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The map label for this gene is thrC [H]

Identifier: 134302490

GI number: 134302490

Start: 1548164

End: 1549399

Strand: Reverse

Name: thrC [H]

Synonym: FTW_1646

Alternate gene names: 134302490

Gene position: 1549399-1548164 (Counterclockwise)

Preceding gene: 134302491

Following gene: 134302488

Centisome position: 81.61

GC content: 34.71

Gene sequence:

>1236_bases
ATGAATTTTATTAGTACTAGAGATAAAAATATTAAAGTTTCACTAAGTGAAGCGATGCAGTCTGGATTAGCTCCTGATGG
AGGATTATTTGTCCTAGAGAGATTTCCTACAGTTAATTGGCAGAGTTTTGCTAAAGATATCAGTTACGCGAAGTTTGCTG
CTAATACTCTAAGAGAATTCTTTAAAGGAGATCAGCTAGAAGACTCTTTAGATAAAATTTGTAATAATGCTTTTACTTTT
GAGGCTCCTGTAAGAAGATTAGATAAAACCACATCAGTTTTAGAGCTTTTTCATGGTCCAACTTTATCTTTTAAAGATTT
CGGTGCGAGATTTTTAGCAAACTGTTTAAGCTCTATCGATAGTGAGAAGCCATTTACTATTTTAGTGGCAACTTCTGGAG
ATACAGGTTCAGCAGTAGCTGCAGCTTTTCATGGTAAGAGCAATATCCGTGTTATAGTGATGTTTCCTAAAGGTAAAATC
TCTAAAAGACAAGAAAAGCAGATAACTTGTTGGGGAGATAATATCCAAGCAGTTGAAGTTGAAGGAGTTTTTGATGACTG
TCAAAGTCTAGTCAAAGAAGCTTTTAAGACACCTTGGTGGACAGAGAGGACTAAGTTAAATACATCAAATAGTATTAATA
TCGGTAGATTACTACCACAATCAACTTATTATGCTTATACATCGTGGCAACATTATTTGCAGACCGGAGAGAAAGCAAAC
TATATAGTTCCATCTGGCAATATTGGTAATATAACTGCTGCTTTTTGGGCAAAGCAAATGGGCTTTCCAATAGGTGAAAT
ATCGATGAGTTTAAATGCTAATGATACTGTTGTTGACTATCTAGAGACTGGTAAGTTTAATCCTAAGGCAAGTGTTGAAA
CGCTAGCAAATGCTATGGATGTTGGTAACCCTAGTAATTTTGAAAGATTGTTATACTTGTTGGGTAATTATGAAAATTTC
AAAGCTAATGTTAAGGCTATATGTGTTTCTGACTTTGAAATTATAGAAGAAATAAAACAAGTGTATCGTCAATATCATGA
AGTTGTTTGTCCACACACAACAACAGGTTTTGTAGCAAAAAATCAGTTAGATAGCAATAAAGATTATATAATCGTAGCAA
CTGCACATCCTGCTAAGTTTGAAAGTGTAATTGAGCCTATATTAGATATACAAGTGCCGCCTACACCGGCGTTACAAAAG
CTTTTGAAGCTTAGCTTAAAAGCGGATGTGATCTGA

Upstream 100 bases:

>100_bases
AGATAAGTTTAAAGAGTTTAACTTAAACTCTAATAGTTGGATAAGTGCTATGAGTGACAAAGACGCGTATATATTAGAGA
AAAAATGATAAAGGTAAAGC

Downstream 100 bases:

>100_bases
TTTTCAGGTCTTTCTTTAACAATAAAAGGTATTACTGCTATAGTGGGAACTATTAAGAGCAAGCAGACAACAATACAACT
AAGTTGCTATAGGGGTTCCT

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 411; Mature: 411

Protein sequence:

>411_residues
MNFISTRDKNIKVSLSEAMQSGLAPDGGLFVLERFPTVNWQSFAKDISYAKFAANTLREFFKGDQLEDSLDKICNNAFTF
EAPVRRLDKTTSVLELFHGPTLSFKDFGARFLANCLSSIDSEKPFTILVATSGDTGSAVAAAFHGKSNIRVIVMFPKGKI
SKRQEKQITCWGDNIQAVEVEGVFDDCQSLVKEAFKTPWWTERTKLNTSNSINIGRLLPQSTYYAYTSWQHYLQTGEKAN
YIVPSGNIGNITAAFWAKQMGFPIGEISMSLNANDTVVDYLETGKFNPKASVETLANAMDVGNPSNFERLLYLLGNYENF
KANVKAICVSDFEIIEEIKQVYRQYHEVVCPHTTTGFVAKNQLDSNKDYIIVATAHPAKFESVIEPILDIQVPPTPALQK
LLKLSLKADVI

Sequences:

>Translated_411_residues
MNFISTRDKNIKVSLSEAMQSGLAPDGGLFVLERFPTVNWQSFAKDISYAKFAANTLREFFKGDQLEDSLDKICNNAFTF
EAPVRRLDKTTSVLELFHGPTLSFKDFGARFLANCLSSIDSEKPFTILVATSGDTGSAVAAAFHGKSNIRVIVMFPKGKI
SKRQEKQITCWGDNIQAVEVEGVFDDCQSLVKEAFKTPWWTERTKLNTSNSINIGRLLPQSTYYAYTSWQHYLQTGEKAN
YIVPSGNIGNITAAFWAKQMGFPIGEISMSLNANDTVVDYLETGKFNPKASVETLANAMDVGNPSNFERLLYLLGNYENF
KANVKAICVSDFEIIEEIKQVYRQYHEVVCPHTTTGFVAKNQLDSNKDYIIVATAHPAKFESVIEPILDIQVPPTPALQK
LLKLSLKADVI
>Mature_411_residues
MNFISTRDKNIKVSLSEAMQSGLAPDGGLFVLERFPTVNWQSFAKDISYAKFAANTLREFFKGDQLEDSLDKICNNAFTF
EAPVRRLDKTTSVLELFHGPTLSFKDFGARFLANCLSSIDSEKPFTILVATSGDTGSAVAAAFHGKSNIRVIVMFPKGKI
SKRQEKQITCWGDNIQAVEVEGVFDDCQSLVKEAFKTPWWTERTKLNTSNSINIGRLLPQSTYYAYTSWQHYLQTGEKAN
YIVPSGNIGNITAAFWAKQMGFPIGEISMSLNANDTVVDYLETGKFNPKASVETLANAMDVGNPSNFERLLYLLGNYENF
KANVKAICVSDFEIIEEIKQVYRQYHEVVCPHTTTGFVAKNQLDSNKDYIIVATAHPAKFESVIEPILDIQVPPTPALQK
LLKLSLKADVI

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI153792148, Length=455, Percent_Identity=32.967032967033, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI149193323, Length=449, Percent_Identity=30.2895322939866, Blast_Score=165, Evalue=7e-41,
Organism=Escherichia coli, GI1786185, Length=396, Percent_Identity=38.1313131313131, Blast_Score=253, Evalue=2e-68,
Organism=Saccharomyces cerevisiae, GI6319901, Length=452, Percent_Identity=32.5221238938053, Blast_Score=211, Evalue=1e-55,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 45842; Mature: 45842

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFISTRDKNIKVSLSEAMQSGLAPDGGLFVLERFPTVNWQSFAKDISYAKFAANTLREF
CCCCCCCCCCEEEEHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
FKGDQLEDSLDKICNNAFTFEAPVRRLDKTTSVLELFHGPTLSFKDFGARFLANCLSSID
HCCCCHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCC
SEKPFTILVATSGDTGSAVAAAFHGKSNIRVIVMFPKGKISKRQEKQITCWGDNIQAVEV
CCCCEEEEEEECCCCCCCEEEEEECCCCCEEEEEECCCCCCCCCCCEEEEECCCEEEEEE
EGVFDDCQSLVKEAFKTPWWTERTKLNTSNSINIGRLLPQSTYYAYTSWQHYLQTGEKAN
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCCCCCEEEEHHHHHHHHCCCCCC
YIVPSGNIGNITAAFWAKQMGFPIGEISMSLNANDTVVDYLETGKFNPKASVETLANAMD
EEECCCCCCCHHHHHHHHHHCCCHHHEEEECCCCCHHHHHHHCCCCCCCHHHHHHHHHHC
VGNPSNFERLLYLLGNYENFKANVKAICVSDFEIIEEIKQVYRQYHEVVCPHTTTGFVAK
CCCCCCHHHHHHHHCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHEECCCCCCCCEEE
NQLDSNKDYIIVATAHPAKFESVIEPILDIQVPPTPALQKLLKLSLKADVI
CCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNFISTRDKNIKVSLSEAMQSGLAPDGGLFVLERFPTVNWQSFAKDISYAKFAANTLREF
CCCCCCCCCCEEEEHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
FKGDQLEDSLDKICNNAFTFEAPVRRLDKTTSVLELFHGPTLSFKDFGARFLANCLSSID
HCCCCHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCC
SEKPFTILVATSGDTGSAVAAAFHGKSNIRVIVMFPKGKISKRQEKQITCWGDNIQAVEV
CCCCEEEEEEECCCCCCCEEEEEECCCCCEEEEEECCCCCCCCCCCEEEEECCCEEEEEE
EGVFDDCQSLVKEAFKTPWWTERTKLNTSNSINIGRLLPQSTYYAYTSWQHYLQTGEKAN
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCCCCCEEEEHHHHHHHHCCCCCC
YIVPSGNIGNITAAFWAKQMGFPIGEISMSLNANDTVVDYLETGKFNPKASVETLANAMD
EEECCCCCCCHHHHHHHHHHCCCHHHEEEECCCCCHHHHHHHCCCCCCCHHHHHHHHHHC
VGNPSNFERLLYLLGNYENFKANVKAICVSDFEIIEEIKQVYRQYHEVVCPHTTTGFVAK
CCCCCCHHHHHHHHCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHEECCCCCCCCEEE
NQLDSNKDYIIVATAHPAKFESVIEPILDIQVPPTPALQKLLKLSLKADVI
CCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]