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The map label for this gene is coxN [H]

Identifier: 146299401

GI number: 146299401

Start: 1896088

End: 1897890

Strand: Direct

Name: coxN [H]

Synonym: Fjoh_1641

Alternate gene names: 146299401

Gene position: 1896088-1897890 (Clockwise)

Preceding gene: 146299400

Following gene: 146299402

Centisome position: 31.1

GC content: 35.16

Gene sequence:

>1803_bases
ATGTCAGCAGAAGCGCACGGTCACGATCACGGACACGATCACGAGCACGAACATCATCATAAAGACACGTTCATTACTAA
ATATATTTTTAGTATTGATCACAAAATGATTGCTAAACAATACTTAATTACAGGTATTGTTATGGGAGTAATTGGGATTG
CAATGTCCTTGCTTTTCAGAATGCAATTAGCGTGGCCAGAAGAGTCTTTTAAAATATTCAATGTTTTATTAGGAGATAAA
TTTGCACCTGATGGTGTAATGGCTAATGATATTTATCTTGCTTTAGTTACAATTCATGGTACCATTATGGTATTCTTTGT
ACTTACGGCAGGTTTAAGTGGAACTTTTAGTAACTTACTTATTCCACTTCAAATTGGAGCGCGAGATATGGCTTCTGGAT
TTATGAACATGATTTCATACTGGTTGTTTTTCTTATCTGCTGTAGTAATGTTAAGTTCTTTATTTGTTGAAGCTGGACCA
GCTTCTGCAGGTTGGACAATTTATCCTCCATTAAGTGCATTGCCTCAAGCAATTCCTGGATCTGGAACAGGTATGACTTT
ATGGTTAGTTTCAATGGCTATATTTATTGCATCTTCTTTAATGGGATCATTAAACTACATTGTAACTGTTATTAACTTAA
GAACAAAAGGAATGTCTATGACTAGACTTCCTCTTACAATCTGGACATTTTTCGTAACAGCTATTATTGGTGTTATTTCA
TTCCCAGTATTATTATCTGCAGCCTTATTATTGATTTTTGACAGAAGTTTTGGTACTTCATTCTTCTTATCAGATATCTA
TATTGCTGGAGAGGTTTTACACTACCAAGGAGGTTCTCCAGTATTGTTTGAGCACTTATTTTGGTTCTTAGGTCACCCTG
AGGTTTACATTGTAATCTTACCGGCAATGGGACTTGTTTCTGAAATTATGGCTACGAACTCTCGTAAACCAATCTTCGGA
TATAGAGCGATGATTATGTCTGTTCTTGCAATTGCATTCTTATCAACTATTGTATGGGGTCACCACATGTTTATTTCTGG
TATGAATCCTTTCTTAGGATCTGTATTTACTTTTACAACTTTATTGGTTGCAATTCCATCTGCTGTAAAAGCGTTCAACT
GGATTACAACTTTATGGAAAGGTAACTTACAATTCAATCCTGCAATGTTATTCTCTATTGGAATGGTTTCTACTTTCATC
ACTGGAGGTTTAACAGGAATCATTTTAGGAGATAGTACTTTAGATATTAACGTTCATGATACTTACTTTGTAATTGCTCA
CTTTCACTTAGTAATGGGTATCTCTGCACTTTACGGAATGTTTGCTGGTATTTATCACTGGTTCCCTAAAATGTACGGAA
GAATGTTAAACAAAAATTTAGGTTATATTCACTTCTGGATTACAGCAGTTTGTGCTTATGGAGTTTTCTTCCCAATGCAC
TTTATCGGATTAGCTGGTTTACCAAGACGTTACTATACAAATACTAACTTCCCATTATTTGATGATTTACAAAATGTGAA
TGTTTTAATTACAACATTTGCTCTTGTAGGAGGTGCATTCCAGTTAGTATTCTTATACAACTTCTTTAGCAGTATTTTCT
ATGGTAAAAAAGCTGTTCAAAACCCATGGAAATCTACAACTTTAGAGTGGACTACTCCAGTTGAACATATCCACGGAAAC
TGGCCGGGAGAAATTCCTCACGTATATCGTTGGCCGTATGACTACAGTAACCCAAATCATGATGTAGATTTTGTTCCTCA
AAATGTACCAATGAAAGAAGGTGAAGAAGTTTTACACCACTAA

Upstream 100 bases:

>100_bases
AGTAAAAGATACCGTAAAAGCGGTAGTTGATACTGTTAAAGCAGCTGTAGCTAAAGTTGCGATGAAATAATATTATTAAG
AAAATTTAAAGTACACATAT

Downstream 100 bases:

>100_bases
AATATATCAAAGGCTGTCAGAAATGACAGCCTTTTTTGTTTGGTTAAGGTTTAAACCTTAAGCTTACTGTTTTACAAACT
AATTAGTTTCTATATCTTTG

Product: cytochrome-c oxidase

Products: NA

Alternate protein names: Alternative cytochrome c oxidase polypeptide I; Cytochrome BB3 subunit 1; Oxidase BB(3) subunit 1 [H]

Number of amino acids: Translated: 600; Mature: 599

Protein sequence:

>600_residues
MSAEAHGHDHGHDHEHEHHHKDTFITKYIFSIDHKMIAKQYLITGIVMGVIGIAMSLLFRMQLAWPEESFKIFNVLLGDK
FAPDGVMANDIYLALVTIHGTIMVFFVLTAGLSGTFSNLLIPLQIGARDMASGFMNMISYWLFFLSAVVMLSSLFVEAGP
ASAGWTIYPPLSALPQAIPGSGTGMTLWLVSMAIFIASSLMGSLNYIVTVINLRTKGMSMTRLPLTIWTFFVTAIIGVIS
FPVLLSAALLLIFDRSFGTSFFLSDIYIAGEVLHYQGGSPVLFEHLFWFLGHPEVYIVILPAMGLVSEIMATNSRKPIFG
YRAMIMSVLAIAFLSTIVWGHHMFISGMNPFLGSVFTFTTLLVAIPSAVKAFNWITTLWKGNLQFNPAMLFSIGMVSTFI
TGGLTGIILGDSTLDINVHDTYFVIAHFHLVMGISALYGMFAGIYHWFPKMYGRMLNKNLGYIHFWITAVCAYGVFFPMH
FIGLAGLPRRYYTNTNFPLFDDLQNVNVLITTFALVGGAFQLVFLYNFFSSIFYGKKAVQNPWKSTTLEWTTPVEHIHGN
WPGEIPHVYRWPYDYSNPNHDVDFVPQNVPMKEGEEVLHH

Sequences:

>Translated_600_residues
MSAEAHGHDHGHDHEHEHHHKDTFITKYIFSIDHKMIAKQYLITGIVMGVIGIAMSLLFRMQLAWPEESFKIFNVLLGDK
FAPDGVMANDIYLALVTIHGTIMVFFVLTAGLSGTFSNLLIPLQIGARDMASGFMNMISYWLFFLSAVVMLSSLFVEAGP
ASAGWTIYPPLSALPQAIPGSGTGMTLWLVSMAIFIASSLMGSLNYIVTVINLRTKGMSMTRLPLTIWTFFVTAIIGVIS
FPVLLSAALLLIFDRSFGTSFFLSDIYIAGEVLHYQGGSPVLFEHLFWFLGHPEVYIVILPAMGLVSEIMATNSRKPIFG
YRAMIMSVLAIAFLSTIVWGHHMFISGMNPFLGSVFTFTTLLVAIPSAVKAFNWITTLWKGNLQFNPAMLFSIGMVSTFI
TGGLTGIILGDSTLDINVHDTYFVIAHFHLVMGISALYGMFAGIYHWFPKMYGRMLNKNLGYIHFWITAVCAYGVFFPMH
FIGLAGLPRRYYTNTNFPLFDDLQNVNVLITTFALVGGAFQLVFLYNFFSSIFYGKKAVQNPWKSTTLEWTTPVEHIHGN
WPGEIPHVYRWPYDYSNPNHDVDFVPQNVPMKEGEEVLHH
>Mature_599_residues
SAEAHGHDHGHDHEHEHHHKDTFITKYIFSIDHKMIAKQYLITGIVMGVIGIAMSLLFRMQLAWPEESFKIFNVLLGDKF
APDGVMANDIYLALVTIHGTIMVFFVLTAGLSGTFSNLLIPLQIGARDMASGFMNMISYWLFFLSAVVMLSSLFVEAGPA
SAGWTIYPPLSALPQAIPGSGTGMTLWLVSMAIFIASSLMGSLNYIVTVINLRTKGMSMTRLPLTIWTFFVTAIIGVISF
PVLLSAALLLIFDRSFGTSFFLSDIYIAGEVLHYQGGSPVLFEHLFWFLGHPEVYIVILPAMGLVSEIMATNSRKPIFGY
RAMIMSVLAIAFLSTIVWGHHMFISGMNPFLGSVFTFTTLLVAIPSAVKAFNWITTLWKGNLQFNPAMLFSIGMVSTFIT
GGLTGIILGDSTLDINVHDTYFVIAHFHLVMGISALYGMFAGIYHWFPKMYGRMLNKNLGYIHFWITAVCAYGVFFPMHF
IGLAGLPRRYYTNTNFPLFDDLQNVNVLITTFALVGGAFQLVFLYNFFSSIFYGKKAVQNPWKSTTLEWTTPVEHIHGNW
PGEIPHVYRWPYDYSNPNHDVDFVPQNVPMKEGEEVLHH

Specific function: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. Co I is the catalytic subunit of the enzyme. Electrons originating in cytochrome

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=528, Percent_Identity=38.4469696969697, Blast_Score=330, Evalue=3e-90,
Organism=Escherichia coli, GI1786634, Length=572, Percent_Identity=32.8671328671329, Blast_Score=299, Evalue=3e-82,
Organism=Saccharomyces cerevisiae, GI6226519, Length=466, Percent_Identity=39.9141630901288, Blast_Score=348, Evalue=2e-96,
Organism=Saccharomyces cerevisiae, GI6226524, Length=351, Percent_Identity=39.3162393162393, Blast_Score=244, Evalue=2e-65,
Organism=Saccharomyces cerevisiae, GI6226523, Length=277, Percent_Identity=36.101083032491, Blast_Score=155, Evalue=1e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014241 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 67174; Mature: 67042

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAEAHGHDHGHDHEHEHHHKDTFITKYIFSIDHKMIAKQYLITGIVMGVIGIAMSLLFR
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MQLAWPEESFKIFNVLLGDKFAPDGVMANDIYLALVTIHGTIMVFFVLTAGLSGTFSNLL
HHHCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCE
IPLQIGARDMASGFMNMISYWLFFLSAVVMLSSLFVEAGPASAGWTIYPPLSALPQAIPG
EEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCHHHCCCCCCC
SGTGMTLWLVSMAIFIASSLMGSLNYIVTVINLRTKGMSMTRLPLTIWTFFVTAIIGVIS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
FPVLLSAALLLIFDRSFGTSFFLSDIYIAGEVLHYQGGSPVLFEHLFWFLGHPEVYIVIL
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHCEEEEECCCCHHHHHHHHHHHCCCCEEEEEE
PAMGLVSEIMATNSRKPIFGYRAMIMSVLAIAFLSTIVWGHHMFISGMNPFLGSVFTFTT
CHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
LLVAIPSAVKAFNWITTLWKGNLQFNPAMLFSIGMVSTFITGGLTGIILGDSTLDINVHD
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCEEEEEECC
TYFVIAHFHLVMGISALYGMFAGIYHWFPKMYGRMLNKNLGYIHFWITAVCAYGVFFPMH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
FIGLAGLPRRYYTNTNFPLFDDLQNVNVLITTFALVGGAFQLVFLYNFFSSIFYGKKAVQ
HHHHCCCCHHHCCCCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHC
NPWKSTTLEWTTPVEHIHGNWPGEIPHVYRWPYDYSNPNHDVDFVPQNVPMKEGEEVLHH
CCCCCCCEEECCCHHHHCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHCC
>Mature Secondary Structure 
SAEAHGHDHGHDHEHEHHHKDTFITKYIFSIDHKMIAKQYLITGIVMGVIGIAMSLLFR
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MQLAWPEESFKIFNVLLGDKFAPDGVMANDIYLALVTIHGTIMVFFVLTAGLSGTFSNLL
HHHCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCE
IPLQIGARDMASGFMNMISYWLFFLSAVVMLSSLFVEAGPASAGWTIYPPLSALPQAIPG
EEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCHHHCCCCCCC
SGTGMTLWLVSMAIFIASSLMGSLNYIVTVINLRTKGMSMTRLPLTIWTFFVTAIIGVIS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
FPVLLSAALLLIFDRSFGTSFFLSDIYIAGEVLHYQGGSPVLFEHLFWFLGHPEVYIVIL
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHCEEEEECCCCHHHHHHHHHHHCCCCEEEEEE
PAMGLVSEIMATNSRKPIFGYRAMIMSVLAIAFLSTIVWGHHMFISGMNPFLGSVFTFTT
CHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
LLVAIPSAVKAFNWITTLWKGNLQFNPAMLFSIGMVSTFITGGLTGIILGDSTLDINVHD
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCEEEEEECC
TYFVIAHFHLVMGISALYGMFAGIYHWFPKMYGRMLNKNLGYIHFWITAVCAYGVFFPMH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
FIGLAGLPRRYYTNTNFPLFDDLQNVNVLITTFALVGGAFQLVFLYNFFSSIFYGKKAVQ
HHHHCCCCHHHCCCCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHC
NPWKSTTLEWTTPVEHIHGNWPGEIPHVYRWPYDYSNPNHDVDFVPQNVPMKEGEEVLHH
CCCCCCCEEECCCHHHHCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1444719; 12597275 [H]