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The map label for this gene is clcB [H]

Identifier: 146302234

GI number: 146302234

Start: 5440904

End: 5442688

Strand: Direct

Name: clcB [H]

Synonym: Fjoh_4507

Alternate gene names: 146302234

Gene position: 5440904-5442688 (Clockwise)

Preceding gene: 146302233

Following gene: 146302235

Centisome position: 89.24

GC content: 34.62

Gene sequence:

>1785_bases
ATGATAAAAAAACTGTTTCGTCGACTGGAAAGTATTATTGCTTTGGCTCAATCTATTTTGACACCAAAACAATTCATTTT
TTTATCAAGTGTTTTAGTGGGTATTTCCTGTTCTTTTGCAGTAATTATCCTGAAAGCTTTTGCCCATAATGTTTTTTCTT
TTGCAACTTATATAAGTGGAATTTTAAAATTAGGTTTTATTAATAGTATCCTGCCTATAATTGGTATTCTGCTTACGGTT
TTGGTTGTAAAAAAGGTTCTAAACGGATCGATTCAAAAAGGAACTTCTCAAATTTTATACGCAGTTGCTAAAAAAGCCAG
CATAATTCCGAGAAAGCAAATGTACGCGCAAATTGTAACAAGCTCGTTAACTGTTGGTTTAGGAGGTTCTGCAGGTTTAG
AAAGTCCAATTGTAATTACAGGAGCCGCTTTTGGTTCTAATTATGCACAAAACTATAAATTAGCTTATAAAGACCGTACT
TTACTTATTGGCTGTGGTGTGGCAGCTGGAATCTCAGCAGCATTTAACGCCCCAATTGCAGGAGTTCTTTTTGCTATTGA
AGTTTTATTGGTAGACGTCAGCATATCGGCTTTTACACCTATTATGATTTCGGCGGCGACGGGTGCTTTGGTATCGGCAA
TTGTATTAGACGAAAGCATTCTTTTATCTTTTAAAAAACAAGAAACTTTTGATTATCATAATATTCCTTTTTACGTAATT
TTAGGCTTAATAACTGGTTTTATGGCTGTTTATTACGCCCGAAATTTTCAAAGGGTAGAACATTATTTCTCAGAACTAAA
AATGGGACCTTATAAAAAAGCCCTGATTGGTTCTTCGCTTTTAGCACTTCTTATTTTTATTTTCCCAACTCTTTTTGGTG
AAGGATACGAAAGCATCAAAACATTATCTGAAAGTGATCCCGGACAATTGTTAGACAATACTTTATTTGCCACATGGAGA
AATAACAACTGGGTTTTACTGCTTTTTATTGGATGCACAATGATGGTAAAAGTCTTTGCATCCGGACTTACGCTTGGAAG
CGGCGGAAATGGAGGTAATTTTGCTCCTTCCCTGTTTTTAGGATCTTATTTAGGATATTTCTTTTCAAAACTTGTTACCC
TTACTGGTTTATCAAAACTGCCTATTACTAATTTTACAATGGTTGGAATGGCTGGAATCCTTAGCGGATTATTTCATGCA
CCATTAACAGCAATATTCCTTATTGCCGAAATTACAGGAGGTTACGGCTTGATGATTCCGCTTATGATTGTTTCCTCAAT
CAGTTTTGCTATTTCTAAACGTTTTGAAAAATATTCGCTTGACGTAAAAAATCTTGCGAAAAAAGGGCACGCTTTTACCA
GTAATAAAGATTCTAATATTCTATCGACTCTGGATATTGATACGATTATCCAAACGGATTATTTAACCGTTTCCCCAGAA
GATCATTTGAGCAAATTAGTCGACCTTATTTCGCATTCTAATCAGGTTGTTTTTGCTGTTGTAAACAATGACAGAGATCT
TGTTGGAATTGTACATTTTAATGATATCCGCGAAATCATTTTTAATGCTTACCGCGTAAAATATACGTTAATTAAAGACG
TAATGAAAACGCCTGCAGCAACCATTTCTTCAAATGACAGTATGGAAATTGTCATGACAAAATTCGAAAGATCAAAATCA
GCTTTTCTTCCTGTACTTAGAAATGACAAATACTTCGGCATCATTTCAAAATCTATTGCACTTGAAGCCTACAGAATGAA
ACTGCGTTCTATGACAATAGAATAA

Upstream 100 bases:

>100_bases
AGCGGCTGGATTTTAAATTCAAAAGATTTAAGTAGAAAAATTTGATAAAAACGAATGTTTAGAGTTAAATTTGCATTCTC
CGTAATTTTTTAAAATACTA

Downstream 100 bases:

>100_bases
GCTTAATATCGGATAAGTTAAAAATTTGCTATAACCGATATTATGAAGTAAATTTGTAGGATTATGTGGAATATTGACTT
AACATACCGAGACGAATTTC

Product: Cl- channel, voltage-gated family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 594; Mature: 594

Protein sequence:

>594_residues
MIKKLFRRLESIIALAQSILTPKQFIFLSSVLVGISCSFAVIILKAFAHNVFSFATYISGILKLGFINSILPIIGILLTV
LVVKKVLNGSIQKGTSQILYAVAKKASIIPRKQMYAQIVTSSLTVGLGGSAGLESPIVITGAAFGSNYAQNYKLAYKDRT
LLIGCGVAAGISAAFNAPIAGVLFAIEVLLVDVSISAFTPIMISAATGALVSAIVLDESILLSFKKQETFDYHNIPFYVI
LGLITGFMAVYYARNFQRVEHYFSELKMGPYKKALIGSSLLALLIFIFPTLFGEGYESIKTLSESDPGQLLDNTLFATWR
NNNWVLLLFIGCTMMVKVFASGLTLGSGGNGGNFAPSLFLGSYLGYFFSKLVTLTGLSKLPITNFTMVGMAGILSGLFHA
PLTAIFLIAEITGGYGLMIPLMIVSSISFAISKRFEKYSLDVKNLAKKGHAFTSNKDSNILSTLDIDTIIQTDYLTVSPE
DHLSKLVDLISHSNQVVFAVVNNDRDLVGIVHFNDIREIIFNAYRVKYTLIKDVMKTPAATISSNDSMEIVMTKFERSKS
AFLPVLRNDKYFGIISKSIALEAYRMKLRSMTIE

Sequences:

>Translated_594_residues
MIKKLFRRLESIIALAQSILTPKQFIFLSSVLVGISCSFAVIILKAFAHNVFSFATYISGILKLGFINSILPIIGILLTV
LVVKKVLNGSIQKGTSQILYAVAKKASIIPRKQMYAQIVTSSLTVGLGGSAGLESPIVITGAAFGSNYAQNYKLAYKDRT
LLIGCGVAAGISAAFNAPIAGVLFAIEVLLVDVSISAFTPIMISAATGALVSAIVLDESILLSFKKQETFDYHNIPFYVI
LGLITGFMAVYYARNFQRVEHYFSELKMGPYKKALIGSSLLALLIFIFPTLFGEGYESIKTLSESDPGQLLDNTLFATWR
NNNWVLLLFIGCTMMVKVFASGLTLGSGGNGGNFAPSLFLGSYLGYFFSKLVTLTGLSKLPITNFTMVGMAGILSGLFHA
PLTAIFLIAEITGGYGLMIPLMIVSSISFAISKRFEKYSLDVKNLAKKGHAFTSNKDSNILSTLDIDTIIQTDYLTVSPE
DHLSKLVDLISHSNQVVFAVVNNDRDLVGIVHFNDIREIIFNAYRVKYTLIKDVMKTPAATISSNDSMEIVMTKFERSKS
AFLPVLRNDKYFGIISKSIALEAYRMKLRSMTIE
>Mature_594_residues
MIKKLFRRLESIIALAQSILTPKQFIFLSSVLVGISCSFAVIILKAFAHNVFSFATYISGILKLGFINSILPIIGILLTV
LVVKKVLNGSIQKGTSQILYAVAKKASIIPRKQMYAQIVTSSLTVGLGGSAGLESPIVITGAAFGSNYAQNYKLAYKDRT
LLIGCGVAAGISAAFNAPIAGVLFAIEVLLVDVSISAFTPIMISAATGALVSAIVLDESILLSFKKQETFDYHNIPFYVI
LGLITGFMAVYYARNFQRVEHYFSELKMGPYKKALIGSSLLALLIFIFPTLFGEGYESIKTLSESDPGQLLDNTLFATWR
NNNWVLLLFIGCTMMVKVFASGLTLGSGGNGGNFAPSLFLGSYLGYFFSKLVTLTGLSKLPITNFTMVGMAGILSGLFHA
PLTAIFLIAEITGGYGLMIPLMIVSSISFAISKRFEKYSLDVKNLAKKGHAFTSNKDSNILSTLDIDTIIQTDYLTVSPE
DHLSKLVDLISHSNQVVFAVVNNDRDLVGIVHFNDIREIIFNAYRVKYTLIKDVMKTPAATISSNDSMEIVMTKFERSKS
AFLPVLRNDKYFGIISKSIALEAYRMKLRSMTIE

