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The map label for this gene is lpd [H]

Identifier: 146302403

GI number: 146302403

Start: 5658421

End: 5659809

Strand: Direct

Name: lpd [H]

Synonym: Fjoh_4676

Alternate gene names: 146302403

Gene position: 5658421-5659809 (Clockwise)

Preceding gene: 146302402

Following gene: 146302404

Centisome position: 92.81

GC content: 38.66

Gene sequence:

>1389_bases
ATGAAATACGACGTTATTGTTTTAGGAAGTGGTCCTGGTGGATATGTAACAGCGATTAGAGCTTCACAATTAGGCTTTAA
AGTAGCTGTAGTTGAAAAAGAAAATCTTGGTGGTGTATGTTTAAACTGGGGATGTATCCCAACAAAAGCATTACTAAAAT
CTGCTCAGGTTTTTGATTACTTAAAACACGCTTCTGATTACGGATTAAAAGTTTCTGAATTCGATAAAGATTTCCCAGCA
GTTATTCAGCGCAGCCGTGGTGTTGCAGAAGGAATGAGCAAAGGAGTTCAATTCTTAATGAAAAAAAACAAAATTGACGT
TATCGAAGGTTTTGGAAAATTAAAACCAGGAAAAAAACTTGACGTTACAGATAAAGACAATAAAGTTACAGAATACAGCG
CTGATCATATTATCATCGCAACTGGAGCTCGTTCTCGTGAGCTGCCAAACTTACCTCAAGACGGTGTAAAAGTAATTGGA
TACCGTCAGGCAATGACATTACCAACTCAGCCAAAATCTATGATTATCGTAGGTTCTGGAGCAATTGGAGTAGAATTTGC
TCACTTCTACAACTCAATGGGAACAGACGTTACTATTGTAGAATTTATGCCAAATATCGTTCCTGTAGAAGACGAAGACG
TTTCTAAACAAATGGAGCGTTCTATGAAAAAAGCAGGTGTAAAAATCATGACAAACTCTTCTGTAGAAAAAATTGACACT
ACAGGAAACGGAGTTAAAGCAACTGTAAAAACTGCAAAAGGAGAAGAAATTCTTGAAGCAGACATCGTACTTTCGGCAGT
TGGAATCAAAACAAACATCGAAAACATTGGTTTAGAAGAAGTTGGAATCGCTGTTGACAGAGATAAAATCTTAGTAAACG
CTTACAACGAAACTAACATTCCTGGATACTACGCAATTGGAGACGTTACTCCTGGTCAGGCCTTAGCTCACGTAGCTTCT
GCAGAAGGAATTAACTGTGTAGAAAAAATCAAAGGTTTACACGTAGACCCAATCGATTACGGAAACATTCCGGGTTGTAC
TTATGCAACTCCAGAAATCGCTTCTGTAGGTTTAACAGAAAAACAAGCAAGAGATAAAGGTTACGAATTAAAAATTGGTA
AATTCCCATTCTCAGCTTCTGGAAAAGCAAAAGCTGCAGGAGCTGCGGACGGATTCGTAAAAGTAATCTTTGATGCAAAA
TATGGAGAATGGTTAGGATGCCACATGATTGGTGCTGGTGTTACAGATATGATTGCTGAGGCAGTTGTAGCTCGTAAACT
AGAAACTACAGGTCACGAAGTCCTTAAATCTATCCACCCTCACCCAACAATGAGCGAGGCTGTTATGGAAGCTGTAGCAG
ATGCTTACGGCGAAGTAATTCACTTGTAA

Upstream 100 bases:

>100_bases
TCCTTAAATTCGCAAGCACAAATAACAAAGAATCATCGAAAAATGAGTTTCGGAAAATTATAAACTTCATTTTCGATAGT
TAATATTAAAAACCAAAAAA

Downstream 100 bases:

>100_bases
AAATATACCGTTTTACGGTTATATATAATTCTCAATTAATTAAATCCGATTTGTGAAAACAGATCGGATTTTTTTATAAA
TATTATTATCATCCAAACAC

Product: dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase; E3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes [H]

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MKYDVIVLGSGPGGYVTAIRASQLGFKVAVVEKENLGGVCLNWGCIPTKALLKSAQVFDYLKHASDYGLKVSEFDKDFPA
VIQRSRGVAEGMSKGVQFLMKKNKIDVIEGFGKLKPGKKLDVTDKDNKVTEYSADHIIIATGARSRELPNLPQDGVKVIG
YRQAMTLPTQPKSMIIVGSGAIGVEFAHFYNSMGTDVTIVEFMPNIVPVEDEDVSKQMERSMKKAGVKIMTNSSVEKIDT
TGNGVKATVKTAKGEEILEADIVLSAVGIKTNIENIGLEEVGIAVDRDKILVNAYNETNIPGYYAIGDVTPGQALAHVAS
AEGINCVEKIKGLHVDPIDYGNIPGCTYATPEIASVGLTEKQARDKGYELKIGKFPFSASGKAKAAGAADGFVKVIFDAK
YGEWLGCHMIGAGVTDMIAEAVVARKLETTGHEVLKSIHPHPTMSEAVMEAVADAYGEVIHL

Sequences:

>Translated_462_residues
MKYDVIVLGSGPGGYVTAIRASQLGFKVAVVEKENLGGVCLNWGCIPTKALLKSAQVFDYLKHASDYGLKVSEFDKDFPA
VIQRSRGVAEGMSKGVQFLMKKNKIDVIEGFGKLKPGKKLDVTDKDNKVTEYSADHIIIATGARSRELPNLPQDGVKVIG
YRQAMTLPTQPKSMIIVGSGAIGVEFAHFYNSMGTDVTIVEFMPNIVPVEDEDVSKQMERSMKKAGVKIMTNSSVEKIDT
TGNGVKATVKTAKGEEILEADIVLSAVGIKTNIENIGLEEVGIAVDRDKILVNAYNETNIPGYYAIGDVTPGQALAHVAS
AEGINCVEKIKGLHVDPIDYGNIPGCTYATPEIASVGLTEKQARDKGYELKIGKFPFSASGKAKAAGAADGFVKVIFDAK
YGEWLGCHMIGAGVTDMIAEAVVARKLETTGHEVLKSIHPHPTMSEAVMEAVADAYGEVIHL
>Mature_462_residues
MKYDVIVLGSGPGGYVTAIRASQLGFKVAVVEKENLGGVCLNWGCIPTKALLKSAQVFDYLKHASDYGLKVSEFDKDFPA
VIQRSRGVAEGMSKGVQFLMKKNKIDVIEGFGKLKPGKKLDVTDKDNKVTEYSADHIIIATGARSRELPNLPQDGVKVIG
YRQAMTLPTQPKSMIIVGSGAIGVEFAHFYNSMGTDVTIVEFMPNIVPVEDEDVSKQMERSMKKAGVKIMTNSSVEKIDT
TGNGVKATVKTAKGEEILEADIVLSAVGIKTNIENIGLEEVGIAVDRDKILVNAYNETNIPGYYAIGDVTPGQALAHVAS
AEGINCVEKIKGLHVDPIDYGNIPGCTYATPEIASVGLTEKQARDKGYELKIGKFPFSASGKAKAAGAADGFVKVIFDAK
YGEWLGCHMIGAGVTDMIAEAVVARKLETTGHEVLKSIHPHPTMSEAVMEAVADAYGEVIHL

Specific function: Lipoamide dehydrogenase is a component of the alpha- ketoacid dehydrogenase complexes [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=469, Percent_Identity=37.1002132196162, Blast_Score=311, Evalue=8e-85,
Organism=Homo sapiens, GI50301238, Length=467, Percent_Identity=28.9079229122056, Blast_Score=172, Evalue=5e-43,
Organism=Homo sapiens, GI33519430, Length=449, Percent_Identity=26.5033407572383, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI33519428, Length=449, Percent_Identity=26.5033407572383, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI33519426, Length=449, Percent_Identity=26.5033407572383, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI148277065, Length=451, Percent_Identity=26.6075388026608, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI148277071, Length=451, Percent_Identity=26.6075388026608, Blast_Score=139, Evalue=7e-33,
Organism=Homo sapiens, GI22035672, Length=459, Percent_Identity=26.1437908496732, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI291045266, Length=431, Percent_Identity=24.3619489559165, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI291045268, Length=283, Percent_Identity=26.1484098939929, Blast_Score=107, Evalue=3e-23,
Organism=Escherichia coli, GI1786307, Length=453, Percent_Identity=33.3333333333333, Blast_Score=246, Evalue=2e-66,
Organism=Escherichia coli, GI87082354, Length=451, Percent_Identity=27.4944567627494, Blast_Score=174, Evalue=1e-44,
Organism=Escherichia coli, GI1789915, Length=444, Percent_Identity=29.954954954955, Blast_Score=174, Evalue=2e-44,
Organism=Escherichia coli, GI87081717, Length=461, Percent_Identity=29.2841648590022, Blast_Score=155, Evalue=5e-39,
Organism=Escherichia coli, GI1788892, Length=188, Percent_Identity=28.1914893617021, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1789065, Length=187, Percent_Identity=25.668449197861, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI32565766, Length=460, Percent_Identity=37.6086956521739, Blast_Score=299, Evalue=2e-81,
Organism=Caenorhabditis elegans, GI17557007, Length=476, Percent_Identity=26.890756302521, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI71982272, Length=388, Percent_Identity=27.0618556701031, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI71983419, Length=360, Percent_Identity=26.1111111111111, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI71983429, Length=360, Percent_Identity=26.1111111111111, Blast_Score=109, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6321091, Length=473, Percent_Identity=38.4778012684989, Blast_Score=285, Evalue=1e-77,
Organism=Saccharomyces cerevisiae, GI6325166, Length=461, Percent_Identity=27.9826464208243, Blast_Score=179, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6325240, Length=469, Percent_Identity=26.865671641791, Blast_Score=168, Evalue=1e-42,
Organism=Drosophila melanogaster, GI21358499, Length=468, Percent_Identity=38.034188034188, Blast_Score=306, Evalue=1e-83,
Organism=Drosophila melanogaster, GI24640549, Length=377, Percent_Identity=27.8514588859416, Blast_Score=125, Evalue=8e-29,
Organism=Drosophila melanogaster, GI24640553, Length=378, Percent_Identity=28.3068783068783, Blast_Score=125, Evalue=8e-29,
Organism=Drosophila melanogaster, GI24640551, Length=378, Percent_Identity=28.3068783068783, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI17737741, Length=469, Percent_Identity=22.3880597014925, Blast_Score=112, Evalue=4e-25,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 49484; Mature: 49484

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYDVIVLGSGPGGYVTAIRASQLGFKVAVVEKENLGGVCLNWGCIPTKALLKSAQVFDY
CCEEEEEEECCCCCEEEEEEECCCCEEEEEEEECCCCCEEEECCCCCHHHHHHHHHHHHH
LKHASDYGLKVSEFDKDFPAVIQRSRGVAEGMSKGVQFLMKKNKIDVIEGFGKLKPGKKL
HHHHHHCCCCHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCEE
DVTDKDNKVTEYSADHIIIATGARSRELPNLPQDGVKVIGYRQAMTLPTQPKSMIIVGSG
CCCCCCCCEEEECCCEEEEEECCCCCCCCCCCCCCCEEEEEEEEEECCCCCCCEEEEECC
AIGVEFAHFYNSMGTDVTIVEFMPNIVPVEDEDVSKQMERSMKKAGVKIMTNSSVEKIDT
CCHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCEEEEECCCCCEEEC
TGNGVKATVKTAKGEEILEADIVLSAVGIKTNIENIGLEEVGIAVDRDKILVNAYNETNI
CCCCEEEEEEECCCCHHHHHHHEEEEECCEECCCCCCHHHHCEEEECCEEEEEECCCCCC
PGYYAIGDVTPGQALAHVASAEGINCVEKIKGLHVDPIDYGNIPGCTYATPEIASVGLTE
CCEEEECCCCCHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHCCCCH
KQARDKGYELKIGKFPFSASGKAKAAGAADGFVKVIFDAKYGEWLGCHMIGAGVTDMIAE
HHHHCCCCEEEEECCCCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEEEECCCHHHHHHH
AVVARKLETTGHEVLKSIHPHPTMSEAVMEAVADAYGEVIHL
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHEECC
>Mature Secondary Structure
MKYDVIVLGSGPGGYVTAIRASQLGFKVAVVEKENLGGVCLNWGCIPTKALLKSAQVFDY
CCEEEEEEECCCCCEEEEEEECCCCEEEEEEEECCCCCEEEECCCCCHHHHHHHHHHHHH
LKHASDYGLKVSEFDKDFPAVIQRSRGVAEGMSKGVQFLMKKNKIDVIEGFGKLKPGKKL
HHHHHHCCCCHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCEE
DVTDKDNKVTEYSADHIIIATGARSRELPNLPQDGVKVIGYRQAMTLPTQPKSMIIVGSG
CCCCCCCCEEEECCCEEEEEECCCCCCCCCCCCCCCEEEEEEEEEECCCCCCCEEEEECC
AIGVEFAHFYNSMGTDVTIVEFMPNIVPVEDEDVSKQMERSMKKAGVKIMTNSSVEKIDT
CCHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCEEEEECCCCCEEEC
TGNGVKATVKTAKGEEILEADIVLSAVGIKTNIENIGLEEVGIAVDRDKILVNAYNETNI
CCCCEEEEEEECCCCHHHHHHHEEEEECCEECCCCCCHHHHCEEEECCEEEEEECCCCCC
PGYYAIGDVTPGQALAHVASAEGINCVEKIKGLHVDPIDYGNIPGCTYATPEIASVGLTE
CCEEEECCCCCHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHCCCCH
KQARDKGYELKIGKFPFSASGKAKAAGAADGFVKVIFDAKYGEWLGCHMIGAGVTDMIAE
HHHHCCCCEEEEECCCCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEEEECCCHHHHHHH
AVVARKLETTGHEVLKSIHPHPTMSEAVMEAVADAYGEVIHL
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9515924 [H]