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The map label for this gene is atsA [H]

Identifier: 146302379

GI number: 146302379

Start: 5627114

End: 5628769

Strand: Direct

Name: atsA [H]

Synonym: Fjoh_4652

Alternate gene names: 146302379

Gene position: 5627114-5628769 (Clockwise)

Preceding gene: 146302378

Following gene: 146302380

Centisome position: 92.3

GC content: 38.47

Gene sequence:

>1656_bases
ATGAATACAAAAATTACAAAACTTCTGTTTTCCATTCTTTTAACCGGAGCTTTCACTTCTCAGGAGTCAAATGCTCAAAC
CGAAACGAAACCCAATATTATTCTGATTTTGGTTGATGATATGGGATATTCAGATTTAGGAAATTATGGTTCAGAAATTA
AAACACCAAATCTTGATAAACTGGCTTCAGAAGGTTTACGATTACGCGAATTTTATAACAATTCGATTTGTGCCCCAACA
AGGGCTTCTCTCCTAACCGGACAATATCAGCATAAAGCCGGAGTTGGATTTTTTGATGTAAATTTAGGTCTACCGGCTTA
TCAGGGCTACTTAAACAAAGAATCTTTAACGCTTGGAGAAGTTTTCCGTTCTGGCGGTTACAGCACACTTTTATCTGGAA
AATGGCACGTGGGTTCTGAAGATCAGGCGCAATGGCCGAATCAAAGAGGATTTGACAAATTTTACGGAATCTTAAAAGGC
GCCTCAAACTATTTTGACACCAAACCGCTTCCATTTGGAAAAACACCTTATCCGGTAAAATTAATCCGCAATAACGAAGA
ACTGCATCCAAAAGATGATTCATATTATTTTACAGATGAAATTGGAAATAATGCAGTGACTTTTTTAGATGAGCAAAACA
AAGAAAATAAACCTTTCTTTTTATACTTAGCCTTTACCGCACCTCACTGGCCGCTACAGGCAAAACCTATTGATATTGCC
AAATACAGAGGAAAATTTGACGAAGGCTGGGATGTTTTAAGAGAAAAAAGAATTCAGAAACTAAAAGCAAACGGCATTTT
ACCGGCAGACCAAACTATATCGCCAAGAGATCCTGAAGTTCCGGAATGGAATAAACTAACGTATGACGAAAAGCAATTTT
GGAAAGCTAAAATGGAAGTTTATGCCGCAATGGTCGACAATATGGATCAAAATGTGGGTAAAGTTCTTGACAAACTAAAA
GCTTTGAAAAAAGACAAAAATACGCTGATTATTTTCATATCAGACAACGGCGCTCAGGGAGGATTCAATACATATAATCC
GCTGGGAAGAGGTTTGGTTCGAAATGATGGACCAGTTGGAACTTCGGGTTCATTTGATTATCAGGAACAAAACTGGGCTT
ACTTATCTAATACTCCGTTACAGCAATATAAAAACAATATGCATGAAGGCGGTTTTAGTTCGCCGTTTATTGCCTGGTAT
CCGTCAAAAATCAAAGCGGGCAGAATTGATAAAGGAACCGGACACATTATTGACCTCGCTCCTACTTTTTATGAACTAGC
CGGAATTGAATACCCAAAAGAATATAATGGTGTGACGACAAACGCCCTGGCTGGAAAAAGTTTGTTACCTGTTTTATTTA
ATAATGTTTCACAGGTCGACAGAGGCGCACCATTATTTTGGGAAAGAGCCGGAAACAGAGCCGTTCGCGATGGAAAATGG
AAGTTAGTTTCGATTTATCCTTCTTATGAATGGGAATTGTATGATCTTGAAAAAGACCGAGGAGAAACTACAAATGTAGC
CCAACAGAATCCGGCAATCGTAAACAAACTTTCGGCTTCGTATTTTGAATGGGCAGACAAAACGGGAGTTGTAGAATACA
GCAAATTCAAACTAAAACCAGAAACAATGCCAGGCGGTGCGGCACTGAAAAAATAA

Upstream 100 bases:

>100_bases
ATTACAAAGGGTCATTTCTGCGGCAACAGAAATGACCTGATTTTAAAGAACATTTATCACTTACAAAAACAAAAACCAAC
ACACAAAAAAGTACATTACA

Downstream 100 bases:

>100_bases
AATTATTAATTTAAACACATAGAAACATAGATCTTTTTTCTTGAGATAAAGATTAAAAAGATGACAGGTCGTCACACATA
GTCACGATAGCTATCGGGAT

Product: sulfatase

Products: NA

Alternate protein names: AS; Aryl-sulfate sulphohydrolase [H]

Number of amino acids: Translated: 551; Mature: 551

Protein sequence:

>551_residues
MNTKITKLLFSILLTGAFTSQESNAQTETKPNIILILVDDMGYSDLGNYGSEIKTPNLDKLASEGLRLREFYNNSICAPT
RASLLTGQYQHKAGVGFFDVNLGLPAYQGYLNKESLTLGEVFRSGGYSTLLSGKWHVGSEDQAQWPNQRGFDKFYGILKG
ASNYFDTKPLPFGKTPYPVKLIRNNEELHPKDDSYYFTDEIGNNAVTFLDEQNKENKPFFLYLAFTAPHWPLQAKPIDIA
KYRGKFDEGWDVLREKRIQKLKANGILPADQTISPRDPEVPEWNKLTYDEKQFWKAKMEVYAAMVDNMDQNVGKVLDKLK
ALKKDKNTLIIFISDNGAQGGFNTYNPLGRGLVRNDGPVGTSGSFDYQEQNWAYLSNTPLQQYKNNMHEGGFSSPFIAWY
PSKIKAGRIDKGTGHIIDLAPTFYELAGIEYPKEYNGVTTNALAGKSLLPVLFNNVSQVDRGAPLFWERAGNRAVRDGKW
KLVSIYPSYEWELYDLEKDRGETTNVAQQNPAIVNKLSASYFEWADKTGVVEYSKFKLKPETMPGGAALKK

Sequences:

>Translated_551_residues
MNTKITKLLFSILLTGAFTSQESNAQTETKPNIILILVDDMGYSDLGNYGSEIKTPNLDKLASEGLRLREFYNNSICAPT
RASLLTGQYQHKAGVGFFDVNLGLPAYQGYLNKESLTLGEVFRSGGYSTLLSGKWHVGSEDQAQWPNQRGFDKFYGILKG
ASNYFDTKPLPFGKTPYPVKLIRNNEELHPKDDSYYFTDEIGNNAVTFLDEQNKENKPFFLYLAFTAPHWPLQAKPIDIA
KYRGKFDEGWDVLREKRIQKLKANGILPADQTISPRDPEVPEWNKLTYDEKQFWKAKMEVYAAMVDNMDQNVGKVLDKLK
ALKKDKNTLIIFISDNGAQGGFNTYNPLGRGLVRNDGPVGTSGSFDYQEQNWAYLSNTPLQQYKNNMHEGGFSSPFIAWY
PSKIKAGRIDKGTGHIIDLAPTFYELAGIEYPKEYNGVTTNALAGKSLLPVLFNNVSQVDRGAPLFWERAGNRAVRDGKW
KLVSIYPSYEWELYDLEKDRGETTNVAQQNPAIVNKLSASYFEWADKTGVVEYSKFKLKPETMPGGAALKK
>Mature_551_residues
MNTKITKLLFSILLTGAFTSQESNAQTETKPNIILILVDDMGYSDLGNYGSEIKTPNLDKLASEGLRLREFYNNSICAPT
RASLLTGQYQHKAGVGFFDVNLGLPAYQGYLNKESLTLGEVFRSGGYSTLLSGKWHVGSEDQAQWPNQRGFDKFYGILKG
ASNYFDTKPLPFGKTPYPVKLIRNNEELHPKDDSYYFTDEIGNNAVTFLDEQNKENKPFFLYLAFTAPHWPLQAKPIDIA
KYRGKFDEGWDVLREKRIQKLKANGILPADQTISPRDPEVPEWNKLTYDEKQFWKAKMEVYAAMVDNMDQNVGKVLDKLK
ALKKDKNTLIIFISDNGAQGGFNTYNPLGRGLVRNDGPVGTSGSFDYQEQNWAYLSNTPLQQYKNNMHEGGFSSPFIAWY
PSKIKAGRIDKGTGHIIDLAPTFYELAGIEYPKEYNGVTTNALAGKSLLPVLFNNVSQVDRGAPLFWERAGNRAVRDGKW
KLVSIYPSYEWELYDLEKDRGETTNVAQQNPAIVNKLSASYFEWADKTGVVEYSKFKLKPETMPGGAALKK

Specific function: Unknown

COG id: COG3119

COG function: function code P; Arylsulfatase A and related enzymes

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sulfatase family [H]

Homologues:

Organism=Homo sapiens, GI109389362, Length=541, Percent_Identity=26.2476894639556, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI59797060, Length=552, Percent_Identity=27.536231884058, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI4503899, Length=460, Percent_Identity=28.695652173913, Blast_Score=144, Evalue=3e-34,
Organism=Homo sapiens, GI38569405, Length=551, Percent_Identity=24.8638838475499, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI38569407, Length=408, Percent_Identity=27.4509803921569, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI53831991, Length=485, Percent_Identity=26.5979381443299, Blast_Score=129, Evalue=6e-30,
Organism=Homo sapiens, GI146229331, Length=520, Percent_Identity=27.8846153846154, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI146229329, Length=520, Percent_Identity=27.8846153846154, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI6005990, Length=520, Percent_Identity=27.8846153846154, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI146229324, Length=520, Percent_Identity=27.8846153846154, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI45430057, Length=443, Percent_Identity=27.5395033860045, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI31742482, Length=162, Percent_Identity=38.8888888888889, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI71852586, Length=140, Percent_Identity=40, Blast_Score=100, Evalue=6e-21,
Organism=Homo sapiens, GI157266309, Length=161, Percent_Identity=34.1614906832298, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI71852584, Length=140, Percent_Identity=40, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI58743319, Length=139, Percent_Identity=38.1294964028777, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI5360208, Length=372, Percent_Identity=25.5376344086022, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI4557659, Length=365, Percent_Identity=25.4794520547945, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI240255483, Length=453, Percent_Identity=24.0618101545254, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI29789100, Length=453, Percent_Identity=24.0618101545254, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI240255478, Length=453, Percent_Identity=24.0618101545254, Blast_Score=73, Evalue=5e-13,
Organism=Escherichia coli, GI87081924, Length=477, Percent_Identity=25.3668763102725, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI1790233, Length=237, Percent_Identity=31.2236286919831, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1790112, Length=436, Percent_Identity=24.7706422018349, Blast_Score=96, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI115533416, Length=520, Percent_Identity=26.3461538461538, Blast_Score=131, Evalue=8e-31,
Organism=Caenorhabditis elegans, GI115533418, Length=506, Percent_Identity=25.6916996047431, Blast_Score=119, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17559078, Length=256, Percent_Identity=27.734375, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI281363223, Length=483, Percent_Identity=28.7784679089027, Blast_Score=158, Evalue=7e-39,
Organism=Drosophila melanogaster, GI24666175, Length=454, Percent_Identity=28.4140969162996, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI281366397, Length=434, Percent_Identity=29.2626728110599, Blast_Score=146, Evalue=4e-35,
Organism=Drosophila melanogaster, GI281366395, Length=434, Percent_Identity=29.2626728110599, Blast_Score=146, Evalue=4e-35,
Organism=Drosophila melanogaster, GI24666163, Length=434, Percent_Identity=29.2626728110599, Blast_Score=146, Evalue=4e-35,
Organism=Drosophila melanogaster, GI24666109, Length=413, Percent_Identity=28.3292978208232, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24647401, Length=471, Percent_Identity=26.1146496815287, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24653364, Length=549, Percent_Identity=24.408014571949, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI19922168, Length=549, Percent_Identity=24.2258652094718, Blast_Score=83, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR000917 [H]

Pfam domain/function: PF00884 Sulfatase [H]

EC number: =3.1.6.1 [H]

Molecular weight: Translated: 62122; Mature: 62122

Theoretical pI: Translated: 8.55; Mature: 8.55

Prosite motif: PS00523 SULFATASE_1 ; PS00149 SULFATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTKITKLLFSILLTGAFTSQESNAQTETKPNIILILVDDMGYSDLGNYGSEIKTPNLDK
CCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHCCCCCCCCCCHHH
LASEGLRLREFYNNSICAPTRASLLTGQYQHKAGVGFFDVNLGLPAYQGYLNKESLTLGE
HHHCCHHHHHHHCCCCCCCCHHHHHCCCHHHHCCCCEEEECCCCHHHHCCCCCCCCCHHH
VFRSGGYSTLLSGKWHVGSEDQAQWPNQRGFDKFYGILKGASNYFDTKPLPFGKTPYPVK
HHHCCCCEEEECCCCCCCCCCHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEE
LIRNNEELHPKDDSYYFTDEIGNNAVTFLDEQNKENKPFFLYLAFTAPHWPLQAKPIDIA
EEECCCCCCCCCCCEEEECCCCCCEEEEEECCCCCCCCEEEEEEEECCCCCCCCCCCHHH
KYRGKFDEGWDVLREKRIQKLKANGILPADQTISPRDPEVPEWNKLTYDEKQFWKAKMEV
HHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
YAAMVDNMDQNVGKVLDKLKALKKDKNTLIIFISDNGAQGGFNTYNPLGRGLVRNDGPVG
HHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCHHHCCCCCCCCCCC
TSGSFDYQEQNWAYLSNTPLQQYKNNMHEGGFSSPFIAWYPSKIKAGRIDKGTGHIIDLA
CCCCCCCCCCCEEEECCCCHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCCCEEECC
PTFYELAGIEYPKEYNGVTTNALAGKSLLPVLFNNVSQVDRGAPLFWERAGNRAVRDGKW
HHHHHHHCCCCCHHHCCCCCHHHCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCEECCCE
KLVSIYPSYEWELYDLEKDRGETTNVAQQNPAIVNKLSASYFEWADKTGVVEYSKFKLKP
EEEEECCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEEECC
ETMPGGAALKK
CCCCCCCCCCC
>Mature Secondary Structure
MNTKITKLLFSILLTGAFTSQESNAQTETKPNIILILVDDMGYSDLGNYGSEIKTPNLDK
CCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHCCCCCCCCCCHHH
LASEGLRLREFYNNSICAPTRASLLTGQYQHKAGVGFFDVNLGLPAYQGYLNKESLTLGE
HHHCCHHHHHHHCCCCCCCCHHHHHCCCHHHHCCCCEEEECCCCHHHHCCCCCCCCCHHH
VFRSGGYSTLLSGKWHVGSEDQAQWPNQRGFDKFYGILKGASNYFDTKPLPFGKTPYPVK
HHHCCCCEEEECCCCCCCCCCHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEE
LIRNNEELHPKDDSYYFTDEIGNNAVTFLDEQNKENKPFFLYLAFTAPHWPLQAKPIDIA
EEECCCCCCCCCCCEEEECCCCCCEEEEEECCCCCCCCEEEEEEEECCCCCCCCCCCHHH
KYRGKFDEGWDVLREKRIQKLKANGILPADQTISPRDPEVPEWNKLTYDEKQFWKAKMEV
HHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
YAAMVDNMDQNVGKVLDKLKALKKDKNTLIIFISDNGAQGGFNTYNPLGRGLVRNDGPVG
HHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCHHHCCCCCCCCCCC
TSGSFDYQEQNWAYLSNTPLQQYKNNMHEGGFSSPFIAWYPSKIKAGRIDKGTGHIIDLA
CCCCCCCCCCCEEEECCCCHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCCCEEECC
PTFYELAGIEYPKEYNGVTTNALAGKSLLPVLFNNVSQVDRGAPLFWERAGNRAVRDGKW
HHHHHHHCCCCCHHHCCCCCHHHCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCEECCCE
KLVSIYPSYEWELYDLEKDRGETTNVAQQNPAIVNKLSASYFEWADKTGVVEYSKFKLKP
EEEEECCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEEECC
ETMPGGAALKK
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7744061; 10984043 [H]