Specific function: Probably acts as an electrical shunt for an outwardly- directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response [H]

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcB subfamily [H]

Homologues:

Organism=Escherichia coli, GI87081943, Length=332, Percent_Identity=27.1084337349398, Blast_Score=93, Evalue=5e-20,
Organism=Escherichia coli, GI1786350, Length=259, Percent_Identity=30.1158301158301, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24665008, Length=548, Percent_Identity=23.3576642335766, Blast_Score=66, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 64844; Mature: 64844

Theoretical pI: Translated: 9.82; Mature: 9.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKKLFRRLESIIALAQSILTPKQFIFLSSVLVGISCSFAVIILKAFAHNVFSFATYISG
CHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILKLGFINSILPIIGILLTVLVVKKVLNGSIQKGTSQILYAVAKKASIIPRKQMYAQIVT
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
SSLTVGLGGSAGLESPIVITGAAFGSNYAQNYKLAYKDRTLLIGCGVAAGISAAFNAPIA
HHHEEECCCCCCCCCCEEEEEECCCCCCCCCCEEEECCCEEEEECCHHHHHHHHHCCCHH
GVLFAIEVLLVDVSISAFTPIMISAATGALVSAIVLDESILLSFKKQETFDYHNIPFYVI
HHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
LGLITGFMAVYYARNFQRVEHYFSELKMGPYKKALIGSSLLALLIFIFPTLFGEGYESIK
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
TLSESDPGQLLDNTLFATWRNNNWVLLLFIGCTMMVKVFASGLTLGSGGNGGNFAPSLFL
HHCCCCCHHHHHCCEEEEEECCCEEEEHHHHHHHHHHHHHCCCEECCCCCCCCCCHHHHH
GSYLGYFFSKLVTLTGLSKLPITNFTMVGMAGILSGLFHAPLTAIFLIAEITGGYGLMIP
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
LMIVSSISFAISKRFEKYSLDVKNLAKKGHAFTSNKDSNILSTLDIDTIIQTDYLTVSPE
HHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCEECCCHHHHEECCEEEECCH
DHLSKLVDLISHSNQVVFAVVNNDRDLVGIVHFNDIREIIFNAYRVKYTLIKDVMKTPAA
HHHHHHHHHHCCCCCEEEEEEECCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCC
TISSNDSMEIVMTKFERSKSAFLPVLRNDKYFGIISKSIALEAYRMKLRSMTIE
CCCCCCCCEEEEEHHHCCCHHCCCHHCCCCEEEEHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIKKLFRRLESIIALAQSILTPKQFIFLSSVLVGISCSFAVIILKAFAHNVFSFATYISG
CHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILKLGFINSILPIIGILLTVLVVKKVLNGSIQKGTSQILYAVAKKASIIPRKQMYAQIVT
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
SSLTVGLGGSAGLESPIVITGAAFGSNYAQNYKLAYKDRTLLIGCGVAAGISAAFNAPIA
HHHEEECCCCCCCCCCEEEEEECCCCCCCCCCEEEECCCEEEEECCHHHHHHHHHCCCHH
GVLFAIEVLLVDVSISAFTPIMISAATGALVSAIVLDESILLSFKKQETFDYHNIPFYVI
HHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
LGLITGFMAVYYARNFQRVEHYFSELKMGPYKKALIGSSLLALLIFIFPTLFGEGYESIK
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
TLSESDPGQLLDNTLFATWRNNNWVLLLFIGCTMMVKVFASGLTLGSGGNGGNFAPSLFL
HHCCCCCHHHHHCCEEEEEECCCEEEEHHHHHHHHHHHHHCCCEECCCCCCCCCCHHHHH
GSYLGYFFSKLVTLTGLSKLPITNFTMVGMAGILSGLFHAPLTAIFLIAEITGGYGLMIP
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
LMIVSSISFAISKRFEKYSLDVKNLAKKGHAFTSNKDSNILSTLDIDTIIQTDYLTVSPE
HHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCEECCCHHHHEECCEEEECCH
DHLSKLVDLISHSNQVVFAVVNNDRDLVGIVHFNDIREIIFNAYRVKYTLIKDVMKTPAA
HHHHHHHHHHCCCCCEEEEEEECCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCC
TISSNDSMEIVMTKFERSKSAFLPVLRNDKYFGIISKSIALEAYRMKLRSMTIE
CCCCCCCCEEEEEHHHCCCHHCCCHHCCCCEEEEHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA