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The map label for this gene is uxaA [H]

Identifier: 146301994

GI number: 146301994

Start: 5143106

End: 5144728

Strand: Reverse

Name: uxaA [H]

Synonym: Fjoh_4258

Alternate gene names: 146301994

Gene position: 5144728-5143106 (Counterclockwise)

Preceding gene: 146301995

Following gene: 146301992

Centisome position: 84.38

GC content: 37.03

Gene sequence:

>1623_bases
ATGGCAGCGCAGAAAAAATTGATAAAAGTTCACCCAACCGACAATGTAGCGGTTGCTTTGGTGGATCTTACAGCAGGCGA
AGTAATTGATTTCGAAGGAGAATCAGTTACAGTTGAGTCTGATGTAAAAATGAAACATAAGATTGCAATGGTTCCTTTTA
ATGTAGGGGACAGAATCATTATGTACGGAGTTTTAGTAGGTAAAGCAAGTGCAAGAATCGAAAGAGGAGGATTGCTTTCT
ACTGCAAATGTAAAACACGAAAGCGATAAAGTTACTGGTAAAACAGAAACTATTGGCTGGAATGCTCCAAATATTGATAA
ATGGAAAGACAGAACGTGGCAGGGTTATCACAGAGAAGACGGACAAGTTGGAACTGAAAATGTTTGGTTATTCTTCCCGT
TAGTATTTTGTGAAAACAGAAACATCGAAATCTTAAAAGATATTTTTGAGAAAGAATTGATGAAACCAAAAGAAAACGAT
TATCAGTTATTGTTACGTTCTTTGGTAAAATCAGAAACAGGAGGAGCAGGAAATCAGGAAGCTTCAAATGATGCGAATTT
ATTCAACAATATTCAGGTAAAATTCATTACACACCAAGGCGGTTGCGGCGGAATTCGTCAGGATTCTCATAGTCTGGCTA
AATTATTAGCTGGTTATGTAAACAATCCAAACGTTGCCGGAGCGACAGTTTTGAGTTTAGGATGCCAGAATCTTCAAATT
TCGATTTTTAAAGATGCTTTAGACGCGATCAATCCAAACAGTAAAAAACCTGTTTTAATCTATGATCAGCAGTCAATTGG
AACTATCGAAACGATGTTAAGCAGTGTTGTAAAAGATACTTTTGAAGCGATTAAAAAAGCAAACGAAATTAAGAGAGAAC
CAGCTCCATTATCTAAATTAAGAATTGGTTTAGAGTGCGGTGGATCTGACGGATTCTCTGGAATTTCTGCAAACCCTACT
TTAGGAGTAACTTCAGATTTATTGGCTGCTTTAGGCGGTACTACAATTCTTTCTGAGTTTCCTGAATTATGTGGTGTTGA
GCAGGAATTAGTAAACCGTTGTGTTGAAGACGAGAGCGGAAAACGTTTCTTAGACTTAATGCAGTGGTATGAAAAAACTG
TTGTTGATGCTGGTTCAGGATTTGATATGAATCCTTCTCCGGGTAATATTAAAGATGGTTTAATTACAGATGCAATGAAA
TCTGCAGGTGCAGCTAAAAAAGGTGGAACTTCACCTATTACCGGAGTATTCGATTACGGTGAATATATCACTAAGCCAGG
TTTAACTTTGCTTTGTACGCCAGGAAATGATGTTGAGTGTACAACTGCAATGGTAGGTTCTGGTGCTAATATGGTATTGT
TTACAACAGGTTTAGGAACACCAACAGGAAACCCAATTGCTCCGGTTGTAAAAATTTCATCAAACACTCAATTAGCAAAC
AAAATGTCAGATATTATCGATATTGACACTGGAGGTATTATTACTGGTGAAAAATCAATCGATGAAATGGCAGATGAAAT
GTTAGAGTTTATTATTGATGTTGCCAGCGGAACAATTAAAACCAAAGCGGCACTTTTAAATCAAAACGACTTTATTCCTT
GGAAAAGAGGAGTTTCGCTTTAG

Upstream 100 bases:

>100_bases
AAGAAATTGATGCTAATGGTATTGAAGCTGGTTTCGCTAAGTTTCAGGAAAGAATCAAATAAAAAAAAGATAAAAAAAAC
AAAAAGAACAAGGGTTAATT

Downstream 100 bases:

>100_bases
GTTTTTAGGTACGAAGGTACAGGGATACAAAGCAGCAAAAGTTTATGTAGAGACGCACAGCAGTGCGTCTTTTTTTATGA
ATACGGTTTACGTAAGATAG

Product: Altronate dehydratase

Products: NA

Alternate protein names: Altronic acid hydratase [H]

Number of amino acids: Translated: 540; Mature: 539

Protein sequence:

>540_residues
MAAQKKLIKVHPTDNVAVALVDLTAGEVIDFEGESVTVESDVKMKHKIAMVPFNVGDRIIMYGVLVGKASARIERGGLLS
TANVKHESDKVTGKTETIGWNAPNIDKWKDRTWQGYHREDGQVGTENVWLFFPLVFCENRNIEILKDIFEKELMKPKEND
YQLLLRSLVKSETGGAGNQEASNDANLFNNIQVKFITHQGGCGGIRQDSHSLAKLLAGYVNNPNVAGATVLSLGCQNLQI
SIFKDALDAINPNSKKPVLIYDQQSIGTIETMLSSVVKDTFEAIKKANEIKREPAPLSKLRIGLECGGSDGFSGISANPT
LGVTSDLLAALGGTTILSEFPELCGVEQELVNRCVEDESGKRFLDLMQWYEKTVVDAGSGFDMNPSPGNIKDGLITDAMK
SAGAAKKGGTSPITGVFDYGEYITKPGLTLLCTPGNDVECTTAMVGSGANMVLFTTGLGTPTGNPIAPVVKISSNTQLAN
KMSDIIDIDTGGIITGEKSIDEMADEMLEFIIDVASGTIKTKAALLNQNDFIPWKRGVSL

Sequences:

>Translated_540_residues
MAAQKKLIKVHPTDNVAVALVDLTAGEVIDFEGESVTVESDVKMKHKIAMVPFNVGDRIIMYGVLVGKASARIERGGLLS
TANVKHESDKVTGKTETIGWNAPNIDKWKDRTWQGYHREDGQVGTENVWLFFPLVFCENRNIEILKDIFEKELMKPKEND
YQLLLRSLVKSETGGAGNQEASNDANLFNNIQVKFITHQGGCGGIRQDSHSLAKLLAGYVNNPNVAGATVLSLGCQNLQI
SIFKDALDAINPNSKKPVLIYDQQSIGTIETMLSSVVKDTFEAIKKANEIKREPAPLSKLRIGLECGGSDGFSGISANPT
LGVTSDLLAALGGTTILSEFPELCGVEQELVNRCVEDESGKRFLDLMQWYEKTVVDAGSGFDMNPSPGNIKDGLITDAMK
SAGAAKKGGTSPITGVFDYGEYITKPGLTLLCTPGNDVECTTAMVGSGANMVLFTTGLGTPTGNPIAPVVKISSNTQLAN
KMSDIIDIDTGGIITGEKSIDEMADEMLEFIIDVASGTIKTKAALLNQNDFIPWKRGVSL
>Mature_539_residues
AAQKKLIKVHPTDNVAVALVDLTAGEVIDFEGESVTVESDVKMKHKIAMVPFNVGDRIIMYGVLVGKASARIERGGLLST
ANVKHESDKVTGKTETIGWNAPNIDKWKDRTWQGYHREDGQVGTENVWLFFPLVFCENRNIEILKDIFEKELMKPKENDY
QLLLRSLVKSETGGAGNQEASNDANLFNNIQVKFITHQGGCGGIRQDSHSLAKLLAGYVNNPNVAGATVLSLGCQNLQIS
IFKDALDAINPNSKKPVLIYDQQSIGTIETMLSSVVKDTFEAIKKANEIKREPAPLSKLRIGLECGGSDGFSGISANPTL
GVTSDLLAALGGTTILSEFPELCGVEQELVNRCVEDESGKRFLDLMQWYEKTVVDAGSGFDMNPSPGNIKDGLITDAMKS
AGAAKKGGTSPITGVFDYGEYITKPGLTLLCTPGNDVECTTAMVGSGANMVLFTTGLGTPTGNPIAPVVKISSNTQLANK
MSDIIDIDTGGIITGEKSIDEMADEMLEFIIDVASGTIKTKAALLNQNDFIPWKRGVSL

Specific function: Hexuronate conversion to KDG. [C]

COG id: COG2721

COG function: function code G; Altronate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uxaA family [H]

Homologues:

Organism=Escherichia coli, GI1789475, Length=539, Percent_Identity=33.7662337662338, Blast_Score=281, Evalue=7e-77,
Organism=Escherichia coli, GI1789516, Length=530, Percent_Identity=32.8301886792453, Blast_Score=243, Evalue=2e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007392
- InterPro:   IPR013974 [H]

Pfam domain/function: PF04295 GD_AH_C; PF08666 SAF [H]

EC number: =4.2.1.7 [H]

Molecular weight: Translated: 58084; Mature: 57953

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAQKKLIKVHPTDNVAVALVDLTAGEVIDFEGESVTVESDVKMKHKIAMVPFNVGDRII
CCCCCCEEEECCCCCEEEEEEEECCCCEEECCCCEEEEECCCCEEEEEEEEEECCCCEEE
MYGVLVGKASARIERGGLLSTANVKHESDKVTGKTETIGWNAPNIDKWKDRTWQGYHRED
EEEEHHCCHHHHHHCCCCEEECCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCC
GQVGTENVWLFFPLVFCENRNIEILKDIFEKELMKPKENDYQLLLRSLVKSETGGAGNQE
CCCCCCCEEEEEEEEEECCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCC
ASNDANLFNNIQVKFITHQGGCGGIRQDSHSLAKLLAGYVNNPNVAGATVLSLGCQNLQI
CCCCCHHHCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCEE
SIFKDALDAINPNSKKPVLIYDQQSIGTIETMLSSVVKDTFEAIKKANEIKREPAPLSKL
EHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHE
RIGLECGGSDGFSGISANPTLGVTSDLLAALGGTTILSEFPELCGVEQELVNRCVEDESG
EEEEEECCCCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHCCCCC
KRFLDLMQWYEKTVVDAGSGFDMNPSPGNIKDGLITDAMKSAGAAKKGGTSPITGVFDYG
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHH
EYITKPGLTLLCTPGNDVECTTAMVGSGANMVLFTTGLGTPTGNPIAPVVKISSNTQLAN
HHHCCCCCEEEECCCCCCEEEEEEECCCCCEEEEEECCCCCCCCCCCEEEEECCCCHHHH
KMSDIIDIDTGGIITGEKSIDEMADEMLEFIIDVASGTIKTKAALLNQNDFIPWKRGVSL
HHHHHEECCCCCEEECCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
AAQKKLIKVHPTDNVAVALVDLTAGEVIDFEGESVTVESDVKMKHKIAMVPFNVGDRII
CCCCCEEEECCCCCEEEEEEEECCCCEEECCCCEEEEECCCCEEEEEEEEEECCCCEEE
MYGVLVGKASARIERGGLLSTANVKHESDKVTGKTETIGWNAPNIDKWKDRTWQGYHRED
EEEEHHCCHHHHHHCCCCEEECCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCC
GQVGTENVWLFFPLVFCENRNIEILKDIFEKELMKPKENDYQLLLRSLVKSETGGAGNQE
CCCCCCCEEEEEEEEEECCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCC
ASNDANLFNNIQVKFITHQGGCGGIRQDSHSLAKLLAGYVNNPNVAGATVLSLGCQNLQI
CCCCCHHHCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCEE
SIFKDALDAINPNSKKPVLIYDQQSIGTIETMLSSVVKDTFEAIKKANEIKREPAPLSKL
EHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHE
RIGLECGGSDGFSGISANPTLGVTSDLLAALGGTTILSEFPELCGVEQELVNRCVEDESG
EEEEEECCCCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHCCCCC
KRFLDLMQWYEKTVVDAGSGFDMNPSPGNIKDGLITDAMKSAGAAKKGGTSPITGVFDYG
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHH
EYITKPGLTLLCTPGNDVECTTAMVGSGANMVLFTTGLGTPTGNPIAPVVKISSNTQLAN
HHHCCCCCEEEECCCCCCEEEEEEECCCCCEEEEEECCCCCCCCCCCEEEEECCCCHHHH
KMSDIIDIDTGGIITGEKSIDEMADEMLEFIIDVASGTIKTKAALLNQNDFIPWKRGVSL
HHHHHEECCCCCEEECCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579062; 9384377 [H]