Click here to switch to the map view.

The map label for this gene is Hgd [H]

Identifier: 146337297

GI number: 146337297

Start: 140245

End: 141123

Strand: Direct

Name: Hgd [H]

Synonym: BRADO0124

Alternate gene names: 146337297

Gene position: 140245-141123 (Clockwise)

Preceding gene: 146337293

Following gene: 146337299

Centisome position: 1.88

GC content: 67.8

Gene sequence:

>879_bases
ATGGCGGCGATCGGATTCATCGGTTTGGGCGTCATGGGCGAGCCGATCTGCCGCAATCTGGCGCGAAAGTCCGGCGCCAC
CGTGCTCGGCTTCGACCGCGCGGATGCGCCGCTGCAGCGGCTCGCCGCGGTCGGCGTCATCAGGGCCGCGTCGCTCGCCG
AGCTGGCGCGCGAGGCCGAATTGATCTTCATGGCGTTGCCGAGCGGCAAGCATGTCCAATCCGTGTGCGACGGGGATGAC
GGCCTGCTCCGCCACGCGGAGGCACGTCACACCATCGTGGACCTCGGCACCTCGCCGGTACAGGCCACCCGCGAGCTCGC
GACGCATTTTGCAGCGAAGGGCGCCGCTTTCGCCGATGCGCCGATCGCCCGCACCCGCCAAGCGGCCGAAGACGGCACGC
TGAGCGTGATGGTGGGCGCCGACGCGGCGACGTTCGAACGGCTGCGGCCGCTGATCGCGATGTTCGCGACCGACATCACC
CATTGCGGTGGCGTCGGCGCCGGCCAGGTCGTGAAGATCCTCAACAACATGGTGCTGATGCAGACCGTGGTGGCGCTCGG
CGAGGCGCTGGAGACCGGCAAGCGCGCGGGCCTCGATCCCAAGCTGCTGTTCGAGACCCTCGCCAAGGGCTCCGCCGACA
GCTTCGCGCTGCGCAACCACGGCATGAAAGCGATGCTGCCCGACACATACCCAGAGCGCGCATTCTCGACCGAATATGCA
CGCAAGGACATCGGTTATGCGCTGGATCTCGCCAGGTCCGTGCAGATCGATCTGCCGGGCGCGGAGCTCGCCGACAGACG
ATTGGGAGAGGCCATCGAGGCGGGCTATGGCGATCTGTATTGGCCGGTGCTGGCGCGCGTGATTGGAGCGTCAGGCTAG

Upstream 100 bases:

>100_bases
AAGGCGACACGTCCGCTGGTCCGGAACCGAACTCGCCTCGTGGCGCGTGCCGTTGCGGTGCGCTCGCCGACGTCAACATT
TTGAATGAAGAGGAGCTTGC

Downstream 100 bases:

>100_bases
GCATGACCTGTTGATAGGGTTTTGTTGGACTGGCGCTTGACTGGTAACGGCGCCTGTGATGGCCGCCTGACAAGGGCGTC
CTCCGCGCTCGTGACGAGCG

Product: putative oxidoreductase 3-hydroxyisobutyrate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 292; Mature: 291

Protein sequence:

>292_residues
MAAIGFIGLGVMGEPICRNLARKSGATVLGFDRADAPLQRLAAVGVIRAASLAELAREAELIFMALPSGKHVQSVCDGDD
GLLRHAEARHTIVDLGTSPVQATRELATHFAAKGAAFADAPIARTRQAAEDGTLSVMVGADAATFERLRPLIAMFATDIT
HCGGVGAGQVVKILNNMVLMQTVVALGEALETGKRAGLDPKLLFETLAKGSADSFALRNHGMKAMLPDTYPERAFSTEYA
RKDIGYALDLARSVQIDLPGAELADRRLGEAIEAGYGDLYWPVLARVIGASG

Sequences:

>Translated_292_residues
MAAIGFIGLGVMGEPICRNLARKSGATVLGFDRADAPLQRLAAVGVIRAASLAELAREAELIFMALPSGKHVQSVCDGDD
GLLRHAEARHTIVDLGTSPVQATRELATHFAAKGAAFADAPIARTRQAAEDGTLSVMVGADAATFERLRPLIAMFATDIT
HCGGVGAGQVVKILNNMVLMQTVVALGEALETGKRAGLDPKLLFETLAKGSADSFALRNHGMKAMLPDTYPERAFSTEYA
RKDIGYALDLARSVQIDLPGAELADRRLGEAIEAGYGDLYWPVLARVIGASG
>Mature_291_residues
AAIGFIGLGVMGEPICRNLARKSGATVLGFDRADAPLQRLAAVGVIRAASLAELAREAELIFMALPSGKHVQSVCDGDDG
LLRHAEARHTIVDLGTSPVQATRELATHFAAKGAAFADAPIARTRQAAEDGTLSVMVGADAATFERLRPLIAMFATDITH
CGGVGAGQVVKILNNMVLMQTVVALGEALETGKRAGLDPKLLFETLAKGSADSFALRNHGMKAMLPDTYPERAFSTEYAR
KDIGYALDLARSVQIDLPGAELADRRLGEAIEAGYGDLYWPVLARVIGASG

Specific function: Catalyzes the conversion of 2-formylglutarate to (S)-2- hydroxymethylglutarate. Has very low activity with (S)-3- hydroxyisobutyrate [H]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=257, Percent_Identity=31.5175097276265, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI40556376, Length=262, Percent_Identity=24.8091603053435, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI145693186, Length=256, Percent_Identity=32.8125, Blast_Score=144, Evalue=6e-36,
Organism=Escherichia coli, GI1786719, Length=261, Percent_Identity=32.9501915708812, Blast_Score=135, Evalue=4e-33,
Organism=Escherichia coli, GI1790315, Length=296, Percent_Identity=30.4054054054054, Blast_Score=114, Evalue=9e-27,
Organism=Escherichia coli, GI1789092, Length=278, Percent_Identity=26.2589928057554, Blast_Score=71, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17557316, Length=272, Percent_Identity=30.8823529411765, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24655230, Length=288, Percent_Identity=28.8194444444444, Blast_Score=114, Evalue=9e-26,
Organism=Drosophila melanogaster, GI19922568, Length=288, Percent_Identity=28.8194444444444, Blast_Score=114, Evalue=9e-26,
Organism=Drosophila melanogaster, GI28574115, Length=276, Percent_Identity=21.3768115942029, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.291 [H]

Molecular weight: Translated: 30740; Mature: 30609

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAIGFIGLGVMGEPICRNLARKSGATVLGFDRADAPLQRLAAVGVIRAASLAELAREAE
CCCCHHEHHCCCCCHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
LIFMALPSGKHVQSVCDGDDGLLRHAEARHTIVDLGTSPVQATRELATHFAAKGAAFADA
EEEEECCCCCHHHHHHCCCHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHCCCCCCCC
PIARTRQAAEDGTLSVMVGADAATFERLRPLIAMFATDITHCGGVGAGQVVKILNNMVLM
CHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
QTVVALGEALETGKRAGLDPKLLFETLAKGSADSFALRNHGMKAMLPDTYPERAFSTEYA
HHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHCCCEECCCCCCCHHHHHHHHH
RKDIGYALDLARSVQIDLPGAELADRRLGEAIEAGYGDLYWPVLARVIGASG
HHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure 
AAIGFIGLGVMGEPICRNLARKSGATVLGFDRADAPLQRLAAVGVIRAASLAELAREAE
CCCHHEHHCCCCCHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
LIFMALPSGKHVQSVCDGDDGLLRHAEARHTIVDLGTSPVQATRELATHFAAKGAAFADA
EEEEECCCCCHHHHHHCCCHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHCCCCCCCC
PIARTRQAAEDGTLSVMVGADAATFERLRPLIAMFATDITHCGGVGAGQVVKILNNMVLM
CHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
QTVVALGEALETGKRAGLDPKLLFETLAKGSADSFALRNHGMKAMLPDTYPERAFSTEYA
HHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHCCCEECCCCCCCHHHHHHHHH
RKDIGYALDLARSVQIDLPGAELADRRLGEAIEAGYGDLYWPVLARVIGASG
HHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA