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The map label for this gene is ggt [H]

Identifier: 146302233

GI number: 146302233

Start: 5439137

End: 5440819

Strand: Direct

Name: ggt [H]

Synonym: Fjoh_4506

Alternate gene names: 146302233

Gene position: 5439137-5440819 (Clockwise)

Preceding gene: 146302232

Following gene: 146302234

Centisome position: 89.21

GC content: 37.37

Gene sequence:

>1683_bases
ATGAAAAAAATTTCACTTCTATTTTATTTTATCTCAATTTATAGTTTCGCACAGCATACGGCACCACCAACAGGATTAGT
TGCCTCAAAAGCAATGGTGGTTTCAGCCCGCGAAGAAGCCTCAAAAATTGGCGTTGAAATCATGAAAAAAGGCGGTAACG
CTTTTGATGCTATGGCAGCAACTGAGCTGGCACTTGCAGTAGCATATCCATACGCTGGAAATCTTGGCGGAGGCGGCTTT
ATGGTTTACAGAAAAGCAAACGGCGAAGTGGGCAGTTTGGATTATCGCGAAAAAGCACCTCTTGCTGCAACAAAAAATAT
GTTTCTGGATAAAGAAGGAAATGTAATAAAAGGCAAAAGTACAGAATCGCCTTTAGCGATTGGTGTTCCGGGAACTATTG
CCGGAGTTTTTGCAGTTCAGAAAAAGCTGGGATCTCTGCCAATGTCAGAAATTTTAAAACCTGTAATTGCCCTTGCAGAA
AAAGGTGTTGTTGTAACCAAAAAACAACAAAAACAATTAGAAGCTTATCACGATGCTATAGTAAAAGCAAATGGGCCCAA
TACATTAATGGCAGGAAAATTTCAAGAAGGCGATACGATTAAATATCCGGCTCTTGCCAGCACTTTAAAGCGAATTTCAA
AAAACGGAAAAGACGAGTTTTATAAAGGTAAAACCGCTCAGGTTTTGGTAGATTATCTAAAGAAAAAAGGCGGTATTATC
ACTCTGAAAGATTTAGCATCTTATGAAGCAAAATGGAGAAATCCATTACAGTTTGATTATAAAGATTTGAAAGTAACATC
GATGGCGCCTCCAAGCAGCGGCGGTATTTGTCTGGCTCAGATCATGAAAATGATTTCTCCTTTTTATTTGTCTAAAATGG
GACATAATTCTGAACAATCCATTCAGGTAATTGTAGAAGCAGAAAGAAGAGCTTATGCCGACAGAAGCCAGTTTTTAGGC
GATCCTGATTTTGTAAAAATTCCAATTAAAGGACTTTTATCAGATTCATATTTAAAAGAAAGAATGTCAAATTTTGATTC
AGAAAAAGCTACTTTATCATCAGACATAAAAGAAGGAAAAGTAACCTATAACGAAAGCACCGAAACTACACATTACTCTA
TTGTAGATCAGTTTGGAAATGCGGTTGCTGCCACAACAACCATCAACGACGGTTTTGGTTCAAAATATTACTGCGATGAA
TTAGGCTTCTTTTTAAATAACGAAATGGATGATTTCAGCGCAAAACCAGGCTCTCCAAATATGTTTGGATTAGTTGGAAA
TGAAGCCAACAGTATTGCACCTCAAAAAAGAATGCTGAGCTCTATGACTCCAACTATTGTAGAAAAAAACGGAAAATTAT
TTATGGTAGTAGGTTCACCAGGCGGATCGACTATTATCACATCGGTGCTTCAGACTATTTTAAATGTTTACGAATACAAT
TTAAGTATGCAGGATGCTGTAAATGCACCACGTTTTCATCATCAATGGCTTCCCGATCTTATAACTTTTGAACCTGATAC
TTTCGATAATAAAACGCTGGAAGGCTTAAAATCTAAAGGATATTTAATTAACGAAAAAACAACGCCTGTAATTGGAAAAG
TAGATGCAATTCTGGTTTATCCTGACAACACACTTGAAGGAGGTGCCGATTTTAGAGGCGATGACAAAGCGGCTGGATTT
TAA

Upstream 100 bases:

>100_bases
AGAATTTTATAACGAATTTGAACAGGAATTCACTGTGTTTTTTGAAGATCTCCAACTACATACCAAACAAAAATTACTCT
CATTATAAATAAAACCGATT

Downstream 100 bases:

>100_bases
ATTCAAAAGATTTAAGTAGAAAAATTTGATAAAAACGAATGTTTAGAGTTAAATTTGCATTCTCCGTAATTTTTTAAAAT
ACTAATGATAAAAAAACTGT

Product: gamma-glutamyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 560; Mature: 560

Protein sequence:

>560_residues
MKKISLLFYFISIYSFAQHTAPPTGLVASKAMVVSAREEASKIGVEIMKKGGNAFDAMAATELALAVAYPYAGNLGGGGF
MVYRKANGEVGSLDYREKAPLAATKNMFLDKEGNVIKGKSTESPLAIGVPGTIAGVFAVQKKLGSLPMSEILKPVIALAE
KGVVVTKKQQKQLEAYHDAIVKANGPNTLMAGKFQEGDTIKYPALASTLKRISKNGKDEFYKGKTAQVLVDYLKKKGGII
TLKDLASYEAKWRNPLQFDYKDLKVTSMAPPSSGGICLAQIMKMISPFYLSKMGHNSEQSIQVIVEAERRAYADRSQFLG
DPDFVKIPIKGLLSDSYLKERMSNFDSEKATLSSDIKEGKVTYNESTETTHYSIVDQFGNAVAATTTINDGFGSKYYCDE
LGFFLNNEMDDFSAKPGSPNMFGLVGNEANSIAPQKRMLSSMTPTIVEKNGKLFMVVGSPGGSTIITSVLQTILNVYEYN
LSMQDAVNAPRFHHQWLPDLITFEPDTFDNKTLEGLKSKGYLINEKTTPVIGKVDAILVYPDNTLEGGADFRGDDKAAGF

Sequences:

>Translated_560_residues
MKKISLLFYFISIYSFAQHTAPPTGLVASKAMVVSAREEASKIGVEIMKKGGNAFDAMAATELALAVAYPYAGNLGGGGF
MVYRKANGEVGSLDYREKAPLAATKNMFLDKEGNVIKGKSTESPLAIGVPGTIAGVFAVQKKLGSLPMSEILKPVIALAE
KGVVVTKKQQKQLEAYHDAIVKANGPNTLMAGKFQEGDTIKYPALASTLKRISKNGKDEFYKGKTAQVLVDYLKKKGGII
TLKDLASYEAKWRNPLQFDYKDLKVTSMAPPSSGGICLAQIMKMISPFYLSKMGHNSEQSIQVIVEAERRAYADRSQFLG
DPDFVKIPIKGLLSDSYLKERMSNFDSEKATLSSDIKEGKVTYNESTETTHYSIVDQFGNAVAATTTINDGFGSKYYCDE
LGFFLNNEMDDFSAKPGSPNMFGLVGNEANSIAPQKRMLSSMTPTIVEKNGKLFMVVGSPGGSTIITSVLQTILNVYEYN
LSMQDAVNAPRFHHQWLPDLITFEPDTFDNKTLEGLKSKGYLINEKTTPVIGKVDAILVYPDNTLEGGADFRGDDKAAGF
>Mature_560_residues
MKKISLLFYFISIYSFAQHTAPPTGLVASKAMVVSAREEASKIGVEIMKKGGNAFDAMAATELALAVAYPYAGNLGGGGF
MVYRKANGEVGSLDYREKAPLAATKNMFLDKEGNVIKGKSTESPLAIGVPGTIAGVFAVQKKLGSLPMSEILKPVIALAE
KGVVVTKKQQKQLEAYHDAIVKANGPNTLMAGKFQEGDTIKYPALASTLKRISKNGKDEFYKGKTAQVLVDYLKKKGGII
TLKDLASYEAKWRNPLQFDYKDLKVTSMAPPSSGGICLAQIMKMISPFYLSKMGHNSEQSIQVIVEAERRAYADRSQFLG
DPDFVKIPIKGLLSDSYLKERMSNFDSEKATLSSDIKEGKVTYNESTETTHYSIVDQFGNAVAATTTINDGFGSKYYCDE
LGFFLNNEMDDFSAKPGSPNMFGLVGNEANSIAPQKRMLSSMTPTIVEKNGKLFMVVGSPGGSTIITSVLQTILNVYEYN
LSMQDAVNAPRFHHQWLPDLITFEPDTFDNKTLEGLKSKGYLINEKTTPVIGKVDAILVYPDNTLEGGADFRGDDKAAGF

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=551, Percent_Identity=31.5789473684211, Blast_Score=217, Evalue=2e-56,
Organism=Homo sapiens, GI73915090, Length=551, Percent_Identity=31.5789473684211, Blast_Score=217, Evalue=2e-56,
Organism=Homo sapiens, GI73915096, Length=551, Percent_Identity=31.5789473684211, Blast_Score=217, Evalue=2e-56,
Organism=Homo sapiens, GI73915094, Length=551, Percent_Identity=31.5789473684211, Blast_Score=217, Evalue=2e-56,
Organism=Homo sapiens, GI113429326, Length=556, Percent_Identity=30.2158273381295, Blast_Score=188, Evalue=1e-47,
Organism=Homo sapiens, GI113429324, Length=551, Percent_Identity=30.1270417422868, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI153266885, Length=549, Percent_Identity=28.0510018214936, Blast_Score=175, Evalue=1e-43,
Organism=Homo sapiens, GI153266901, Length=550, Percent_Identity=28.5454545454545, Blast_Score=172, Evalue=5e-43,
Organism=Homo sapiens, GI153266907, Length=572, Percent_Identity=26.7482517482518, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI109148539, Length=530, Percent_Identity=26.6037735849057, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI30581157, Length=193, Percent_Identity=38.3419689119171, Blast_Score=106, Evalue=7e-23,
Organism=Homo sapiens, GI30581155, Length=193, Percent_Identity=38.3419689119171, Blast_Score=106, Evalue=7e-23,
Organism=Homo sapiens, GI218505805, Length=170, Percent_Identity=35.8823529411765, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI310124095, Length=170, Percent_Identity=33.5294117647059, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1789856, Length=538, Percent_Identity=46.4684014869888, Blast_Score=480, Evalue=1e-137,
Organism=Caenorhabditis elegans, GI72000294, Length=559, Percent_Identity=33.8103756708408, Blast_Score=239, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI212646519, Length=559, Percent_Identity=33.9892665474061, Blast_Score=239, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI193208247, Length=545, Percent_Identity=32.4770642201835, Blast_Score=221, Evalue=6e-58,
Organism=Caenorhabditis elegans, GI193208245, Length=545, Percent_Identity=32.4770642201835, Blast_Score=221, Evalue=6e-58,
Organism=Caenorhabditis elegans, GI17506189, Length=552, Percent_Identity=31.7028985507246, Blast_Score=213, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI17542894, Length=545, Percent_Identity=32.1100917431193, Blast_Score=207, Evalue=8e-54,
Organism=Caenorhabditis elegans, GI17564448, Length=435, Percent_Identity=27.5862068965517, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI72001497, Length=227, Percent_Identity=29.9559471365639, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI72001495, Length=227, Percent_Identity=29.9559471365639, Blast_Score=99, Evalue=7e-21,
Organism=Saccharomyces cerevisiae, GI6323330, Length=565, Percent_Identity=31.6814159292035, Blast_Score=191, Evalue=3e-49,
Organism=Drosophila melanogaster, GI45551474, Length=547, Percent_Identity=30.5301645338208, Blast_Score=224, Evalue=8e-59,
Organism=Drosophila melanogaster, GI18859893, Length=511, Percent_Identity=33.0724070450098, Blast_Score=224, Evalue=9e-59,
Organism=Drosophila melanogaster, GI161077880, Length=547, Percent_Identity=30.5301645338208, Blast_Score=224, Evalue=1e-58,
Organism=Drosophila melanogaster, GI24642670, Length=547, Percent_Identity=30.5301645338208, Blast_Score=224, Evalue=1e-58,
Organism=Drosophila melanogaster, GI24642666, Length=547, Percent_Identity=30.5301645338208, Blast_Score=224, Evalue=1e-58,
Organism=Drosophila melanogaster, GI161077878, Length=547, Percent_Identity=30.5301645338208, Blast_Score=224, Evalue=1e-58,
Organism=Drosophila melanogaster, GI161077496, Length=493, Percent_Identity=31.8458417849899, Blast_Score=214, Evalue=1e-55,
Organism=Drosophila melanogaster, GI18859741, Length=564, Percent_Identity=27.1276595744681, Blast_Score=155, Evalue=1e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 60963; Mature: 60963

Theoretical pI: Translated: 8.88; Mature: 8.88

Prosite motif: PS00462 G_GLU_TRANSPEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKISLLFYFISIYSFAQHTAPPTGLVASKAMVVSAREEASKIGVEIMKKGGNAFDAMAA
CCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHEEECHHHHHHHHHHHHHCCCCHHHHHHH
TELALAVAYPYAGNLGGGGFMVYRKANGEVGSLDYREKAPLAATKNMFLDKEGNVIKGKS
HHHHHHEECCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHCCEECCCCCEEECCC
TESPLAIGVPGTIAGVFAVQKKLGSLPMSEILKPVIALAEKGVVVTKKQQKQLEAYHDAI
CCCCEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHE
VKANGPNTLMAGKFQEGDTIKYPALASTLKRISKNGKDEFYKGKTAQVLVDYLKKKGGII
EECCCCCCEEECCCCCCCCEECHHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHCCCEE
TLKDLASYEAKWRNPLQFDYKDLKVTSMAPPSSGGICLAQIMKMISPFYLSKMGHNSEQS
EEHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCC
IQVIVEAERRAYADRSQFLGDPDFVKIPIKGLLSDSYLKERMSNFDSEKATLSSDIKEGK
EEEEEEHHHHHHHHHHHHCCCCCEEEECHHHHHCHHHHHHHHHCCCCHHHHHHHHHHCCC
VTYNESTETTHYSIVDQFGNAVAATTTINDGFGSKYYCDELGFFLNNEMDDFSAKPGSPN
EEECCCCCCHHHHHHHHHCCEEEEEEEECCCCCCCEEHHHHHHHHCCCCCCCCCCCCCCC
MFGLVGNEANSIAPQKRMLSSMTPTIVEKNGKLFMVVGSPGGSTIITSVLQTILNVYEYN
EEEEECCCCCCCCHHHHHHHHCCCCEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHCC
LSMQDAVNAPRFHHQWLPDLITFEPDTFDNKTLEGLKSKGYLINEKTTPVIGKVDAILVY
CCHHHHCCCCCHHHHHCCHHEECCCCCCCCHHHHHHCCCCEEECCCCCCEEECCCEEEEE
PDNTLEGGADFRGDDKAAGF
CCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKKISLLFYFISIYSFAQHTAPPTGLVASKAMVVSAREEASKIGVEIMKKGGNAFDAMAA
CCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHEEECHHHHHHHHHHHHHCCCCHHHHHHH
TELALAVAYPYAGNLGGGGFMVYRKANGEVGSLDYREKAPLAATKNMFLDKEGNVIKGKS
HHHHHHEECCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHCCEECCCCCEEECCC
TESPLAIGVPGTIAGVFAVQKKLGSLPMSEILKPVIALAEKGVVVTKKQQKQLEAYHDAI
CCCCEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHE
VKANGPNTLMAGKFQEGDTIKYPALASTLKRISKNGKDEFYKGKTAQVLVDYLKKKGGII
EECCCCCCEEECCCCCCCCEECHHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHCCCEE
TLKDLASYEAKWRNPLQFDYKDLKVTSMAPPSSGGICLAQIMKMISPFYLSKMGHNSEQS
EEHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCC
IQVIVEAERRAYADRSQFLGDPDFVKIPIKGLLSDSYLKERMSNFDSEKATLSSDIKEGK
EEEEEEHHHHHHHHHHHHCCCCCEEEECHHHHHCHHHHHHHHHCCCCHHHHHHHHHHCCC
VTYNESTETTHYSIVDQFGNAVAATTTINDGFGSKYYCDELGFFLNNEMDDFSAKPGSPN
EEECCCCCCHHHHHHHHHCCEEEEEEEECCCCCCCEEHHHHHHHHCCCCCCCCCCCCCCC
MFGLVGNEANSIAPQKRMLSSMTPTIVEKNGKLFMVVGSPGGSTIITSVLQTILNVYEYN
EEEEECCCCCCCCHHHHHHHHCCCCEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHCC
LSMQDAVNAPRFHHQWLPDLITFEPDTFDNKTLEGLKSKGYLINEKTTPVIGKVDAILVY
CCHHHHCCCCCHHHHHCCHHEECCCCCCCCHHHHHHCCCCEEECCCCCCEEECCCEEEEE
PDNTLEGGADFRGDDKAAGF
CCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2570061; 9278503; 8041620; 1360205 [H]