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The map label for this gene is nhaB [H]

Identifier: 145299259

GI number: 145299259

Start: 2437011

End: 2438591

Strand: Direct

Name: nhaB [H]

Synonym: ASA_2302

Alternate gene names: 145299259

Gene position: 2437011-2438591 (Clockwise)

Preceding gene: 145299257

Following gene: 145299260

Centisome position: 51.82

GC content: 55.85

Gene sequence:

>1581_bases
ATGCCAATCAGCTTAGGGAACGCATTTGCCAAGAACTTTTTGGGTAATGCGCCAAAGTGGTACAAGAGCGCAATTCTGTT
ATTTCTGGTGATCAATCCGATCGCCTTTTATCTCGATCCCTTTGCTGCCGGTTGGCTGCTGGTCGTCGAGTTCATCTTCA
CCCTGGCCATGGCGCTCAAATGCTATCCGTTGCAACCCGGTGGCCTGCTGGCCATTGAAGCAGTGCTCATTGGCATGACT
TCCGCAGAACAAGTCAAACATGAACTGGTAGCCAACATTGAAGTGCTGCTGCTGCTGGTGTTTATGGTGGCAGGTATTTA
CTTCATGAAGCAGTTGCTGCTCTATGTGTTTACCAAACTGCTGATCCGGATCCACTCCAAGACCCTGCTATCTCTGGCAT
TCTGCCTGGTGTCTGCCTTTCTGTCAGCTTTCCTCGACGCCCTGACCGTGATCGCGGTAGTGATCAGTGTGGCGACCGGT
TTCTATGCCATCTACCACAAGGTCTCCTCCGGCAAGGAATTTGGCCATCAACATGATCACACCGACGATCACTCTGTTCA
CGAACTCAGTCGCCAACACCTGGACGATTTTCGCGCCTTCCTGCGCAGCTTGATGATGCATGCCGCCATCGGAACGGCGC
TGGGGGGTGTCTGCACTCTGGTGGGTGAGCCACAAAACCTGATCATTGGTGAGCAGGCTGGTTGGAGCTTCGGCGAGTTT
GCCATTCGCATGGCACCAGTGACCATCCCCGTTTTCATCTGTGGCTTGCTCACCTGTATTCTGGTGGAAAAGTGCCGCTG
GTTTGGCTATGGCGCAAAGTTGCCGGATGCCGTGCGTCACATAATGGAAGATTACAACCGTTACGAGGAAGCCGGGCGCT
CCCCGCAGGACAAAGCCAAGCTGATCGTGCAGGCAGTGATAGCCATCTGGTTGATCTTGGGTCTCGCCATGCACCTTGCG
GCCGTGGGGTTGATCGGGCTGTCGGTCATAGTGCTGGCTACCTCGTTGACCGGCATCAACGACGAACACTCTCTGGGCAA
GGCCTTTCAGGAAGCTCTGCCCTTCACTGCCCTGCTTGCCGTCTTCTTCAGTGTGGTCGCCGTGATCATCGATCAACAGT
TGTTCCGGCCCGTGATCCAGTGGGTACTGGCCGCAGAACCGGATGATCAACTCGCCCTCTTCTATCTGGCAAACGGCCTG
CTCTCCATGGTCAGTGACAACGTCTTCGTCGGCACTGTCTACATCAACGAGGTGAAAACAGCACTGCTCAACAATGCCAT
CAATCGCGAACAGTTCGATCTGTTGGCGGTCGCCATCAATACCGGCACCAACCTGCCCTCGGTCGCCACCCCTAATGGCC
AGGCGGCTTTCCTGTTTATGCTGACCTCGGCGCTGGCCCCCCTGTTGCGGCTCTCCTATGGTCGCATGGTGTGGATGGCG
CTGCCTTACACCCTGGTGCTGGGTCTGGTCGGTTTCTTCTCGGTAGAGCTGCTGCTCGGTCCTGCCACCGAGTGGTTTTA
TCAGGCCGGGTGGCTTCTGCCTCACAGCGGTGCCCCCGCTGTATTGCCTGCTCTGCACTAA

Upstream 100 bases:

>100_bases
GAAGAATCAATCTGATATGGGACAGCATCCGGATGTTCGGGTCGAGCTAGCCTCGACTGCATAGACGCAGAAATCAACAA
CAAAACAGAGACCCATTATT

Downstream 100 bases:

>100_bases
AGACCAAGGGCCCCGCAGGGGCCCTTTCTTTTAGCTATTCCCAATTATCTGTTGTATGGGGCACCGCATACAAACAATGC
CTTATATTCCCCCTCTTTCA

Product: sodium/proton antiporter

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaB [H]

Number of amino acids: Translated: 526; Mature: 525

Protein sequence:

>526_residues
MPISLGNAFAKNFLGNAPKWYKSAILLFLVINPIAFYLDPFAAGWLLVVEFIFTLAMALKCYPLQPGGLLAIEAVLIGMT
SAEQVKHELVANIEVLLLLVFMVAGIYFMKQLLLYVFTKLLIRIHSKTLLSLAFCLVSAFLSAFLDALTVIAVVISVATG
FYAIYHKVSSGKEFGHQHDHTDDHSVHELSRQHLDDFRAFLRSLMMHAAIGTALGGVCTLVGEPQNLIIGEQAGWSFGEF
AIRMAPVTIPVFICGLLTCILVEKCRWFGYGAKLPDAVRHIMEDYNRYEEAGRSPQDKAKLIVQAVIAIWLILGLAMHLA
AVGLIGLSVIVLATSLTGINDEHSLGKAFQEALPFTALLAVFFSVVAVIIDQQLFRPVIQWVLAAEPDDQLALFYLANGL
LSMVSDNVFVGTVYINEVKTALLNNAINREQFDLLAVAINTGTNLPSVATPNGQAAFLFMLTSALAPLLRLSYGRMVWMA
LPYTLVLGLVGFFSVELLLGPATEWFYQAGWLLPHSGAPAVLPALH

Sequences:

>Translated_526_residues
MPISLGNAFAKNFLGNAPKWYKSAILLFLVINPIAFYLDPFAAGWLLVVEFIFTLAMALKCYPLQPGGLLAIEAVLIGMT
SAEQVKHELVANIEVLLLLVFMVAGIYFMKQLLLYVFTKLLIRIHSKTLLSLAFCLVSAFLSAFLDALTVIAVVISVATG
FYAIYHKVSSGKEFGHQHDHTDDHSVHELSRQHLDDFRAFLRSLMMHAAIGTALGGVCTLVGEPQNLIIGEQAGWSFGEF
AIRMAPVTIPVFICGLLTCILVEKCRWFGYGAKLPDAVRHIMEDYNRYEEAGRSPQDKAKLIVQAVIAIWLILGLAMHLA
AVGLIGLSVIVLATSLTGINDEHSLGKAFQEALPFTALLAVFFSVVAVIIDQQLFRPVIQWVLAAEPDDQLALFYLANGL
LSMVSDNVFVGTVYINEVKTALLNNAINREQFDLLAVAINTGTNLPSVATPNGQAAFLFMLTSALAPLLRLSYGRMVWMA
LPYTLVLGLVGFFSVELLLGPATEWFYQAGWLLPHSGAPAVLPALH
>Mature_525_residues
PISLGNAFAKNFLGNAPKWYKSAILLFLVINPIAFYLDPFAAGWLLVVEFIFTLAMALKCYPLQPGGLLAIEAVLIGMTS
AEQVKHELVANIEVLLLLVFMVAGIYFMKQLLLYVFTKLLIRIHSKTLLSLAFCLVSAFLSAFLDALTVIAVVISVATGF
YAIYHKVSSGKEFGHQHDHTDDHSVHELSRQHLDDFRAFLRSLMMHAAIGTALGGVCTLVGEPQNLIIGEQAGWSFGEFA
IRMAPVTIPVFICGLLTCILVEKCRWFGYGAKLPDAVRHIMEDYNRYEEAGRSPQDKAKLIVQAVIAIWLILGLAMHLAA
VGLIGLSVIVLATSLTGINDEHSLGKAFQEALPFTALLAVFFSVVAVIIDQQLFRPVIQWVLAAEPDDQLALFYLANGLL
SMVSDNVFVGTVYINEVKTALLNNAINREQFDLLAVAINTGTNLPSVATPNGQAAFLFMLTSALAPLLRLSYGRMVWMAL
PYTLVLGLVGFFSVELLLGPATEWFYQAGWLLPHSGAPAVLPALH

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG3067

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaB Na(+)/H(+) (TC 2.A.34) antiporter family [H]

Homologues:

Organism=Escherichia coli, GI1787435, Length=512, Percent_Identity=68.5546875, Blast_Score=694, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004671 [H]

Pfam domain/function: PF06450 NhaB [H]

EC number: NA

Molecular weight: Translated: 57523; Mature: 57392

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PISLGNAFAKNFLGNAPKWYKSAILLFLVINPIAFYLDPFAAGWLLVVEFIFTLAMALK
CCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH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HHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3 Proton [Periplasm]; Na (I) [Cytoplasm] [C]

Specific reaction: 3 Proton [Periplasm] + 2 Na (I) [Cytoplasm] = 2 Na (I) [Periplasm] + 3 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA