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The map label for this gene is recQ [H]

Identifier: 145299254

GI number: 145299254

Start: 2428664

End: 2430589

Strand: Direct

Name: recQ [H]

Synonym: ASA_2297

Alternate gene names: 145299254

Gene position: 2428664-2430589 (Clockwise)

Preceding gene: 145299252

Following gene: 145299255

Centisome position: 51.65

GC content: 59.71

Gene sequence:

>1926_bases
ATGATCTCATCCCTGTTGACCCGTCACTTCGGTTTCGACCAGTTAAGGCCCGGTCAGGAAACGGTGATCAGCCGGTTGCT
GGCAGGCCAGAGTGCGGCTGCCATCTTCCCCACCGGCTCCGGCAAATCCCTCTGCTATCAGCTGCCAGCACTCGCCCTGC
CCCACCTGACCCTGGTGATCTCCCCCCTGATAGCGCTGATGCACGACCAGCTCGCTTTTCTCCACAGCAAAGGGATTCCC
GCGGCTACCCTGGATTCGAGCCAGACACCGGAGGAGAGTCGTCGCGTGATGCAGCAGGCCAGTGACGGTCAGCTCAAGAT
CCTGATGATCTCGGTGGAGCGGCTCAAGAACGAGCGTTTCCGTCGCTTCATCCAGCAGGTACCGCTGTCGATGCTGGTGG
TGGATGAAGCGCACTGCATCTCGGAGTGGGGCCACAACTTTCGACCCGACTACCTCAAGCTGCCGGCTTATCGCCGTGAG
CTGAAGATCCCTCAGGTATTGCTGCTGACCGCGACTGCCACCCCGGCTGTCATGGCCGACATGCAGGCCAAATTCGACAT
CGAGGATGAGGGACTGATCGTCACGGGTTTTTATCGCGCCAACCTGGATCTGGCGGTCGTGCCGCAGCCTGCCGAGGCGC
GTGATAACTGGCTGCAAGCAGAAGTACGACGAGAGCCCACTGCCCCCACCATCGTCTATGTCACCTTGCAGCACACCGCG
CAGCATTGTGCCGACCTGCTGCAACGGGCGGGGATCAGGGCGCGTGCCTATCATGCCGGGCTCGACTCGGCCCTGCGTAG
CCAGATCCAGCATGACTTCATGGCTGGCAAGGTGGACTGCATTGTCGCCACCATCGCCTTTGGCATGGGGATCGACAAGG
CGGATATTCGCCGGGTCATTCACTACGATCTACCTAAATCCATCGAGAACTACAGTCAGGAAATTGGCCGTGCCGGGCGG
GATGGGCTCCCTTCCCGCTGCATAGTGCTGGCCAATCGCGCCCAGCTCCCCGTGCTGGAGAATTTCGTGTACGGGGATAC
GCCCGATCGCGCCGCCATAGTGGCGCTGCTCGAGATCCTGTCGCAAAGTGGCAGCGAGTGGGAGTTTGGTCTGCTGCGTC
TCTCCAACGACACCAACATCCGCCAGTTGCCGCTCAAGACTCTGCTGGTCTATCTGGAAATGGCGGGCATCATAATGCCA
GCCTACAGCTACTTCGCCGAATATCGCTTCAAGTTCGTGCTGGACAAGGCCGAGATCCTGACCCGTTTCAATCCCGACCG
ACGCCAGTTTCTGGAGCAGCTGTTTGCCTGTGCATCGCAGGCGCGCAGCTGGTGCACCATGGACTTCGATGCCCTCTGGC
AGGGTTATCAGGGGGAACGGCACCGTGCGGCAGCAGCCCTGGATTATCTGCAACAACAGGGCTGGATAGAGCTGGAAAGC
AAGCAGATGACCGATGTTTATCGGGTGCTGCGTCAAGATGTTGATATCAATGCACTGGCAGACGAGCTCTATGCCCTGTT
CGAGAAGAAGGAGCTGAGTGAACTGGCCCGGCTACAGGCCTTGCTGGCCTTTTTTACATCAAGCCACTGCCTGAGTCAGG
AACTGGCCCGATATTTTGCCAACGAGCAGGCACCCAGCAAATGCGGGCACTGCTCCGTCTGCCGTGGCGAGGTTGCCGTA
CTGCCGCCATTGCCAACCCTCACCCTGCCCAACGAAAACGGGTTGCGTGCCTGGTGCGATCCTCTGATAGCCTTGTGCCA
CACCCGCCATCCTCGCATTCTGACCCGTTTTCTGTGCGGTATCGCCACGCCATTGACCACCCGGGTCAAGGCAAAAAGCC
TGGCTGGATTTGGCCAGCTGGCGGCGCATCCATTCGCCGAAGTGCTGGCAGCGGTATCACGGTTCTACCCCACCCATAAC
AACTGA

Upstream 100 bases:

>100_bases
AATATCAACAGCGCCCAAATGGGCGCTGTTTTCCTCTGAAGGGCCGTTCAGGCACTCCCGAGCGGTGGTATTATGGTGGT
TTTGCGCTGGAGTCCCTGCC

Downstream 100 bases:

>100_bases
TCATGCCAGTGCACATCAACAACCCGCTGAAAAAATAAGACCCTCGCATATGCGAGGGTCAAGCCAACGGAAACGTGCTT
AAACAGAGCTTTGTATCAGT

Product: ATP-dependent DNA helicase RecQ

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 641; Mature: 641

Protein sequence:

>641_residues
MISSLLTRHFGFDQLRPGQETVISRLLAGQSAAAIFPTGSGKSLCYQLPALALPHLTLVISPLIALMHDQLAFLHSKGIP
AATLDSSQTPEESRRVMQQASDGQLKILMISVERLKNERFRRFIQQVPLSMLVVDEAHCISEWGHNFRPDYLKLPAYRRE
LKIPQVLLLTATATPAVMADMQAKFDIEDEGLIVTGFYRANLDLAVVPQPAEARDNWLQAEVRREPTAPTIVYVTLQHTA
QHCADLLQRAGIRARAYHAGLDSALRSQIQHDFMAGKVDCIVATIAFGMGIDKADIRRVIHYDLPKSIENYSQEIGRAGR
DGLPSRCIVLANRAQLPVLENFVYGDTPDRAAIVALLEILSQSGSEWEFGLLRLSNDTNIRQLPLKTLLVYLEMAGIIMP
AYSYFAEYRFKFVLDKAEILTRFNPDRRQFLEQLFACASQARSWCTMDFDALWQGYQGERHRAAAALDYLQQQGWIELES
KQMTDVYRVLRQDVDINALADELYALFEKKELSELARLQALLAFFTSSHCLSQELARYFANEQAPSKCGHCSVCRGEVAV
LPPLPTLTLPNENGLRAWCDPLIALCHTRHPRILTRFLCGIATPLTTRVKAKSLAGFGQLAAHPFAEVLAAVSRFYPTHN
N

Sequences:

>Translated_641_residues
MISSLLTRHFGFDQLRPGQETVISRLLAGQSAAAIFPTGSGKSLCYQLPALALPHLTLVISPLIALMHDQLAFLHSKGIP
AATLDSSQTPEESRRVMQQASDGQLKILMISVERLKNERFRRFIQQVPLSMLVVDEAHCISEWGHNFRPDYLKLPAYRRE
LKIPQVLLLTATATPAVMADMQAKFDIEDEGLIVTGFYRANLDLAVVPQPAEARDNWLQAEVRREPTAPTIVYVTLQHTA
QHCADLLQRAGIRARAYHAGLDSALRSQIQHDFMAGKVDCIVATIAFGMGIDKADIRRVIHYDLPKSIENYSQEIGRAGR
DGLPSRCIVLANRAQLPVLENFVYGDTPDRAAIVALLEILSQSGSEWEFGLLRLSNDTNIRQLPLKTLLVYLEMAGIIMP
AYSYFAEYRFKFVLDKAEILTRFNPDRRQFLEQLFACASQARSWCTMDFDALWQGYQGERHRAAAALDYLQQQGWIELES
KQMTDVYRVLRQDVDINALADELYALFEKKELSELARLQALLAFFTSSHCLSQELARYFANEQAPSKCGHCSVCRGEVAV
LPPLPTLTLPNENGLRAWCDPLIALCHTRHPRILTRFLCGIATPLTTRVKAKSLAGFGQLAAHPFAEVLAAVSRFYPTHN
N
>Mature_641_residues
MISSLLTRHFGFDQLRPGQETVISRLLAGQSAAAIFPTGSGKSLCYQLPALALPHLTLVISPLIALMHDQLAFLHSKGIP
AATLDSSQTPEESRRVMQQASDGQLKILMISVERLKNERFRRFIQQVPLSMLVVDEAHCISEWGHNFRPDYLKLPAYRRE
LKIPQVLLLTATATPAVMADMQAKFDIEDEGLIVTGFYRANLDLAVVPQPAEARDNWLQAEVRREPTAPTIVYVTLQHTA
QHCADLLQRAGIRARAYHAGLDSALRSQIQHDFMAGKVDCIVATIAFGMGIDKADIRRVIHYDLPKSIENYSQEIGRAGR
DGLPSRCIVLANRAQLPVLENFVYGDTPDRAAIVALLEILSQSGSEWEFGLLRLSNDTNIRQLPLKTLLVYLEMAGIIMP
AYSYFAEYRFKFVLDKAEILTRFNPDRRQFLEQLFACASQARSWCTMDFDALWQGYQGERHRAAAALDYLQQQGWIELES
KQMTDVYRVLRQDVDINALADELYALFEKKELSELARLQALLAFFTSSHCLSQELARYFANEQAPSKCGHCSVCRGEVAV
LPPLPTLTLPNENGLRAWCDPLIALCHTRHPRILTRFLCGIATPLTTRVKAKSLAGFGQLAAHPFAEVLAAVSRFYPTHN
N

Specific function: Probable DNA helicase. Required for DNA repair and intramolecular recombination; probably has overlapping function with recS (AC P50729). It probably acts to help generate ss-DNA from ds-DNA breaks [H]

COG id: COG0514

COG function: function code L; Superfamily II DNA helicase

Gene ontology:

Cell location: Cytoplasm, nucleoid. Note=Localized throughout the nucleoid in the presence or absence of DNA double- strand breaks [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI51242947, Length=350, Percent_Identity=40, Blast_Score=231, Evalue=2e-60,
Organism=Homo sapiens, GI51242943, Length=350, Percent_Identity=40, Blast_Score=231, Evalue=2e-60,
Organism=Homo sapiens, GI14591902, Length=339, Percent_Identity=37.4631268436578, Blast_Score=229, Evalue=6e-60,
Organism=Homo sapiens, GI14591904, Length=339, Percent_Identity=37.4631268436578, Blast_Score=229, Evalue=6e-60,
Organism=Homo sapiens, GI148612816, Length=350, Percent_Identity=40, Blast_Score=226, Evalue=5e-59,
Organism=Homo sapiens, GI110735439, Length=334, Percent_Identity=37.4251497005988, Blast_Score=224, Evalue=2e-58,
Organism=Homo sapiens, GI4557365, Length=335, Percent_Identity=38.8059701492537, Blast_Score=224, Evalue=2e-58,
Organism=Homo sapiens, GI169218196, Length=334, Percent_Identity=37.4251497005988, Blast_Score=224, Evalue=3e-58,
Organism=Homo sapiens, GI284005309, Length=379, Percent_Identity=36.6754617414248, Blast_Score=199, Evalue=1e-50,
Organism=Homo sapiens, GI222352149, Length=357, Percent_Identity=24.0896358543417, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI21071032, Length=350, Percent_Identity=25.1428571428571, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI48994977, Length=332, Percent_Identity=40.0602409638554, Blast_Score=258, Evalue=9e-70,
Organism=Escherichia coli, GI87082221, Length=357, Percent_Identity=24.9299719887955, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1787016, Length=340, Percent_Identity=25.2941176470588, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI1790214, Length=367, Percent_Identity=22.3433242506812, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI25145561, Length=334, Percent_Identity=40.7185628742515, Blast_Score=258, Evalue=5e-69,
Organism=Caenorhabditis elegans, GI71987993, Length=337, Percent_Identity=38.8724035608309, Blast_Score=246, Evalue=3e-65,
Organism=Caenorhabditis elegans, GI71987997, Length=337, Percent_Identity=38.8724035608309, Blast_Score=246, Evalue=3e-65,
Organism=Caenorhabditis elegans, GI32564293, Length=334, Percent_Identity=40.7185628742515, Blast_Score=230, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI17552866, Length=382, Percent_Identity=33.7696335078534, Blast_Score=213, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI115533224, Length=318, Percent_Identity=26.1006289308176, Blast_Score=76, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17510307, Length=342, Percent_Identity=24.5614035087719, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17510309, Length=342, Percent_Identity=24.5614035087719, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71995514, Length=342, Percent_Identity=24.5614035087719, Blast_Score=68, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI32565321, Length=102, Percent_Identity=33.3333333333333, Blast_Score=66, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6323844, Length=346, Percent_Identity=35.8381502890173, Blast_Score=217, Evalue=4e-57,
Organism=Saccharomyces cerevisiae, GI6320224, Length=360, Percent_Identity=23.3333333333333, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324217, Length=329, Percent_Identity=25.8358662613982, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6321360, Length=341, Percent_Identity=23.7536656891496, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24646066, Length=349, Percent_Identity=37.2492836676218, Blast_Score=234, Evalue=2e-61,
Organism=Drosophila melanogaster, GI21358123, Length=389, Percent_Identity=38.3033419023136, Blast_Score=222, Evalue=6e-58,
Organism=Drosophila melanogaster, GI62472181, Length=385, Percent_Identity=34.2857142857143, Blast_Score=195, Evalue=8e-50,
Organism=Drosophila melanogaster, GI24664230, Length=385, Percent_Identity=34.2857142857143, Blast_Score=195, Evalue=8e-50,
Organism=Drosophila melanogaster, GI24664226, Length=385, Percent_Identity=34.2857142857143, Blast_Score=194, Evalue=2e-49,
Organism=Drosophila melanogaster, GI24584994, Length=369, Percent_Identity=23.8482384823848, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17977678, Length=106, Percent_Identity=32.0754716981132, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR004589
- InterPro:   IPR006293
- InterPro:   IPR002121
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR010997
- InterPro:   IPR018982 [H]

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C; PF00570 HRDC; PF09382 RQC [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 71902; Mature: 71902

Theoretical pI: Translated: 7.39; Mature: 7.39

Prosite motif: PS00690 DEAH_ATP_HELICASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISSLLTRHFGFDQLRPGQETVISRLLAGQSAAAIFPTGSGKSLCYQLPALALPHLTLVI
CHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHH
SPLIALMHDQLAFLHSKGIPAATLDSSQTPEESRRVMQQASDGQLKILMISVERLKNERF
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEEHHHHHHHHH
RRFIQQVPLSMLVVDEAHCISEWGHNFRPDYLKLPAYRRELKIPQVLLLTATATPAVMAD
HHHHHHCCHHEEEEHHHHHHHHCCCCCCCCCEECCHHHHHCCCCEEEEEEECCCHHHHHH
MQAKFDIEDEGLIVTGFYRANLDLAVVPQPAEARDNWLQAEVRREPTAPTIVYVTLQHTA
HHHCCCCCCCCEEEEEEEEECCEEEEECCCHHHHHHHHHHHHHCCCCCCEEEEEEHHHHH
QHCADLLQRAGIRARAYHAGLDSALRSQIQHDFMAGKVDCIVATIAFGMGIDKADIRRVI
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHH
HYDLPKSIENYSQEIGRAGRDGLPSRCIVLANRAQLPVLENFVYGDTPDRAAIVALLEIL
HHCCHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCHHHHCCCCCCCCHHHHHHHHHHH
SQSGSEWEFGLLRLSNDTNIRQLPLKTLLVYLEMAGIIMPAYSYFAEYRFKFVLDKAEIL
HCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
TRFNPDRRQFLEQLFACASQARSWCTMDFDALWQGYQGERHRAAAALDYLQQQGWIELES
HHCCCHHHHHHHHHHHHHHHHCCEECCCHHHHHCCCCCCHHHHHHHHHHHHHCCCEEECH
KQMTDVYRVLRQDVDINALADELYALFEKKELSELARLQALLAFFTSSHCLSQELARYFA
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NEQAPSKCGHCSVCRGEVAVLPPLPTLTLPNENGLRAWCDPLIALCHTRHPRILTRFLCG
CCCCCCCCCCCCCCCCCEEEECCCCEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHH
IATPLTTRVKAKSLAGFGQLAAHPFAEVLAAVSRFYPTHNN
HCCCHHHHHHHHHHHCHHHHHHCHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MISSLLTRHFGFDQLRPGQETVISRLLAGQSAAAIFPTGSGKSLCYQLPALALPHLTLVI
CHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHH
SPLIALMHDQLAFLHSKGIPAATLDSSQTPEESRRVMQQASDGQLKILMISVERLKNERF
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEEHHHHHHHHH
RRFIQQVPLSMLVVDEAHCISEWGHNFRPDYLKLPAYRRELKIPQVLLLTATATPAVMAD
HHHHHHCCHHEEEEHHHHHHHHCCCCCCCCCEECCHHHHHCCCCEEEEEEECCCHHHHHH
MQAKFDIEDEGLIVTGFYRANLDLAVVPQPAEARDNWLQAEVRREPTAPTIVYVTLQHTA
HHHCCCCCCCCEEEEEEEEECCEEEEECCCHHHHHHHHHHHHHCCCCCCEEEEEEHHHHH
QHCADLLQRAGIRARAYHAGLDSALRSQIQHDFMAGKVDCIVATIAFGMGIDKADIRRVI
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHH
HYDLPKSIENYSQEIGRAGRDGLPSRCIVLANRAQLPVLENFVYGDTPDRAAIVALLEIL
HHCCHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCHHHHCCCCCCCCHHHHHHHHHHH
SQSGSEWEFGLLRLSNDTNIRQLPLKTLLVYLEMAGIIMPAYSYFAEYRFKFVLDKAEIL
HCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
TRFNPDRRQFLEQLFACASQARSWCTMDFDALWQGYQGERHRAAAALDYLQQQGWIELES
HHCCCHHHHHHHHHHHHHHHHCCEECCCHHHHHCCCCCCHHHHHHHHHHHHHCCCEEECH
KQMTDVYRVLRQDVDINALADELYALFEKKELSELARLQALLAFFTSSHCLSQELARYFA
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NEQAPSKCGHCSVCRGEVAVLPPLPTLTLPNENGLRAWCDPLIALCHTRHPRILTRFLCG
CCCCCCCCCCCCCCCCCEEEECCCCEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHH
IATPLTTRVKAKSLAGFGQLAAHPFAEVLAAVSRFYPTHNN
HCCCHHHHHHHHHHHCHHHHHHCHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9642195 [H]