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The map label for this gene is cadA [H]

Identifier: 134302511

GI number: 134302511

Start: 1578897

End: 1581038

Strand: Reverse

Name: cadA [H]

Synonym: FTW_1667

Alternate gene names: 134302511

Gene position: 1581038-1578897 (Counterclockwise)

Preceding gene: 134302512

Following gene: 134302510

Centisome position: 83.28

GC content: 32.96

Gene sequence:

>2142_bases
ATGAAAACTGTTGTATTTGTCTATAAAGATACCTTAAAGTCATATAAGGAAAAATTTTTACTAAAAATTGAGAAAGATCT
TAAAAATCATCATGAGTATTATACTTTGAAGCTTGATGATTTATCCGAAGTGGTTGAAATTCTTGAGGAGAACTCTAGAA
TATGCTGTATTGTTTTAGATAGAGCTAGTTTCAATATTGAAGCTTTTCATAATATTGCGCACCTTAATACAAAGCTGCCA
ATATTTGTAGCATCTGACTATAGTCAAAGTATTAAGCTTAATCTGCGTGATTTTAATCTAAATATCAACTTCTTGCAGTA
TGATGCTTTAGCTGGTGAGGATTCTGACTTTATTCACAAAACTATCACAAATTATTTTAATTATATATTGCCACCGTTGA
CTTATGAGTTATTTAAGTACTCTAAATCTTTTAATTCGGCTTTTTGTACTCCAGGTCACCAAGGAGGTTATGGTTTTCAG
CGTTCTGCAGTAGGGGCTTTGTTTTATGATTTTTATGGCGAGAATATTTTTAAGACAGATTTATCTATTTCAATGAAAGA
GCTGGGAAGCTTGCTTGATCATTCTGAAGCACATAAGGACGCTGAAGAATATATATCTAAAGTTTTTAAATCAGACAGAT
CACTTATTGTTACAAATGGTACTTCAACAGCTAATAAAATAGTGGGAATGTATAGTGTTGCTGATGGTGATACGATTCTT
GTAGATAGAAATTGCCATAAATCAGTGACACATCTAATGATGATGGTTGATGTTAACCCAATATATCTAAAACCAACCAG
AAATGCTTATGGAATAATTGGTGGGATTCCTAAAAAAGAGTTCAAAAGAGAAACTATCCAAGAAAAGATAGATAATAGTA
ATATTGCTGATAAGTGGCCTGAATATGCGGTAGTTACAAACTCAACTTATGACGGTATCCTTTATAATACTGATACGATA
CATCGAGAGCTTGATGTTAAAAAACTACATTTTGATAGTGCTTGGATACCATATGCAATATTTCATCCAATTTATAAGCA
TAAATCAGCAATGCAAATTGAGCCAAGACCAGAACATATAATTTTTGAAACACAGTCAACACATAAACTTTTAGCGGCCT
TTAGCCAATCATCAATGCTGCATATAAAAGGCGACTATAATGAAGAAGTATTAAATGAAGCGTTTATGCTGCATACTTCA
ACATCACCTTTTTATCCGATAGTTGCTAGCGTGGAAACAGCAGCAGCAATGATGGAGGGCGAGCAAGGCTATAATCTTAT
CGACAAGACTATTAACTTAGCTATAGATTTTAGAAGAGAACTAATCAAACTAAGATCTGAAGCAAATGGTTGGTTTTTTG
ATGTTTGGCAACCTGATAATATCTCTAATAAAGAGGCATGGCTTCTGAGAAATGGTGATAAATGGCATGGATTTAAAAAT
GTTGATGGTGATTTTCTCTCATTAGACCCTATCAAAATAACAATTCTAACTCCTGGGATAAAAGATAATGATGTTCAAGA
TTGGGGAGTACCAGCTGATGTGGTCGCTAAATTCTTAGATGAGCATGATATTGTGGTTGAGAAGTCTGGACCATATTCAT
TACTATTTATATTTAGTTTAGGTACAACAAAAGCTAAATCAGTAAGGCTAATTTCGGTATTGAATAAATTCAAACAAATG
TATGATGAAAATACACTTGTTGAAAAAATGCTACCAACTTTATATGCGGAAGATCCTAAATTTTATGAAGATATGAGAAT
TCAAGAAGTTAGTGAAAGATTACATCAGTATATGAAAGAGGCTAATCTTCCTAATCTCATGTATCATGCTTTTAATGTGC
TACCAGAGCAACAGCTAAATCCTCATAGGGCTTTTCAGAAATTATTAAAAGGTAAGGTTAAAAAGGTTCCTCTAGTAGAA
CTGTATGAGCATACTTCAGCTGTTATGATATTACCTTATCCACCTGGGATACCTGTTATTTTTCCTGGAGAGAAGATAAC
CGAAGAATCTAAAGTAATATTGGATTTCTTATTAATGCTTGAGAAAATAGGTTCGATGTTGCCTGGCTTTGATACAGATA
TTCATGGTCCTGAGAGGGCAAAAGATGGTAAGCTCTATATCAAAGTTATTGATGATAAATAA

Upstream 100 bases:

>100_bases
CTATATTTTTCTATTATATTATGATAAAAAAATATTTTTAATTTAGGTACTTTTAGTATACTGAATTAATACTGTAGTTA
TTTTTCTAAGTCGTAAAATT

Downstream 100 bases:

>100_bases
TATCTTATTTTTTGAAATAAAATGCTTATAAAACACTAAAAAAAAATGTATAGTGTCATTATCGAGCATAATTTTTTAGG
TGGATAGTTCATGCTGAAAA

Product: Lys decarboxylase

Products: NA

Alternate protein names: LDC [H]

Number of amino acids: Translated: 713; Mature: 713

Protein sequence:

>713_residues
MKTVVFVYKDTLKSYKEKFLLKIEKDLKNHHEYYTLKLDDLSEVVEILEENSRICCIVLDRASFNIEAFHNIAHLNTKLP
IFVASDYSQSIKLNLRDFNLNINFLQYDALAGEDSDFIHKTITNYFNYILPPLTYELFKYSKSFNSAFCTPGHQGGYGFQ
RSAVGALFYDFYGENIFKTDLSISMKELGSLLDHSEAHKDAEEYISKVFKSDRSLIVTNGTSTANKIVGMYSVADGDTIL
VDRNCHKSVTHLMMMVDVNPIYLKPTRNAYGIIGGIPKKEFKRETIQEKIDNSNIADKWPEYAVVTNSTYDGILYNTDTI
HRELDVKKLHFDSAWIPYAIFHPIYKHKSAMQIEPRPEHIIFETQSTHKLLAAFSQSSMLHIKGDYNEEVLNEAFMLHTS
TSPFYPIVASVETAAAMMEGEQGYNLIDKTINLAIDFRRELIKLRSEANGWFFDVWQPDNISNKEAWLLRNGDKWHGFKN
VDGDFLSLDPIKITILTPGIKDNDVQDWGVPADVVAKFLDEHDIVVEKSGPYSLLFIFSLGTTKAKSVRLISVLNKFKQM
YDENTLVEKMLPTLYAEDPKFYEDMRIQEVSERLHQYMKEANLPNLMYHAFNVLPEQQLNPHRAFQKLLKGKVKKVPLVE
LYEHTSAVMILPYPPGIPVIFPGEKITEESKVILDFLLMLEKIGSMLPGFDTDIHGPERAKDGKLYIKVIDDK

Sequences:

>Translated_713_residues
MKTVVFVYKDTLKSYKEKFLLKIEKDLKNHHEYYTLKLDDLSEVVEILEENSRICCIVLDRASFNIEAFHNIAHLNTKLP
IFVASDYSQSIKLNLRDFNLNINFLQYDALAGEDSDFIHKTITNYFNYILPPLTYELFKYSKSFNSAFCTPGHQGGYGFQ
RSAVGALFYDFYGENIFKTDLSISMKELGSLLDHSEAHKDAEEYISKVFKSDRSLIVTNGTSTANKIVGMYSVADGDTIL
VDRNCHKSVTHLMMMVDVNPIYLKPTRNAYGIIGGIPKKEFKRETIQEKIDNSNIADKWPEYAVVTNSTYDGILYNTDTI
HRELDVKKLHFDSAWIPYAIFHPIYKHKSAMQIEPRPEHIIFETQSTHKLLAAFSQSSMLHIKGDYNEEVLNEAFMLHTS
TSPFYPIVASVETAAAMMEGEQGYNLIDKTINLAIDFRRELIKLRSEANGWFFDVWQPDNISNKEAWLLRNGDKWHGFKN
VDGDFLSLDPIKITILTPGIKDNDVQDWGVPADVVAKFLDEHDIVVEKSGPYSLLFIFSLGTTKAKSVRLISVLNKFKQM
YDENTLVEKMLPTLYAEDPKFYEDMRIQEVSERLHQYMKEANLPNLMYHAFNVLPEQQLNPHRAFQKLLKGKVKKVPLVE
LYEHTSAVMILPYPPGIPVIFPGEKITEESKVILDFLLMLEKIGSMLPGFDTDIHGPERAKDGKLYIKVIDDK
>Mature_713_residues
MKTVVFVYKDTLKSYKEKFLLKIEKDLKNHHEYYTLKLDDLSEVVEILEENSRICCIVLDRASFNIEAFHNIAHLNTKLP
IFVASDYSQSIKLNLRDFNLNINFLQYDALAGEDSDFIHKTITNYFNYILPPLTYELFKYSKSFNSAFCTPGHQGGYGFQ
RSAVGALFYDFYGENIFKTDLSISMKELGSLLDHSEAHKDAEEYISKVFKSDRSLIVTNGTSTANKIVGMYSVADGDTIL
VDRNCHKSVTHLMMMVDVNPIYLKPTRNAYGIIGGIPKKEFKRETIQEKIDNSNIADKWPEYAVVTNSTYDGILYNTDTI
HRELDVKKLHFDSAWIPYAIFHPIYKHKSAMQIEPRPEHIIFETQSTHKLLAAFSQSSMLHIKGDYNEEVLNEAFMLHTS
TSPFYPIVASVETAAAMMEGEQGYNLIDKTINLAIDFRRELIKLRSEANGWFFDVWQPDNISNKEAWLLRNGDKWHGFKN
VDGDFLSLDPIKITILTPGIKDNDVQDWGVPADVVAKFLDEHDIVVEKSGPYSLLFIFSLGTTKAKSVRLISVLNKFKQM
YDENTLVEKMLPTLYAEDPKFYEDMRIQEVSERLHQYMKEANLPNLMYHAFNVLPEQQLNPHRAFQKLLKGKVKKVPLVE
LYEHTSAVMILPYPPGIPVIFPGEKITEESKVILDFLLMLEKIGSMLPGFDTDIHGPERAKDGKLYIKVIDDK

Specific function: Appears To Play A Role In pH Homeostasis By Consuming Protons And Neutralizing The Acidic By-Products Of Carbohydrate Fermentation. [C]

COG id: COG1982

COG function: function code E; Arginine/lysine/ornithine decarboxylases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-I family [H]

Homologues:

Organism=Escherichia coli, GI1790573, Length=677, Percent_Identity=54.9483013293944, Blast_Score=798, Evalue=0.0,
Organism=Escherichia coli, GI1786384, Length=670, Percent_Identity=50.8955223880597, Blast_Score=749, Evalue=0.0,
Organism=Escherichia coli, GI221142684, Length=698, Percent_Identity=34.8137535816619, Blast_Score=456, Evalue=1e-129,
Organism=Escherichia coli, GI87082193, Length=722, Percent_Identity=31.8559556786704, Blast_Score=331, Evalue=8e-92,
Organism=Escherichia coli, GI1786909, Length=609, Percent_Identity=31.3628899835796, Blast_Score=295, Evalue=5e-81,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005308
- InterPro:   IPR011193
- InterPro:   IPR000310
- InterPro:   IPR008286
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01276 OKR_DC_1; PF03711 OKR_DC_1_C; PF03709 OKR_DC_1_N [H]

EC number: =4.1.1.18 [H]

Molecular weight: Translated: 81894; Mature: 81894

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00703 OKR_DC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTVVFVYKDTLKSYKEKFLLKIEKDLKNHHEYYTLKLDDLSEVVEILEENSRICCIVLD
CCEEEEEEHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHCCCCEEEEEEE
RASFNIEAFHNIAHLNTKLPIFVASDYSQSIKLNLRDFNLNINFLQYDALAGEDSDFIHK
CCCCCHHHHHHHHHCCCCCEEEEECCCCCEEEEEEEEEEEEEEEEEEECCCCCCCHHHHH
TITNYFNYILPPLTYELFKYSKSFNSAFCTPGHQGGYGFQRSAVGALFYDFYGENIFKTD
HHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEECC
LSISMKELGSLLDHSEAHKDAEEYISKVFKSDRSLIVTNGTSTANKIVGMYSVADGDTIL
CCEEHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEECCCCCHHHEEEEEEECCCCEEE
VDRNCHKSVTHLMMMVDVNPIYLKPTRNAYGIIGGIPKKEFKRETIQEKIDNSNIADKWP
EECCCHHHHHHEEEEEECCEEEEEECCCCCEEECCCCHHHHHHHHHHHHHCCCCCCCCCC
EYAVVTNSTYDGILYNTDTIHRELDVKKLHFDSAWIPYAIFHPIYKHKSAMQIEPRPEHI
CEEEEECCCCCCEEECCHHHHHHCCCEEEECCCCCCCHHHHHHHHHCCCCEEECCCCCEE
IFETQSTHKLLAAFSQSSMLHIKGDYNEEVLNEAFMLHTSTSPFYPIVASVETAAAMMEG
EEECCCHHHHHHHHCCCCEEEEECCCCHHHHHCEEEEEECCCCCCHHHHHHHHHHHHHCC
EQGYNLIDKTINLAIDFRRELIKLRSEANGWFFDVWQPDNISNKEAWLLRNGDKWHGFKN
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEECCCCCCCCCC
VDGDFLSLDPIKITILTPGIKDNDVQDWGVPADVVAKFLDEHDIVVEKSGPYSLLFIFSL
CCCCEEEECCEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCCEEEECCCCEEEEEEEEC
GTTKAKSVRLISVLNKFKQMYDENTLVEKMLPTLYAEDPKFYEDMRIQEVSERLHQYMKE
CCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
ANLPNLMYHAFNVLPEQQLNPHRAFQKLLKGKVKKVPLVELYEHTSAVMILPYPPGIPVI
CCCCHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHCCCCEEEEEECCCCCCEE
FPGEKITEESKVILDFLLMLEKIGSMLPGFDTDIHGPERAKDGKLYIKVIDDK
ECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCC
>Mature Secondary Structure
MKTVVFVYKDTLKSYKEKFLLKIEKDLKNHHEYYTLKLDDLSEVVEILEENSRICCIVLD
CCEEEEEEHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHCCCCEEEEEEE
RASFNIEAFHNIAHLNTKLPIFVASDYSQSIKLNLRDFNLNINFLQYDALAGEDSDFIHK
CCCCCHHHHHHHHHCCCCCEEEEECCCCCEEEEEEEEEEEEEEEEEEECCCCCCCHHHHH
TITNYFNYILPPLTYELFKYSKSFNSAFCTPGHQGGYGFQRSAVGALFYDFYGENIFKTD
HHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEECC
LSISMKELGSLLDHSEAHKDAEEYISKVFKSDRSLIVTNGTSTANKIVGMYSVADGDTIL
CCEEHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEECCCCCHHHEEEEEEECCCCEEE
VDRNCHKSVTHLMMMVDVNPIYLKPTRNAYGIIGGIPKKEFKRETIQEKIDNSNIADKWP
EECCCHHHHHHEEEEEECCEEEEEECCCCCEEECCCCHHHHHHHHHHHHHCCCCCCCCCC
EYAVVTNSTYDGILYNTDTIHRELDVKKLHFDSAWIPYAIFHPIYKHKSAMQIEPRPEHI
CEEEEECCCCCCEEECCHHHHHHCCCEEEECCCCCCCHHHHHHHHHCCCCEEECCCCCEE
IFETQSTHKLLAAFSQSSMLHIKGDYNEEVLNEAFMLHTSTSPFYPIVASVETAAAMMEG
EEECCCHHHHHHHHCCCCEEEEECCCCHHHHHCEEEEEECCCCCCHHHHHHHHHHHHHCC
EQGYNLIDKTINLAIDFRRELIKLRSEANGWFFDVWQPDNISNKEAWLLRNGDKWHGFKN
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEECCCCCCCCCC
VDGDFLSLDPIKITILTPGIKDNDVQDWGVPADVVAKFLDEHDIVVEKSGPYSLLFIFSL
CCCCEEEECCEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCCEEEECCCCEEEEEEEEC
GTTKAKSVRLISVLNKFKQMYDENTLVEKMLPTLYAEDPKFYEDMRIQEVSERLHQYMKE
CCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
ANLPNLMYHAFNVLPEQQLNPHRAFQKLLKGKVKKVPLVELYEHTSAVMILPYPPGIPVI
CCCCHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHCCCCEEEEEECCCCCCEE
FPGEKITEESKVILDFLLMLEKIGSMLPGFDTDIHGPERAKDGKLYIKVIDDK
ECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]