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The map label for this gene is hemH [H]

Identifier: 134302128

GI number: 134302128

Start: 1111182

End: 1112183

Strand: Direct

Name: hemH [H]

Synonym: FTW_1172

Alternate gene names: 134302128

Gene position: 1111182-1112183 (Clockwise)

Preceding gene: 134302125

Following gene: 134302129

Centisome position: 58.53

GC content: 29.44

Gene sequence:

>1002_bases
ATGCAACAATATAGCAGCAAATATAACAAACAAGCTATTCTATTAGTCAATCTTGGAACTCCAGACAATTATGATACTAA
ATCTATAAAAAGATATTTAAAAGAATTTCTATCTGACCCTAGAGTAATAGAAGCCAACCCTGTATTATGGAAAATAATCT
TAAACTTGATCATTTTACCAATTCGTGCTAAAAAAAATGTTCATACTTATAAAACTGTTTGGAATAAACAACATAACAAA
TCTCCACTATTATTCTACACAGAAAATTTAGCAGATAAATTGGATAAAAAACTAGATAACTATATCGTTGATTATGCTAT
GCGTTATGGCAATCCAAGTATAGAAAGTAAAATTAAAAGCTTACAAGATCAAGGCGCTACTGAAATAATAATATTTCCAC
TGTATCCCCAATATTCTGCTACTACTACAGCAACAGTATATGATGAGGTTTATAGAGTTTTATCAAAACTAAGATGGCAA
CCTACTATTAAGGGAATAAATCCTTATTATGATAATAAGTTTCATATTCAGACTATTTCTCAACAGATAAAAGAACATCT
AAAAAAGCTAGATAGTACTCCTGATACTGTTTTGTTTTCATTTCATGGTTTACCAAAAGAATATTTTGATAAAGGCGACC
CTTACTACTGTCACTGCTACAAAACTTATCGTTTAGTCAAAGAAGAATTACAAAACGAATATCCTAATATAGATTTTGAA
CTATCCTTCCAATCTCGCTTTGGACCTAAGAAGTGGTTAGAACCATATACTACCGTAAAGTTAGAAGAATTTGCTAAGCA
AAATAAGAGTGTAGTCGTTATTGCTCCAGGATTTAGTGCTGATTGTTTGGAGACATTAGAAGAGTTAGCAATTTCTGAAA
AAGAAAATTTCATTAAAAAAGGTGGTAAAGAATTTAGTCTAATACCATGTTTAAATGATTCTAATCAACATGTCGATATG
TTATACAATATAATAGATGAGGAAATATGTCTAAAAAAATAG

Upstream 100 bases:

>100_bases
TTATAACTTGTTTATAGACTTATATGAAAAAAAATTAACTTTGGTAACGAGATTATTTGCTAAAATTACTTTTAGATTAT
AAATTAAAATTAGTAAAAAT

Downstream 100 bases:

>100_bases
CTATACATTGGTTTCGTCAAGATTTACGCTTAGCAGACAATCCTGCTCTATATCAGGTTAGTCAAGCCGATGAAACAATT
ACAATATTTATACTAGATAA

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MQQYSSKYNKQAILLVNLGTPDNYDTKSIKRYLKEFLSDPRVIEANPVLWKIILNLIILPIRAKKNVHTYKTVWNKQHNK
SPLLFYTENLADKLDKKLDNYIVDYAMRYGNPSIESKIKSLQDQGATEIIIFPLYPQYSATTTATVYDEVYRVLSKLRWQ
PTIKGINPYYDNKFHIQTISQQIKEHLKKLDSTPDTVLFSFHGLPKEYFDKGDPYYCHCYKTYRLVKEELQNEYPNIDFE
LSFQSRFGPKKWLEPYTTVKLEEFAKQNKSVVVIAPGFSADCLETLEELAISEKENFIKKGGKEFSLIPCLNDSNQHVDM
LYNIIDEEICLKK

Sequences:

>Translated_333_residues
MQQYSSKYNKQAILLVNLGTPDNYDTKSIKRYLKEFLSDPRVIEANPVLWKIILNLIILPIRAKKNVHTYKTVWNKQHNK
SPLLFYTENLADKLDKKLDNYIVDYAMRYGNPSIESKIKSLQDQGATEIIIFPLYPQYSATTTATVYDEVYRVLSKLRWQ
PTIKGINPYYDNKFHIQTISQQIKEHLKKLDSTPDTVLFSFHGLPKEYFDKGDPYYCHCYKTYRLVKEELQNEYPNIDFE
LSFQSRFGPKKWLEPYTTVKLEEFAKQNKSVVVIAPGFSADCLETLEELAISEKENFIKKGGKEFSLIPCLNDSNQHVDM
LYNIIDEEICLKK
>Mature_333_residues
MQQYSSKYNKQAILLVNLGTPDNYDTKSIKRYLKEFLSDPRVIEANPVLWKIILNLIILPIRAKKNVHTYKTVWNKQHNK
SPLLFYTENLADKLDKKLDNYIVDYAMRYGNPSIESKIKSLQDQGATEIIIFPLYPQYSATTTATVYDEVYRVLSKLRWQ
PTIKGINPYYDNKFHIQTISQQIKEHLKKLDSTPDTVLFSFHGLPKEYFDKGDPYYCHCYKTYRLVKEELQNEYPNIDFE
LSFQSRFGPKKWLEPYTTVKLEEFAKQNKSVVVIAPGFSADCLETLEELAISEKENFIKKGGKEFSLIPCLNDSNQHVDM
LYNIIDEEICLKK

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499025, Length=315, Percent_Identity=28.2539682539683, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI60499021, Length=315, Percent_Identity=28.2539682539683, Blast_Score=103, Evalue=2e-22,
Organism=Escherichia coli, GI1786681, Length=320, Percent_Identity=38.125, Blast_Score=240, Evalue=1e-64,
Organism=Saccharomyces cerevisiae, GI6324750, Length=315, Percent_Identity=26.3492063492064, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI17864156, Length=347, Percent_Identity=24.7838616714697, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI24651774, Length=273, Percent_Identity=24.9084249084249, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI45552018, Length=159, Percent_Identity=28.9308176100629, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 39020; Mature: 39020

Theoretical pI: Translated: 8.38; Mature: 8.38

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQYSSKYNKQAILLVNLGTPDNYDTKSIKRYLKEFLSDPRVIEANPVLWKIILNLIILP
CCCHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHC
IRAKKNVHTYKTVWNKQHNKSPLLFYTENLADKLDKKLDNYIVDYAMRYGNPSIESKIKS
CCCCCCCHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
LQDQGATEIIIFPLYPQYSATTTATVYDEVYRVLSKLRWQPTIKGINPYYDNKFHIQTIS
HHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEHHHHHH
QQIKEHLKKLDSTPDTVLFSFHGLPKEYFDKGDPYYCHCYKTYRLVKEELQNEYPNIDFE
HHHHHHHHHHCCCCCEEEEEECCCCHHHHCCCCCEEEEHHHHHHHHHHHHHHHCCCCEEE
LSFQSRFGPKKWLEPYTTVKLEEFAKQNKSVVVIAPGFSADCLETLEELAISEKENFIKK
EEEHHCCCCHHHCCCHHHEEHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHC
GGKEFSLIPCLNDSNQHVDMLYNIIDEEICLKK
CCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQQYSSKYNKQAILLVNLGTPDNYDTKSIKRYLKEFLSDPRVIEANPVLWKIILNLIILP
CCCHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHC
IRAKKNVHTYKTVWNKQHNKSPLLFYTENLADKLDKKLDNYIVDYAMRYGNPSIESKIKS
CCCCCCCHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
LQDQGATEIIIFPLYPQYSATTTATVYDEVYRVLSKLRWQPTIKGINPYYDNKFHIQTIS
HHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEHHHHHH
QQIKEHLKKLDSTPDTVLFSFHGLPKEYFDKGDPYYCHCYKTYRLVKEELQNEYPNIDFE
HHHHHHHHHHCCCCCEEEEEECCCCHHHHCCCCCEEEEHHHHHHHHHHHHHHHCCCCEEE
LSFQSRFGPKKWLEPYTTVKLEEFAKQNKSVVVIAPGFSADCLETLEELAISEKENFIKK
EEEHHCCCCHHHCCCHHHEEHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHC
GGKEFSLIPCLNDSNQHVDMLYNIIDEEICLKK
CCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA