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The map label for this gene is gntU [H]

Identifier: 145300959

GI number: 145300959

Start: 4399448

End: 4400788

Strand: Direct

Name: gntU [H]

Synonym: ASA_4111

Alternate gene names: 145300959

Gene position: 4399448-4400788 (Clockwise)

Preceding gene: 145300955

Following gene: 145300960

Centisome position: 93.56

GC content: 64.43

Gene sequence:

>1341_bases
ATGTCTGACCTCTCCCTGATCATGACGGCCGCGGGCTCCATAGTGCTGCTGCTCTTTCTGGTGATGAAGGCCCGCCTGCA
CGCGGTCGTCTCCCTCATCCTGGTCTCCATGGTGGCCGGCCTCGCCGCCGGCATGAACCCGGCTGAGATCGCCACTACCA
TCCAGAAAGGGATGGGTGGCACCCTGGGCTTCGTCGCCGTTGTGGTGGCGCTGGGCGCCATGTTTGGCAAGGTGATGGAA
GTCACCGGCGCCCTCGACCGGGTAGCCCATACCCTGCTCGGTACCTTCGGCGTCAAGCGCGCCAACTGGGCCATGTCACT
GACTGGCTTCGTCTGCGCTCTGCCGCTCTTCTTCGACGTCGCCGTAGTGCTGCTGATCGGGGTGGCCTTTGCCATTGTCC
GCCGTGGCGGTGGCAGCGTGGTGAAGATAGGCATAGCGCTGCTGGCGGGCATCGCCACCTGCCAGGCGTTCCTCATCCCC
GCGCCAGGCCCCATTCTGGTAGCGTCCCAGCTGGGGGCCGATTTTGGCTACATGATACTGTTCGGTCTGATCGCCGCCGT
GCCAGCCCTGATCCTGGCGGGCCCCCTGTTCGGCGACCTGATCAGCAAGGTGGTGGATGTGCCGCTCCCTGCCGATGCCC
AGAGCAGCGCCCATGACGATAGCAAGACTCTCCCCTCCTTCGGACTGGCCATGGGCCTGATCGGTCTGCCGCTGCTGATG
ATTGGCCTCAAGACCATAGTCGGCCGCTTCGTCGAGGCGGGATCCACCCTGCATAACTGGCTGGAGTTCGTCGGCCACCC
CTTCACCGCCATCATGGTCGCCTGTCTGGCCGCCTTCTATCTGCTGGGGGTGCGCCGCGGCATGTCCCGTGACGAGGTGA
TGAACGTCTGCAACAGCGCCATCCAGCCTGCCGGCGTCATCATACTGGTGACCGGTGCCGGTGGCGTCTTCAAGCAGATA
CTGGTGGATTCCGGTGTGGGCGCCGCCCTTGGCAACATGCTGGCAGACTCCGGCCTGCCCATAGTCGCGCTGGCCTTTAT
CCTGGCGGCGGCCGTGCGGGTCATTCAGGGTTCTGCCACCGTCGCCATGCTGACCGCCTGCGGCCTGCTGCTGCCCATGC
TGGAACCGCTCGGTCTGAACGGAGCCCAACTGGCGGCCGTGACCATCGCCATCGGCGGCGGAGCCATCGTCCTCTCCCAC
GTCAACGACTCGGGTTTCTGGCTGGCCAACCGCTACCTGGGCCTCTCCGAGAAGCAGACCCTGCAAACCTGGACAGTGAT
GGAGACCATCATAGGCACCACGGGTGGCGTCATGGCGATGATTATCTACAGCTTCCTTTGA

Upstream 100 bases:

>100_bases
CTTGAGCCCTGGCCATAAATCTAAATAAATCATAAAGATATGGTCTGCTGACGGATCAGCAGGGTGTCGATACTGAACTT
GGAACAAGGAACGCACAACA

Downstream 100 bases:

>100_bases
ACATAACCGCTGTCAAAAAGGCCTCCGATGTGAGGCCTTTTTCATCTTTATGACGATTCTTTCTTTGGCTAACAGGTTGA
GGTTGCTAGAATCGCCTATC

Product: low affinity gluconate transporter

Products: Proton [Cytoplasm]; gluconate [Cytoplasm] [C]

Alternate protein names: Gluconate permease; Gnt-I system [H]

Number of amino acids: Translated: 446; Mature: 445

Protein sequence:

>446_residues
MSDLSLIMTAAGSIVLLLFLVMKARLHAVVSLILVSMVAGLAAGMNPAEIATTIQKGMGGTLGFVAVVVALGAMFGKVME
VTGALDRVAHTLLGTFGVKRANWAMSLTGFVCALPLFFDVAVVLLIGVAFAIVRRGGGSVVKIGIALLAGIATCQAFLIP
APGPILVASQLGADFGYMILFGLIAAVPALILAGPLFGDLISKVVDVPLPADAQSSAHDDSKTLPSFGLAMGLIGLPLLM
IGLKTIVGRFVEAGSTLHNWLEFVGHPFTAIMVACLAAFYLLGVRRGMSRDEVMNVCNSAIQPAGVIILVTGAGGVFKQI
LVDSGVGAALGNMLADSGLPIVALAFILAAAVRVIQGSATVAMLTACGLLLPMLEPLGLNGAQLAAVTIAIGGGAIVLSH
VNDSGFWLANRYLGLSEKQTLQTWTVMETIIGTTGGVMAMIIYSFL

Sequences:

>Translated_446_residues
MSDLSLIMTAAGSIVLLLFLVMKARLHAVVSLILVSMVAGLAAGMNPAEIATTIQKGMGGTLGFVAVVVALGAMFGKVME
VTGALDRVAHTLLGTFGVKRANWAMSLTGFVCALPLFFDVAVVLLIGVAFAIVRRGGGSVVKIGIALLAGIATCQAFLIP
APGPILVASQLGADFGYMILFGLIAAVPALILAGPLFGDLISKVVDVPLPADAQSSAHDDSKTLPSFGLAMGLIGLPLLM
IGLKTIVGRFVEAGSTLHNWLEFVGHPFTAIMVACLAAFYLLGVRRGMSRDEVMNVCNSAIQPAGVIILVTGAGGVFKQI
LVDSGVGAALGNMLADSGLPIVALAFILAAAVRVIQGSATVAMLTACGLLLPMLEPLGLNGAQLAAVTIAIGGGAIVLSH
VNDSGFWLANRYLGLSEKQTLQTWTVMETIIGTTGGVMAMIIYSFL
>Mature_445_residues
SDLSLIMTAAGSIVLLLFLVMKARLHAVVSLILVSMVAGLAAGMNPAEIATTIQKGMGGTLGFVAVVVALGAMFGKVMEV
TGALDRVAHTLLGTFGVKRANWAMSLTGFVCALPLFFDVAVVLLIGVAFAIVRRGGGSVVKIGIALLAGIATCQAFLIPA
PGPILVASQLGADFGYMILFGLIAAVPALILAGPLFGDLISKVVDVPLPADAQSSAHDDSKTLPSFGLAMGLIGLPLLMI
GLKTIVGRFVEAGSTLHNWLEFVGHPFTAIMVACLAAFYLLGVRRGMSRDEVMNVCNSAIQPAGVIILVTGAGGVFKQIL
VDSGVGAALGNMLADSGLPIVALAFILAAAVRVIQGSATVAMLTACGLLLPMLEPLGLNGAQLAAVTIAIGGGAIVLSHV
NDSGFWLANRYLGLSEKQTLQTWTVMETIIGTTGGVMAMIIYSFL

Specific function: Part of the gluconate utilization system Gnt-I; low- affinity intake of gluconate [H]

COG id: COG2610

COG function: function code GE; H+/gluconate symporter and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gntP permease family [H]

Homologues:

Organism=Escherichia coli, GI48994939, Length=446, Percent_Identity=58.5201793721973, Blast_Score=486, Evalue=1e-138,
Organism=Escherichia coli, GI1790716, Length=439, Percent_Identity=35.9908883826879, Blast_Score=279, Evalue=2e-76,
Organism=Escherichia coli, GI48994935, Length=432, Percent_Identity=34.2592592592593, Blast_Score=268, Evalue=7e-73,
Organism=Escherichia coli, GI1789097, Length=454, Percent_Identity=36.3436123348018, Blast_Score=244, Evalue=1e-65,
Organism=Escherichia coli, GI2367370, Length=421, Percent_Identity=31.8289786223278, Blast_Score=238, Evalue=5e-64,
Organism=Escherichia coli, GI1788707, Length=430, Percent_Identity=35.1162790697674, Blast_Score=238, Evalue=5e-64,
Organism=Escherichia coli, GI1790776, Length=430, Percent_Identity=29.5348837209302, Blast_Score=216, Evalue=2e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003474 [H]

Pfam domain/function: PF02447 GntP_permease [H]

EC number: NA

Molecular weight: Translated: 45698; Mature: 45566

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHCCCCHHHHHHHHHHC
>Mature Secondary Structure 
SDLSLIMTAAGSIVLLLFLVMKARLHAVVSLILVSMVAGLAAGMNPAEIATTIQKGMGG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCC
TLGFVAVVVALGAMFGKVMEVTGALDRVAHTLLGTFGVKRANWAMSLTGFVCALPLFFDV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
AVVLLIGVAFAIVRRGGGSVVKIGIALLAGIATCQAFLIPAPGPILVASQLGADFGYMIL
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHEECCCCCEEEHHHHCCCHHHHHH
FGLIAAVPALILAGPLFGDLISKVVDVPLPADAQSSAHDDSKTLPSFGLAMGLIGLPLLM
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
IGLKTIVGRFVEAGSTLHNWLEFVGHPFTAIMVACLAAFYLLGVRRGMSRDEVMNVCNSA
HHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHC
IQPAGVIILVTGAGGVFKQILVDSGVGAALGNMLADSGLPIVALAFILAAAVRVIQGSAT
CCCCCEEEEEECCCHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHH
VAMLTACGLLLPMLEPLGLNGAQLAAVTIAIGGGAIVLSHVNDSGFWLANRYLGLSEKQT
HHHHHHHHHHHHHHHCCCCCCHHEEEEEEEECCCEEEEEEECCCCCCHHHHHCCCCCHHH
LQTWTVMETIIGTTGGVMAMIIYSFL
HHHHHHHHHHHCCCCHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; gluconate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + gluconate [Periplasm] = Proton [Cytoplasm] + gluconate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]