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The map label for this gene is panB [H]

Identifier: 134301570

GI number: 134301570

Start: 490059

End: 490856

Strand: Reverse

Name: panB [H]

Synonym: FTW_0499

Alternate gene names: 134301570

Gene position: 490856-490059 (Counterclockwise)

Preceding gene: 134301571

Following gene: 134301569

Centisome position: 25.86

GC content: 34.84

Gene sequence:

>798_bases
ATGAAATCAGTTTTAGGCTTCAAAAAAGCTAAAGTAACTCAAGAAAAAATCTCGATGGTAACATGCTATGACTATACTTT
AGCTAAAATTATAAACTCAACAGATATAGACTGTATCCTCGTTGGCGATAGTGGTGGTATGGTATTACTTGGTAAAAAAA
ATACTACTTATACAACCCTTGATGACATGCAGTTCATGACTCAAGCGGTAGCTAATGGTGCTACAGATAAATTCATAGTC
GCTGATTTACCATTTATGAGTTATCGCCAATCATTAGAAACAACAATGCAGGCTGTAATGGCACTGATTCAATCAGGAGC
TCATGCGATTAAGCTTGAAGGTAGTTCAGGAAATTTAGATATTATTAAACATATCGTAGATTCTGGTGTTCCAGTAATGG
GACACATTGGTATGACACCACAATTTATAAATAGCTTTGGAGGTTTTAAAGTTCAAGGTAGAACTGAAGAAGCCGCCAAA
CACTTACTTGAAGAAGCTAAGCTTCTCGAGCAAGCAGGATGCTTTGGAATAGTTCTAGAATGTATACCAGCAAATATTGC
TAAAGATATTACGCAAAATTTAGACATCCCAACAATAGGTATTGGTGCTGGTAGCAATACTGATGGTCAGATTTTAGTTC
TCCAAGATATGCTTGGCATGAATACTGACTTTCAACCAAAATTTGTCAAAAAATATATAGACGGCTCAAAGTTATTTTCT
GATGCTATAAATACATATGTTAAAGAAACAAAAGCTAATACTTTTCCTACTAAGGAGCATTGTTATGATTATTGCTGA

Upstream 100 bases:

>100_bases
CTTACGCTACAAAAAGATCTCGATGCTTTAATTGGTGATGATTTCTATGATGTTTTTAGAGCAATTGCTAATCAATTTTC
AAACAAGGAGAAAAGATGAA

Downstream 100 bases:

>100_bases
TAATATTAAACAATTTCATTCAATAAGAAATAGTCTTATTAAACAACAAAAAATAGGTTTTGTACCTACAATGGGAGCTC
TACACAATGGCCATATAAGT

Product: 3-methyl-2-oxobutanoate hydroxymethyltransferase

Products: NA

Alternate protein names: Ketopantoate hydroxymethyltransferase; KPHMT [H]

Number of amino acids: Translated: 265; Mature: 265

Protein sequence:

>265_residues
MKSVLGFKKAKVTQEKISMVTCYDYTLAKIINSTDIDCILVGDSGGMVLLGKKNTTYTTLDDMQFMTQAVANGATDKFIV
ADLPFMSYRQSLETTMQAVMALIQSGAHAIKLEGSSGNLDIIKHIVDSGVPVMGHIGMTPQFINSFGGFKVQGRTEEAAK
HLLEEAKLLEQAGCFGIVLECIPANIAKDITQNLDIPTIGIGAGSNTDGQILVLQDMLGMNTDFQPKFVKKYIDGSKLFS
DAINTYVKETKANTFPTKEHCYDYC

Sequences:

>Translated_265_residues
MKSVLGFKKAKVTQEKISMVTCYDYTLAKIINSTDIDCILVGDSGGMVLLGKKNTTYTTLDDMQFMTQAVANGATDKFIV
ADLPFMSYRQSLETTMQAVMALIQSGAHAIKLEGSSGNLDIIKHIVDSGVPVMGHIGMTPQFINSFGGFKVQGRTEEAAK
HLLEEAKLLEQAGCFGIVLECIPANIAKDITQNLDIPTIGIGAGSNTDGQILVLQDMLGMNTDFQPKFVKKYIDGSKLFS
DAINTYVKETKANTFPTKEHCYDYC
>Mature_265_residues
MKSVLGFKKAKVTQEKISMVTCYDYTLAKIINSTDIDCILVGDSGGMVLLGKKNTTYTTLDDMQFMTQAVANGATDKFIV
ADLPFMSYRQSLETTMQAVMALIQSGAHAIKLEGSSGNLDIIKHIVDSGVPVMGHIGMTPQFINSFGGFKVQGRTEEAAK
HLLEEAKLLEQAGCFGIVLECIPANIAKDITQNLDIPTIGIGAGSNTDGQILVLQDMLGMNTDFQPKFVKKYIDGSKLFS
DAINTYVKETKANTFPTKEHCYDYC

Specific function: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate [H]

COG id: COG0413

COG function: function code H; Ketopantoate hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the panB family [H]

Homologues:

Organism=Escherichia coli, GI1786326, Length=256, Percent_Identity=39.453125, Blast_Score=209, Evalue=1e-55,
Organism=Saccharomyces cerevisiae, GI6319653, Length=250, Percent_Identity=34.8, Blast_Score=172, Evalue=3e-44,

Paralogues:

None

Copy number: 1080 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003700
- InterPro:   IPR015813 [H]

Pfam domain/function: PF02548 Pantoate_transf [H]

EC number: =2.1.2.11 [H]

Molecular weight: Translated: 28865; Mature: 28865

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSVLGFKKAKVTQEKISMVTCYDYTLAKIINSTDIDCILVGDSGGMVLLGKKNTTYTTL
CCCCCCCHHHHHHHHHHHEEEEHHHHHHHHHCCCCCEEEEEECCCCEEEEECCCCCEEEH
DDMQFMTQAVANGATDKFIVADLPFMSYRQSLETTMQAVMALIQSGAHAIKLEGSSGNLD
HHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHH
IIKHIVDSGVPVMGHIGMTPQFINSFGGFKVQGRTEEAAKHLLEEAKLLEQAGCFGIVLE
HHHHHHHCCCCEEEECCCCHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHCCHHHHHHH
CIPANIAKDITQNLDIPTIGIGAGSNTDGQILVLQDMLGMNTDFQPKFVKKYIDGSKLFS
HHHHHHHHHHHHCCCCCEEEECCCCCCCCEEEEEEHHHCCCCCCCHHHHHHHHCHHHHHH
DAINTYVKETKANTFPTKEHCYDYC
HHHHHHHHHHCCCCCCCHHHHCCCC
>Mature Secondary Structure
MKSVLGFKKAKVTQEKISMVTCYDYTLAKIINSTDIDCILVGDSGGMVLLGKKNTTYTTL
CCCCCCCHHHHHHHHHHHEEEEHHHHHHHHHCCCCCEEEEEECCCCEEEEECCCCCEEEH
DDMQFMTQAVANGATDKFIVADLPFMSYRQSLETTMQAVMALIQSGAHAIKLEGSSGNLD
HHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHH
IIKHIVDSGVPVMGHIGMTPQFINSFGGFKVQGRTEEAAKHLLEEAKLLEQAGCFGIVLE
HHHHHHHCCCCEEEECCCCHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHCCHHHHHHH
CIPANIAKDITQNLDIPTIGIGAGSNTDGQILVLQDMLGMNTDFQPKFVKKYIDGSKLFS
HHHHHHHHHHHHCCCCCEEEECCCCCCCCEEEEEEHHHCCCCCCCHHHHHHHHCHHHHHH
DAINTYVKETKANTFPTKEHCYDYC
HHHHHHHHHHCCCCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA