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The map label for this gene is thrB [H]

Identifier: 134302491

GI number: 134302491

Start: 1549412

End: 1550365

Strand: Reverse

Name: thrB [H]

Synonym: FTW_1647

Alternate gene names: 134302491

Gene position: 1550365-1549412 (Counterclockwise)

Preceding gene: 134302492

Following gene: 134302490

Centisome position: 81.66

GC content: 34.49

Gene sequence:

>954_bases
ATGAAATTAGCTAATATTAAATCAGCTAAGGCATTTGCTCCAGCAACTAGTGCAAATTTTGCAGTTGGTTATGATTTGCT
TGGTTTTGCTATTGATGGAGTTGGTGATATAGTTGAGCTTATCAAAAGAGATGATACAGAGTTAGTTATCAAGCAAATCA
GTGGTGCAACTGGTGCAGATAAATTACCTTTTGATAGTGATAAAAATGTTGCTACAGCTGTAATCAAAAAATTTCTAGCA
GATAGGGATATCAAAATAGGATTCGATGTTTATATACAAAAAGGCATTACTTTAGGTTCTGGTATGGGTGGTTCAGCAGC
TTCTTCTGTTGCTGCTCTAGTCGCGATGAATGCTTTTTTTGAAACACCGTATAACTATGATGATTTGATTGACTATGCTA
TCTATGGAGAGAGTTTGATATCAGGATCATTTCACGGTGATAATGCTGTGCCGTGCATGTTTGGCGGATTAGTATTGTTA
CAAAGCTCGAAACCATGCAAAAAAATAGACTTACCAATAGTTGACTGTAATGTGGTTATAGTTTGTCCTGATCTTTCAAT
TGAGACTAAAAAAGCGCGTGAGCTTTTAAAGGATCCTTATGATTTATCTACAATAGTTGAGCATAGTGCATGTTTAGCGG
CTACGATAAGTGCTTTGTATACACAAGATATTGAATTATTAGGTCAGAGTTTAAAAGACATTTTAATTGAACCAAGAAGA
TCTAAGTTAATAACTGGATTTTATGATGTTCAAAAAGCTGCTTATGCTACTGGAGCTATAGCTTGTGGTATATCAGGATC
TGGACCAACGATGTTTGCACTTGTAAGAAAACAACATGATGCAAATATAGTTACTAAAGCAATGCAAGATAAGTTTAAAG
AGTTTAACTTAAACTCTAATAGTTGGATAAGTGCTATGAGTGACAAAGACGCGTATATATTAGAGAAAAAATGA

Upstream 100 bases:

>100_bases
ATACTCAGCCTATGGTTATCCAAGGTGCTGGTGCGGGTGTTGAGGTTACAGCAGCAGGTGTATATGCTGATGTTATAACT
GTGATAAGAGAAAAATAGTC

Downstream 100 bases:

>100_bases
TAAAGGTAAAGCATGAATTTTATTAGTACTAGAGATAAAAATATTAAAGTTTCACTAAGTGAAGCGATGCAGTCTGGATT
AGCTCCTGATGGAGGATTAT

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK [H]

Number of amino acids: Translated: 317; Mature: 317

Protein sequence:

>317_residues
MKLANIKSAKAFAPATSANFAVGYDLLGFAIDGVGDIVELIKRDDTELVIKQISGATGADKLPFDSDKNVATAVIKKFLA
DRDIKIGFDVYIQKGITLGSGMGGSAASSVAALVAMNAFFETPYNYDDLIDYAIYGESLISGSFHGDNAVPCMFGGLVLL
QSSKPCKKIDLPIVDCNVVIVCPDLSIETKKARELLKDPYDLSTIVEHSACLAATISALYTQDIELLGQSLKDILIEPRR
SKLITGFYDVQKAAYATGAIACGISGSGPTMFALVRKQHDANIVTKAMQDKFKEFNLNSNSWISAMSDKDAYILEKK

Sequences:

>Translated_317_residues
MKLANIKSAKAFAPATSANFAVGYDLLGFAIDGVGDIVELIKRDDTELVIKQISGATGADKLPFDSDKNVATAVIKKFLA
DRDIKIGFDVYIQKGITLGSGMGGSAASSVAALVAMNAFFETPYNYDDLIDYAIYGESLISGSFHGDNAVPCMFGGLVLL
QSSKPCKKIDLPIVDCNVVIVCPDLSIETKKARELLKDPYDLSTIVEHSACLAATISALYTQDIELLGQSLKDILIEPRR
SKLITGFYDVQKAAYATGAIACGISGSGPTMFALVRKQHDANIVTKAMQDKFKEFNLNSNSWISAMSDKDAYILEKK
>Mature_317_residues
MKLANIKSAKAFAPATSANFAVGYDLLGFAIDGVGDIVELIKRDDTELVIKQISGATGADKLPFDSDKNVATAVIKKFLA
DRDIKIGFDVYIQKGITLGSGMGGSAASSVAALVAMNAFFETPYNYDDLIDYAIYGESLISGSFHGDNAVPCMFGGLVLL
QSSKPCKKIDLPIVDCNVVIVCPDLSIETKKARELLKDPYDLSTIVEHSACLAATISALYTQDIELLGQSLKDILIEPRR
SKLITGFYDVQKAAYATGAIACGISGSGPTMFALVRKQHDANIVTKAMQDKFKEFNLNSNSWISAMSDKDAYILEKK

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate [H]

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786184, Length=281, Percent_Identity=35.9430604982206, Blast_Score=160, Evalue=9e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.39 [H]

Molecular weight: Translated: 34096; Mature: 34096

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLANIKSAKAFAPATSANFAVGYDLLGFAIDGVGDIVELIKRDDTELVIKQISGATGAD
CCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHCCCCCCC
KLPFDSDKNVATAVIKKFLADRDIKIGFDVYIQKGITLGSGMGGSAASSVAALVAMNAFF
CCCCCCCCHHHHHHHHHHHCCCCCEECCEEEEECCEEECCCCCCHHHHHHHHHHHHHHHH
ETPYNYDDLIDYAIYGESLISGSFHGDNAVPCMFGGLVLLQSSKPCKKIDLPIVDCNVVI
CCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCEEEEECCCCCCCCCCEEEECEEEE
VCPDLSIETKKARELLKDPYDLSTIVEHSACLAATISALYTQDIELLGQSLKDILIEPRR
ECCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
SKLITGFYDVQKAAYATGAIACGISGSGPTMFALVRKQHDANIVTKAMQDKFKEFNLNSN
HHEEHHHHHHHHHHHHCCEEEECCCCCCCCEEEEHHHHHCHHHHHHHHHHHHHHCCCCCC
SWISAMSDKDAYILEKK
CEEEECCCCCCEEEECC
>Mature Secondary Structure
MKLANIKSAKAFAPATSANFAVGYDLLGFAIDGVGDIVELIKRDDTELVIKQISGATGAD
CCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHCCCCCCC
KLPFDSDKNVATAVIKKFLADRDIKIGFDVYIQKGITLGSGMGGSAASSVAALVAMNAFF
CCCCCCCCHHHHHHHHHHHCCCCCEECCEEEEECCEEECCCCCCHHHHHHHHHHHHHHHH
ETPYNYDDLIDYAIYGESLISGSFHGDNAVPCMFGGLVLLQSSKPCKKIDLPIVDCNVVI
CCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCEEEEECCCCCCCCCCEEEECEEEE
VCPDLSIETKKARELLKDPYDLSTIVEHSACLAATISALYTQDIELLGQSLKDILIEPRR
ECCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
SKLITGFYDVQKAAYATGAIACGISGSGPTMFALVRKQHDANIVTKAMQDKFKEFNLNSN
HHEEHHHHHHHHHHHHCCEEEECCCCCCCCEEEEHHHHHCHHHHHHHHHHHHHHCCCCCC
SWISAMSDKDAYILEKK
CEEEECCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA