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The map label for this gene is lysS [H]

Identifier: 138893753

GI number: 138893753

Start: 84588

End: 86072

Strand: Direct

Name: lysS [H]

Synonym: GTNG_0074

Alternate gene names: 138893753

Gene position: 84588-86072 (Clockwise)

Preceding gene: 138893752

Following gene: 138893754

Centisome position: 2.38

GC content: 47.54

Gene sequence:

>1485_bases
ATGAGCCATGAAGAATTGAACGACCAATTGCGTGTCCGCCGGGAAAAGTTAAAAAAAATCGAAGAGCTAGGTGTCGACCC
GTTTGGCAAACGGTTCGAGCGCACGCATAAAGCAGAAGAACTGTTTAAACTGTACGGCGATTTGTCCAAAGAAGAACTTG
AAGAGCAGCAAATTGAAGTCGCTGTCGCCGGCCGCATTATGACGAAACGCGGTAAAGGAAAAGCAGGATTTGCTCACATT
CAAGACGTCACAGGGCAAATTCAAATTTATGTCCGCCAAGACGATGTCGGCGAACAGCAATATGAGCTGTTTAAAATCTC
TGACCTTGGTGATATCGTCGGTGTGCGCGGCACTATGTTCAAAACAAAAGTCGGCGAGCTTTCCATCAAAGTGTCATCAT
ATGAATTTTTAACAAAAGCATTGCGTCCATTGCCGGAAAAATACCATGGTTTAAAGGACGTCGAACAACGTTACCGCCAA
CGTTATCTCGACTTAACTATGAATCCGCAAAGTAAGCAGACGTTTATCACCCGTAGTCTCATTATTCAATCGATGCGGCG
TTATCTCGACAGCCAAGGTTATTTGGAAGTCGAAACACCGATGATGCACGCCATAGCAGGTGGTGCGGCTGCACGTCCGT
TTATTACGCACCATAATGCCCTTGATATGACACTTTATATGCGAATCGCCATCGAACTCCATTTAAAACGGCTCATCGTC
GGCGGTTTGGAAAAAGTGTATGAAATCGGACGCGTCTTCCGGAATGAGGGGATTTCCACCCGTCACAATCCGGAGTTTAC
GATGCTTGAACTGTACGAGGCATATGCCGACTTCCGTGACATCATGAAATTGACAGAAAACTTAATTGCTCACATTGCCA
CGGAAGTGCTTGGCACGACGAAAATTCAATACGGCGAACATACCGTCGATTTAACGCCTGAATGGCGGCGACTTCATATG
GTCGATGCGATTAAAGAATACGTCGGCGTTGATTTCTGGCGGCACATGGACGACGAGGAAGCGCGGGCGTTGGCGAAAGA
ACATGGGGTCGAAATCGCCCCGCACATGACGTTTGGTCATATCGTCAATGAATTTTTTGAACAAAAAGTCGAGTCGCAAC
TCATCCAACCGACGTTCATTTATGGCCACCCTGTCGAAATTTCGCCGTTAGCTAAGAAAAACCCGGACGATCCACGCTTT
ACCGATCGATTTGAGCTATTTATCGTTGGACGTGAACATGCGAACGCGTTTACGGAACTAAACGATCCGATCGACCAGCG
CCAACGTTTCGAAGCACAGTTGAAAGAACGTGAACAAGGGAACGATGAAGCGCACGAAATGGACGAAGATTTCCTCGAAG
CGCTCGAGTACGGTATGCCTCCAACAGGCGGACTCGGCATCGGCGTTGACCGTCTAGTCATGCTCTTGACTAACTCTCCG
TCCATTCGGGATGTGTTACTCTTCCCGCAAATGCGTCATAAATAA

Upstream 100 bases:

>100_bases
CGCCCGGGCCGTATAGGAGCGGAATTTGATGAAGCGGATGACTGCCAGCACGCGCTGGCAGTATTTTTCGTAAAAAATCA
TTAAATGGAGTGAATGAAGG

Downstream 100 bases:

>100_bases
AAAGTATTGTCCCCTGTGTGAAAATGCACAGGGGACGATTTGTTTTTTAAAAAACTATTGACTTTTAACATATAAACAAT
ATAAAATGAAAATCGTCGCT

Product: lysyl-tRNA synthetase

Products: NA

Alternate protein names: Lysine--tRNA ligase; LysRS [H]

Number of amino acids: Translated: 494; Mature: 493

Protein sequence:

>494_residues
MSHEELNDQLRVRREKLKKIEELGVDPFGKRFERTHKAEELFKLYGDLSKEELEEQQIEVAVAGRIMTKRGKGKAGFAHI
QDVTGQIQIYVRQDDVGEQQYELFKISDLGDIVGVRGTMFKTKVGELSIKVSSYEFLTKALRPLPEKYHGLKDVEQRYRQ
RYLDLTMNPQSKQTFITRSLIIQSMRRYLDSQGYLEVETPMMHAIAGGAAARPFITHHNALDMTLYMRIAIELHLKRLIV
GGLEKVYEIGRVFRNEGISTRHNPEFTMLELYEAYADFRDIMKLTENLIAHIATEVLGTTKIQYGEHTVDLTPEWRRLHM
VDAIKEYVGVDFWRHMDDEEARALAKEHGVEIAPHMTFGHIVNEFFEQKVESQLIQPTFIYGHPVEISPLAKKNPDDPRF
TDRFELFIVGREHANAFTELNDPIDQRQRFEAQLKEREQGNDEAHEMDEDFLEALEYGMPPTGGLGIGVDRLVMLLTNSP
SIRDVLLFPQMRHK

Sequences:

>Translated_494_residues
MSHEELNDQLRVRREKLKKIEELGVDPFGKRFERTHKAEELFKLYGDLSKEELEEQQIEVAVAGRIMTKRGKGKAGFAHI
QDVTGQIQIYVRQDDVGEQQYELFKISDLGDIVGVRGTMFKTKVGELSIKVSSYEFLTKALRPLPEKYHGLKDVEQRYRQ
RYLDLTMNPQSKQTFITRSLIIQSMRRYLDSQGYLEVETPMMHAIAGGAAARPFITHHNALDMTLYMRIAIELHLKRLIV
GGLEKVYEIGRVFRNEGISTRHNPEFTMLELYEAYADFRDIMKLTENLIAHIATEVLGTTKIQYGEHTVDLTPEWRRLHM
VDAIKEYVGVDFWRHMDDEEARALAKEHGVEIAPHMTFGHIVNEFFEQKVESQLIQPTFIYGHPVEISPLAKKNPDDPRF
TDRFELFIVGREHANAFTELNDPIDQRQRFEAQLKEREQGNDEAHEMDEDFLEALEYGMPPTGGLGIGVDRLVMLLTNSP
SIRDVLLFPQMRHK
>Mature_493_residues
SHEELNDQLRVRREKLKKIEELGVDPFGKRFERTHKAEELFKLYGDLSKEELEEQQIEVAVAGRIMTKRGKGKAGFAHIQ
DVTGQIQIYVRQDDVGEQQYELFKISDLGDIVGVRGTMFKTKVGELSIKVSSYEFLTKALRPLPEKYHGLKDVEQRYRQR
YLDLTMNPQSKQTFITRSLIIQSMRRYLDSQGYLEVETPMMHAIAGGAAARPFITHHNALDMTLYMRIAIELHLKRLIVG
GLEKVYEIGRVFRNEGISTRHNPEFTMLELYEAYADFRDIMKLTENLIAHIATEVLGTTKIQYGEHTVDLTPEWRRLHMV
DAIKEYVGVDFWRHMDDEEARALAKEHGVEIAPHMTFGHIVNEFFEQKVESQLIQPTFIYGHPVEISPLAKKNPDDPRFT
DRFELFIVGREHANAFTELNDPIDQRQRFEAQLKEREQGNDEAHEMDEDFLEALEYGMPPTGGLGIGVDRLVMLLTNSPS
IRDVLLFPQMRHK

Specific function: Also Can Synthesize A Number Of Adenyl Dinucleotides (In Particular Appppa). These Dinucleotides Have Been Proposed To Act As Modulators Of The Heat-Shock Response And Stress Response. [C]

COG id: COG1190

COG function: function code J; Lysyl-tRNA synthetase (class II)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI5031815, Length=503, Percent_Identity=42.3459244532803, Blast_Score=387, Evalue=1e-107,
Organism=Homo sapiens, GI194272210, Length=503, Percent_Identity=42.3459244532803, Blast_Score=387, Evalue=1e-107,
Organism=Homo sapiens, GI45439306, Length=472, Percent_Identity=23.728813559322, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI40789249, Length=245, Percent_Identity=27.3469387755102, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI1790571, Length=490, Percent_Identity=54.6938775510204, Blast_Score=543, Evalue=1e-156,
Organism=Escherichia coli, GI1789256, Length=490, Percent_Identity=54.2857142857143, Blast_Score=535, Evalue=1e-153,
Organism=Escherichia coli, GI87082379, Length=328, Percent_Identity=32.6219512195122, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI1788173, Length=249, Percent_Identity=26.1044176706827, Blast_Score=81, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17535925, Length=501, Percent_Identity=46.5069860279441, Blast_Score=421, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI17535927, Length=501, Percent_Identity=46.5069860279441, Blast_Score=421, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI71994340, Length=500, Percent_Identity=46.6, Blast_Score=421, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI32566633, Length=280, Percent_Identity=24.2857142857143, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6320242, Length=494, Percent_Identity=44.5344129554656, Blast_Score=400, Evalue=1e-112,
Organism=Saccharomyces cerevisiae, GI6324256, Length=475, Percent_Identity=33.0526315789474, Blast_Score=215, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6323011, Length=483, Percent_Identity=23.1884057971014, Blast_Score=90, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6321807, Length=454, Percent_Identity=26.8722466960352, Blast_Score=90, Evalue=9e-19,
Organism=Drosophila melanogaster, GI24640849, Length=504, Percent_Identity=41.8650793650794, Blast_Score=387, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24640851, Length=504, Percent_Identity=41.8650793650794, Blast_Score=387, Evalue=1e-107,
Organism=Drosophila melanogaster, GI17136276, Length=458, Percent_Identity=23.3624454148472, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24584738, Length=267, Percent_Identity=25.4681647940075, Blast_Score=75, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004364
- InterPro:   IPR018150
- InterPro:   IPR006195
- InterPro:   IPR002313
- InterPro:   IPR018149
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004365 [H]

Pfam domain/function: PF00152 tRNA-synt_2; PF01336 tRNA_anti [H]

EC number: =6.1.1.6 [H]

Molecular weight: Translated: 57275; Mature: 57144

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHEELNDQLRVRREKLKKIEELGVDPFGKRFERTHKAEELFKLYGDLSKEELEEQQIEV
CCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
AVAGRIMTKRGKGKAGFAHIQDVTGQIQIYVRQDDVGEQQYELFKISDLGDIVGVRGTMF
HHHHHHHHCCCCCCCCHHHHHCCCCEEEEEEECCCCCCCHHHEEEECCCHHHHCCCCHHH
KTKVGELSIKVSSYEFLTKALRPLPEKYHGLKDVEQRYRQRYLDLTMNPQSKQTFITRSL
EEECCCEEEEEHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
IIQSMRRYLDSQGYLEVETPMMHAIAGGAAARPFITHHNALDMTLYMRIAIELHLKRLIV
HHHHHHHHHCCCCCEEECCHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHH
GGLEKVYEIGRVFRNEGISTRHNPEFTMLELYEAYADFRDIMKLTENLIAHIATEVLGTT
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KIQYGEHTVDLTPEWRRLHMVDAIKEYVGVDFWRHMDDEEARALAKEHGVEIAPHMTFGH
EEECCCEEECCCCHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHCCCEECCCCHHHH
IVNEFFEQKVESQLIQPTFIYGHPVEISPLAKKNPDDPRFTDRFELFIVGREHANAFTEL
HHHHHHHHHHHHHHCCCEEEECCCCEECCCCCCCCCCCCCCCEEEEEEEECHHHHHHHHC
NDPIDQRQRFEAQLKEREQGNDEAHEMDEDFLEALEYGMPPTGGLGIGVDRLVMLLTNSP
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCC
SIRDVLLFPQMRHK
CHHHEEECCCCCCC
>Mature Secondary Structure 
SHEELNDQLRVRREKLKKIEELGVDPFGKRFERTHKAEELFKLYGDLSKEELEEQQIEV
CHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
AVAGRIMTKRGKGKAGFAHIQDVTGQIQIYVRQDDVGEQQYELFKISDLGDIVGVRGTMF
HHHHHHHHCCCCCCCCHHHHHCCCCEEEEEEECCCCCCCHHHEEEECCCHHHHCCCCHHH
KTKVGELSIKVSSYEFLTKALRPLPEKYHGLKDVEQRYRQRYLDLTMNPQSKQTFITRSL
EEECCCEEEEEHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
IIQSMRRYLDSQGYLEVETPMMHAIAGGAAARPFITHHNALDMTLYMRIAIELHLKRLIV
HHHHHHHHHCCCCCEEECCHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHH
GGLEKVYEIGRVFRNEGISTRHNPEFTMLELYEAYADFRDIMKLTENLIAHIATEVLGTT
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KIQYGEHTVDLTPEWRRLHMVDAIKEYVGVDFWRHMDDEEARALAKEHGVEIAPHMTFGH
EEECCCEEECCCCHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHCCCEECCCCHHHH
IVNEFFEQKVESQLIQPTFIYGHPVEISPLAKKNPDDPRFTDRFELFIVGREHANAFTEL
HHHHHHHHHHHHHHCCCEEEECCCCEECCCCCCCCCCCCCCCEEEEEEEECHHHHHHHHC
NDPIDQRQRFEAQLKEREQGNDEAHEMDEDFLEALEYGMPPTGGLGIGVDRLVMLLTNSP
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCC
SIRDVLLFPQMRHK
CHHHEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10737207 [H]