Click here to switch to the map view.

The map label for this gene is nuoE [H]

Identifier: 134301250

GI number: 134301250

Start: 118851

End: 119339

Strand: Direct

Name: nuoE [H]

Synonym: FTW_0110

Alternate gene names: 134301250

Gene position: 118851-119339 (Clockwise)

Preceding gene: 134301249

Following gene: 134301251

Centisome position: 6.26

GC content: 36.2

Gene sequence:

>489_bases
ATGTCTTTAGTAGATTTAATATCGCCACAAGCGAGAGAAGATATTGACAGGGTTTTAAGTAAGTTTCCAGCTGATCAACG
AAGATCGGCGATATTGGAGGGCTTGCATATTTTGCAAGATCAAAATGGTGGCTACTTAACCGATGATTTGCAAACAGCTT
TAGCAGAGTACTTACAGGTTAGTAAAGTTGATGTTTATGAGGTTGCTACATTTTATTGTATGTATAACCTAAAACCGGTT
GGAAGACATAAATTGAATGTATGTACAAATGTTTCATGCATGTTAAATGGTGCTTATGAAATTTTAGCGCATATAGAGAA
AAAACTTGCTATTAAGCCTGGCGAGACCACTAAAGATGGTCGTATAACTCTAAAAGAAGTTGAGTGCCAAGGTGCGTGCT
GTGGTTCGCCTATGCTTGAGGTCGATAAGGTTTTTTATGAAAATCTAACTATAGAAAAAGTGAATCAAATAATTGATTCT
TTGGAGTAG

Upstream 100 bases:

>100_bases
AATGGATGAATTATTATCTGGGCATATGTTAGCAGATACTCCAGCGATTATCTCAACAATAGATGTCGTATTTGGTGATG
TAGATAGATAGAGGAAAAAG

Downstream 100 bases:

>100_bases
TTATAAATGGCAAATGAAGTTTGTTTTCGTACTCTACATTTAGATAAGCCATACAGTTTGGAGTCTTATTTATCTGTGGG
AGGGTATTCCTACTGGAATA

Product: NADH dehydrogenase I, E subunit

Products: NA

Alternate protein names: NADH dehydrogenase I subunit E; NDH-1 subunit E [H]

Number of amino acids: Translated: 162; Mature: 161

Protein sequence:

>162_residues
MSLVDLISPQAREDIDRVLSKFPADQRRSAILEGLHILQDQNGGYLTDDLQTALAEYLQVSKVDVYEVATFYCMYNLKPV
GRHKLNVCTNVSCMLNGAYEILAHIEKKLAIKPGETTKDGRITLKEVECQGACCGSPMLEVDKVFYENLTIEKVNQIIDS
LE

Sequences:

>Translated_162_residues
MSLVDLISPQAREDIDRVLSKFPADQRRSAILEGLHILQDQNGGYLTDDLQTALAEYLQVSKVDVYEVATFYCMYNLKPV
GRHKLNVCTNVSCMLNGAYEILAHIEKKLAIKPGETTKDGRITLKEVECQGACCGSPMLEVDKVFYENLTIEKVNQIIDS
LE
>Mature_161_residues
SLVDLISPQAREDIDRVLSKFPADQRRSAILEGLHILQDQNGGYLTDDLQTALAEYLQVSKVDVYEVATFYCMYNLKPVG
RHKLNVCTNVSCMLNGAYEILAHIEKKLAIKPGETTKDGRITLKEVECQGACCGSPMLEVDKVFYENLTIEKVNQIIDSL
E

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cyto

COG id: COG1905

COG function: function code C; NADH:ubiquinone oxidoreductase 24 kD subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 24 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI222080062, Length=156, Percent_Identity=44.2307692307692, Blast_Score=138, Evalue=2e-33,
Organism=Escherichia coli, GI1788621, Length=153, Percent_Identity=37.9084967320261, Blast_Score=100, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17561328, Length=151, Percent_Identity=43.046357615894, Blast_Score=132, Evalue=1e-31,
Organism=Drosophila melanogaster, GI18859877, Length=151, Percent_Identity=38.4105960264901, Blast_Score=118, Evalue=2e-27,
Organism=Drosophila melanogaster, GI21355353, Length=148, Percent_Identity=34.4594594594595, Blast_Score=99, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002023
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF01257 Complex1_24kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 18171; Mature: 18040

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
3.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLVDLISPQAREDIDRVLSKFPADQRRSAILEGLHILQDQNGGYLTDDLQTALAEYLQV
CCCHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHH
SKVDVYEVATFYCMYNLKPVGRHKLNVCTNVSCMLNGAYEILAHIEKKLAIKPGETTKDG
HCCHHHHHHHHHHHHCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
RITLKEVECQGACCGSPMLEVDKVFYENLTIEKVNQIIDSLE
CEEEEEECCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHCC
>Mature Secondary Structure 
SLVDLISPQAREDIDRVLSKFPADQRRSAILEGLHILQDQNGGYLTDDLQTALAEYLQV
CCHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHH
SKVDVYEVATFYCMYNLKPVGRHKLNVCTNVSCMLNGAYEILAHIEKKLAIKPGETTKDG
HCCHHHHHHHHHHHHCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
RITLKEVECQGACCGSPMLEVDKVFYENLTIEKVNQIIDSLE
CEEEEEECCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA