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The map label for this gene is nrdE [H]

Identifier: 138894465

GI number: 138894465

Start: 869223

End: 871580

Strand: Direct

Name: nrdE [H]

Synonym: GTNG_0795

Alternate gene names: 138894465

Gene position: 869223-871580 (Clockwise)

Preceding gene: 138894460

Following gene: 138894466

Centisome position: 24.48

GC content: 49.45

Gene sequence:

>2358_bases
ATGCCTTTTTCTGTCTGTCGTTTCATCCGCTCGTTCACCCGAGCGGATTTTTTTATTGAAGGAGAGGGAAAACGAATGAC
AGCGGTCACGAAATCCATTGTTGTTGATGATCAAGGAAAAGAGAAGTCGCTTTCGCGCAGAGAGTTTGCCGCGTTAATTG
AGCAGGCGACGGCAGGCTTTGTCCGTTTGTCGCTTGAGGAATATGAAGAGCGTGTATGGCAGCTTCTCAGTCGAAAAGAG
TTCGTCACCGTTGATCAACTGTATCAAACCGCTATTTTAGAAGGGTTGTCGTACATTAGTGAAGAGGAGCCGGAATGGAC
GTTTGTGTGCGCGCGGTTGTATTTGCGGATGATGTACCGCGAGGCGGCACGGCAGCGCGGGTACGATGCGCGCGAGCGGT
ATGGTGATTTTTATTCATTAATCGTTTCTTTGACAGAACAAGGGGTGTACAGCCCGCTATTGCTTGAGCGTTATACAAAA
GAAGAGATCGAGACGGCTGGCTCATTTCTTGATCCAGACAAAGACTTGTTGTTTACGTATATCGGGTTGCGCACGCTCGC
TGACCGTTATTTGGCCCGCGATTATGAGCGGCGGCTGTACGAACTGCCACAAGAACGGTTTCTCATCATTGCTATGACCT
TGATGGTGAACGAACCGCCTAAGCGGCGCCTCGAGTTGGTGAAGGAAGCGTATTGGGCGTTAAGCAACCTATATATGACG
GTGGCCACGCCGACACTTGCCAATGCCGGGAAGTCATACGGTCAGTTGTCAAGCTGCTTTGTCGACACGGTGGATGACAG
CTTGCAGGCGATTTACGACAGCAACACTGACATTGCCAATTTATCGAAGTCAGGCGGCGGCATCGGTGTCTATCTTGGCA
AAATCCGTTCGCGCGGCAGCGACATCAGAGGATTTAAAGGTGTTTCGTCAGGCGTCATTCCGTGGATGAAACAGCTGAAC
AATACGGCGGTGAGCGTTGATCAGTTAGGGCAACGCAAAGGGGCGATTTCCGTCTATTTAGATGTGTGGCATAAAGACAT
TTTTGCCTTTCTTGATGCACGGCTCAATAACGGCGACGAACGGCTGCGCACGCACGACTTGTTTACCGGTGTTTGCATTC
CTGATTTGTTCATGGAACAAGTCGAACAGCGAGGCGACTGGTATTTGTTTGACCCACATGAGGTGCGGAAGGTGATGGGG
TTTAGCCTCGAAGACTTTTATGATGAGGAAAAAGGGCGTGGCAGCTTTCGCGAGAAATATTGGCAATGCGTCAATGACTC
GAGGCTGTCAAAAGAAAAAGTGCCAGCGATTGAAGTGATGAAAAGCATTATGCGCAGCCAGCTCGAGTCGGGGACGCCGT
TTATGTTTTACCGCGATGAAGTCAACCGGCAAAATCCCAACCGCCATCTTGGCATGATCTACTGCAGCAATCTTTGTACG
GAAATTGCGCAAAACCAAAGTCCGACGGTGACGAAGCAGCAATATGTGAAAGATGGAACGATCATCATCGAAAAAATACC
GGGCGATTTTGTCGTCTGCAATTTATCGTCAATCAATTTGGCGCGCGCCGTCACCGATGGAGTGTTCGAACGTTTGATTC
CGATTCAACTGCGGATGCTTGATAATGTCATTGATTTGAACAACATTCCTGTGCTGCAAGCAAGCTTGACGAACAAAAAA
TACCGTGCTGTCGGTCTCGGTACATTTGGCTGGCATCATCTGTTGGCGTTAAAAGGGATTCGCTGGGAGTCAGAGGAAGC
CGTCCGCTACACTGATGAGCTGTATGAAACGATTGCTTATTTGGCGATACAAGCTAGCATGGAGCTGGCGAAAGAAAAAG
GGAGCTACCCGGGGTTTTCAGGGTCAGATTGGCAAACGGGTGCTTATTTTGAGCGGCGTGGCTACAAAAACCACGGCGAA
CGGGATTGGGATCGGTTGAAGAGAGAGGTGGCACGCTACGGGATGCGCAACGGCTATCTCATGGCGGTCGCCCCAAACGC
ATCGACATCGATCATCGCTGGCAGCACGGCGAGCATTGACCCGATTTTTCGAAAAGTGTATGCCGAGGAAAAGAAAGATT
ATAAGATTCCTGTTACGGTGCCGGATTTAAACGAACAGACGACATGGTATTACAAATCAGCGTATTATATTGACCAGCGT
TGGAGCATTAGACAAAACGCTGCCCGTCAGCGCCATATCGATCAAGCAATCTCGTTTAACTTCTACGTCATGAATACGAT
TAAGGCGAAAGAATTGTTGGAGTTGCATTTGACGGCGTGGAAGTCGGGGCTGAAAACGACGTATTATGTCCGCTCAACGT
CAGGGACGATGGAAGAATGTGATGCTTGTGCGAGCTGA

Upstream 100 bases:

>100_bases
TAGGACGATGCACGAGTCAGGAGACCTGCCTTGCTTGGAAGTTTCATGTTCTTCGGGGTGTGAGAAGATGAAACGATAGG
GAAATAGAAAAAGGAATCGT

Downstream 100 bases:

>100_bases
CCGCGGACAACGCCATGCTATTTGTCGGATCGGGTTTCTTATGTTAGAAGAGATGTCCGGTGAGTGGGTTGCCTAGGAAT
ACGATGACACGAGGGGGAAT

Product: ribonucleotide-diphosphate reductase subunit alpha

Products: NA

Alternate protein names: Ribonucleotide reductase [H]

Number of amino acids: Translated: 785; Mature: 784

Protein sequence:

>785_residues
MPFSVCRFIRSFTRADFFIEGEGKRMTAVTKSIVVDDQGKEKSLSRREFAALIEQATAGFVRLSLEEYEERVWQLLSRKE
FVTVDQLYQTAILEGLSYISEEEPEWTFVCARLYLRMMYREAARQRGYDARERYGDFYSLIVSLTEQGVYSPLLLERYTK
EEIETAGSFLDPDKDLLFTYIGLRTLADRYLARDYERRLYELPQERFLIIAMTLMVNEPPKRRLELVKEAYWALSNLYMT
VATPTLANAGKSYGQLSSCFVDTVDDSLQAIYDSNTDIANLSKSGGGIGVYLGKIRSRGSDIRGFKGVSSGVIPWMKQLN
NTAVSVDQLGQRKGAISVYLDVWHKDIFAFLDARLNNGDERLRTHDLFTGVCIPDLFMEQVEQRGDWYLFDPHEVRKVMG
FSLEDFYDEEKGRGSFREKYWQCVNDSRLSKEKVPAIEVMKSIMRSQLESGTPFMFYRDEVNRQNPNRHLGMIYCSNLCT
EIAQNQSPTVTKQQYVKDGTIIIEKIPGDFVVCNLSSINLARAVTDGVFERLIPIQLRMLDNVIDLNNIPVLQASLTNKK
YRAVGLGTFGWHHLLALKGIRWESEEAVRYTDELYETIAYLAIQASMELAKEKGSYPGFSGSDWQTGAYFERRGYKNHGE
RDWDRLKREVARYGMRNGYLMAVAPNASTSIIAGSTASIDPIFRKVYAEEKKDYKIPVTVPDLNEQTTWYYKSAYYIDQR
WSIRQNAARQRHIDQAISFNFYVMNTIKAKELLELHLTAWKSGLKTTYYVRSTSGTMEECDACAS

Sequences:

>Translated_785_residues
MPFSVCRFIRSFTRADFFIEGEGKRMTAVTKSIVVDDQGKEKSLSRREFAALIEQATAGFVRLSLEEYEERVWQLLSRKE
FVTVDQLYQTAILEGLSYISEEEPEWTFVCARLYLRMMYREAARQRGYDARERYGDFYSLIVSLTEQGVYSPLLLERYTK
EEIETAGSFLDPDKDLLFTYIGLRTLADRYLARDYERRLYELPQERFLIIAMTLMVNEPPKRRLELVKEAYWALSNLYMT
VATPTLANAGKSYGQLSSCFVDTVDDSLQAIYDSNTDIANLSKSGGGIGVYLGKIRSRGSDIRGFKGVSSGVIPWMKQLN
NTAVSVDQLGQRKGAISVYLDVWHKDIFAFLDARLNNGDERLRTHDLFTGVCIPDLFMEQVEQRGDWYLFDPHEVRKVMG
FSLEDFYDEEKGRGSFREKYWQCVNDSRLSKEKVPAIEVMKSIMRSQLESGTPFMFYRDEVNRQNPNRHLGMIYCSNLCT
EIAQNQSPTVTKQQYVKDGTIIIEKIPGDFVVCNLSSINLARAVTDGVFERLIPIQLRMLDNVIDLNNIPVLQASLTNKK
YRAVGLGTFGWHHLLALKGIRWESEEAVRYTDELYETIAYLAIQASMELAKEKGSYPGFSGSDWQTGAYFERRGYKNHGE
RDWDRLKREVARYGMRNGYLMAVAPNASTSIIAGSTASIDPIFRKVYAEEKKDYKIPVTVPDLNEQTTWYYKSAYYIDQR
WSIRQNAARQRHIDQAISFNFYVMNTIKAKELLELHLTAWKSGLKTTYYVRSTSGTMEECDACAS
>Mature_784_residues
PFSVCRFIRSFTRADFFIEGEGKRMTAVTKSIVVDDQGKEKSLSRREFAALIEQATAGFVRLSLEEYEERVWQLLSRKEF
VTVDQLYQTAILEGLSYISEEEPEWTFVCARLYLRMMYREAARQRGYDARERYGDFYSLIVSLTEQGVYSPLLLERYTKE
EIETAGSFLDPDKDLLFTYIGLRTLADRYLARDYERRLYELPQERFLIIAMTLMVNEPPKRRLELVKEAYWALSNLYMTV
ATPTLANAGKSYGQLSSCFVDTVDDSLQAIYDSNTDIANLSKSGGGIGVYLGKIRSRGSDIRGFKGVSSGVIPWMKQLNN
TAVSVDQLGQRKGAISVYLDVWHKDIFAFLDARLNNGDERLRTHDLFTGVCIPDLFMEQVEQRGDWYLFDPHEVRKVMGF
SLEDFYDEEKGRGSFREKYWQCVNDSRLSKEKVPAIEVMKSIMRSQLESGTPFMFYRDEVNRQNPNRHLGMIYCSNLCTE
IAQNQSPTVTKQQYVKDGTIIIEKIPGDFVVCNLSSINLARAVTDGVFERLIPIQLRMLDNVIDLNNIPVLQASLTNKKY
RAVGLGTFGWHHLLALKGIRWESEEAVRYTDELYETIAYLAIQASMELAKEKGSYPGFSGSDWQTGAYFERRGYKNHGER
DWDRLKREVARYGMRNGYLMAVAPNASTSIIAGSTASIDPIFRKVYAEEKKDYKIPVTVPDLNEQTTWYYKSAYYIDQRW
SIRQNAARQRHIDQAISFNFYVMNTIKAKELLELHLTAWKSGLKTTYYVRSTSGTMEECDACAS

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=721, Percent_Identity=33.2871012482663, Blast_Score=343, Evalue=4e-94,
Organism=Escherichia coli, GI1789030, Length=672, Percent_Identity=31.3988095238095, Blast_Score=300, Evalue=3e-82,
Organism=Escherichia coli, GI2367133, Length=780, Percent_Identity=27.1794871794872, Blast_Score=272, Evalue=6e-74,
Organism=Caenorhabditis elegans, GI17555242, Length=728, Percent_Identity=31.8681318681319, Blast_Score=332, Evalue=6e-91,
Organism=Saccharomyces cerevisiae, GI6322123, Length=737, Percent_Identity=32.0217096336499, Blast_Score=343, Evalue=6e-95,
Organism=Saccharomyces cerevisiae, GI6320914, Length=746, Percent_Identity=32.3056300268097, Blast_Score=340, Evalue=7e-94,
Organism=Drosophila melanogaster, GI17352481, Length=719, Percent_Identity=31.2934631432545, Blast_Score=323, Evalue=3e-88,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013346
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 90387; Mature: 90256

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: PS00089 RIBORED_LARGE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPFSVCRFIRSFTRADFFIEGEGKRMTAVTKSIVVDDQGKEKSLSRREFAALIEQATAGF
CCHHHHHHHHHHHHCCEEEECCCCEEHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHH
VRLSLEEYEERVWQLLSRKEFVTVDQLYQTAILEGLSYISEEEPEWTFVCARLYLRMMYR
EEEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
EAARQRGYDARERYGDFYSLIVSLTEQGVYSPLLLERYTKEEIETAGSFLDPDKDLLFTY
HHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
IGLRTLADRYLARDYERRLYELPQERFLIIAMTLMVNEPPKRRLELVKEAYWALSNLYMT
HHHHHHHHHHHHHHHHHHHHHCCHHHEEHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHE
VATPTLANAGKSYGQLSSCFVDTVDDSLQAIYDSNTDIANLSKSGGGIGVYLGKIRSRGS
EECCHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCEEEEEHHHHCCCC
DIRGFKGVSSGVIPWMKQLNNTAVSVDQLGQRKGAISVYLDVWHKDIFAFLDARLNNGDE
CCCCCCCCCCCHHHHHHHHCCCEEEHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHCCCHH
RLRTHDLFTGVCIPDLFMEQVEQRGDWYLFDPHEVRKVMGFSLEDFYDEEKGRGSFREKY
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHCCCHHHHHCCCCCCCHHHHHH
WQCVNDSRLSKEKVPAIEVMKSIMRSQLESGTPFMFYRDEVNRQNPNRHLGMIYCSNLCT
HHHHCCCCCCHHCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEHHHHHHHHHH
EIAQNQSPTVTKQQYVKDGTIIIEKIPGDFVVCNLSSINLARAVTDGVFERLIPIQLRML
HHHCCCCCCCHHHHHHCCCCEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
DNVIDLNNIPVLQASLTNKKYRAVGLGTFGWHHLLALKGIRWESEEAVRYTDELYETIAY
HHHHCCCCCCEEEECCCCCCEEEEEECCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
LAIQASMELAKEKGSYPGFSGSDWQTGAYFERRGYKNHGERDWDRLKREVARYGMRNGYL
HHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCEE
MAVAPNASTSIIAGSTASIDPIFRKVYAEEKKDYKIPVTVPDLNEQTTWYYKSAYYIDQR
EEECCCCCCEEEECCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCEEEEEEEEEECCC
WSIRQNAARQRHIDQAISFNFYVMNTIKAKELLELHLTAWKSGLKTTYYVRSTSGTMEEC
CCHHHHHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHH
DACAS
HHCCC
>Mature Secondary Structure 
PFSVCRFIRSFTRADFFIEGEGKRMTAVTKSIVVDDQGKEKSLSRREFAALIEQATAGF
CHHHHHHHHHHHHCCEEEECCCCEEHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHH
VRLSLEEYEERVWQLLSRKEFVTVDQLYQTAILEGLSYISEEEPEWTFVCARLYLRMMYR
EEEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
EAARQRGYDARERYGDFYSLIVSLTEQGVYSPLLLERYTKEEIETAGSFLDPDKDLLFTY
HHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
IGLRTLADRYLARDYERRLYELPQERFLIIAMTLMVNEPPKRRLELVKEAYWALSNLYMT
HHHHHHHHHHHHHHHHHHHHHCCHHHEEHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHE
VATPTLANAGKSYGQLSSCFVDTVDDSLQAIYDSNTDIANLSKSGGGIGVYLGKIRSRGS
EECCHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCEEEEEHHHHCCCC
DIRGFKGVSSGVIPWMKQLNNTAVSVDQLGQRKGAISVYLDVWHKDIFAFLDARLNNGDE
CCCCCCCCCCCHHHHHHHHCCCEEEHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHCCCHH
RLRTHDLFTGVCIPDLFMEQVEQRGDWYLFDPHEVRKVMGFSLEDFYDEEKGRGSFREKY
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHCCCHHHHHCCCCCCCHHHHHH
WQCVNDSRLSKEKVPAIEVMKSIMRSQLESGTPFMFYRDEVNRQNPNRHLGMIYCSNLCT
HHHHCCCCCCHHCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEHHHHHHHHHH
EIAQNQSPTVTKQQYVKDGTIIIEKIPGDFVVCNLSSINLARAVTDGVFERLIPIQLRML
HHHCCCCCCCHHHHHHCCCCEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
DNVIDLNNIPVLQASLTNKKYRAVGLGTFGWHHLLALKGIRWESEEAVRYTDELYETIAY
HHHHCCCCCCEEEECCCCCCEEEEEECCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
LAIQASMELAKEKGSYPGFSGSDWQTGAYFERRGYKNHGERDWDRLKREVARYGMRNGYL
HHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCEE
MAVAPNASTSIIAGSTASIDPIFRKVYAEEKKDYKIPVTVPDLNEQTTWYYKSAYYIDQR
EEECCCCCCEEEECCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCEEEEEEEEEECCC
WSIRQNAARQRHIDQAISFNFYVMNTIKAKELLELHLTAWKSGLKTTYYVRSTSGTMEEC
CCHHHHHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHH
DACAS
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9665876 [H]