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The map label for this gene is gppA [H]

Identifier: 145301127

GI number: 145301127

Start: 4596109

End: 4597599

Strand: Direct

Name: gppA [H]

Synonym: ASA_4296

Alternate gene names: 145301127

Gene position: 4596109-4597599 (Clockwise)

Preceding gene: 145301126

Following gene: 145301128

Centisome position: 97.74

GC content: 61.97

Gene sequence:

>1491_bases
TTGCACAACTCGCCTCTCTATGCCGCCATTGACCTCGGCTCCAACAGCTTTCACATGCTGGTGGTGCGCGAGGTCGCCGG
TGCCCTGCGCACCGTCACCAAGGTCAAGCGCAAGGTTCGCCTCGCCGCCGGGCTCGATCCGGAATTTCGTCTCAGCCGTG
CCGCCATGGAGCGGGGCTGGGACTGCCTGCGTCTGTTCTCCGAGCAGCTGCAGGACATTCCGGCCGACAATATACGGGTG
GTGGGCACGGCCACACTGCGCCTTGCCACCAACGTCGACGAGTTCCTGAGCGAAGCGGAACGGGTGCTCAACCACAGCAT
AGAGATCATCTCTGGCGAGGAAGAGGCCAAGACCATCTACGAGGGTGTGTCCTGGACCTCGGCCGGGGAAGGCAACCGGC
TGGTGATCGACATCGGCGGCGCCAGCACAGAGCTGGTGATTGGCGAGCACAGCGAAGCGAAACTGCTCAACAGCCTGCAC
ATGGGCTGCGTCACCTGGCTCAACAACCACTTCGGTGATGGCGAGCTGAGTGAAGCCCGCTTTGCGCAGGCGATTGCCGC
TGCCAAGGCGGTGCTGGAGAAGGTGGCGGAAGATTACTGCGTCCTTGGCTGGCGCACCTGCGTCGGCGCCTCCGGCACTG
TACAGGCGCTGCAGGAGATCATGCTGGCGCAAGGGAAGAGCGAGCGGGTCACCCTGCCCAAGTTGCAGGAGCTGATGGGT
CAGGCCATCGCCTGCGGCAGGCTGGACCGGCTACAGCTGGAAGGACTGGCGGCCGAGCGGCTGACCGTGTTCCCCTCCGG
TCTCGCCATCCTGATCGCCATCTTCGAAACCCTGAACATAGAGAGCATGACCCTGGCGGGCGGTGCCTTGCGCGAAGGGC
TTATCTACGGTCTGCTTGGCAACAATCACGACTGCGATGCCCGGGATCGTACCGCCGACAGCCTCATCAGCTGCTATCAG
CTGGATAAAGAGCACGCCGAGCGGGTACGTGACACCGCCATAGAAGCGTTCAATCAGCTGCAACCGGCCTGGCGCCTATC
CAAACGTTACGGTCGCCCTATCCTGCGTTATGCGGCCCTGCTGCACGAGATTGGCCTCTGTATCGAGTACAAGAAGGCCC
CACAACACGCGGCCTATATCATAGACAACATCGACATGCCGGGTTTTACCCCTGCACAGAAGAAGTTGTTGTCGGCCCTG
CTGTTCAACCAGCGGGATGAATTCAAGCTGGAAACCCTGGAAAAACAGGGTGCCGTCACGGGTCGTCAGGCGATCCGGTT
GGCCCGCATCCTGCGCATCTCGCTGATCCTCTGCATGCGCCGTACCCAGGGCACAGTACCCAACTTCACCCTGCAGGCCG
AGGAAGAGGCGTTGACCCTGACCCTGCCCAAGGGGTGGATGGACGAACACTACCTGCGCGCCAGCGAATTGCGTCTCGAA
GTGGAACGCCAGCAGAAGATGGGCTGGCCTACTCGCTTGCTGGAAGCCTGA

Upstream 100 bases:

>100_bases
AACCGTCAGCCAGTGAACCGCAACATGCGGGATCGCCAGGGCGGTGGCAACAGCAACAACCGTCGTCGTCCGCCACGCAA
GAGCTGAAGGACAGGCCCAG

Downstream 100 bases:

>100_bases
CACAGAAACTTGCTCGTTTGGGAGCCGATCATGCCGGATTACCAACCCATCAGCTGCGATCTCTACGACTGGCTTGAAAT
TGCCGCCAGCTGGCAATTAC

Product: guanosine-5'-triphosphate, 3'-diphosphatepyrophosphatase

Products: NA

Alternate protein names: Guanosine pentaphosphate phosphohydrolase; pppGpp-5'-phosphohydrolase [H]

Number of amino acids: Translated: 496; Mature: 496

Protein sequence:

>496_residues
MHNSPLYAAIDLGSNSFHMLVVREVAGALRTVTKVKRKVRLAAGLDPEFRLSRAAMERGWDCLRLFSEQLQDIPADNIRV
VGTATLRLATNVDEFLSEAERVLNHSIEIISGEEEAKTIYEGVSWTSAGEGNRLVIDIGGASTELVIGEHSEAKLLNSLH
MGCVTWLNNHFGDGELSEARFAQAIAAAKAVLEKVAEDYCVLGWRTCVGASGTVQALQEIMLAQGKSERVTLPKLQELMG
QAIACGRLDRLQLEGLAAERLTVFPSGLAILIAIFETLNIESMTLAGGALREGLIYGLLGNNHDCDARDRTADSLISCYQ
LDKEHAERVRDTAIEAFNQLQPAWRLSKRYGRPILRYAALLHEIGLCIEYKKAPQHAAYIIDNIDMPGFTPAQKKLLSAL
LFNQRDEFKLETLEKQGAVTGRQAIRLARILRISLILCMRRTQGTVPNFTLQAEEEALTLTLPKGWMDEHYLRASELRLE
VERQQKMGWPTRLLEA

Sequences:

>Translated_496_residues
MHNSPLYAAIDLGSNSFHMLVVREVAGALRTVTKVKRKVRLAAGLDPEFRLSRAAMERGWDCLRLFSEQLQDIPADNIRV
VGTATLRLATNVDEFLSEAERVLNHSIEIISGEEEAKTIYEGVSWTSAGEGNRLVIDIGGASTELVIGEHSEAKLLNSLH
MGCVTWLNNHFGDGELSEARFAQAIAAAKAVLEKVAEDYCVLGWRTCVGASGTVQALQEIMLAQGKSERVTLPKLQELMG
QAIACGRLDRLQLEGLAAERLTVFPSGLAILIAIFETLNIESMTLAGGALREGLIYGLLGNNHDCDARDRTADSLISCYQ
LDKEHAERVRDTAIEAFNQLQPAWRLSKRYGRPILRYAALLHEIGLCIEYKKAPQHAAYIIDNIDMPGFTPAQKKLLSAL
LFNQRDEFKLETLEKQGAVTGRQAIRLARILRISLILCMRRTQGTVPNFTLQAEEEALTLTLPKGWMDEHYLRASELRLE
VERQQKMGWPTRLLEA
>Mature_496_residues
MHNSPLYAAIDLGSNSFHMLVVREVAGALRTVTKVKRKVRLAAGLDPEFRLSRAAMERGWDCLRLFSEQLQDIPADNIRV
VGTATLRLATNVDEFLSEAERVLNHSIEIISGEEEAKTIYEGVSWTSAGEGNRLVIDIGGASTELVIGEHSEAKLLNSLH
MGCVTWLNNHFGDGELSEARFAQAIAAAKAVLEKVAEDYCVLGWRTCVGASGTVQALQEIMLAQGKSERVTLPKLQELMG
QAIACGRLDRLQLEGLAAERLTVFPSGLAILIAIFETLNIESMTLAGGALREGLIYGLLGNNHDCDARDRTADSLISCYQ
LDKEHAERVRDTAIEAFNQLQPAWRLSKRYGRPILRYAALLHEIGLCIEYKKAPQHAAYIIDNIDMPGFTPAQKKLLSAL
LFNQRDEFKLETLEKQGAVTGRQAIRLARILRISLILCMRRTQGTVPNFTLQAEEEALTLTLPKGWMDEHYLRASELRLE
VERQQKMGWPTRLLEA

Specific function: Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in th

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family. GppA subfamily [H]

Homologues:

Organism=Escherichia coli, GI48994966, Length=488, Percent_Identity=55.327868852459, Blast_Score=530, Evalue=1e-152,
Organism=Escherichia coli, GI1788848, Length=499, Percent_Identity=39.2785571142285, Blast_Score=338, Evalue=5e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.40 [H]

Molecular weight: Translated: 55129; Mature: 55129

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHNSPLYAAIDLGSNSFHMLVVREVAGALRTVTKVKRKVRLAAGLDPEFRLSRAAMERGW
CCCCCEEEEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCH
DCLRLFSEQLQDIPADNIRVVGTATLRLATNVDEFLSEAERVLNHSIEIISGEEEAKTIY
HHHHHHHHHHHCCCCCCEEEEEEEEEEECCCHHHHHHHHHHHHHCCEEEECCCHHHHHHH
EGVSWTSAGEGNRLVIDIGGASTELVIGEHSEAKLLNSLHMGCVTWLNNHFGDGELSEAR
HCCCCCCCCCCCEEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
FAQAIAAAKAVLEKVAEDYCVLGWRTCVGASGTVQALQEIMLAQGKSERVTLPKLQELMG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
QAIACGRLDRLQLEGLAAERLTVFPSGLAILIAIFETLNIESMTLAGGALREGLIYGLLG
HHHHCCCCCHHHHCCCCHHHHEECCCHHHHHHHHHHHCCCCCEEECCHHHHHCEEEEECC
NNHDCDARDRTADSLISCYQLDKEHAERVRDTAIEAFNQLQPAWRLSKRYGRPILRYAAL
CCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHH
LHEIGLCIEYKKAPQHAAYIIDNIDMPGFTPAQKKLLSALLFNQRDEFKLETLEKQGAVT
HHHHCCCEEECCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCH
GRQAIRLARILRISLILCMRRTQGTVPNFTLQAEEEALTLTLPKGWMDEHYLRASELRLE
HHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCEEEEECCCCCCHHHHHHHHHHHHH
VERQQKMGWPTRLLEA
HHHHHHCCCCHHHHCC
>Mature Secondary Structure
MHNSPLYAAIDLGSNSFHMLVVREVAGALRTVTKVKRKVRLAAGLDPEFRLSRAAMERGW
CCCCCEEEEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCH
DCLRLFSEQLQDIPADNIRVVGTATLRLATNVDEFLSEAERVLNHSIEIISGEEEAKTIY
HHHHHHHHHHHCCCCCCEEEEEEEEEEECCCHHHHHHHHHHHHHCCEEEECCCHHHHHHH
EGVSWTSAGEGNRLVIDIGGASTELVIGEHSEAKLLNSLHMGCVTWLNNHFGDGELSEAR
HCCCCCCCCCCCEEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
FAQAIAAAKAVLEKVAEDYCVLGWRTCVGASGTVQALQEIMLAQGKSERVTLPKLQELMG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
QAIACGRLDRLQLEGLAAERLTVFPSGLAILIAIFETLNIESMTLAGGALREGLIYGLLG
HHHHCCCCCHHHHCCCCHHHHEECCCHHHHHHHHHHHCCCCCEEECCHHHHHCEEEEECC
NNHDCDARDRTADSLISCYQLDKEHAERVRDTAIEAFNQLQPAWRLSKRYGRPILRYAAL
CCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHH
LHEIGLCIEYKKAPQHAAYIIDNIDMPGFTPAQKKLLSALLFNQRDEFKLETLEKQGAVT
HHHHCCCEEECCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCH
GRQAIRLARILRISLILCMRRTQGTVPNFTLQAEEEALTLTLPKGWMDEHYLRASELRLE
HHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCEEEEECCCCCCHHHHHHHHHHHHH
VERQQKMGWPTRLLEA
HHHHHHCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA