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The map label for this gene is fklB [C]

Identifier: 145294999

GI number: 145294999

Start: 1043826

End: 1044182

Strand: Direct

Name: fklB [C]

Synonym: cgR_0944

Alternate gene names: 145294999

Gene position: 1043826-1044182 (Clockwise)

Preceding gene: 145294998

Following gene: 145295001

Centisome position: 31.5

GC content: 57.42

Gene sequence:

>357_bases
ATGGAAAAGCCACAGATTGAGCTACCGGTCGGTCCAGCACCGGAAGATCTCGTAATCTCTGACATCATCGTTGGCGAAGG
CGCAGAAGCCCGCCCAGGCGGAGAAGTTGAGGTCCACTACGTGGGCGTTGACTTTGAAACCGGCGAGGAGTTTGACTCTT
CCTGGGATCGTGGACAGACCAGCCAGTTCCCACTCAACGGCCTCATTGCAGGTTGGCAAGAGGGAATTCCAGGCATGAAG
GTCGGCGGACGTCGTCAGCTGACCATTCCACCAGAGGCTGCTTACGGCCCTGAGGGTTCCGGCCACCCACTGTCTGGCCG
TACCCTGGTGTTCATTATCGATTTGATCAGCGCATAG

Upstream 100 bases:

>100_bases
CTTCGGCCGAAGCCACTTCGTCTGTCATAATGACAGGGATGGTTTCGGCCGTTTTTGCATGAAACCAAAAAATACGATTT
TCAAGGAGCATGTACAGCAC

Downstream 100 bases:

>100_bases
TTTTCTTTACTGCGCTAGGCGCTCAAATCGTGTGAAGCGACTGTCGCGTCCCGCCCTCTCCGGATTGTTATCTAATTCGG
AGAGGGCGTTGCTGATTGTG

Product: hypothetical protein

Products: NA

Alternate protein names: Peptidyl-prolyl cis-trans isomerase; PPIase; Rotamase

Number of amino acids: Translated: 118; Mature: 118

Protein sequence:

>118_residues
MEKPQIELPVGPAPEDLVISDIIVGEGAEARPGGEVEVHYVGVDFETGEEFDSSWDRGQTSQFPLNGLIAGWQEGIPGMK
VGGRRQLTIPPEAAYGPEGSGHPLSGRTLVFIIDLISA

Sequences:

>Translated_118_residues
MEKPQIELPVGPAPEDLVISDIIVGEGAEARPGGEVEVHYVGVDFETGEEFDSSWDRGQTSQFPLNGLIAGWQEGIPGMK
VGGRRQLTIPPEAAYGPEGSGHPLSGRTLVFIIDLISA
>Mature_118_residues
MEKPQIELPVGPAPEDLVISDIIVGEGAEARPGGEVEVHYVGVDFETGEEFDSSWDRGQTSQFPLNGLIAGWQEGIPGMK
VGGRRQLTIPPEAAYGPEGSGHPLSGRTLVFIIDLISA

Specific function: PPIases accelerate the folding of proteins

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Cytoplasm And Periplasmic Protein [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain

Homologues:

Organism=Homo sapiens, GI17149836, Length=92, Percent_Identity=42.3913043478261, Blast_Score=62, Evalue=9e-11,
Organism=Homo sapiens, GI4503725, Length=92, Percent_Identity=42.3913043478261, Blast_Score=62, Evalue=9e-11,
Organism=Escherichia coli, GI87082390, Length=95, Percent_Identity=46.3157894736842, Blast_Score=69, Evalue=6e-14,
Organism=Escherichia coli, GI1789745, Length=100, Percent_Identity=40, Blast_Score=60, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6320727, Length=73, Percent_Identity=46.5753424657534, Blast_Score=68, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6324194, Length=107, Percent_Identity=40.1869158878505, Blast_Score=61, Evalue=4e-11,
Organism=Drosophila melanogaster, GI281363946, Length=108, Percent_Identity=37.962962962963, Blast_Score=72, Evalue=7e-14,
Organism=Drosophila melanogaster, GI17352457, Length=108, Percent_Identity=37.962962962963, Blast_Score=72, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24647110, Length=121, Percent_Identity=37.1900826446281, Blast_Score=72, Evalue=9e-14,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): FKBP_CORGL (P42458)

Other databases:

- EMBL:   X66112
- EMBL:   BA000036
- EMBL:   BX927150
- PIR:   I40718
- RefSeq:   NP_600059.1
- RefSeq:   YP_225122.1
- ProteinModelPortal:   P42458
- SMR:   P42458
- GeneID:   1018825
- GeneID:   3343627
- GenomeReviews:   BA000036_GR
- GenomeReviews:   BX927147_GR
- KEGG:   cgb:cg0950
- KEGG:   cgl:NCgl0796
- HOGENOM:   HBG731200
- OMA:   FESGEEF
- ProtClustDB:   CLSK811397
- BioCyc:   CGLU196627:CG0950-MONOMER
- BRENDA:   5.2.1.8
- InterPro:   IPR001179
- PANTHER:   PTHR10516

Pfam domain/function: PF00254 FKBP_C

EC number: =5.2.1.8

Molecular weight: Translated: 12539; Mature: 12539

Theoretical pI: Translated: 4.02; Mature: 4.02

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKPQIELPVGPAPEDLVISDIIVGEGAEARPGGEVEVHYVGVDFETGEEFDSSWDRGQT
CCCCCEEECCCCCCCCEEEEEEEECCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCC
SQFPLNGLIAGWQEGIPGMKVGGRRQLTIPPEAAYGPEGSGHPLSGRTLVFIIDLISA
CCCCCCCEEECHHCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEEEEECCC
>Mature Secondary Structure
MEKPQIELPVGPAPEDLVISDIIVGEGAEARPGGEVEVHYVGVDFETGEEFDSSWDRGQT
CCCCCEEECCCCCCCCEEEEEEEECCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCC
SQFPLNGLIAGWQEGIPGMKVGGRRQLTIPPEAAYGPEGSGHPLSGRTLVFIIDLISA
CCCCCCCEEECHHCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7522844; 12948626