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The map label for this gene is trpF

Identifier: 138895779

GI number: 138895779

Start: 2266639

End: 2267304

Strand: Reverse

Name: trpF

Synonym: GTNG_2135

Alternate gene names: 138895779

Gene position: 2267304-2266639 (Counterclockwise)

Preceding gene: 138895780

Following gene: 138895778

Centisome position: 63.86

GC content: 55.26

Gene sequence:

>666_bases
ATGGCAATGGTTCGTCTTAAATATTGCGGCAACCGTTCGGCGGACGATGTGCAAGTCGCGCTCGCGAGCGGGGCGGATTA
TCTTGGCTTTATTTTTACTGAAAGCAAACGGAACGTTTCACCTGAGGAGGTGAAGCACTGGTTAGCACTAGCATCACTCG
GCGATAAGCAGCTCGTCGGTGTCTTTGTCAATGCCTCTGTTGATCAGATCGCTTCTGTCACCGAACAGCTGCCGCTTCAT
GTCGTCCAATGCCATGGTCATGAGACACCAGCTGAGCTGGCCGTCGTAAAGGAAGCGACACGGCTCTCGGTTTGGAAAGC
GATTCATCACGACGATGGGGCGCTCGAGACGATGAAGCAATATGCAGGGGTAGCTGACGGCTACGTTGTCGACAGCCGCG
TCGCTGGTGCATGGGGAGGAACGGGCGTCTCTTTTGACTGGGAGGCGGTGCCGCGCTATTTGGAAGAGGCAGCACGCCAA
GGTGTGCCGTGCTTCATCGCCGGCGGCATCACCCCGGACAATATCGAGCGGCTGCTCGCCTATCGTCCCGACGGGATCGA
CATTAGCAGCGGCATTGAAACAGACGGACGCAAAGACCCGGCTAAGATGAAGCAGATAGAAGAAAAAACAAAACAGTATC
TCGCAGTAGGAAAAGGCGCGAAATGA

Upstream 100 bases:

>100_bases
ACGATCCGCTCATACGGGGTACAGGCGATGCTTGTCGGTGAGTCGCTCATGCGCCAAGCGGATGTCGAACGGGCGGTTTA
CCGGCTGTTTGGAGAGGATG

Downstream 100 bases:

>100_bases
TCGTTTCGCTCCATGCTCGGACGATGAAACAGCGCCGCTTCGGCAATCGAGAGGTGCGCTTTCACACGAAATTCGACATT
TAATCTTAAGAAAAAAGAAG

Product: N-(5'-phosphoribosyl)anthranilate isomerase

Products: NA

Alternate protein names: PRAI

Number of amino acids: Translated: 221; Mature: 220

Protein sequence:

>221_residues
MAMVRLKYCGNRSADDVQVALASGADYLGFIFTESKRNVSPEEVKHWLALASLGDKQLVGVFVNASVDQIASVTEQLPLH
VVQCHGHETPAELAVVKEATRLSVWKAIHHDDGALETMKQYAGVADGYVVDSRVAGAWGGTGVSFDWEAVPRYLEEAARQ
GVPCFIAGGITPDNIERLLAYRPDGIDISSGIETDGRKDPAKMKQIEEKTKQYLAVGKGAK

Sequences:

>Translated_221_residues
MAMVRLKYCGNRSADDVQVALASGADYLGFIFTESKRNVSPEEVKHWLALASLGDKQLVGVFVNASVDQIASVTEQLPLH
VVQCHGHETPAELAVVKEATRLSVWKAIHHDDGALETMKQYAGVADGYVVDSRVAGAWGGTGVSFDWEAVPRYLEEAARQ
GVPCFIAGGITPDNIERLLAYRPDGIDISSGIETDGRKDPAKMKQIEEKTKQYLAVGKGAK
>Mature_220_residues
AMVRLKYCGNRSADDVQVALASGADYLGFIFTESKRNVSPEEVKHWLALASLGDKQLVGVFVNASVDQIASVTEQLPLHV
VQCHGHETPAELAVVKEATRLSVWKAIHHDDGALETMKQYAGVADGYVVDSRVAGAWGGTGVSFDWEAVPRYLEEAARQG
VPCFIAGGITPDNIERLLAYRPDGIDISSGIETDGRKDPAKMKQIEEKTKQYLAVGKGAK

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0135

COG function: function code E; Phosphoribosylanthranilate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpF family

Homologues:

Organism=Escherichia coli, GI87081863, Length=211, Percent_Identity=29.8578199052133, Blast_Score=69, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6320210, Length=218, Percent_Identity=27.5229357798165, Blast_Score=68, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPF_GEOTN (A4IQ83)

Other databases:

- EMBL:   CP000557
- RefSeq:   YP_001126232.1
- ProteinModelPortal:   A4IQ83
- SMR:   A4IQ83
- STRING:   A4IQ83
- GeneID:   4967063
- GenomeReviews:   CP000557_GR
- KEGG:   gtn:GTNG_2135
- NMPDR:   fig|420246.5.peg.2042
- eggNOG:   COG0135
- HOGENOM:   HBG554803
- OMA:   IQLHGRE
- PhylomeDB:   A4IQ83
- ProtClustDB:   PRK01222
- BioCyc:   GTHE420246:GTNG_2135-MONOMER
- HAMAP:   MF_00135_B
- InterPro:   IPR013785
- InterPro:   IPR001240
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00697 PRAI; SSF51366 RibP_bind_barrel

EC number: =5.3.1.24

Molecular weight: Translated: 23927; Mature: 23796

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAMVRLKYCGNRSADDVQVALASGADYLGFIFTESKRNVSPEEVKHWLALASLGDKQLVG
CCEEEEEECCCCCCCHHEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEE
VFVNASVDQIASVTEQLPLHVVQCHGHETPAELAVVKEATRLSVWKAIHHDDGALETMKQ
EEECCCHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
YAGVADGYVVDSRVAGAWGGTGVSFDWEAVPRYLEEAARQGVPCFIAGGITPDNIERLLA
HCCCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHH
YRPDGIDISSGIETDGRKDPAKMKQIEEKTKQYLAVGKGAK
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
AMVRLKYCGNRSADDVQVALASGADYLGFIFTESKRNVSPEEVKHWLALASLGDKQLVG
CEEEEEECCCCCCCHHEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEE
VFVNASVDQIASVTEQLPLHVVQCHGHETPAELAVVKEATRLSVWKAIHHDDGALETMKQ
EEECCCHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
YAGVADGYVVDSRVAGAWGGTGVSFDWEAVPRYLEEAARQGVPCFIAGGITPDNIERLLA
HCCCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHH
YRPDGIDISSGIETDGRKDPAKMKQIEEKTKQYLAVGKGAK
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA