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The map label for this gene is panC

Identifier: 134301569

GI number: 134301569

Start: 489287

End: 490072

Strand: Reverse

Name: panC

Synonym: FTW_0498

Alternate gene names: 134301569

Gene position: 490072-489287 (Counterclockwise)

Preceding gene: 134301570

Following gene: 134301568

Centisome position: 25.81

GC content: 30.41

Gene sequence:

>786_bases
ATGATTATTGCTGATAATATTAAACAATTTCATTCAATAAGAAATAGTCTTATTAAACAACAAAAAATAGGTTTTGTACC
TACAATGGGAGCTCTACACAATGGCCATATAAGTCTAATCAAAAAAGCTAAATCAGAAAATGATGTGGTTATTGTAAGTA
TATTTGTAAATCCAACTCAATTTAATAATCCAAATGATTATCAAACATATCCAAACCAACTACAACAAGATATACAAATA
TTAGCATCACTCGACGTTGATGTGTTATTTAACCCTAGTGAGAAAGATATCTACCCAGATGGTAACCTATTGAGAATAGA
ACCAAAGCTTGAAATTGCGAATATTCTAGAAGGTAAATCTAGACCTGGGCATTTCAGTGGCATGCTAACTGTTGTACTAA
AGCTACTACAAATAACTAAACCTAATAATCTGTATTTAGGTGAAAAAGACTATCAACAAGTTATGCTAATCAAACAACTT
GTTAAAGATTTTTTTATCAACACAAAAATCATAGTCTGCCCAACACAAAGACAACCATCTGGCTTACCGCTTAGCTCTAG
AAATAAAAATCTAACTTCTACTGACATAGAGATTGCTAATAAGATATACGAAATACTTAGACAAGATGATTTCTCAAACT
TAGAAGAGCTAACTAATAAGATTAATTCTACTGGTGCAAAACTACAATACATTCAAAAACTTAATAACAGAATATTTTTG
GCATTTTACATTGGTAAAGTACGTTTAATTGATAACTTCCTAAAGGAGACCGGACCATCATGTTAA

Upstream 100 bases:

>100_bases
GTCAAAAAATATATAGACGGCTCAAAGTTATTTTCTGATGCTATAAATACATATGTTAAAGAAACAAAAGCTAATACTTT
TCCTACTAAGGAGCATTGTT

Downstream 100 bases:

>100_bases
TTTCAGTTTTGAAATCAAAAATCTCATACGCTACTGTAACTGGTAAAGATTTATTTTATGTCGGAAGTATCACTATCGAT
AGTGAGATAATGAAACAAGC

Product: pantoate--beta-alanine ligase

Products: NA

Alternate protein names: PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme

Number of amino acids: Translated: 261; Mature: 261

Protein sequence:

>261_residues
MIIADNIKQFHSIRNSLIKQQKIGFVPTMGALHNGHISLIKKAKSENDVVIVSIFVNPTQFNNPNDYQTYPNQLQQDIQI
LASLDVDVLFNPSEKDIYPDGNLLRIEPKLEIANILEGKSRPGHFSGMLTVVLKLLQITKPNNLYLGEKDYQQVMLIKQL
VKDFFINTKIIVCPTQRQPSGLPLSSRNKNLTSTDIEIANKIYEILRQDDFSNLEELTNKINSTGAKLQYIQKLNNRIFL
AFYIGKVRLIDNFLKETGPSC

Sequences:

>Translated_261_residues
MIIADNIKQFHSIRNSLIKQQKIGFVPTMGALHNGHISLIKKAKSENDVVIVSIFVNPTQFNNPNDYQTYPNQLQQDIQI
LASLDVDVLFNPSEKDIYPDGNLLRIEPKLEIANILEGKSRPGHFSGMLTVVLKLLQITKPNNLYLGEKDYQQVMLIKQL
VKDFFINTKIIVCPTQRQPSGLPLSSRNKNLTSTDIEIANKIYEILRQDDFSNLEELTNKINSTGAKLQYIQKLNNRIFL
AFYIGKVRLIDNFLKETGPSC
>Mature_261_residues
MIIADNIKQFHSIRNSLIKQQKIGFVPTMGALHNGHISLIKKAKSENDVVIVSIFVNPTQFNNPNDYQTYPNQLQQDIQI
LASLDVDVLFNPSEKDIYPDGNLLRIEPKLEIANILEGKSRPGHFSGMLTVVLKLLQITKPNNLYLGEKDYQQVMLIKQL
VKDFFINTKIIVCPTQRQPSGLPLSSRNKNLTSTDIEIANKIYEILRQDDFSNLEELTNKINSTGAKLQYIQKLNNRIFL
AFYIGKVRLIDNFLKETGPSC

Specific function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pantothenate synthetase family

Homologues:

Organism=Escherichia coli, GI1786325, Length=270, Percent_Identity=37.7777777777778, Blast_Score=181, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6322046, Length=195, Percent_Identity=44.1025641025641, Blast_Score=163, Evalue=3e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANC_FRAT1 (Q14GL0)

Other databases:

- EMBL:   AM286280
- RefSeq:   YP_667467.1
- ProteinModelPortal:   Q14GL0
- SMR:   Q14GL0
- STRING:   Q14GL0
- GeneID:   4200091
- GenomeReviews:   AM286280_GR
- KEGG:   ftf:FTF1390
- eggNOG:   COG0414
- HOGENOM:   HBG428839
- OMA:   GQASHEE
- PhylomeDB:   Q14GL0
- ProtClustDB:   CLSK935002
- BioCyc:   FTUL393115:FTF1390-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00158
- InterPro:   IPR004821
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00125
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02569 Pantoate_ligase

EC number: =6.3.2.1

Molecular weight: Translated: 29716; Mature: 29716

Theoretical pI: Translated: 9.43; Mature: 9.43

Prosite motif: NA

Important sites: ACT_SITE 36-36 BINDING 60-60 BINDING 60-60 BINDING 153-153

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIADNIKQFHSIRNSLIKQQKIGFVPTMGALHNGHISLIKKAKSENDVVIVSIFVNPTQ
CEECHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCCCEEEEEEEECCCC
FNNPNDYQTYPNQLQQDIQILASLDVDVLFNPSEKDIYPDGNLLRIEPKLEIANILEGKS
CCCCCCCCCCHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCEEEECCCHHHHHHHCCCC
RPGHFSGMLTVVLKLLQITKPNNLYLGEKDYQQVMLIKQLVKDFFINTKIIVCPTQRQPS
CCCHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCC
GLPLSSRNKNLTSTDIEIANKIYEILRQDDFSNLEELTNKINSTGAKLQYIQKLNNRIFL
CCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCEEE
AFYIGKVRLIDNFLKETGPSC
EEEHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MIIADNIKQFHSIRNSLIKQQKIGFVPTMGALHNGHISLIKKAKSENDVVIVSIFVNPTQ
CEECHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCCCEEEEEEEECCCC
FNNPNDYQTYPNQLQQDIQILASLDVDVLFNPSEKDIYPDGNLLRIEPKLEIANILEGKS
CCCCCCCCCCHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCEEEECCCHHHHHHHCCCC
RPGHFSGMLTVVLKLLQITKPNNLYLGEKDYQQVMLIKQLVKDFFINTKIIVCPTQRQPS
CCCHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCC
GLPLSSRNKNLTSTDIEIANKIYEILRQDDFSNLEELTNKINSTGAKLQYIQKLNNRIFL
CCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCEEE
AFYIGKVRLIDNFLKETGPSC
EEEHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA