Click here to switch to the map view.

The map label for this gene is nuoF [H]

Identifier: 134301251

GI number: 134301251

Start: 119346

End: 120620

Strand: Direct

Name: nuoF [H]

Synonym: FTW_0111

Alternate gene names: 134301251

Gene position: 119346-120620 (Clockwise)

Preceding gene: 134301250

Following gene: 134301252

Centisome position: 6.29

GC content: 40.16

Gene sequence:

>1275_bases
ATGGCAAATGAAGTTTGTTTTCGTACTCTACATTTAGATAAGCCATACAGTTTGGAGTCTTATTTATCTGTGGGAGGGTA
TTCCTACTGGAATAAAATATTGACAGAAAAAATTCCACCTGAGCAAATTATTGAAGAGCTCAAAATATCTGGGCTTAGGG
GTCGTGGTGGTGCTGGTTTCCCTACGGGATTGAAATGGAGTTTTATGCCACGTAATGCTCCGGGACAGAAATACGTTGTA
TGCAACTCTGATGAGGGTGAGCCTGGTACATGTAAGGATAGAGAAATTCTTAGGAATAATCCTCATCAATTGATTGAAGG
TATAGCTATTGCTGGATATGTTGTTGGGGCTACTGCAGGCTATAACTATACTAGAGGCGAGTTCTATGAGCCAATAGCTA
GGTTTGAAGACGCGCTTATTGAGGCATATCAAGCAGGTTTATTGGGTACAAATATCAAATCATCAGGAATCTCTTTTGAT
TTATACTCAGCTATTGGTGCTGGTGCTTATATCTGTGGTGAAGAAACAGCATTGCTTAACTCACTTGAGGGTAAAAAAGG
TCGCCCAAGATTTAAGCCACCATTTCCTGCATTTAAAGGTCTTTATGACAAGCCAACAAATATAAATAATACAGAAACAT
ATGCTTCAGTGCCGGCAATATTACAATATGGCGGTGAGTGGTTTAAGAAATTGGGTACTGAGAAAAGTGGCGGTACTAAG
TTATTCTGTGTCTCTGGACATGTACAGCAGCAAAGAGTTGTTGAAATAGGTTTAGGTATGCCGTTTAAAGAGCTTTTAGA
CATGTGCGGAGGTGTTCGCAATGGTAATAAGCTTAAGGCAGTAATCCCTGGTGGCAGCTCATCTAAGATCTTGACAGCTG
ATGAGATGATGGCTGTTACTATGGATTATGAGTCAATAGCAGCGGCAGGTTCAATGCTTGGTTCAGGAGCAGTTGTAGTG
TTGGATGAGACTACATGTATTGTTAGAACTCTAGCAAGGCTTGCTGATTTCTATTATGAAGAGTCTTGTGGTCAATGTAC
GCCTTGTAGAGAGGGTACTGGGTGGTTAGCACGAACTTTACATAGAATTGTTGCTGGTGAAGGAAGACCGGAGGATATTG
ATACTTTAGTTAGAGTAGCAACAAATATAGAGGGTAATACTATTTGTAGTTTGGGTGATGCAGCTGCATGGCCAGTCCAG
AGTTATATAGATAAATTTAGGCATGAGTTTGTTTATATGATCGAGAATAATGGTAGAAGTATAGTGGATCAATAG

Upstream 100 bases:

>100_bases
GTGCTGTGGTTCGCCTATGCTTGAGGTCGATAAGGTTTTTTATGAAAATCTAACTATAGAAAAAGTGAATCAAATAATTG
ATTCTTTGGAGTAGTTATAA

Downstream 100 bases:

>100_bases
TTGATTGGAGTAGTTCTGTGTCAGACAATAAAGAATCCAAAAAGATAAGTATAGAGATTGATGGTAAGGATTATCAAGCC
CTACCAAACCAATCGATAAT

Product: NADH dehydrogenase I subunit F

Products: NA

Alternate protein names: NADH dehydrogenase I, chain 1; NDH-1, chain 1 [H]

Number of amino acids: Translated: 424; Mature: 423

Protein sequence:

>424_residues
MANEVCFRTLHLDKPYSLESYLSVGGYSYWNKILTEKIPPEQIIEELKISGLRGRGGAGFPTGLKWSFMPRNAPGQKYVV
CNSDEGEPGTCKDREILRNNPHQLIEGIAIAGYVVGATAGYNYTRGEFYEPIARFEDALIEAYQAGLLGTNIKSSGISFD
LYSAIGAGAYICGEETALLNSLEGKKGRPRFKPPFPAFKGLYDKPTNINNTETYASVPAILQYGGEWFKKLGTEKSGGTK
LFCVSGHVQQQRVVEIGLGMPFKELLDMCGGVRNGNKLKAVIPGGSSSKILTADEMMAVTMDYESIAAAGSMLGSGAVVV
LDETTCIVRTLARLADFYYEESCGQCTPCREGTGWLARTLHRIVAGEGRPEDIDTLVRVATNIEGNTICSLGDAAAWPVQ
SYIDKFRHEFVYMIENNGRSIVDQ

Sequences:

>Translated_424_residues
MANEVCFRTLHLDKPYSLESYLSVGGYSYWNKILTEKIPPEQIIEELKISGLRGRGGAGFPTGLKWSFMPRNAPGQKYVV
CNSDEGEPGTCKDREILRNNPHQLIEGIAIAGYVVGATAGYNYTRGEFYEPIARFEDALIEAYQAGLLGTNIKSSGISFD
LYSAIGAGAYICGEETALLNSLEGKKGRPRFKPPFPAFKGLYDKPTNINNTETYASVPAILQYGGEWFKKLGTEKSGGTK
LFCVSGHVQQQRVVEIGLGMPFKELLDMCGGVRNGNKLKAVIPGGSSSKILTADEMMAVTMDYESIAAAGSMLGSGAVVV
LDETTCIVRTLARLADFYYEESCGQCTPCREGTGWLARTLHRIVAGEGRPEDIDTLVRVATNIEGNTICSLGDAAAWPVQ
SYIDKFRHEFVYMIENNGRSIVDQ
>Mature_423_residues
ANEVCFRTLHLDKPYSLESYLSVGGYSYWNKILTEKIPPEQIIEELKISGLRGRGGAGFPTGLKWSFMPRNAPGQKYVVC
NSDEGEPGTCKDREILRNNPHQLIEGIAIAGYVVGATAGYNYTRGEFYEPIARFEDALIEAYQAGLLGTNIKSSGISFDL
YSAIGAGAYICGEETALLNSLEGKKGRPRFKPPFPAFKGLYDKPTNINNTETYASVPAILQYGGEWFKKLGTEKSGGTKL
FCVSGHVQQQRVVEIGLGMPFKELLDMCGGVRNGNKLKAVIPGGSSSKILTADEMMAVTMDYESIAAAGSMLGSGAVVVL
DETTCIVRTLARLADFYYEESCGQCTPCREGTGWLARTLHRIVAGEGRPEDIDTLVRVATNIEGNTICSLGDAAAWPVQS
YIDKFRHEFVYMIENNGRSIVDQ

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI20149568, Length=407, Percent_Identity=51.1056511056511, Blast_Score=413, Evalue=1e-115,
Organism=Homo sapiens, GI260656005, Length=407, Percent_Identity=51.1056511056511, Blast_Score=413, Evalue=1e-115,
Organism=Escherichia coli, GI1788620, Length=409, Percent_Identity=43.7652811735941, Blast_Score=340, Evalue=1e-94,
Organism=Caenorhabditis elegans, GI17531727, Length=407, Percent_Identity=50.1228501228501, Blast_Score=407, Evalue=1e-114,
Organism=Drosophila melanogaster, GI19920794, Length=420, Percent_Identity=48.8095238095238, Blast_Score=411, Evalue=1e-115,
Organism=Drosophila melanogaster, GI45550452, Length=404, Percent_Identity=48.5148514851485, Blast_Score=391, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24653819, Length=405, Percent_Identity=39.0123456790123, Blast_Score=286, Evalue=2e-77,
Organism=Drosophila melanogaster, GI24653817, Length=347, Percent_Identity=39.193083573487, Blast_Score=253, Evalue=2e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011537
- InterPro:   IPR011538
- InterPro:   IPR019554 [H]

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 46282; Mature: 46151

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: PS00644 COMPLEX1_51K_1 ; PS00645 COMPLEX1_51K_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANEVCFRTLHLDKPYSLESYLSVGGYSYWNKILTEKIPPEQIIEELKISGLRGRGGAGF
CCCHHEEEEEECCCCCCHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCC
PTGLKWSFMPRNAPGQKYVVCNSDEGEPGTCKDREILRNNPHQLIEGIAIAGYVVGATAG
CCCCEEEECCCCCCCCEEEEECCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHEEEECCCC
YNYTRGEFYEPIARFEDALIEAYQAGLLGTNIKSSGISFDLYSAIGAGAYICGEETALLN
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEHHHHHCCCEEEECCHHHHHH
SLEGKKGRPRFKPPFPAFKGLYDKPTNINNTETYASVPAILQYGGEWFKKLGTEKSGGTK
HCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCE
LFCVSGHVQQQRVVEIGLGMPFKELLDMCGGVRNGNKLKAVIPGGSSSKILTADEMMAVT
EEEECCCCCHHHHHHHCCCCCHHHHHHHHCCCCCCCEEEEEECCCCCCCEEEHHHEEEEE
MDYESIAAAGSMLGSGAVVVLDETTCIVRTLARLADFYYEESCGQCTPCREGTGWLARTL
ECHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHH
HRIVAGEGRPEDIDTLVRVATNIEGNTICSLGDAAAWPVQSYIDKFRHEFVYMIENNGRS
HHHHCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHEEEEEECCCCC
IVDQ
CCCC
>Mature Secondary Structure 
ANEVCFRTLHLDKPYSLESYLSVGGYSYWNKILTEKIPPEQIIEELKISGLRGRGGAGF
CCHHEEEEEECCCCCCHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCC
PTGLKWSFMPRNAPGQKYVVCNSDEGEPGTCKDREILRNNPHQLIEGIAIAGYVVGATAG
CCCCEEEECCCCCCCCEEEEECCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHEEEECCCC
YNYTRGEFYEPIARFEDALIEAYQAGLLGTNIKSSGISFDLYSAIGAGAYICGEETALLN
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEHHHHHCCCEEEECCHHHHHH
SLEGKKGRPRFKPPFPAFKGLYDKPTNINNTETYASVPAILQYGGEWFKKLGTEKSGGTK
HCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCE
LFCVSGHVQQQRVVEIGLGMPFKELLDMCGGVRNGNKLKAVIPGGSSSKILTADEMMAVT
EEEECCCCCHHHHHHHCCCCCHHHHHHHHCCCCCCCEEEEEECCCCCCCEEEHHHEEEEE
MDYESIAAAGSMLGSGAVVVLDETTCIVRTLARLADFYYEESCGQCTPCREGTGWLARTL
ECHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHH
HRIVAGEGRPEDIDTLVRVATNIEGNTICSLGDAAAWPVQSYIDKFRHEFVYMIENNGRS
HHHHCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHEEEEEECCCCC
IVDQ
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1905152; 1909571; 1605643 [H]