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The map label for this gene is phrB1 [H]

Identifier: 134302129

GI number: 134302129

Start: 1112168

End: 1113562

Strand: Direct

Name: phrB1 [H]

Synonym: FTW_1173

Alternate gene names: 134302129

Gene position: 1112168-1113562 (Clockwise)

Preceding gene: 134302128

Following gene: 134302131

Centisome position: 58.58

GC content: 31.68

Gene sequence:

>1395_bases
ATGTCTAAAAAAATAGCTATACATTGGTTTCGTCAAGATTTACGCTTAGCAGACAATCCTGCTCTATATCAGGTTAGTCA
AGCCGATGAAACAATTACAATATTTATACTAGATAAAAATCAAGATATAGGTAGTGCAAGTAAACTTTGGCTACACCATT
CTTTGAATAGCTTAAATAGTTCTCTAGACAATAAACTTAACTTTTATAGTGGTAACCCTCTAGAAATTATAAAAAAAATT
ATCAAAGAAAATAACATTACAGACTTCTATTGGAATAGATGTTATGACAAGTACAGTATAGATAGAGATACCCAGATTAA
ACAGTTTCTGCAACAACATAAAATAAATGTAAATAGCTTTAATGGTAGTTTACTTATAGAGCCATGGCAATGCAAAAAAG
ATGATGGTACGCACTATAAAGTTTACACTCCATTTTATAAAGAGCTTATCAAAATAAGAAAATATCGATCAAATATTGCT
AAACCAAATTTTAGTTATCTAAGAAAGCTTAATAATTCTGAAAATTTAGACTCATTAAAACTAATAGAACCAAAACACTC
TTGGCAAAATATAATAAAACAATGGCAAATTGGTGAAAGTGCTTCTCACCAAATACTTGAGGAGTTTTTAGATAATAAAG
TAAAAGAATACAAAACAGCTAGAGACTTCATGAGCACAGACTCAACATCTAAATTATCGCCATACCTTCATTTCGGTGAG
ATATCTCCTAACCAAATTTTTAATGCTGTACAAAGTTTAGACTATATTGGTAACAATGAAGAGCATTTTATCAAAGAGTT
AGTTTGGCGTGATTTTTCTTATTATCAAATATATTATTATCCAGAATTACACAACAAGAATATCAACCAAAAATTTGATA
GTTTTAAATGGGATAATGATCCTACTCTTCTCAAGAAATGGCAAAAAGGACAGACTGGCATTCCAATAGTAGATGCTGGA
ATGAGAGAACTTTGGCAGGCTGGCTATATGCACAATCGCGTACGGATGATTGTTGCTAGTTTTCTTATCAAAAACTGTCT
TATCCATTGGAAGTATGGTGAAAAATGGTTTTTTGATACCTTATTTGATGCTGACTTTGCAAGTAATAACGCTAACTGGC
AATGGGTAGCAGGCTGTGGTTTAGATGCAGCACCCTATTTTAGAATTTTTAACCCAGTGTTACAAGCTGAAAAATTTGAA
GCTTATGAGTATATCCGTAAATATGTACCAGAATTAAAGCTTTTGCCCAATAAATTAATTGCCAAACCATGGGAAGCTAG
TGAGCTAGTATTACAAGAAGCTGGTATCACACTAGGTCAGAACTATCCAAAACCAATAGTAGATCTGAAAAAATCTCGTG
ACAGAGCTTTACAATTACATAATCAAATAAAGTAA

Upstream 100 bases:

>100_bases
ATTTCATTAAAAAAGGTGGTAAAGAATTTAGTCTAATACCATGTTTAAATGATTCTAATCAACATGTCGATATGTTATAC
AATATAATAGATGAGGAAAT

Downstream 100 bases:

>100_bases
ATTTGACTATCACTTATGAGTAAAGATTATTATAAGGCTATAAAAATTTAGTTTAGAATTTTTGTTTAGAAATTGTCAAA
AATTTATTTTATTATTATTT

Product: deoxyribodipyrimidine photolyase

Products: NA

Alternate protein names: DNA photolyase; Photoreactivating enzyme [H]

Number of amino acids: Translated: 464; Mature: 463

Protein sequence:

>464_residues
MSKKIAIHWFRQDLRLADNPALYQVSQADETITIFILDKNQDIGSASKLWLHHSLNSLNSSLDNKLNFYSGNPLEIIKKI
IKENNITDFYWNRCYDKYSIDRDTQIKQFLQQHKINVNSFNGSLLIEPWQCKKDDGTHYKVYTPFYKELIKIRKYRSNIA
KPNFSYLRKLNNSENLDSLKLIEPKHSWQNIIKQWQIGESASHQILEEFLDNKVKEYKTARDFMSTDSTSKLSPYLHFGE
ISPNQIFNAVQSLDYIGNNEEHFIKELVWRDFSYYQIYYYPELHNKNINQKFDSFKWDNDPTLLKKWQKGQTGIPIVDAG
MRELWQAGYMHNRVRMIVASFLIKNCLIHWKYGEKWFFDTLFDADFASNNANWQWVAGCGLDAAPYFRIFNPVLQAEKFE
AYEYIRKYVPELKLLPNKLIAKPWEASELVLQEAGITLGQNYPKPIVDLKKSRDRALQLHNQIK

Sequences:

>Translated_464_residues
MSKKIAIHWFRQDLRLADNPALYQVSQADETITIFILDKNQDIGSASKLWLHHSLNSLNSSLDNKLNFYSGNPLEIIKKI
IKENNITDFYWNRCYDKYSIDRDTQIKQFLQQHKINVNSFNGSLLIEPWQCKKDDGTHYKVYTPFYKELIKIRKYRSNIA
KPNFSYLRKLNNSENLDSLKLIEPKHSWQNIIKQWQIGESASHQILEEFLDNKVKEYKTARDFMSTDSTSKLSPYLHFGE
ISPNQIFNAVQSLDYIGNNEEHFIKELVWRDFSYYQIYYYPELHNKNINQKFDSFKWDNDPTLLKKWQKGQTGIPIVDAG
MRELWQAGYMHNRVRMIVASFLIKNCLIHWKYGEKWFFDTLFDADFASNNANWQWVAGCGLDAAPYFRIFNPVLQAEKFE
AYEYIRKYVPELKLLPNKLIAKPWEASELVLQEAGITLGQNYPKPIVDLKKSRDRALQLHNQIK
>Mature_463_residues
SKKIAIHWFRQDLRLADNPALYQVSQADETITIFILDKNQDIGSASKLWLHHSLNSLNSSLDNKLNFYSGNPLEIIKKII
KENNITDFYWNRCYDKYSIDRDTQIKQFLQQHKINVNSFNGSLLIEPWQCKKDDGTHYKVYTPFYKELIKIRKYRSNIAK
PNFSYLRKLNNSENLDSLKLIEPKHSWQNIIKQWQIGESASHQILEEFLDNKVKEYKTARDFMSTDSTSKLSPYLHFGEI
SPNQIFNAVQSLDYIGNNEEHFIKELVWRDFSYYQIYYYPELHNKNINQKFDSFKWDNDPTLLKKWQKGQTGIPIVDAGM
RELWQAGYMHNRVRMIVASFLIKNCLIHWKYGEKWFFDTLFDADFASNNANWQWVAGCGLDAAPYFRIFNPVLQAEKFEA
YEYIRKYVPELKLLPNKLIAKPWEASELVLQEAGITLGQNYPKPIVDLKKSRDRALQLHNQIK

Specific function: Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ul

COG id: COG0415

COG function: function code L; Deoxyribodipyrimidine photolyase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DNA photolyase domain [H]

Homologues:

Organism=Homo sapiens, GI188536100, Length=488, Percent_Identity=26.844262295082, Blast_Score=176, Evalue=6e-44,
Organism=Homo sapiens, GI4758072, Length=489, Percent_Identity=28.4253578732106, Blast_Score=168, Evalue=8e-42,
Organism=Homo sapiens, GI188536103, Length=445, Percent_Identity=26.0674157303371, Blast_Score=149, Evalue=5e-36,
Organism=Escherichia coli, GI1786926, Length=484, Percent_Identity=34.7107438016529, Blast_Score=279, Evalue=3e-76,
Organism=Saccharomyces cerevisiae, GI6324962, Length=514, Percent_Identity=31.1284046692607, Blast_Score=217, Evalue=4e-57,
Organism=Drosophila melanogaster, GI17137248, Length=484, Percent_Identity=30.1652892561983, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24585455, Length=484, Percent_Identity=30.1652892561983, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24648152, Length=510, Percent_Identity=25.0980392156863, Blast_Score=136, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002081
- InterPro:   IPR018394
- InterPro:   IPR006050
- InterPro:   IPR005101
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00875 DNA_photolyase; PF03441 FAD_binding_7 [H]

EC number: =4.1.99.3 [H]

Molecular weight: Translated: 54932; Mature: 54801

Theoretical pI: Translated: 9.20; Mature: 9.20

Prosite motif: PS00394 DNA_PHOTOLYASES_1_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKKIAIHWFRQDLRLADNPALYQVSQADETITIFILDKNQDIGSASKLWLHHSLNSLNS
CCCCEEEHHHHHHHHCCCCCCEEEEECCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHH
SLDNKLNFYSGNPLEIIKKIIKENNITDFYWNRCYDKYSIDRDTQIKQFLQQHKINVNSF
HHHCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCEEEC
NGSLLIEPWQCKKDDGTHYKVYTPFYKELIKIRKYRSNIAKPNFSYLRKLNNSENLDSLK
CCEEEECCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCEE
LIEPKHSWQNIIKQWQIGESASHQILEEFLDNKVKEYKTARDFMSTDSTSKLSPYLHFGE
EECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECC
ISPNQIFNAVQSLDYIGNNEEHFIKELVWRDFSYYQIYYYPELHNKNINQKFDSFKWDND
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHCCCCCCC
PTLLKKWQKGQTGIPIVDAGMRELWQAGYMHNRVRMIVASFLIKNCLIHWKYGEKWFFDT
HHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHH
LFDADFASNNANWQWVAGCGLDAAPYFRIFNPVLQAEKFEAYEYIRKYVPELKLLPNKLI
HHCCHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCHHHH
AKPWEASELVLQEAGITLGQNYPKPIVDLKKSRDRALQLHNQIK
CCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SKKIAIHWFRQDLRLADNPALYQVSQADETITIFILDKNQDIGSASKLWLHHSLNSLNS
CCCEEEHHHHHHHHCCCCCCEEEEECCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHH
SLDNKLNFYSGNPLEIIKKIIKENNITDFYWNRCYDKYSIDRDTQIKQFLQQHKINVNSF
HHHCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCEEEC
NGSLLIEPWQCKKDDGTHYKVYTPFYKELIKIRKYRSNIAKPNFSYLRKLNNSENLDSLK
CCEEEECCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCEE
LIEPKHSWQNIIKQWQIGESASHQILEEFLDNKVKEYKTARDFMSTDSTSKLSPYLHFGE
EECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECC
ISPNQIFNAVQSLDYIGNNEEHFIKELVWRDFSYYQIYYYPELHNKNINQKFDSFKWDND
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHCCCCCCC
PTLLKKWQKGQTGIPIVDAGMRELWQAGYMHNRVRMIVASFLIKNCLIHWKYGEKWFFDT
HHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHH
LFDADFASNNANWQWVAGCGLDAAPYFRIFNPVLQAEKFEAYEYIRKYVPELKLLPNKLI
HHCCHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCHHHH
AKPWEASELVLQEAGITLGQNYPKPIVDLKKSRDRALQLHNQIK
CCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6325460; 8905232; 9278503; 2200511; 7604260 [H]