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The map label for this gene is uxaB [H]

Identifier: 146301995

GI number: 146301995

Start: 5144767

End: 5146215

Strand: Reverse

Name: uxaB [H]

Synonym: Fjoh_4259

Alternate gene names: 146301995

Gene position: 5146215-5144767 (Counterclockwise)

Preceding gene: 146301996

Following gene: 146301994

Centisome position: 84.41

GC content: 32.71

Gene sequence:

>1449_bases
ATGGAAAAAATTAACAGATCAAATTCAGAGTTTTCAAACAGGCTTCCAATTAAAATTGTACAATTTGGAGAAGGTAATTT
CTTAAGAGCTTTTGTTGAGTATGCTATTCAGAAATTAAACCAAAAAGCAGATTTTAATGCTGGTATTGCAGTTGTACAGC
CTATTGATAAAGGGCTTGTGAATATGATCAATGCACAGGACGGATTGTACACTTTATTCATGAAAGGTGTAAAAAAAGGC
GAAGAAATTCAGGAAAAAGAATTGATTACCAATATTGTAAAAGCAGTAGACCCTTATGCTTCTTTTCAGGAGTATTTATC
TTTAGCTAAAGAAGAAGAACTGGCTTTTATTATTTCGAATACTACTGAAGCGGGTATTGAATATATTGCTTCAGATCTTC
CAACGATGACGCCTCCTGTATCTTTTCCTGCAAAATTAACAGTGCTTTTAAACGAAAGATTCAAGCATTTTAATGGAGCA
GCAGATAAAGGATTAACAATCATTCCTTGCGAGTTAATTAATTATAATGCAGATACTTTAAAAGAAATTGTTTTTAAATA
CAGTGCAGACTGGAAATTAGGAGCAGAATTTGAATCTTGGTTAACAAACAGCTGTTCTTGGCATAACACATTGGTAGACA
GAATCGTTCCAGGTTATCCAAAAGACCAGATTGAAGAATATAATGCACAGCTTTCATATAAAGATGATTTAATTGTAAGT
GCAGAAACTTTCTTTTTATGGGTAATTGAAGGTGATGATAAACTGAAAGCAAAACTTCCGTTTGACAAAACAGATTTAGA
TGTAAAAATTATTTCTGATATGCAGCCGTACAGAACCCGTAAAGTTAGAATCCTTAACGGAGCGCACACAGCAATGGTGC
CATTCTCTTTACTATACGGAAATGAAACTGTAAAAGAAACAGTTGATAATGAATTTACTGGTGGTTTTATCAATAAAGCA
TTGTTTGAAGAAATCAACGAAACTTTAAACATGGATAAAGCAGAATTGGCTGGTTTCTCTGAAGAAATTTTAGACCGTTT
CAGAAATCCATTTGTGAAGCACTTATTATCATCAATCGCTTTAAATTCAATCTCTAAGTTTAAAGTTCGTGTATTACCAA
GTTTAACAGGATATGTAGATATTCACGGTAAACTTCCAGTTCATTTAACATTTGCTTTTGCAGCTTTAATTCGTTTCTAC
AAAGGAACTTGGAACGGACAAAGTTTACCGGTAAATGATAGTGAAGATATTGTAACTTTCTTTGATGGTTTGTGGAAATC
AGATGATTATGAGAAAATTGCAAGACTTACTTTGCAGAACAAAAATTTCTGGGATGAAGATTTAACTGAAATATCAGGAT
TAACAAGAGCAATTACAATTGCTTTAGAAGAAATTGATGCTAATGGTATTGAAGCTGGTTTCGCTAAGTTTCAGGAAAGA
ATCAAATAA

Upstream 100 bases:

>100_bases
TTTTATTTTAAAATCAGGTGTAATGTTTCATTTACAATGTTTTAAAGGAACGAATAAGGTTTAAGTGATTATTTATAACA
CTTTTAAAGAGAGAATTAAA

Downstream 100 bases:

>100_bases
AAAAAAGATAAAAAAAACAAAAAGAACAAGGGTTAATTATGGCAGCGCAGAAAAAATTGATAAAAGTTCACCCAACCGAC
AATGTAGCGGTTGCTTTGGT

Product: altronate oxidoreductase

Products: NA

Alternate protein names: Tagaturonate dehydrogenase; Tagaturonate reductase [H]

Number of amino acids: Translated: 482; Mature: 482

Protein sequence:

>482_residues
MEKINRSNSEFSNRLPIKIVQFGEGNFLRAFVEYAIQKLNQKADFNAGIAVVQPIDKGLVNMINAQDGLYTLFMKGVKKG
EEIQEKELITNIVKAVDPYASFQEYLSLAKEEELAFIISNTTEAGIEYIASDLPTMTPPVSFPAKLTVLLNERFKHFNGA
ADKGLTIIPCELINYNADTLKEIVFKYSADWKLGAEFESWLTNSCSWHNTLVDRIVPGYPKDQIEEYNAQLSYKDDLIVS
AETFFLWVIEGDDKLKAKLPFDKTDLDVKIISDMQPYRTRKVRILNGAHTAMVPFSLLYGNETVKETVDNEFTGGFINKA
LFEEINETLNMDKAELAGFSEEILDRFRNPFVKHLLSSIALNSISKFKVRVLPSLTGYVDIHGKLPVHLTFAFAALIRFY
KGTWNGQSLPVNDSEDIVTFFDGLWKSDDYEKIARLTLQNKNFWDEDLTEISGLTRAITIALEEIDANGIEAGFAKFQER
IK

Sequences:

>Translated_482_residues
MEKINRSNSEFSNRLPIKIVQFGEGNFLRAFVEYAIQKLNQKADFNAGIAVVQPIDKGLVNMINAQDGLYTLFMKGVKKG
EEIQEKELITNIVKAVDPYASFQEYLSLAKEEELAFIISNTTEAGIEYIASDLPTMTPPVSFPAKLTVLLNERFKHFNGA
ADKGLTIIPCELINYNADTLKEIVFKYSADWKLGAEFESWLTNSCSWHNTLVDRIVPGYPKDQIEEYNAQLSYKDDLIVS
AETFFLWVIEGDDKLKAKLPFDKTDLDVKIISDMQPYRTRKVRILNGAHTAMVPFSLLYGNETVKETVDNEFTGGFINKA
LFEEINETLNMDKAELAGFSEEILDRFRNPFVKHLLSSIALNSISKFKVRVLPSLTGYVDIHGKLPVHLTFAFAALIRFY
KGTWNGQSLPVNDSEDIVTFFDGLWKSDDYEKIARLTLQNKNFWDEDLTEISGLTRAITIALEEIDANGIEAGFAKFQER
IK
>Mature_482_residues
MEKINRSNSEFSNRLPIKIVQFGEGNFLRAFVEYAIQKLNQKADFNAGIAVVQPIDKGLVNMINAQDGLYTLFMKGVKKG
EEIQEKELITNIVKAVDPYASFQEYLSLAKEEELAFIISNTTEAGIEYIASDLPTMTPPVSFPAKLTVLLNERFKHFNGA
ADKGLTIIPCELINYNADTLKEIVFKYSADWKLGAEFESWLTNSCSWHNTLVDRIVPGYPKDQIEEYNAQLSYKDDLIVS
AETFFLWVIEGDDKLKAKLPFDKTDLDVKIISDMQPYRTRKVRILNGAHTAMVPFSLLYGNETVKETVDNEFTGGFINKA
LFEEINETLNMDKAELAGFSEEILDRFRNPFVKHLLSSIALNSISKFKVRVLPSLTGYVDIHGKLPVHLTFAFAALIRFY
KGTWNGQSLPVNDSEDIVTFFDGLWKSDDYEKIARLTLQNKNFWDEDLTEISGLTRAITIALEEIDANGIEAGFAKFQER
IK

Specific function: Hexuronate conversion to KDG. [C]

COG id: COG0246

COG function: function code G; Mannitol-1-phosphate/altronate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannitol dehydrogenase family. UxaB subfamily [H]

Homologues:

Organism=Escherichia coli, GI48994885, Length=476, Percent_Identity=43.4873949579832, Blast_Score=416, Evalue=1e-117,
Organism=Escherichia coli, GI1790779, Length=408, Percent_Identity=25.7352941176471, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1788497, Length=476, Percent_Identity=24.5798319327731, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1787823, Length=478, Percent_Identity=22.5941422594142, Blast_Score=109, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6324401, Length=433, Percent_Identity=25.4041570438799, Blast_Score=107, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6320765, Length=433, Percent_Identity=25.4041570438799, Blast_Score=107, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR000669
- InterPro:   IPR013118
- InterPro:   IPR013131
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01232 Mannitol_dh; PF08125 Mannitol_dh_C [H]

EC number: =1.1.1.58 [H]

Molecular weight: Translated: 54668; Mature: 54668

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKINRSNSEFSNRLPIKIVQFGEGNFLRAFVEYAIQKLNQKADFNAGIAVVQPIDKGLV
CCCCCCCCCHHHCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCEEEECHHHHHHH
NMINAQDGLYTLFMKGVKKGEEIQEKELITNIVKAVDPYASFQEYLSLAKEEELAFIISN
HHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEEEC
TTEAGIEYIASDLPTMTPPVSFPAKLTVLLNERFKHFNGAADKGLTIIPCELINYNADTL
CHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEHHHCCCCHHHH
KEIVFKYSADWKLGAEFESWLTNSCSWHNTLVDRIVPGYPKDQIEEYNAQLSYKDDLIVS
HHHHHHHCCCCCCCCCHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHCCCEEECCCEEEE
AETFFLWVIEGDDKLKAKLPFDKTDLDVKIISDMQPYRTRKVRILNGAHTAMVPFSLLYG
EEEEEEEEEECCCCEEEECCCCCCCCCEEEECCCCCCCCCEEEEECCCCHHHHHHHHHHC
NETVKETVDNEFTGGFINKALFEEINETLNMDKAELAGFSEEILDRFRNPFVKHLLSSIA
CHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHCHHHHHHHHHHH
LNSISKFKVRVLPSLTGYVDIHGKLPVHLTFAFAALIRFYKGTWNGQSLPVNDSEDIVTF
HHHHHHHEEEEECCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
FDGLWKSDDYEKIARLTLQNKNFWDEDLTEISGLTRAITIALEEIDANGIEAGFAKFQER
HHHHCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
IK
CC
>Mature Secondary Structure
MEKINRSNSEFSNRLPIKIVQFGEGNFLRAFVEYAIQKLNQKADFNAGIAVVQPIDKGLV
CCCCCCCCCHHHCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCEEEECHHHHHHH
NMINAQDGLYTLFMKGVKKGEEIQEKELITNIVKAVDPYASFQEYLSLAKEEELAFIISN
HHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEEEC
TTEAGIEYIASDLPTMTPPVSFPAKLTVLLNERFKHFNGAADKGLTIIPCELINYNADTL
CHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEHHHCCCCHHHH
KEIVFKYSADWKLGAEFESWLTNSCSWHNTLVDRIVPGYPKDQIEEYNAQLSYKDDLIVS
HHHHHHHCCCCCCCCCHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHCCCEEECCCEEEE
AETFFLWVIEGDDKLKAKLPFDKTDLDVKIISDMQPYRTRKVRILNGAHTAMVPFSLLYG
EEEEEEEEEECCCCEEEECCCCCCCCCEEEECCCCCCCCCEEEEECCCCHHHHHHHHHHC
NETVKETVDNEFTGGFINKALFEEINETLNMDKAELAGFSEEILDRFRNPFVKHLLSSIA
CHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHCHHHHHHHHHHH
LNSISKFKVRVLPSLTGYVDIHGKLPVHLTFAFAALIRFYKGTWNGQSLPVNDSEDIVTF
HHHHHHHEEEEECCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
FDGLWKSDDYEKIARLTLQNKNFWDEDLTEISGLTRAITIALEEIDANGIEAGFAKFQER
HHHHCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
IK
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]