Click here to switch to the map view.

The map label for this gene is nrdF [H]

Identifier: 138894466

GI number: 138894466

Start: 871686

End: 872720

Strand: Direct

Name: nrdF [H]

Synonym: GTNG_0796

Alternate gene names: 138894466

Gene position: 871686-872720 (Clockwise)

Preceding gene: 138894465

Following gene: 138894467

Centisome position: 24.55

GC content: 48.02

Gene sequence:

>1035_bases
ATGAACTTGACGAAACGACCGATTATGGATCCAGAAGCGCCAAACCGCTCAACAGGCATGATCAATGGACGCTGCTCGAA
TGTGTTGAACTGGGACGATATCGCCTACCCTTGGGCGTATGCGAAATATAAGCGGATGCTCGCCAACTTTTGGACGCCGT
TTGAAATCAATATGGCGCAAGATGTGAAGCAGTTTCCGCAACTAACCGCACGCGAGCAGGATGCATTTTTAAAAATTATC
GGGCTCTTGGCGCTCCTTGACAGCATCCAAACCGATTACGCAGGACGTGTTGCCGATTACATCACCGACCCGAGCATTAA
TGCGCTGATGATTATGCTCGCCCAGCAAGAGGTGATTCACAATCACTCGTATTCGTACGTGCTCTCAAGTCTTGTACCAA
AAGCGAAGCAAGATGAAGTGTTTGATTTTTGGCGGAATGAACCGACGTTGCGCAAGCGAAACGACTTTGTGACGAACGGC
TACAAGGCGTTTGCCGAAAAGCCGAACGTCGAGAACTTGCTTCGGTCGATCGTTTTTGACGTGATTTTGGAAGGGCTGTT
TTTCTACTCAGGATTCGCTTTCTTTTACAATCTCGCCCGCCAGCAAAAAATGGTGGCGACAAGCACGATGATCAATTACA
TTAATCGTGACGAGCACATTCATGTTGACTTGTTTGCGAAAATTTTCAAGGAAGTGCTGAATGAATATCCAGAGTATCGG
ACGCCCGAGTTGGCTGATTTTGCCCGCAGTACGTTTATGAAAGCGGCCGAGCTGGAAATCGAATGGGCTGGGGAAATCAT
CGGAAATGACATTGATGGCATCGACTTGGCGGATTTGGAAGCGTATATTAAGTTTTACGCCAACGTCCGCGCCCATCAGC
TTGGGTTCGACCGTCCGTTTGACGGCTACCGGACAAACCCGCTCCGCTGGATTAAGGCGTATGAAGAAGTCGACCTTGGC
AAGTCCGACTTTTTTGAACAAAAACCGCGCCAATATACGAAAGTGCAAGTGGATAACGGATTTGATGAATTATAA

Upstream 100 bases:

>100_bases
GACAACGCCATGCTATTTGTCGGATCGGGTTTCTTATGTTAGAAGAGATGTCCGGTGAGTGGGTTGCCTAGGAATACGAT
GACACGAGGGGGAATCGACG

Downstream 100 bases:

>100_bases
TGAGGAAAGCCACGTTTGACGATGGTCAGGCGTGGCTTTTTTGTCAGACAAGGCCGTTCGTCTCTCTTTTGATTGATCGT
CTTTCGTGATATGATGGCGG

Product: ribonucleoside-diphosphate reductase subunit beta

Products: NA

Alternate protein names: Ribonucleotide reductase small subunit [H]

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MNLTKRPIMDPEAPNRSTGMINGRCSNVLNWDDIAYPWAYAKYKRMLANFWTPFEINMAQDVKQFPQLTAREQDAFLKII
GLLALLDSIQTDYAGRVADYITDPSINALMIMLAQQEVIHNHSYSYVLSSLVPKAKQDEVFDFWRNEPTLRKRNDFVTNG
YKAFAEKPNVENLLRSIVFDVILEGLFFYSGFAFFYNLARQQKMVATSTMINYINRDEHIHVDLFAKIFKEVLNEYPEYR
TPELADFARSTFMKAAELEIEWAGEIIGNDIDGIDLADLEAYIKFYANVRAHQLGFDRPFDGYRTNPLRWIKAYEEVDLG
KSDFFEQKPRQYTKVQVDNGFDEL

Sequences:

>Translated_344_residues
MNLTKRPIMDPEAPNRSTGMINGRCSNVLNWDDIAYPWAYAKYKRMLANFWTPFEINMAQDVKQFPQLTAREQDAFLKII
GLLALLDSIQTDYAGRVADYITDPSINALMIMLAQQEVIHNHSYSYVLSSLVPKAKQDEVFDFWRNEPTLRKRNDFVTNG
YKAFAEKPNVENLLRSIVFDVILEGLFFYSGFAFFYNLARQQKMVATSTMINYINRDEHIHVDLFAKIFKEVLNEYPEYR
TPELADFARSTFMKAAELEIEWAGEIIGNDIDGIDLADLEAYIKFYANVRAHQLGFDRPFDGYRTNPLRWIKAYEEVDLG
KSDFFEQKPRQYTKVQVDNGFDEL
>Mature_344_residues
MNLTKRPIMDPEAPNRSTGMINGRCSNVLNWDDIAYPWAYAKYKRMLANFWTPFEINMAQDVKQFPQLTAREQDAFLKII
GLLALLDSIQTDYAGRVADYITDPSINALMIMLAQQEVIHNHSYSYVLSSLVPKAKQDEVFDFWRNEPTLRKRNDFVTNG
YKAFAEKPNVENLLRSIVFDVILEGLFFYSGFAFFYNLARQQKMVATSTMINYINRDEHIHVDLFAKIFKEVLNEYPEYR
TPELADFARSTFMKAAELEIEWAGEIIGNDIDGIDLADLEAYIKFYANVRAHQLGFDRPFDGYRTNPLRWIKAYEEVDLG
KSDFFEQKPRQYTKVQVDNGFDEL

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0208

COG function: function code F; Ribonucleotide reductase, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribonucleoside diphosphate reductase small chain family [H]

Homologues:

Organism=Homo sapiens, GI289177074, Length=311, Percent_Identity=24.7588424437299, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI42544136, Length=311, Percent_Identity=24.7588424437299, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI260064013, Length=311, Percent_Identity=23.4726688102894, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI4557845, Length=311, Percent_Identity=23.4726688102894, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI289177076, Length=290, Percent_Identity=23.448275862069, Blast_Score=75, Evalue=9e-14,
Organism=Escherichia coli, GI1789031, Length=276, Percent_Identity=22.8260869565217, Blast_Score=85, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17551968, Length=299, Percent_Identity=22.0735785953177, Blast_Score=71, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6321619, Length=307, Percent_Identity=22.4755700325733, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI18079279, Length=311, Percent_Identity=22.1864951768489, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009078
- InterPro:   IPR012348
- InterPro:   IPR000358 [H]

Pfam domain/function: PF00268 Ribonuc_red_sm [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 40092; Mature: 40092

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLTKRPIMDPEAPNRSTGMINGRCSNVLNWDDIAYPWAYAKYKRMLANFWTPFEINMAQ
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCHHHHHHHHHHHHCCCCEECCHHH
DVKQFPQLTAREQDAFLKIIGLLALLDSIQTDYAGRVADYITDPSINALMIMLAQQEVIH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
NHSYSYVLSSLVPKAKQDEVFDFWRNEPTLRKRNDFVTNGYKAFAEKPNVENLLRSIVFD
CCHHHHHHHHHCCCCCCHHHHHHHCCCCCCHHCCCHHHCCHHHHHCCCCHHHHHHHHHHH
VILEGLFFYSGFAFFYNLARQQKMVATSTMINYINRDEHIHVDLFAKIFKEVLNEYPEYR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHCCCCC
TPELADFARSTFMKAAELEIEWAGEIIGNDIDGIDLADLEAYIKFYANVRAHQLGFDRPF
CCHHHHHHHHHHHHHHHEEHEEHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
DGYRTNPLRWIKAYEEVDLGKSDFFEQKPRQYTKVQVDNGFDEL
CCCCCCHHHHHHHHHHHCCCHHHHHHHCCCHHEEEEECCCCCCC
>Mature Secondary Structure
MNLTKRPIMDPEAPNRSTGMINGRCSNVLNWDDIAYPWAYAKYKRMLANFWTPFEINMAQ
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCHHHHHHHHHHHHCCCCEECCHHH
DVKQFPQLTAREQDAFLKIIGLLALLDSIQTDYAGRVADYITDPSINALMIMLAQQEVIH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
NHSYSYVLSSLVPKAKQDEVFDFWRNEPTLRKRNDFVTNGYKAFAEKPNVENLLRSIVFD
CCHHHHHHHHHCCCCCCHHHHHHHCCCCCCHHCCCHHHCCHHHHHCCCCHHHHHHHHHHH
VILEGLFFYSGFAFFYNLARQQKMVATSTMINYINRDEHIHVDLFAKIFKEVLNEYPEYR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHCCCCC
TPELADFARSTFMKAAELEIEWAGEIIGNDIDGIDLADLEAYIKFYANVRAHQLGFDRPF
CCHHHHHHHHHHHHHHHEEHEEHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
DGYRTNPLRWIKAYEEVDLGKSDFFEQKPRQYTKVQVDNGFDEL
CCCCCCHHHHHHHHHHHCCCHHHHHHHCCCHHEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]