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The map label for this gene is moaA

Identifier: 145295336

GI number: 145295336

Start: 1404460

End: 1405593

Strand: Reverse

Name: moaA

Synonym: cgR_1276

Alternate gene names: 145295336

Gene position: 1405593-1404460 (Counterclockwise)

Preceding gene: 145295337

Following gene: 145295335

Centisome position: 42.41

GC content: 58.47

Gene sequence:

>1134_bases
ATGACTACTCGCCTTTATCTTTCGCCAACGCCGCCCCGAAATGATCGGGAGGGGGCGTCGAAAAGCACTTCTGCGAGCAT
CAAACATGATGCGTACCTGCCACCCGCAGACGGCAATCGCGTGCTTGTGGACAGATTCGGACGCATCGCGCGTGACCTGC
GGGTGTCACTGACCGACCGATGCAACCTCCGCTGCACCTATTGCATGCCCGCGGAGGGTTTAGAGTGGCTGCCCACCGAG
CAGACGCTTAACGACGCCGAGGTGCTGCGACTCCTCCACATTGCGGTGGTTAAGCTGGGCATTCGTCAAATTCGATTCAC
CGGCGGCGAGCCTTTACTGCGGAAAAATTTGGAAGACATCATCGCCGGCACCGCAGCCCTGCGCACCGACGAAGGCGAAA
AAGTTCACATCGCTCTCACCACCAACGGACTTGGCCTAGACAAACGCATCGCAGGACTGAAGGAAGCTGGCCTTGACCGG
GTCAATATTTCACTCGACACCATCGACGCCGAACGCTACGTCTCACTGACCAGGCGCGATCGTTTGTCCGGTGTGTTGGC
GTCCATCGACGCTGCTGTTGCTGCGGGGTTGCATCCCGTGAAGATCAACGCCGTGGTCATGCCTGGGGTCAATGAGGTAG
ATATTGTCCCTCTTGCGGAATACTGCATTTCCAAAGGCGCCCAACTGCGATTCATCGAACAAATGCCACTTGGTCCGCGA
GAGCAGTGGAAACGCGGCGATATGGTCACAGCCGAAGAAATCCTGGCGCGCCTGGAAGAAAAATTCACCCTGTCCCCCGC
CAAGGAACCACGAGGTGCTGCCCCTGCTGCGCTGTGGAATGCGGTAGATAAATCCAATCCTGTTATCACTGGACAAATCG
GCATCATCGCCTCGGTGACGCACCCATTTTGCGGAGATTGCGATCGCTCCCGCCTCACCACCGACGGCACCATCCGAAAC
TGCCTTTTCTCCCGCACTGAAACTCCCCTACGTGACGCGCTTCGCGACGGCGCCTCCGACGATGAGCTCGCGCAACTGTG
GGCAGGCGCCATGTGGGAGAAGAAACCCGGCCATGGCATCGACGATGAAGGCTTCCTCCAACCAGATCGCCCCATGTCTG
CCATCGGTGGTTAG

Upstream 100 bases:

>100_bases
GAAGTAATTAAGCTTAAAGGGCCAGGTGAGAAATAATTTCCCTATTTATTCCGGCTTTTACTGGCTTTATTCCGCAGCTC
TTTCTAGGATGGGCAAGAAG

Downstream 100 bases:

>100_bases
CCCATACCAGCCCCAACCAGACAGGCCTGACAAGATTCGAGAATTTCCACAGCTTTTGGCACGTGTGTCTGGTTTTTGCT
CCCGATAACCGGACAGGTGT

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 377; Mature: 376

Protein sequence:

>377_residues
MTTRLYLSPTPPRNDREGASKSTSASIKHDAYLPPADGNRVLVDRFGRIARDLRVSLTDRCNLRCTYCMPAEGLEWLPTE
QTLNDAEVLRLLHIAVVKLGIRQIRFTGGEPLLRKNLEDIIAGTAALRTDEGEKVHIALTTNGLGLDKRIAGLKEAGLDR
VNISLDTIDAERYVSLTRRDRLSGVLASIDAAVAAGLHPVKINAVVMPGVNEVDIVPLAEYCISKGAQLRFIEQMPLGPR
EQWKRGDMVTAEEILARLEEKFTLSPAKEPRGAAPAALWNAVDKSNPVITGQIGIIASVTHPFCGDCDRSRLTTDGTIRN
CLFSRTETPLRDALRDGASDDELAQLWAGAMWEKKPGHGIDDEGFLQPDRPMSAIGG

Sequences:

>Translated_377_residues
MTTRLYLSPTPPRNDREGASKSTSASIKHDAYLPPADGNRVLVDRFGRIARDLRVSLTDRCNLRCTYCMPAEGLEWLPTE
QTLNDAEVLRLLHIAVVKLGIRQIRFTGGEPLLRKNLEDIIAGTAALRTDEGEKVHIALTTNGLGLDKRIAGLKEAGLDR
VNISLDTIDAERYVSLTRRDRLSGVLASIDAAVAAGLHPVKINAVVMPGVNEVDIVPLAEYCISKGAQLRFIEQMPLGPR
EQWKRGDMVTAEEILARLEEKFTLSPAKEPRGAAPAALWNAVDKSNPVITGQIGIIASVTHPFCGDCDRSRLTTDGTIRN
CLFSRTETPLRDALRDGASDDELAQLWAGAMWEKKPGHGIDDEGFLQPDRPMSAIGG
>Mature_376_residues
TTRLYLSPTPPRNDREGASKSTSASIKHDAYLPPADGNRVLVDRFGRIARDLRVSLTDRCNLRCTYCMPAEGLEWLPTEQ
TLNDAEVLRLLHIAVVKLGIRQIRFTGGEPLLRKNLEDIIAGTAALRTDEGEKVHIALTTNGLGLDKRIAGLKEAGLDRV
NISLDTIDAERYVSLTRRDRLSGVLASIDAAVAAGLHPVKINAVVMPGVNEVDIVPLAEYCISKGAQLRFIEQMPLGPRE
QWKRGDMVTAEEILARLEEKFTLSPAKEPRGAAPAALWNAVDKSNPVITGQIGIIASVTHPFCGDCDRSRLTTDGTIRNC
LFSRTETPLRDALRDGASDDELAQLWAGAMWEKKPGHGIDDEGFLQPDRPMSAIGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family

Homologues:

Organism=Homo sapiens, GI116734668, Length=338, Percent_Identity=38.7573964497041, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI22027536, Length=338, Percent_Identity=38.7573964497041, Blast_Score=219, Evalue=3e-57,
Organism=Escherichia coli, GI1786999, Length=338, Percent_Identity=33.4319526627219, Blast_Score=181, Evalue=6e-47,
Organism=Caenorhabditis elegans, GI32566329, Length=370, Percent_Identity=35.1351351351351, Blast_Score=214, Evalue=5e-56,
Organism=Caenorhabditis elegans, GI17561210, Length=345, Percent_Identity=36.8115942028986, Blast_Score=210, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI32566331, Length=357, Percent_Identity=34.453781512605, Blast_Score=207, Evalue=5e-54,
Organism=Drosophila melanogaster, GI28574488, Length=340, Percent_Identity=40.8823529411765, Blast_Score=223, Evalue=1e-58,
Organism=Drosophila melanogaster, GI28574490, Length=322, Percent_Identity=41.304347826087, Blast_Score=219, Evalue=3e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MOAA_CORGB (A4QDF8)

Other databases:

- EMBL:   AP009044
- RefSeq:   YP_001138157.1
- ProteinModelPortal:   A4QDF8
- SMR:   A4QDF8
- STRING:   A4QDF8
- GeneID:   4994303
- GenomeReviews:   AP009044_GR
- KEGG:   cgt:cgR_1276
- eggNOG:   COG2896
- HOGENOM:   HBG529885
- OMA:   TEDPCFL
- ProtClustDB:   PRK00164
- HAMAP:   MF_01225_B
- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197
- Gene3D:   G3DSA:3.20.20.70
- SMART:   SM00729
- TIGRFAMs:   TIGR02666

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM

EC number: NA

Molecular weight: Translated: 41202; Mature: 41070

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: BINDING 54-54 BINDING 67-67 BINDING 105-105 BINDING 109-109 BINDING 140-140 BINDING 164-164 BINDING 201-201 BINDING 235-235

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTRLYLSPTPPRNDREGASKSTSASIKHDAYLPPADGNRVLVDRFGRIARDLRVSLTDR
CCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHEECCC
CNLRCTYCMPAEGLEWLPTEQTLNDAEVLRLLHIAVVKLGIRQIRFTGGEPLLRKNLEDI
CCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHH
IAGTAALRTDEGEKVHIALTTNGLGLDKRIAGLKEAGLDRVNISLDTIDAERYVSLTRRD
HHHHHHEECCCCCEEEEEEEECCCCHHHHHHHHHHCCCCEEEEEEEECCHHHHHHHHHHH
RLSGVLASIDAAVAAGLHPVKINAVVMPGVNEVDIVPLAEYCISKGAQLRFIEQMPLGPR
HHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCEEEEEHHHHHHCCCCEEEEHHHCCCCCH
EQWKRGDMVTAEEILARLEEKFTLSPAKEPRGAAPAALWNAVDKSNPVITGQIGIIASVT
HHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCEEEECCEEEEEEC
HPFCGDCDRSRLTTDGTIRNCLFSRTETPLRDALRDGASDDELAQLWAGAMWEKKPGHGI
CCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCC
DDEGFLQPDRPMSAIGG
CCCCCCCCCCCHHHCCC
>Mature Secondary Structure 
TTRLYLSPTPPRNDREGASKSTSASIKHDAYLPPADGNRVLVDRFGRIARDLRVSLTDR
CEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHEECCC
CNLRCTYCMPAEGLEWLPTEQTLNDAEVLRLLHIAVVKLGIRQIRFTGGEPLLRKNLEDI
CCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHH
IAGTAALRTDEGEKVHIALTTNGLGLDKRIAGLKEAGLDRVNISLDTIDAERYVSLTRRD
HHHHHHEECCCCCEEEEEEEECCCCHHHHHHHHHHCCCCEEEEEEEECCHHHHHHHHHHH
RLSGVLASIDAAVAAGLHPVKINAVVMPGVNEVDIVPLAEYCISKGAQLRFIEQMPLGPR
HHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCEEEEEHHHHHHCCCCEEEEHHHCCCCCH
EQWKRGDMVTAEEILARLEEKFTLSPAKEPRGAAPAALWNAVDKSNPVITGQIGIIASVT
HHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCEEEECCEEEEEEC
HPFCGDCDRSRLTTDGTIRNCLFSRTETPLRDALRDGASDDELAQLWAGAMWEKKPGHGI
CCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCC
DDEGFLQPDRPMSAIGG
CCCCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA