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The map label for this gene is gcvT [H]

Identifier: 134302510

GI number: 134302510

Start: 1577730

End: 1578806

Strand: Reverse

Name: gcvT [H]

Synonym: FTW_1666

Alternate gene names: 134302510

Gene position: 1578806-1577730 (Counterclockwise)

Preceding gene: 134302511

Following gene: 134302509

Centisome position: 83.16

GC content: 37.14

Gene sequence:

>1077_bases
ATGCTGAAAACTCCTCTTTATGAATCACATATAGCAGCAAATGCTAAGATGGTTGATTTCTCAGGCTGGTCAATGCCAAT
TAACTATGGTTCACAAATTCAAGAGCATAATAATGTTAGAGAAGATTGTGGTATTTTTGATGTATCACATATGTTAGCAG
TTGATATTCAAGGTTCTGAAGCTGAGAAGTTTTTACGCTATCTTTTAGCCAATGATGTTGCTAAATTACAGGAGAATAAA
GCTCAATATGGCTGTATGTTAAATCATGATGCTGGTATTGTTGATGATTTGATTACTTATAAAGTTACAGATGAGCATTT
TAGAATAGTTGTCAATGCTGGTAATAGAGAGTCAGATGTTGCATGGTTTAATCAAAATGCTCAAAATTTTGATGTTGCGA
TAACCCCACAGACTGATTTAGCTATAGTTGCAGTACAGGGACCAAAAGCTGTTGCCGTTATTAAGCGTGTTGTTACCAAA
GAAATTGCTGCTGAAATTGAAGCGCTATTGCCTTTTTCATTTAAGTTTTTTAGTAAATGGATGGTAGCACGTACTGGTTA
TACTGGTGAAGATGGTTTTGAGGTGATTCTCCCTGCAACACAGGTCAAAAAATTCTGGGATAGTCTGCTTGAAAATGGAG
CACAACCTGCAGGGTTAGGCGCTCGTGATACATTAAGATTAGAAGCTGGGATGCATCTATATGGTGCTGATATGGATACC
TCTACGACACCTCTAGAAAGAGGCTTGGGCTGGAGCGTTGATTTATCTGACGAACATAGGGACTTTATTGGTAAGAAAGC
ATACCTTGCTAAAAAAGCACAAGGAGTTGATACTAAATGGGTCGGTGTAGTACTAAAAACAAAAGGTGTCCTTAGAGCAG
GTCAAGAAATTGATTTTGATAATGGTGAAAAAGGCTATATAACCAGTGGGAGTTTTTCACCAACTTTGAAAGTAGCTATT
GGATTAGCTTATGTGCCTAAGCAAGCTGATAATCCTGTGGTAAATATTAGAGGTAAGGAGCTCGAAGTCGAGCTAGTTAA
ACCTAAGTTTGTTAAAAATGGTAAATCTTTGATATAA

Upstream 100 bases:

>100_bases
TGATAAATAATATCTTATTTTTTGAAATAAAATGCTTATAAAACACTAAAAAAAAATGTATAGTGTCATTATCGAGCATA
ATTTTTTAGGTGGATAGTTC

Downstream 100 bases:

>100_bases
AGTAAATAAGTATTTTTTAAAAAAACAATTAATCGTAGTCAACACGGAGGTATAAAATGTCAAATATTCCTAAAGAATTA
AAGTATACAAAGTCGCATGA

Product: glycine cleavage system aminomethyltransferase T

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 358; Mature: 358

Protein sequence:

>358_residues
MLKTPLYESHIAANAKMVDFSGWSMPINYGSQIQEHNNVREDCGIFDVSHMLAVDIQGSEAEKFLRYLLANDVAKLQENK
AQYGCMLNHDAGIVDDLITYKVTDEHFRIVVNAGNRESDVAWFNQNAQNFDVAITPQTDLAIVAVQGPKAVAVIKRVVTK
EIAAEIEALLPFSFKFFSKWMVARTGYTGEDGFEVILPATQVKKFWDSLLENGAQPAGLGARDTLRLEAGMHLYGADMDT
STTPLERGLGWSVDLSDEHRDFIGKKAYLAKKAQGVDTKWVGVVLKTKGVLRAGQEIDFDNGEKGYITSGSFSPTLKVAI
GLAYVPKQADNPVVNIRGKELEVELVKPKFVKNGKSLI

Sequences:

>Translated_358_residues
MLKTPLYESHIAANAKMVDFSGWSMPINYGSQIQEHNNVREDCGIFDVSHMLAVDIQGSEAEKFLRYLLANDVAKLQENK
AQYGCMLNHDAGIVDDLITYKVTDEHFRIVVNAGNRESDVAWFNQNAQNFDVAITPQTDLAIVAVQGPKAVAVIKRVVTK
EIAAEIEALLPFSFKFFSKWMVARTGYTGEDGFEVILPATQVKKFWDSLLENGAQPAGLGARDTLRLEAGMHLYGADMDT
STTPLERGLGWSVDLSDEHRDFIGKKAYLAKKAQGVDTKWVGVVLKTKGVLRAGQEIDFDNGEKGYITSGSFSPTLKVAI
GLAYVPKQADNPVVNIRGKELEVELVKPKFVKNGKSLI
>Mature_358_residues
MLKTPLYESHIAANAKMVDFSGWSMPINYGSQIQEHNNVREDCGIFDVSHMLAVDIQGSEAEKFLRYLLANDVAKLQENK
AQYGCMLNHDAGIVDDLITYKVTDEHFRIVVNAGNRESDVAWFNQNAQNFDVAITPQTDLAIVAVQGPKAVAVIKRVVTK
EIAAEIEALLPFSFKFFSKWMVARTGYTGEDGFEVILPATQVKKFWDSLLENGAQPAGLGARDTLRLEAGMHLYGADMDT
STTPLERGLGWSVDLSDEHRDFIGKKAYLAKKAQGVDTKWVGVVLKTKGVLRAGQEIDFDNGEKGYITSGSFSPTLKVAI
GLAYVPKQADNPVVNIRGKELEVELVKPKFVKNGKSLI

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=370, Percent_Identity=35.6756756756757, Blast_Score=205, Evalue=5e-53,
Organism=Homo sapiens, GI257796258, Length=360, Percent_Identity=36.3888888888889, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI257796254, Length=364, Percent_Identity=32.1428571428571, Blast_Score=165, Evalue=7e-41,
Organism=Homo sapiens, GI257796256, Length=316, Percent_Identity=33.5443037974684, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI24797151, Length=336, Percent_Identity=28.2738095238095, Blast_Score=115, Evalue=9e-26,
Organism=Homo sapiens, GI197927446, Length=332, Percent_Identity=23.1927710843373, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI21361378, Length=332, Percent_Identity=23.1927710843373, Blast_Score=89, Evalue=6e-18,
Organism=Escherichia coli, GI1789272, Length=361, Percent_Identity=47.9224376731302, Blast_Score=347, Evalue=7e-97,
Organism=Caenorhabditis elegans, GI17560118, Length=369, Percent_Identity=34.6883468834688, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI71994052, Length=326, Percent_Identity=26.6871165644172, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71994045, Length=326, Percent_Identity=26.6871165644172, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6320222, Length=378, Percent_Identity=36.2433862433862, Blast_Score=194, Evalue=2e-50,
Organism=Drosophila melanogaster, GI20129441, Length=375, Percent_Identity=36.5333333333333, Blast_Score=201, Evalue=6e-52,
Organism=Drosophila melanogaster, GI28571104, Length=271, Percent_Identity=26.1992619926199, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI20130091, Length=338, Percent_Identity=24.2603550295858, Blast_Score=83, Evalue=3e-16,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 39502; Mature: 39502

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKTPLYESHIAANAKMVDFSGWSMPINYGSQIQEHNNVREDCGIFDVSHMLAVDIQGSE
CCCCCCCHHHHHCCCEEEEECCCCCCCCCCCHHHHHCCCHHHCCEEEECEEEEEEECCCH
AEKFLRYLLANDVAKLQENKAQYGCMLNHDAGIVDDLITYKVTDEHFRIVVNAGNRESDV
HHHHHHHHHHHHHHHHHHCCHHCCEEECCCCCCHHHHEEEEEECCEEEEEEECCCCCCCE
AWFNQNAQNFDVAITPQTDLAIVAVQGPKAVAVIKRVVTKEIAAEIEALLPFSFKFFSKW
EEECCCCCCEEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
MVARTGYTGEDGFEVILPATQVKKFWDSLLENGAQPAGLGARDTLRLEAGMHLYGADMDT
HHHCCCCCCCCCCEEEECHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCEEEECCCCC
STTPLERGLGWSVDLSDEHRDFIGKKAYLAKKAQGVDTKWVGVVLKTKGVLRAGQEIDFD
CCCHHHHCCCCEEECCCHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCHHHCCCCCCCC
NGEKGYITSGSFSPTLKVAIGLAYVPKQADNPVVNIRGKELEVELVKPKFVKNGKSLI
CCCCCEEECCCCCCEEEEEEEEEECCCCCCCCEEEEECCEEEEEEECCHHHCCCCCCC
>Mature Secondary Structure
MLKTPLYESHIAANAKMVDFSGWSMPINYGSQIQEHNNVREDCGIFDVSHMLAVDIQGSE
CCCCCCCHHHHHCCCEEEEECCCCCCCCCCCHHHHHCCCHHHCCEEEECEEEEEEECCCH
AEKFLRYLLANDVAKLQENKAQYGCMLNHDAGIVDDLITYKVTDEHFRIVVNAGNRESDV
HHHHHHHHHHHHHHHHHHCCHHCCEEECCCCCCHHHHEEEEEECCEEEEEEECCCCCCCE
AWFNQNAQNFDVAITPQTDLAIVAVQGPKAVAVIKRVVTKEIAAEIEALLPFSFKFFSKW
EEECCCCCCEEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
MVARTGYTGEDGFEVILPATQVKKFWDSLLENGAQPAGLGARDTLRLEAGMHLYGADMDT
HHHCCCCCCCCCCEEEECHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCEEEECCCCC
STTPLERGLGWSVDLSDEHRDFIGKKAYLAKKAQGVDTKWVGVVLKTKGVLRAGQEIDFD
CCCHHHHCCCCEEECCCHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCHHHCCCCCCCC
NGEKGYITSGSFSPTLKVAIGLAYVPKQADNPVVNIRGKELEVELVKPKFVKNGKSLI
CCCCCEEECCCCCCEEEEEEEEEECCCCCCCCEEEEECCEEEEEEECCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA