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The map label for this gene is gltA [H]

Identifier: 145294998

GI number: 145294998

Start: 1042388

End: 1043701

Strand: Direct

Name: gltA [H]

Synonym: cgR_0943

Alternate gene names: 145294998

Gene position: 1042388-1043701 (Clockwise)

Preceding gene: 145294994

Following gene: 145294999

Centisome position: 31.45

GC content: 54.87

Gene sequence:

>1314_bases
ATGTTTGAAAGGGATATCGTGGCTACTGATAACAACAAGGCTGTCCTGCACTACCCCGGTGGCGAGTTCGAAATGGACAT
CATCGAGGCTTCTGAGGGTAACAACGGTGTTGTCCTGGGCAAGATGCTGTCTGAGACTGGACTGATCACTTTTGACCCAG
GTTATGTGAGCACTGGCTCCACCGAGTCGAAGATCACCTACATCGATGGCGATGCGGGAATCCTGCGTTACCGCGGCTAT
GACATCGCTGATCTGGCTGAGAATGCCACCTTCAACGAGGTTTCCTACCTACTTATCAACGGTGAGCTACCAACCCCAGA
TGAGCTTCACAAGTTTAACGACGAGATTCGCCACCACACCCTTCTGGACGAGGACTTCAAGTCCCAGTTCAACGTGTTCC
CACGCGACGCTCACCCAATGGCAACCTTGGCTTCCTCGGTTAACATTTTGTCTACCTACTACCAGGATCAGCTGAACCCA
CTCGATGAGGCACAGCTTGATAAGGCAACCGTTCGCCTCATGGCAAAGGTTCCAATGCTGGCTGCGTACGCACACCGCGC
ACGCAAGGGTGCTCCTTACATGTACCCAGACAACTCCCTCAACGCGCGTGAGAACTTCCTGCGCATGATGTTCGGTTACC
CAACCGAGCCATACGAGATCGACCCAATCATGGTCAAGGCTCTGGACAAGCTGCTCATCCTGCACGCTGACCACGAGCAG
AACTGCTCCACCTCCACCGTTCGTATGATCGGTTCCGCACAGGCCAACATGTTTGTCTCCATCGCTGGTGGCATCAACGC
TCTGTCCGGCCCACTGCACGGTGGCGCAAACCAGGCTGTTCTGGAGATGCTCGAAGACATCAAGAACAACCACGGTGGCG
ACGCAACCGAGTTCATGAACAAGGTCAAGAACAAGGAAGACGGCGTCCGCCTCATGGGCTTCGGACACCGCGTTTACAAG
AACTACGATCCACGTGCAGCAATCGTCAAGGAGACCGCACACGAGATCCTCGAGCACCTCGGTGGCGACGATCTTCTGGA
TCTGGCAATCAAGCTGGAAGAAATTGCACTGGCTGATGATTACTTCATCTCCCGCAAGCTCTACCCGAACGTAGACTTCT
ACACCGGCCTGATCTACCGCGCAATGGGCTTCCCAACTGACTTCTTCACCGTATTGTTCGCAATCGGTCGTCTGCCAGGA
TGGATCGCTCACTACCGCGAGCAGCTTGGTGCACCAGGCAACAAGATCAACCGCCCACGCCAGGTCTACACCGGCAAGGA
ATCCCGCAAGTTTGTTCCTCGCGAGGAGCGCTAA

Upstream 100 bases:

>100_bases
GTGTCGAGTAACAAAAACTGACATGCGCTTGGCGCATCCCAGTTGGTAAGAATAAACGGGACTACTTCCGTAATCCGGAA
GAGTTTTTTTCCGAACAAAT

Downstream 100 bases:

>100_bases
ATTTAGCGGATGATTCTCGTTCAACTTCGGCCGAAGCCACTTCGTCTGTCATAATGACAGGGATGGTTTCGGCCGTTTTT
GCATGAAACCAAAAAATACG

Product: type II citrate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 437; Mature: 437

Protein sequence:

>437_residues
MFERDIVATDNNKAVLHYPGGEFEMDIIEASEGNNGVVLGKMLSETGLITFDPGYVSTGSTESKITYIDGDAGILRYRGY
DIADLAENATFNEVSYLLINGELPTPDELHKFNDEIRHHTLLDEDFKSQFNVFPRDAHPMATLASSVNILSTYYQDQLNP
LDEAQLDKATVRLMAKVPMLAAYAHRARKGAPYMYPDNSLNARENFLRMMFGYPTEPYEIDPIMVKALDKLLILHADHEQ
NCSTSTVRMIGSAQANMFVSIAGGINALSGPLHGGANQAVLEMLEDIKNNHGGDATEFMNKVKNKEDGVRLMGFGHRVYK
NYDPRAAIVKETAHEILEHLGGDDLLDLAIKLEEIALADDYFISRKLYPNVDFYTGLIYRAMGFPTDFFTVLFAIGRLPG
WIAHYREQLGAPGNKINRPRQVYTGKESRKFVPREER

Sequences:

>Translated_437_residues
MFERDIVATDNNKAVLHYPGGEFEMDIIEASEGNNGVVLGKMLSETGLITFDPGYVSTGSTESKITYIDGDAGILRYRGY
DIADLAENATFNEVSYLLINGELPTPDELHKFNDEIRHHTLLDEDFKSQFNVFPRDAHPMATLASSVNILSTYYQDQLNP
LDEAQLDKATVRLMAKVPMLAAYAHRARKGAPYMYPDNSLNARENFLRMMFGYPTEPYEIDPIMVKALDKLLILHADHEQ
NCSTSTVRMIGSAQANMFVSIAGGINALSGPLHGGANQAVLEMLEDIKNNHGGDATEFMNKVKNKEDGVRLMGFGHRVYK
NYDPRAAIVKETAHEILEHLGGDDLLDLAIKLEEIALADDYFISRKLYPNVDFYTGLIYRAMGFPTDFFTVLFAIGRLPG
WIAHYREQLGAPGNKINRPRQVYTGKESRKFVPREER
>Mature_437_residues
MFERDIVATDNNKAVLHYPGGEFEMDIIEASEGNNGVVLGKMLSETGLITFDPGYVSTGSTESKITYIDGDAGILRYRGY
DIADLAENATFNEVSYLLINGELPTPDELHKFNDEIRHHTLLDEDFKSQFNVFPRDAHPMATLASSVNILSTYYQDQLNP
LDEAQLDKATVRLMAKVPMLAAYAHRARKGAPYMYPDNSLNARENFLRMMFGYPTEPYEIDPIMVKALDKLLILHADHEQ
NCSTSTVRMIGSAQANMFVSIAGGINALSGPLHGGANQAVLEMLEDIKNNHGGDATEFMNKVKNKEDGVRLMGFGHRVYK
NYDPRAAIVKETAHEILEHLGGDDLLDLAIKLEEIALADDYFISRKLYPNVDFYTGLIYRAMGFPTDFFTVLFAIGRLPG
WIAHYREQLGAPGNKINRPRQVYTGKESRKFVPREER

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=389, Percent_Identity=28.0205655526992, Blast_Score=133, Evalue=3e-31,
Organism=Escherichia coli, GI1786939, Length=409, Percent_Identity=50.3667481662592, Blast_Score=427, Evalue=1e-121,
Organism=Escherichia coli, GI1786527, Length=367, Percent_Identity=34.6049046321526, Blast_Score=200, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI17555174, Length=417, Percent_Identity=27.0983213429257, Blast_Score=124, Evalue=9e-29,
Organism=Saccharomyces cerevisiae, GI6319850, Length=405, Percent_Identity=28.1481481481481, Blast_Score=124, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6324328, Length=422, Percent_Identity=28.9099526066351, Blast_Score=123, Evalue=7e-29,
Organism=Saccharomyces cerevisiae, GI6325257, Length=398, Percent_Identity=27.1356783919598, Blast_Score=93, Evalue=8e-20,
Organism=Drosophila melanogaster, GI24640124, Length=389, Percent_Identity=29.305912596401, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24640126, Length=389, Percent_Identity=29.305912596401, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI21356863, Length=402, Percent_Identity=26.6169154228856, Blast_Score=108, Evalue=7e-24,

Paralogues:

None

Copy number: 624 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810
- InterPro:   IPR010953 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 49031; Mature: 49031

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFERDIVATDNNKAVLHYPGGEFEMDIIEASEGNNGVVLGKMLSETGLITFDPGYVSTGS
CCCCCEEEECCCCEEEECCCCCEEEEEEEECCCCCCEEEEEEHHHCCEEEECCCCCCCCC
TESKITYIDGDAGILRYRGYDIADLAENATFNEVSYLLINGELPTPDELHKFNDEIRHHT
CCCEEEEEECCCCEEEECCCCHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHH
LLDEDFKSQFNVFPRDAHPMATLASSVNILSTYYQDQLNPLDEAQLDKATVRLMAKVPML
HCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
AAYAHRARKGAPYMYPDNSLNARENFLRMMFGYPTEPYEIDPIMVKALDKLLILHADHEQ
HHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHEEEECCCCC
NCSTSTVRMIGSAQANMFVSIAGGINALSGPLHGGANQAVLEMLEDIKNNHGGDATEFMN
CCCHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHH
KVKNKEDGVRLMGFGHRVYKNYDPRAAIVKETAHEILEHLGGDDLLDLAIKLEEIALADD
HHCCCCCCEEEEECCHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
YFISRKLYPNVDFYTGLIYRAMGFPTDFFTVLFAIGRLPGWIAHYREQLGAPGNKINRPR
HHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCC
QVYTGKESRKFVPREER
HHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MFERDIVATDNNKAVLHYPGGEFEMDIIEASEGNNGVVLGKMLSETGLITFDPGYVSTGS
CCCCCEEEECCCCEEEECCCCCEEEEEEEECCCCCCEEEEEEHHHCCEEEECCCCCCCCC
TESKITYIDGDAGILRYRGYDIADLAENATFNEVSYLLINGELPTPDELHKFNDEIRHHT
CCCEEEEEECCCCEEEECCCCHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHH
LLDEDFKSQFNVFPRDAHPMATLASSVNILSTYYQDQLNPLDEAQLDKATVRLMAKVPML
HCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
AAYAHRARKGAPYMYPDNSLNARENFLRMMFGYPTEPYEIDPIMVKALDKLLILHADHEQ
HHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHEEEECCCCC
NCSTSTVRMIGSAQANMFVSIAGGINALSGPLHGGANQAVLEMLEDIKNNHGGDATEFMN
CCCHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHH
KVKNKEDGVRLMGFGHRVYKNYDPRAAIVKETAHEILEHLGGDDLLDLAIKLEEIALADD
HHCCCCCCEEEEECCHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
YFISRKLYPNVDFYTGLIYRAMGFPTDFFTVLFAIGRLPGWIAHYREQLGAPGNKINRPR
HHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCC
QVYTGKESRKFVPREER
HHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7522844; 12948626 [H]