSI
HHHHHHHCCCCCCCCCCCEECCCHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCHHHHH
YALNKYAQERMCLITGKAYGIPTLALRFFNVFGPRQALSNPYTGVLAIFAARLLNDRSPL
HHHHHHHHHCEEEEECCCCCCHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHCCCCCE
VFEDGLQRRDFVHVHDVARACVLALESDRVDDVFNVGSGQSRSIVSVAEDLARVMGRSQM
EECCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHCCCCC
TPTITGKYRAGDIRHCFADISKTERLLGFKPAVRFEDGLDELAHYLADQIADDQAEKATE
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHCCHHHHHHHHHHHHCCHHHHHHHH
ELSQRGLVA
HHHHCCCCC
>Mature Secondary Structure 
TRVLITGGAGFIGSHTADALISAGYEVRLLDTLAPQVHGSQRQRPSYLHADAELLIGDV
CEEEEECCCCCCCCHHHHHHHHCCCEEEEHHHHCHHHCCCCCCCCCEECCCHHEEEECC
TDPIAVERALRGVDKVLHLASSVGVGQSMYDIESYVRTNELGTAVLLQALVNRPVARLVV
CCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
ASSMSVYGEGACRAGDASVVAPEERTLDQLKRGEWELAGAGGALEPIPTPETKQPTLSSI
HHHHHHHCCCCCCCCCCCEECCCHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCHHHHH
YALNKYAQERMCLITGKAYGIPTLALRFFNVFGPRQALSNPYTGVLAIFAARLLNDRSPL
HHHHHHHHHCEEEEECCCCCCHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHCCCCCE
VFEDGLQRRDFVHVHDVARACVLALESDRVDDVFNVGSGQSRSIVSVAEDLARVMGRSQM
EECCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHCCCCC
TPTITGKYRAGDIRHCFADISKTERLLGFKPAVRFEDGLDELAHYLADQIADDQAEKATE
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHCCHHHHHHHHHHHHCCHHHHHHHH
ELSQRGLVA
HHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]