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The map label for this gene is dtxR [H]

Identifier: 145295825

GI number: 145295825

Start: 1941370

End: 1942056

Strand: Direct

Name: dtxR [H]

Synonym: cgR_1750

Alternate gene names: 145295825

Gene position: 1941370-1942056 (Clockwise)

Preceding gene: 145295824

Following gene: 145295826

Centisome position: 58.58

GC content: 56.62

Gene sequence:

>687_bases
GTGAAGGATCTGGTCGATACCACCGAAATGTATCTGCGCACTATTTACGAGCTGGAAGAAGAGGGCATTGTTCCTCTGCG
TGCTCGTATCGCAGAACGCCTTGAGCAGTCCGGCCCAACTGTCAGCCAGACTGTCGCCCGTATGGAACGCGACGGTCTTG
TGCACGTCAGCCCCGACCGCAGCCTCGAAATGACTCCAGAGGGACGTTCCCTCGCCATCGCCGTGATGCGTAAGCACCGC
CTGGCAGAACGCCTCCTTACCGACATCATCGGCTTGGACATCCACAAGGTCCACGACGAAGCATGCCGCTGGGAGCACGT
GATGAGTGATGAGGTTGAACGTCGCCTCGTTGAAGTTCTTGACGATGTGCAGCGCTCCCCTTTCGGTAACCCAATTCCTG
GCCTCGGCGAAATCGGTTTGGATCAAGCAGATGAGCCTGATTCCGGCGTTCGTGCCATCGATCTGCCTCTCGGTGAGAAC
CTGAAGGCTCGCATCGTACAGCTCAACGAGATCCTGCAGGTAGATCTTGAGCAGTTCCAGGCACTCACCGACGCGGGTGT
TGAAATCGGTACCGAAGTAGACATCATCAATGAGCAGGGCCGGGTCGTGATCACCCACAACGGCTCCAGCGTAGAACTGA
TTGACGATCTTGCACATGCAGTCCGCGTAGAAAAGGTTGAGGGCTAA

Upstream 100 bases:

>100_bases
GTGTTTTAAGAAGTGTTTTTAAGAGAATACGCATTGAAGTAGTTTTCCCTGCTGGCAGCGGCATAAATTGAGTTTGGAAA
AACAAGGAAGGCAGCCTCCT

Downstream 100 bases:

>100_bases
CACACGATGAAGCTTCTGGTTACCGGTGGCGCTGGCTATGTTGGCAGCGTTGCTGCCGCTGTTCTTCTAGAACATGGGCA
CGATGTCACAATCATTGACA

Product: hypothetical protein

Products: NA

Alternate protein names: Iron-dependent diphtheria tox regulatory element; Tox regulatory factor [H]

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MKDLVDTTEMYLRTIYELEEEGIVPLRARIAERLEQSGPTVSQTVARMERDGLVHVSPDRSLEMTPEGRSLAIAVMRKHR
LAERLLTDIIGLDIHKVHDEACRWEHVMSDEVERRLVEVLDDVQRSPFGNPIPGLGEIGLDQADEPDSGVRAIDLPLGEN
LKARIVQLNEILQVDLEQFQALTDAGVEIGTEVDIINEQGRVVITHNGSSVELIDDLAHAVRVEKVEG

Sequences:

>Translated_228_residues
MKDLVDTTEMYLRTIYELEEEGIVPLRARIAERLEQSGPTVSQTVARMERDGLVHVSPDRSLEMTPEGRSLAIAVMRKHR
LAERLLTDIIGLDIHKVHDEACRWEHVMSDEVERRLVEVLDDVQRSPFGNPIPGLGEIGLDQADEPDSGVRAIDLPLGEN
LKARIVQLNEILQVDLEQFQALTDAGVEIGTEVDIINEQGRVVITHNGSSVELIDDLAHAVRVEKVEG
>Mature_228_residues
MKDLVDTTEMYLRTIYELEEEGIVPLRARIAERLEQSGPTVSQTVARMERDGLVHVSPDRSLEMTPEGRSLAIAVMRKHR
LAERLLTDIIGLDIHKVHDEACRWEHVMSDEVERRLVEVLDDVQRSPFGNPIPGLGEIGLDQADEPDSGVRAIDLPLGEN
LKARIVQLNEILQVDLEQFQALTDAGVEIGTEVDIINEQGRVVITHNGSSVELIDDLAHAVRVEKVEG

Specific function: Iron-binding repressor of the dipheteria toxin gene expression. May serve as a global regulator of gene expression. Represses ripA under iron excess [H]

COG id: COG1321

COG function: function code K; Mn-dependent transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH dtxR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007167
- InterPro:   IPR001367
- InterPro:   IPR022689
- InterPro:   IPR022687
- InterPro:   IPR008988
- InterPro:   IPR011991 [H]

Pfam domain/function: PF02742 Fe_dep_repr_C; PF01325 Fe_dep_repress; PF04023 FeoA [H]

EC number: NA

Molecular weight: Translated: 25476; Mature: 25476

Theoretical pI: Translated: 4.34; Mature: 4.34

Prosite motif: PS50944 HTH_DTXR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDLVDTTEMYLRTIYELEEEGIVPLRARIAERLEQSGPTVSQTVARMERDGLVHVSPDR
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCEEEECCCC
SLEMTPEGRSLAIAVMRKHRLAERLLTDIIGLDIHKVHDEACRWEHVMSDEVERRLVEVL
CEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DDVQRSPFGNPIPGLGEIGLDQADEPDSGVRAIDLPLGENLKARIVQLNEILQVDLEQFQ
HHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
ALTDAGVEIGTEVDIINEQGRVVITHNGSSVELIDDLAHAVRVEKVEG
HHHHCCCCCCCEEEEECCCCCEEEEECCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKDLVDTTEMYLRTIYELEEEGIVPLRARIAERLEQSGPTVSQTVARMERDGLVHVSPDR
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCEEEECCCC
SLEMTPEGRSLAIAVMRKHRLAERLLTDIIGLDIHKVHDEACRWEHVMSDEVERRLVEVL
CEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DDVQRSPFGNPIPGLGEIGLDQADEPDSGVRAIDLPLGENLKARIVQLNEILQVDLEQFQ
HHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
ALTDAGVEIGTEVDIINEQGRVVITHNGSSVELIDDLAHAVRVEKVEG
HHHHCCCCCCCEEEEECCCCCEEEEECCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12840036 [H]