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The map label for this gene is msrA [H]

Identifier: 146300544

GI number: 146300544

Start: 3327570

End: 3328103

Strand: Reverse

Name: msrA [H]

Synonym: Fjoh_2794

Alternate gene names: 146300544

Gene position: 3328103-3327570 (Counterclockwise)

Preceding gene: 146300546

Following gene: 146300543

Centisome position: 54.59

GC content: 36.52

Gene sequence:

>534_bases
ATGGGAAATTTATCAACAGCCACTTTTGGTGGTGGATGTTTTTGGTGTGTAGAAGCTGTAATTCAGCGTTTAAAAGGAGT
TGAAATAATAAAATCTGGTTATTCAGACGGCTTTATAAAAAATCCGGCGTATCGTGAGGTATGCACAGGAAGAACGGGAC
ATGCAGAAGTTATTCAGGTTACGTTTGACTCTGACATAATTTCATATCATGATTTGCTTACTGTTTTTATGACAAGCCAC
GACCCTACAACTTTAAATCGTCAGGGAGGCGACAGCGGAACGCAATACCGCTCTATCATTTTATATCATGATGAAGCACA
AAAAGAAATTGCTGAAAAAGTATTTGAAGAAGTACAGCCAGTTTATGCTGATCAAATTGTAACGCAGTTAAAACCGTTTG
AAGTGTTTTATGAAGCCGAAGATTATCATCAAAACTATTACAATAACAATCAGGAAGCTGGTTACTGCCAGTTTGTAATC
GATCCAAAGGTTCAAAAACTAAAAAAAATGTACGCTGATAAATTGATCAGCTAA

Upstream 100 bases:

>100_bases
AATAAACTTTTGGTATCTTTAGTTAAAAGGATGTTTTTTAGATAAATTATCACAATATTCTATCGGATTAATAGGGCATG
TAAACTTAAACATTACATTT

Downstream 100 bases:

>100_bases
AAAGAATAGACCACAGATTACACAGATTAAACGGATTTCTTTTTTTTATGCAAATAAAAGACAGATTATAGATTTAAATA
GATCCGTTTGATCAGTTTTT

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 177; Mature: 176

Protein sequence:

>177_residues
MGNLSTATFGGGCFWCVEAVIQRLKGVEIIKSGYSDGFIKNPAYREVCTGRTGHAEVIQVTFDSDIISYHDLLTVFMTSH
DPTTLNRQGGDSGTQYRSIILYHDEAQKEIAEKVFEEVQPVYADQIVTQLKPFEVFYEAEDYHQNYYNNNQEAGYCQFVI
DPKVQKLKKMYADKLIS

Sequences:

>Translated_177_residues
MGNLSTATFGGGCFWCVEAVIQRLKGVEIIKSGYSDGFIKNPAYREVCTGRTGHAEVIQVTFDSDIISYHDLLTVFMTSH
DPTTLNRQGGDSGTQYRSIILYHDEAQKEIAEKVFEEVQPVYADQIVTQLKPFEVFYEAEDYHQNYYNNNQEAGYCQFVI
DPKVQKLKKMYADKLIS
>Mature_176_residues
GNLSTATFGGGCFWCVEAVIQRLKGVEIIKSGYSDGFIKNPAYREVCTGRTGHAEVIQVTFDSDIISYHDLLTVFMTSHD
PTTLNRQGGDSGTQYRSIILYHDEAQKEIAEKVFEEVQPVYADQIVTQLKPFEVFYEAEDYHQNYYNNNQEAGYCQFVID
PKVQKLKKMYADKLIS

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=154, Percent_Identity=44.1558441558442, Blast_Score=129, Evalue=1e-30,
Organism=Homo sapiens, GI208609995, Length=154, Percent_Identity=44.1558441558442, Blast_Score=128, Evalue=2e-30,
Organism=Homo sapiens, GI208609993, Length=110, Percent_Identity=43.6363636363636, Blast_Score=87, Evalue=1e-17,
Organism=Escherichia coli, GI1790665, Length=152, Percent_Identity=43.421052631579, Blast_Score=125, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17533973, Length=147, Percent_Identity=36.0544217687075, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6320881, Length=157, Percent_Identity=37.5796178343949, Blast_Score=113, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24664627, Length=164, Percent_Identity=35.3658536585366, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24664631, Length=164, Percent_Identity=35.3658536585366, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI45553131, Length=157, Percent_Identity=33.7579617834395, Blast_Score=86, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 20162; Mature: 20031

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGNLSTATFGGGCFWCVEAVIQRLKGVEIIKSGYSDGFIKNPAYREVCTGRTGHAEVIQV
CCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCHHHHHHCCCCCCCEEEEE
TFDSDIISYHDLLTVFMTSHDPTTLNRQGGDSGTQYRSIILYHDEAQKEIAEKVFEEVQP
EECCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHH
VYADQIVTQLKPFEVFYEAEDYHQNYYNNNQEAGYCQFVIDPKVQKLKKMYADKLIS
HHHHHHHHHCCCHHEEECHHHHHHHHCCCCCCCCEEEEEECHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GNLSTATFGGGCFWCVEAVIQRLKGVEIIKSGYSDGFIKNPAYREVCTGRTGHAEVIQV
CCCCCCCCCCHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCHHHHHHCCCCCCCEEEEE
TFDSDIISYHDLLTVFMTSHDPTTLNRQGGDSGTQYRSIILYHDEAQKEIAEKVFEEVQP
EECCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHH
VYADQIVTQLKPFEVFYEAEDYHQNYYNNNQEAGYCQFVIDPKVQKLKKMYADKLIS
HHHHHHHHHCCCHHEEECHHHHHHHHCCCCCCCCEEEEEECHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11427726 [H]