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The map label for this gene is panE [H]

Identifier: 145300108

GI number: 145300108

Start: 3469661

End: 3470593

Strand: Direct

Name: panE [H]

Synonym: ASA_3208

Alternate gene names: 145300108

Gene position: 3469661-3470593 (Clockwise)

Preceding gene: 145300106

Following gene: 145300109

Centisome position: 73.78

GC content: 63.77

Gene sequence:

>933_bases
ATGCCAAGCGGATTACAGAGTTCCCGACTGCCCTCCTCCCCCCAATGGTCACTGCTGGGCTGCGGCGCCCTGGGTGGCGT
TTTCGCCTCCCTGCTGACTCAAAGCGGCCAATCGACCCGCGTCTTGCTGCGCGATCGCCACCGTTCGACCCTGCACCCCG
GGATCGACTTCACCTCGCTGGAAGGCCAGACCCAGCTGATCGCCATCGAGCGCGGCTTCGTCGAGCAGCCCGGTCAGATC
AAGCGCCTGCTGGTGATGACCAAGGCAGGTCAAGTCGTGTCGGCCTTGACCCCCTTGGCAGGCAAGCTGGCGGCGGGTGT
GCCCATAGTGCTGCTGCACAATGGCATGGGCATTGCCGAGCAGGTGGTGCAGCTGTTTCCGCATAATCCTGTCATTGCGG
GCGTCACCAGCCACGGCGCCATGCAGAGCGGTCACTTCGTGTTCCGCCACACCGGCAAGGGCGAGACCTGGCTCGGCCCG
GTCAATGAAGCGGCCAGGGCTCATGCCTCCCTGGCAGAGGATCTCACCGCCGCCCTCGGTCAGGCCGGTTGGGATGAGCA
GATCCTGGCTCGCCAGTGGCAAAAACTCGCCATCAACTGCGCCATCAATCCACTGACGGCGCTCTATAAGCTCAAAAATG
GCGAGCTGGCCGGCCCTCGCTTCGCCGATGCCCTGCAACAGATCTGCGTGGAAGTGGCCGACGTCATGCAGGCCGAAGGC
CAGCCCACCAGCAGCGATGAGCTGCTGCGCCGCGCCATGACGGTGGTCGAGTTGACCGCCGACAACTACTCCTCCATGCA
TCAGGATATGGAGCAGGGGCGCGAGACAGAGATCGAGGCCATCACCGGCTTCCTGCTGGCCTGCGCTGCCAAACACGGCA
TAGCGGTGCCGGTCAATCAGGGCCTCTATCAGGCCATCAAAGAGAAGAGCTGA

Upstream 100 bases:

>100_bases
ACAGGAATGGCGAGACCCGTTAGTGTCCGCCAAGCGACATTTCACTTATCCCCGGTAAATGGTTGATCGGAATGCAACCC
TACCTTGATTGAGTCTCTCC

Downstream 100 bases:

>100_bases
GCCCGGCGAGGTGGCCGGTAACCAAGGAGCGCAGCATGACAGTACTGGTATTGGTAGCACCGGGGTCTGAAGAGATCGAA
ACCGTCGCCATCGTCGACAC

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase; KPR [H]

Number of amino acids: Translated: 310; Mature: 309

Protein sequence:

>310_residues
MPSGLQSSRLPSSPQWSLLGCGALGGVFASLLTQSGQSTRVLLRDRHRSTLHPGIDFTSLEGQTQLIAIERGFVEQPGQI
KRLLVMTKAGQVVSALTPLAGKLAAGVPIVLLHNGMGIAEQVVQLFPHNPVIAGVTSHGAMQSGHFVFRHTGKGETWLGP
VNEAARAHASLAEDLTAALGQAGWDEQILARQWQKLAINCAINPLTALYKLKNGELAGPRFADALQQICVEVADVMQAEG
QPTSSDELLRRAMTVVELTADNYSSMHQDMEQGRETEIEAITGFLLACAAKHGIAVPVNQGLYQAIKEKS

Sequences:

>Translated_310_residues
MPSGLQSSRLPSSPQWSLLGCGALGGVFASLLTQSGQSTRVLLRDRHRSTLHPGIDFTSLEGQTQLIAIERGFVEQPGQI
KRLLVMTKAGQVVSALTPLAGKLAAGVPIVLLHNGMGIAEQVVQLFPHNPVIAGVTSHGAMQSGHFVFRHTGKGETWLGP
VNEAARAHASLAEDLTAALGQAGWDEQILARQWQKLAINCAINPLTALYKLKNGELAGPRFADALQQICVEVADVMQAEG
QPTSSDELLRRAMTVVELTADNYSSMHQDMEQGRETEIEAITGFLLACAAKHGIAVPVNQGLYQAIKEKS
>Mature_309_residues
PSGLQSSRLPSSPQWSLLGCGALGGVFASLLTQSGQSTRVLLRDRHRSTLHPGIDFTSLEGQTQLIAIERGFVEQPGQIK
RLLVMTKAGQVVSALTPLAGKLAAGVPIVLLHNGMGIAEQVVQLFPHNPVIAGVTSHGAMQSGHFVFRHTGKGETWLGPV
NEAARAHASLAEDLTAALGQAGWDEQILARQWQKLAINCAINPLTALYKLKNGELAGPRFADALQQICVEVADVMQAEGQ
PTSSDELLRRAMTVVELTADNYSSMHQDMEQGRETEIEAITGFLLACAAKHGIAVPVNQGLYQAIKEKS

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786627, Length=296, Percent_Identity=37.5, Blast_Score=181, Evalue=8e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 33136; Mature: 33005

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSGLQSSRLPSSPQWSLLGCGALGGVFASLLTQSGQSTRVLLRDRHRSTLHPGIDFTSL
CCCCCCCCCCCCCCCCCEEECHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCEEEC
EGQTQLIAIERGFVEQPGQIKRLLVMTKAGQVVSALTPLAGKLAAGVPIVLLHNGMGIAE
CCCEEEEEEECCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEEECCCCHHH
QVVQLFPHNPVIAGVTSHGAMQSGHFVFRHTGKGETWLGPVNEAARAHASLAEDLTAALG
HHHHHCCCCCEEEEECCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHC
QAGWDEQILARQWQKLAINCAINPLTALYKLKNGELAGPRFADALQQICVEVADVMQAEG
CCCCCHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCC
QPTSSDELLRRAMTVVELTADNYSSMHQDMEQGRETEIEAITGFLLACAAKHGIAVPVNQ
CCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEECCCH
GLYQAIKEKS
HHHHHHHCCC
>Mature Secondary Structure 
PSGLQSSRLPSSPQWSLLGCGALGGVFASLLTQSGQSTRVLLRDRHRSTLHPGIDFTSL
CCCCCCCCCCCCCCCCEEECHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCEEEC
EGQTQLIAIERGFVEQPGQIKRLLVMTKAGQVVSALTPLAGKLAAGVPIVLLHNGMGIAE
CCCEEEEEEECCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEEECCCCHHH
QVVQLFPHNPVIAGVTSHGAMQSGHFVFRHTGKGETWLGPVNEAARAHASLAEDLTAALG
HHHHHCCCCCEEEEECCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHC
QAGWDEQILARQWQKLAINCAINPLTALYKLKNGELAGPRFADALQQICVEVADVMQAEG
CCCCCHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCC
QPTSSDELLRRAMTVVELTADNYSSMHQDMEQGRETEIEAITGFLLACAAKHGIAVPVNQ
CCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEECCCH
GLYQAIKEKS
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]