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The map label for this gene is msrA [H]

Identifier: 138896272

GI number: 138896272

Start: 2744837

End: 2745361

Strand: Reverse

Name: msrA [H]

Synonym: GTNG_2635

Alternate gene names: 138896272

Gene position: 2745361-2744837 (Counterclockwise)

Preceding gene: 138896274

Following gene: 138896271

Centisome position: 77.33

GC content: 52.19

Gene sequence:

>525_bases
ATGGAAAAAGCGACATTCGCTGGAGGTTGCTTTTGGTGCATGGTGACGCCGTTTGAAGAGCTGGACGGCATTTACGGCAT
CGTCTCTGGCTATACGGGTGGGCATGTTGAAAATCCGACGTATGAGCAAGTGAAAACAGGGACGACCGGCCATTATGAAG
CGGTGCAAATCACGTTTGACCCGGACGTGTTCCCATATGAGCGGCTTTTAGAGCTGTATTGGTGCCAAATTGACCCGACC
GATGACGGCGGTCAGTTTCATGACCGTGGACCGCAATACCGGACGGCGATTTTTTACCATAACGAAACACAGCGCCGGCT
CGCTGAGCAGTCAAAGCGGGCGTTAGAAGAAAGCGGGCGTTTCTCAAAGCCGATTGTGACAAAAATTTTGCCAGCTACAA
CGTTTTACCCGGCGGAAGAGCACCATCAAAACTACCATAAGAAAAATCCGGAGCATTACAAGCAAGATCGTGCCGCTTCC
GGGCGCGACGAGTTTATCGCCAAACATTGGGGGGCGAAGCGGTGA

Upstream 100 bases:

>100_bases
TGCCAATGGCAGCGGATTTATACATCGGTGGTTCACGTCTATGGTATAATGGGGAGCAAATATCAAAATGAAGAAACTTG
ACGTATGAGGTGACGACACA

Downstream 100 bases:

>100_bases
AGCGGATCGAATCGCCGAAAAATGCACGTGTAAAGCATTGGAAAAAGTTATTGACGAAAAAAGGACGCGAGGAAACCGGG
TGCTTTTTGCTAGAAGGATT

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 174; Mature: 174

Protein sequence:

>174_residues
MEKATFAGGCFWCMVTPFEELDGIYGIVSGYTGGHVENPTYEQVKTGTTGHYEAVQITFDPDVFPYERLLELYWCQIDPT
DDGGQFHDRGPQYRTAIFYHNETQRRLAEQSKRALEESGRFSKPIVTKILPATTFYPAEEHHQNYHKKNPEHYKQDRAAS
GRDEFIAKHWGAKR

Sequences:

>Translated_174_residues
MEKATFAGGCFWCMVTPFEELDGIYGIVSGYTGGHVENPTYEQVKTGTTGHYEAVQITFDPDVFPYERLLELYWCQIDPT
DDGGQFHDRGPQYRTAIFYHNETQRRLAEQSKRALEESGRFSKPIVTKILPATTFYPAEEHHQNYHKKNPEHYKQDRAAS
GRDEFIAKHWGAKR
>Mature_174_residues
MEKATFAGGCFWCMVTPFEELDGIYGIVSGYTGGHVENPTYEQVKTGTTGHYEAVQITFDPDVFPYERLLELYWCQIDPT
DDGGQFHDRGPQYRTAIFYHNETQRRLAEQSKRALEESGRFSKPIVTKILPATTFYPAEEHHQNYHKKNPEHYKQDRAAS
GRDEFIAKHWGAKR

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=156, Percent_Identity=39.7435897435897, Blast_Score=110, Evalue=5e-25,
Organism=Homo sapiens, GI208609995, Length=156, Percent_Identity=39.7435897435897, Blast_Score=110, Evalue=7e-25,
Organism=Homo sapiens, GI208609993, Length=152, Percent_Identity=36.8421052631579, Blast_Score=74, Evalue=5e-14,
Organism=Escherichia coli, GI1790665, Length=153, Percent_Identity=44.4444444444444, Blast_Score=123, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI17533973, Length=146, Percent_Identity=36.3013698630137, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6320881, Length=157, Percent_Identity=33.1210191082803, Blast_Score=78, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24664627, Length=143, Percent_Identity=35.6643356643357, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24664631, Length=143, Percent_Identity=34.965034965035, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI45553131, Length=138, Percent_Identity=34.7826086956522, Blast_Score=77, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 20127; Mature: 20127

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKATFAGGCFWCMVTPFEELDGIYGIVSGYTGGHVENPTYEQVKTGTTGHYEAVQITFD
CCCCCCCCCEEEEEECCHHHHCCHHHHHCCCCCCCCCCCCHHHHHCCCCCCEEEEEEEEC
PDVFPYERLLELYWCQIDPTDDGGQFHDRGPQYRTAIFYHNETQRRLAEQSKRALEESGR
CCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEEECHHHHHHHHHHHHHHHHCCC
FSKPIVTKILPATTFYPAEEHHQNYHKKNPEHYKQDRAASGRDEFIAKHWGAKR
CCCCHHHHHCCCCCCCCCHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHCCCCC
>Mature Secondary Structure
MEKATFAGGCFWCMVTPFEELDGIYGIVSGYTGGHVENPTYEQVKTGTTGHYEAVQITFD
CCCCCCCCCEEEEEECCHHHHCCHHHHHCCCCCCCCCCCCHHHHHCCCCCCEEEEEEEEC
PDVFPYERLLELYWCQIDPTDDGGQFHDRGPQYRTAIFYHNETQRRLAEQSKRALEESGR
CCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEEECHHHHHHHHHHHHHHHHCCC
FSKPIVTKILPATTFYPAEEHHQNYHKKNPEHYKQDRAASGRDEFIAKHWGAKR
CCCCHHHHHCCCCCCCCCHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]