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The map label for this gene is thiJ [H]

Identifier: 145300109

GI number: 145300109

Start: 3470629

End: 3471309

Strand: Direct

Name: thiJ [H]

Synonym: ASA_3209

Alternate gene names: 145300109

Gene position: 3470629-3471309 (Clockwise)

Preceding gene: 145300108

Following gene: 145300111

Centisome position: 73.81

GC content: 66.96

Gene sequence:

>681_bases
ATGACAGTACTGGTATTGGTAGCACCGGGGTCTGAAGAGATCGAAACCGTCGCCATCGTCGACACCCTGGTGCGCGCCCG
CATCGAGGTGCTGCTGGCCTCCTGCTGTCCGGCGGGTCTGCGCCAGATCCGCGCCTCCCGCGGGGTACAGCTGGTCGCTG
ACTATCATATCGACGAGCTGACCAGCCGTGACTTCGAAGCCATCGTCGTGCCGGGCGGCTTGCCCGGCAGCGAGGCAATC
CGCGATACGCCGCTCGCCATCGATCTGCTCAGGGAACAGGCGGCGCTCGGCCGCTGGCGGGCGGCTATGTGCGCCGCCCC
CGTGGTGGTACTGCAGCATCATGATCTGCTGGGAGATGCCAGCGTGACCTGCCACCCGGGCTTGCAGGCCCAACTGCCCA
CCAGCCAGCTCAGCACGGCGCGGGTCGTGACGGATGATGCTCATCGCCTGATCACCAGCCAGGGGCCGGGCTCTGCCATC
GAATTTGCCCTCGAAATCGTGCGGGTGCTGCGCGGGGACGACACTGCCCTCACGGTCGCCGGCCCCATGGGCTCCCCCCC
TCGATCACGCCATAACGGGTTTGGCCATCGGGGATCACTCCTGGTCACAACAGAGCGCCCCTTGCCGATTGGCAAGGGGC
GCTCTGCTATTGGCCGGGCGCAACTCGGGCTGCCCCCTTGA

Upstream 100 bases:

>100_bases
CCAAACACGGCATAGCGGTGCCGGTCAATCAGGGCCTCTATCAGGCCATCAAAGAGAAGAGCTGAGCCCGGCGAGGTGGC
CGGTAACCAAGGAGCGCAGC

Downstream 100 bases:

>100_bases
TCGCTAGCTCAACAACTCTGGCCTGAGCTGCTCCATCAGCAGATGGTTGTCACTGTAATCCACCGGTATGGCCACTACGG
CAGGCCCAACGACCGCCATG

Product: 4-methyl-5(B-hydroxyethyl)-thiazol monophosphate biosynthesis enzyme

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 226; Mature: 225

Protein sequence:

>226_residues
MTVLVLVAPGSEEIETVAIVDTLVRARIEVLLASCCPAGLRQIRASRGVQLVADYHIDELTSRDFEAIVVPGGLPGSEAI
RDTPLAIDLLREQAALGRWRAAMCAAPVVVLQHHDLLGDASVTCHPGLQAQLPTSQLSTARVVTDDAHRLITSQGPGSAI
EFALEIVRVLRGDDTALTVAGPMGSPPRSRHNGFGHRGSLLVTTERPLPIGKGRSAIGRAQLGLPP

Sequences:

>Translated_226_residues
MTVLVLVAPGSEEIETVAIVDTLVRARIEVLLASCCPAGLRQIRASRGVQLVADYHIDELTSRDFEAIVVPGGLPGSEAI
RDTPLAIDLLREQAALGRWRAAMCAAPVVVLQHHDLLGDASVTCHPGLQAQLPTSQLSTARVVTDDAHRLITSQGPGSAI
EFALEIVRVLRGDDTALTVAGPMGSPPRSRHNGFGHRGSLLVTTERPLPIGKGRSAIGRAQLGLPP
>Mature_225_residues
TVLVLVAPGSEEIETVAIVDTLVRARIEVLLASCCPAGLRQIRASRGVQLVADYHIDELTSRDFEAIVVPGGLPGSEAIR
DTPLAIDLLREQAALGRWRAAMCAAPVVVLQHHDLLGDASVTCHPGLQAQLPTSQLSTARVVTDDAHRLITSQGPGSAIE
FALEIVRVLRGDDTALTVAGPMGSPPRSRHNGFGHRGSLLVTTERPLPIGKGRSAIGRAQLGLPP

Specific function: Involved in biogenesis of ribosomal proteins, probably as a ribosomal protein-folding chaperone. Interacts with ribosomal subunits, ribosomes and polysomes. Confers resistance to oxidative stress [H]

COG id: COG0693

COG function: function code R; Putative intracellular protease/amidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C56 family [H]

Homologues:

Organism=Homo sapiens, GI183227678, Length=184, Percent_Identity=33.695652173913, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI31543380, Length=184, Percent_Identity=33.695652173913, Blast_Score=90, Evalue=2e-18,
Organism=Escherichia coli, GI87081736, Length=182, Percent_Identity=41.7582417582418, Blast_Score=135, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17531319, Length=183, Percent_Identity=34.9726775956284, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17558714, Length=186, Percent_Identity=32.258064516129, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI28571932, Length=181, Percent_Identity=40.3314917127072, Blast_Score=114, Evalue=5e-26,
Organism=Drosophila melanogaster, GI24653499, Length=186, Percent_Identity=36.5591397849462, Blast_Score=100, Evalue=8e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006287
- InterPro:   IPR002818 [H]

Pfam domain/function: PF01965 DJ-1_PfpI [H]

EC number: NA

Molecular weight: Translated: 23852; Mature: 23721

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVLVLVAPGSEEIETVAIVDTLVRARIEVLLASCCPAGLRQIRASRGVQLVADYHIDEL
CEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCEEEEEECCHHHH
TSRDFEAIVVPGGLPGSEAIRDTPLAIDLLREQAALGRWRAAMCAAPVVVLQHHDLLGDA
CCCCCEEEEECCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCC
SVTCHPGLQAQLPTSQLSTARVVTDDAHRLITSQGPGSAIEFALEIVRVLRGDDTALTVA
CEEECCCCCCCCCHHHCCEEEEEECCHHHHEECCCCCHHHHHHHHHHHHHCCCCCEEEEE
GPMGSPPRSRHNGFGHRGSLLVTTERPLPIGKGRSAIGRAQLGLPP
CCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TVLVLVAPGSEEIETVAIVDTLVRARIEVLLASCCPAGLRQIRASRGVQLVADYHIDEL
EEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCEEEEEECCHHHH
TSRDFEAIVVPGGLPGSEAIRDTPLAIDLLREQAALGRWRAAMCAAPVVVLQHHDLLGDA
CCCCCEEEEECCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCC
SVTCHPGLQAQLPTSQLSTARVVTDDAHRLITSQGPGSAIEFALEIVRVLRGDDTALTVA
CEEECCCCCCCCCHHHCCEEEEEECCHHHHEECCCCCHHHHHHHHHHHHHCCCCCEEEEE
GPMGSPPRSRHNGFGHRGSLLVTTERPLPIGKGRSAIGRAQLGLPP
CCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9278503; 9592144 [H]