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The map label for this gene is trpC

Identifier: 138895780

GI number: 138895780

Start: 2267285

End: 2268061

Strand: Reverse

Name: trpC

Synonym: GTNG_2136

Alternate gene names: 138895780

Gene position: 2268061-2267285 (Counterclockwise)

Preceding gene: 138895781

Following gene: 138895779

Centisome position: 63.88

GC content: 56.37

Gene sequence:

>777_bases
ATGCTTGAGCAAATTTTAGCGACAAAACGAGAGGAACTTGACACATTGACATTGCCGGAACCGTTGCCGGAGCCGAAACG
CCGTCCTTTCGCGGCGGCGCTCCGCCGGCCGCGGCGGGCGCTCGGGCTAATCGCCGAAGTAAAAAAAGCGTCTCCGTCTA
AAGGCATCATCCGCCCGGACTTTGATCCGGTCGCCATTGCCAAAGCGTATGAGCGCGCGGGGGCTGATGCGATCAGTGTG
CTGACGGACGAGCGCTATTTCCAAGGGCACCGCCGCTATTTGCAGGAAGTGAAAGAAGCGGTCAACATCCCGGTGTTGCG
CAAAGATTTCATCATCGACCGCCGGCAAGTGGAAGAAAGCGCCCGGCTCGGGGCGGATGCAATTTTATTGATCGGCGAAG
CGCTGTCGCCGGAAATGCTCGAGGCGCTCTATCAAGAAGCGTACAGCATCGGGCTGGAATGTTTAGTGGAAGTGCATGCG
AAAGAAACGCTTGAGCGGATTTTGGCTCGGTTTACGCCTGAAGTGGTTGGCATTAACAACCGCGATTTGCATACGTTTGT
CACAACACTTGAGGCGACAAAAGCGCTCGCTTCCCTCATTCCGCCGTCGAGCGTCATCGTCAGCGAAAGCGGGATCAGCT
CATACCGTGATGTACGAACGATCCGCTCATACGGGGTACAGGCGATGCTTGTCGGTGAGTCGCTCATGCGCCAAGCGGAT
GTCGAACGGGCGGTTTACCGGCTGTTTGGAGAGGATGATGGCAATGGTTCGTCTTAA

Upstream 100 bases:

>100_bases
AAAACGATCGCTGATGGGGTGACGATGGCGAAAGACGCTATTTTGTCCAACGCTGCTTATAGGCAGTTGCAGCGGCTGCG
GGCAAAGGAAGTGGTCCGTG

Downstream 100 bases:

>100_bases
ATATTGCGGCAACCGTTCGGCGGACGATGTGCAAGTCGCGCTCGCGAGCGGGGCGGATTATCTTGGCTTTATTTTTACTG
AAAGCAAACGGAACGTTTCA

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS

Number of amino acids: Translated: 258; Mature: 258

Protein sequence:

>258_residues
MLEQILATKREELDTLTLPEPLPEPKRRPFAAALRRPRRALGLIAEVKKASPSKGIIRPDFDPVAIAKAYERAGADAISV
LTDERYFQGHRRYLQEVKEAVNIPVLRKDFIIDRRQVEESARLGADAILLIGEALSPEMLEALYQEAYSIGLECLVEVHA
KETLERILARFTPEVVGINNRDLHTFVTTLEATKALASLIPPSSVIVSESGISSYRDVRTIRSYGVQAMLVGESLMRQAD
VERAVYRLFGEDDGNGSS

Sequences:

>Translated_258_residues
MLEQILATKREELDTLTLPEPLPEPKRRPFAAALRRPRRALGLIAEVKKASPSKGIIRPDFDPVAIAKAYERAGADAISV
LTDERYFQGHRRYLQEVKEAVNIPVLRKDFIIDRRQVEESARLGADAILLIGEALSPEMLEALYQEAYSIGLECLVEVHA
KETLERILARFTPEVVGINNRDLHTFVTTLEATKALASLIPPSSVIVSESGISSYRDVRTIRSYGVQAMLVGESLMRQAD
VERAVYRLFGEDDGNGSS
>Mature_258_residues
MLEQILATKREELDTLTLPEPLPEPKRRPFAAALRRPRRALGLIAEVKKASPSKGIIRPDFDPVAIAKAYERAGADAISV
LTDERYFQGHRRYLQEVKEAVNIPVLRKDFIIDRRQVEESARLGADAILLIGEALSPEMLEALYQEAYSIGLECLVEVHA
KETLERILARFTPEVVGINNRDLHTFVTTLEATKALASLIPPSSVIVSESGISSYRDVRTIRSYGVQAMLVGESLMRQAD
VERAVYRLFGEDDGNGSS

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family

Homologues:

Organism=Escherichia coli, GI87081863, Length=259, Percent_Identity=40.5405405405405, Blast_Score=152, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6322638, Length=232, Percent_Identity=37.9310344827586, Blast_Score=145, Evalue=6e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPC_GEOTN (A4IQ84)

Other databases:

- EMBL:   CP000557
- RefSeq:   YP_001126233.1
- ProteinModelPortal:   A4IQ84
- SMR:   A4IQ84
- STRING:   A4IQ84
- GeneID:   4967064
- GenomeReviews:   CP000557_GR
- KEGG:   gtn:GTNG_2136
- NMPDR:   fig|420246.5.peg.2043
- eggNOG:   COG0134
- HOGENOM:   HBG540956
- OMA:   VDLPLLC
- PhylomeDB:   A4IQ84
- ProtClustDB:   PRK00278
- BioCyc:   GTHE420246:GTNG_2136-MONOMER
- HAMAP:   MF_00134_B
- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00218 IGPS; SSF51366 RibP_bind_barrel

EC number: =4.1.1.48

Molecular weight: Translated: 28729; Mature: 28729

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEQILATKREELDTLTLPEPLPEPKRRPFAAALRRPRRALGLIAEVKKASPSKGIIRPD
CHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHCHHHHHHHHHHHHHCCCCCCCCCCC
FDPVAIAKAYERAGADAISVLTDERYFQGHRRYLQEVKEAVNIPVLRKDFIIDRRQVEES
CCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
ARLGADAILLIGEALSPEMLEALYQEAYSIGLECLVEVHAKETLERILARFTPEVVGINN
HHCCCCHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCC
RDLHTFVTTLEATKALASLIPPSSVIVSESGISSYRDVRTIRSYGVQAMLVGESLMRQAD
CHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
VERAVYRLFGEDDGNGSS
HHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MLEQILATKREELDTLTLPEPLPEPKRRPFAAALRRPRRALGLIAEVKKASPSKGIIRPD
CHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHCHHHHHHHHHHHHHCCCCCCCCCCC
FDPVAIAKAYERAGADAISVLTDERYFQGHRRYLQEVKEAVNIPVLRKDFIIDRRQVEES
CCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
ARLGADAILLIGEALSPEMLEALYQEAYSIGLECLVEVHAKETLERILARFTPEVVGINN
HHCCCCHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCC
RDLHTFVTTLEATKALASLIPPSSVIVSESGISSYRDVRTIRSYGVQAMLVGESLMRQAD
CHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
VERAVYRLFGEDDGNGSS
HHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA