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The map label for this gene is cysK [H]

Identifier: 146302380

GI number: 146302380

Start: 5628968

End: 5629888

Strand: Direct

Name: cysK [H]

Synonym: Fjoh_4653

Alternate gene names: 146302380

Gene position: 5628968-5629888 (Clockwise)

Preceding gene: 146302379

Following gene: 146302381

Centisome position: 92.33

GC content: 38.11

Gene sequence:

>921_bases
ATGAAATATCAAAACATTTTAGAAACCATTGGCAATACGCCGCACATTAAGCTCAACAAGCTTTTTAAAACCCATGAGGT
ATGGATTAAGTTAGAAAAATCAAATCCGGGATCGAGTATCAAAGACAGGATTGCTCTGGCTATGATTGAAGATGCAGAGA
AAAAAGGACTTTTAAATCCGGATTCTATTATTATTGAGCCAACATCCGGAAATACCGGAATTGGGCTTTCGTTAGTGGCA
GCCGTAAAAGGGTATAAAGTAATTATTGTAATGCCGGAATCGATGAGTGTTGAACGCCGAAAAATTATCGAAGCTTATGG
TGCCGAATATGTTTTGACACCGAGGGAAAAAGGAACTTCTGGAGCGGTTGAAAAAGCAAATGAACTGGCATCGACTATTA
AAAACTCTTTCCTCCCTTCTCAATTTACCAATAGAGCCAATGTTGAAGTTCACGAAAGAACAACGGCACAGGAAATCCTT
GCCGATTTTCCAGACGGTATTGATTATTTGATTACGGGAGTTGGTACAGGCGGGCACATTACTGGAGTTTCTAAAATTTT
GAAACAGCATTTTCCAAATCTTAAAACAATTGCAGTAGAGCCTGCCCTTTCTCCGGTTTTAAGCGGCGGTATTCCTGCTC
CTCACCCATTACAGGGAATTGGCGCCGGATTTATTCCTGAAGTTTTTAACTGTGAATATGTAGATGAGATTGTAACGATC
GAAAAAAATGATGCTTTTTCATTTGCTAAAAAAATAGCAAAAGAGGAAGGCATTTTTGGAGGAATTTCTACTGGAGCAGC
ATTAGCAGCGGTTTCTAAAAAAATAAAAAATATTCCGGAAGATGCCGTAATACTGACTTTTAATTATGATACCGGAGAAC
GTTATCTTTCTGTAGAAGAATTATTCGATTTTTTCTCATAA

Upstream 100 bases:

>100_bases
ATAAGTTAATGCAAGTGAAACGTCTTTTTTAAAGTGTCGAAATTCTATGTTTCTATGTGTTTAAATTACTCAATAATTGA
AGTTTAAAAATATCAAACAC

Downstream 100 bases:

>100_bases
AAAACTAAATACCAAAACATTACATAAAAATAAAACCCGTAATTTTAAGAGTTAAATCTTAGAATTGTTCAAAAAAATAA
AAAGTAACCAAAAAACCTTA

Product: cysteine synthase

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MKYQNILETIGNTPHIKLNKLFKTHEVWIKLEKSNPGSSIKDRIALAMIEDAEKKGLLNPDSIIIEPTSGNTGIGLSLVA
AVKGYKVIIVMPESMSVERRKIIEAYGAEYVLTPREKGTSGAVEKANELASTIKNSFLPSQFTNRANVEVHERTTAQEIL
ADFPDGIDYLITGVGTGGHITGVSKILKQHFPNLKTIAVEPALSPVLSGGIPAPHPLQGIGAGFIPEVFNCEYVDEIVTI
EKNDAFSFAKKIAKEEGIFGGISTGAALAAVSKKIKNIPEDAVILTFNYDTGERYLSVEELFDFFS

Sequences:

>Translated_306_residues
MKYQNILETIGNTPHIKLNKLFKTHEVWIKLEKSNPGSSIKDRIALAMIEDAEKKGLLNPDSIIIEPTSGNTGIGLSLVA
AVKGYKVIIVMPESMSVERRKIIEAYGAEYVLTPREKGTSGAVEKANELASTIKNSFLPSQFTNRANVEVHERTTAQEIL
ADFPDGIDYLITGVGTGGHITGVSKILKQHFPNLKTIAVEPALSPVLSGGIPAPHPLQGIGAGFIPEVFNCEYVDEIVTI
EKNDAFSFAKKIAKEEGIFGGISTGAALAAVSKKIKNIPEDAVILTFNYDTGERYLSVEELFDFFS
>Mature_306_residues
MKYQNILETIGNTPHIKLNKLFKTHEVWIKLEKSNPGSSIKDRIALAMIEDAEKKGLLNPDSIIIEPTSGNTGIGLSLVA
AVKGYKVIIVMPESMSVERRKIIEAYGAEYVLTPREKGTSGAVEKANELASTIKNSFLPSQFTNRANVEVHERTTAQEIL
ADFPDGIDYLITGVGTGGHITGVSKILKQHFPNLKTIAVEPALSPVLSGGIPAPHPLQGIGAGFIPEVFNCEYVDEIVTI
EKNDAFSFAKKIAKEEGIFGGISTGAALAAVSKKIKNIPEDAVILTFNYDTGERYLSVEELFDFFS

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=305, Percent_Identity=40, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI295821200, Length=305, Percent_Identity=40, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI4557415, Length=305, Percent_Identity=40, Blast_Score=204, Evalue=1e-52,
Organism=Escherichia coli, GI1788754, Length=312, Percent_Identity=45.1923076923077, Blast_Score=226, Evalue=1e-60,
Organism=Escherichia coli, GI2367138, Length=292, Percent_Identity=39.7260273972603, Blast_Score=214, Evalue=8e-57,
Organism=Caenorhabditis elegans, GI17535051, Length=295, Percent_Identity=44.7457627118644, Blast_Score=243, Evalue=7e-65,
Organism=Caenorhabditis elegans, GI17562970, Length=308, Percent_Identity=39.9350649350649, Blast_Score=220, Evalue=8e-58,
Organism=Caenorhabditis elegans, GI115535073, Length=299, Percent_Identity=44.8160535117057, Blast_Score=218, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI32566674, Length=301, Percent_Identity=40.531561461794, Blast_Score=218, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI17561720, Length=298, Percent_Identity=39.5973154362416, Blast_Score=187, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI17534315, Length=312, Percent_Identity=38.7820512820513, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI25147552, Length=310, Percent_Identity=36.1290322580645, Blast_Score=155, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI32566672, Length=218, Percent_Identity=38.5321100917431, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17561716, Length=117, Percent_Identity=35.8974358974359, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6321594, Length=319, Percent_Identity=36.3636363636364, Blast_Score=182, Evalue=7e-47,
Organism=Saccharomyces cerevisiae, GI6321449, Length=329, Percent_Identity=32.2188449848024, Blast_Score=112, Evalue=9e-26,
Organism=Drosophila melanogaster, GI24643623, Length=296, Percent_Identity=38.5135135135135, Blast_Score=177, Evalue=7e-45,
Organism=Drosophila melanogaster, GI20129101, Length=296, Percent_Identity=38.5135135135135, Blast_Score=177, Evalue=7e-45,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 33220; Mature: 33220

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYQNILETIGNTPHIKLNKLFKTHEVWIKLEKSNPGSSIKDRIALAMIEDAEKKGLLNP
CCHHHHHHHHCCCCCEEHHHHHEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCC
DSIIIEPTSGNTGIGLSLVAAVKGYKVIIVMPESMSVERRKIIEAYGAEYVLTPREKGTS
CCEEEEECCCCCCCHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHCCCEEECCCCCCCC
GAVEKANELASTIKNSFLPSQFTNRANVEVHERTTAQEILADFPDGIDYLITGVGTGGHI
CHHHHHHHHHHHHHHHCCCHHHCCCCCEEEHHHHHHHHHHHHCCCCCEEEEEECCCCCCH
TGVSKILKQHFPNLKTIAVEPALSPVLSGGIPAPHPLQGIGAGFIPEVFNCEYVDEIVTI
HHHHHHHHHHCCCCEEEEECCHHHHHHCCCCCCCCCCCCCCCCCCHHHHCCHHHHHEEEE
EKNDAFSFAKKIAKEEGIFGGISTGAALAAVSKKIKNIPEDAVILTFNYDTGERYLSVEE
ECCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCEEEHHH
LFDFFS
HHHHCC
>Mature Secondary Structure
MKYQNILETIGNTPHIKLNKLFKTHEVWIKLEKSNPGSSIKDRIALAMIEDAEKKGLLNP
CCHHHHHHHHCCCCCEEHHHHHEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCC
DSIIIEPTSGNTGIGLSLVAAVKGYKVIIVMPESMSVERRKIIEAYGAEYVLTPREKGTS
CCEEEEECCCCCCCHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHCCCEEECCCCCCCC
GAVEKANELASTIKNSFLPSQFTNRANVEVHERTTAQEILADFPDGIDYLITGVGTGGHI
CHHHHHHHHHHHHHHHCCCHHHCCCCCEEEHHHHHHHHHHHHCCCCCEEEEEECCCCCCH
TGVSKILKQHFPNLKTIAVEPALSPVLSGGIPAPHPLQGIGAGFIPEVFNCEYVDEIVTI
HHHHHHHHHHCCCCEEEEECCHHHHHHCCCCCCCCCCCCCCCCCCHHHHCCHHHHHEEEE
EKNDAFSFAKKIAKEEGIFGGISTGAALAAVSKKIKNIPEDAVILTFNYDTGERYLSVEE
ECCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCEEEHHH
LFDFFS
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8867384 [H]