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The map label for this gene is nuoD [H]

Identifier: 134301249

GI number: 134301249

Start: 117588

End: 118841

Strand: Direct

Name: nuoD [H]

Synonym: FTW_0109

Alternate gene names: 134301249

Gene position: 117588-118841 (Clockwise)

Preceding gene: 134301248

Following gene: 134301250

Centisome position: 6.19

GC content: 38.84

Gene sequence:

>1254_bases
ATGGCAGAGTATAAAAACTATACACTAAATTTTGGACCAGTTCATCCTGCAGCGCATGGTGTTCTTAGGCTTATTTTAGA
ACTTGATGGCGAAAATGTTGTGCGAGCTGATCCACACGTTGGATTGTTGCATAGAGGTACAGAAAAACTTGCTGAATTTA
AGCCATATAACCAAAGTATTGGTTATATGGACAGGCTTGATTATGTCTCGATGATGTGTAATGAGCATGCTTATGTGATG
GCGATTGAAAAGCTTTTACAGTTAGAGGTTCCCGAGAGGGCTAAATATATTCGCGTAATGTTTGCTGAGATGACTAGAAT
TTTAAATCATCTATTATGGGTTGCAGCATGTGGTATCGACCTTGGTGCAATGACTGTGTTTTTGTATGCTTTTAGGGTCA
GAGAAGATTTGTTTGATTGCTATGAGGCTGTATCTGGTGCACGTATGCATGCGGCATATTTTAGACCTGGTGGTGTTGCT
AGAGATTTGCCAACGCAGATGCCTCAATATCAAAAGACTAGATTTACTAGTAAGAGAAAAGCAAAGAAATTAAATGAGCC
AAGGCAAGGAAGTATGCTTGATTTCTTGGATCATTTTGTTGTTGATTTTGAGAAATCTTTAGATGAGATTGATACTCTTT
TAACTGATAATAGATTGTGGAAGCAGCGGACGGTTGATATTGGTACTGTAACTGCTGAGAGGGCTAAAGAGCTTGGTTTT
ACAGGCCCAATGTTAAGAGGAAGTGGAGTTGCGTGGGATCTTAGAAAAACTCAGCCTTATGAGGTGTATCATAAGCTGGA
GTTTGATATTCCAATTGGTGCAAATGGTGACTGTTATGATAGGTATCTTGTCAGAATGGCTGAGATGCGTGAGTCAAATA
AGCTTATCAAACAATGTGTTGATTGGCTTAGGGCTAATCCAGGACCTGTGTTGTCAGATAATCATAAGGTTGCGCCTCCT
AAGAGAAATGCGATGAAAAATAATATGGAAGAGCTTATACATCACTTTAAACTTTTCTCAGAAGGCTATTGTACTACTGA
GGGTGAGGTTTATGTTGGTACTGAACATCCAAAAGGTGAGTTTGGTGTGTATATCAAATCAGATGGTGCAAATAAGCCGT
ATAGATTAAAAATGAGAGCGCCAGGATTTGCACATATTAGTGCAATGGATGAATTATTATCTGGGCATATGTTAGCAGAT
ACTCCAGCGATTATCTCAACAATAGATGTCGTATTTGGTGATGTAGATAGATAG

Upstream 100 bases:

>100_bases
TGAAAACCTTGGTCGAGTTGTGTATGAGCCGGTAGAGATTGATGATAGGGTTAATACACCAAGAGTGATTCGTAACTAAA
TATAACTATGGGTTTATATA

Downstream 100 bases:

>100_bases
AGGAAAAAGATGTCTTTAGTAGATTTAATATCGCCACAAGCGAGAGAAGATATTGACAGGGTTTTAAGTAAGTTTCCAGC
TGATCAACGAAGATCGGCGA

Product: NADH dehydrogenase subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D; NDH-1 subunit D [H]

Number of amino acids: Translated: 417; Mature: 416

Protein sequence:

>417_residues
MAEYKNYTLNFGPVHPAAHGVLRLILELDGENVVRADPHVGLLHRGTEKLAEFKPYNQSIGYMDRLDYVSMMCNEHAYVM
AIEKLLQLEVPERAKYIRVMFAEMTRILNHLLWVAACGIDLGAMTVFLYAFRVREDLFDCYEAVSGARMHAAYFRPGGVA
RDLPTQMPQYQKTRFTSKRKAKKLNEPRQGSMLDFLDHFVVDFEKSLDEIDTLLTDNRLWKQRTVDIGTVTAERAKELGF
TGPMLRGSGVAWDLRKTQPYEVYHKLEFDIPIGANGDCYDRYLVRMAEMRESNKLIKQCVDWLRANPGPVLSDNHKVAPP
KRNAMKNNMEELIHHFKLFSEGYCTTEGEVYVGTEHPKGEFGVYIKSDGANKPYRLKMRAPGFAHISAMDELLSGHMLAD
TPAIISTIDVVFGDVDR

Sequences:

>Translated_417_residues
MAEYKNYTLNFGPVHPAAHGVLRLILELDGENVVRADPHVGLLHRGTEKLAEFKPYNQSIGYMDRLDYVSMMCNEHAYVM
AIEKLLQLEVPERAKYIRVMFAEMTRILNHLLWVAACGIDLGAMTVFLYAFRVREDLFDCYEAVSGARMHAAYFRPGGVA
RDLPTQMPQYQKTRFTSKRKAKKLNEPRQGSMLDFLDHFVVDFEKSLDEIDTLLTDNRLWKQRTVDIGTVTAERAKELGF
TGPMLRGSGVAWDLRKTQPYEVYHKLEFDIPIGANGDCYDRYLVRMAEMRESNKLIKQCVDWLRANPGPVLSDNHKVAPP
KRNAMKNNMEELIHHFKLFSEGYCTTEGEVYVGTEHPKGEFGVYIKSDGANKPYRLKMRAPGFAHISAMDELLSGHMLAD
TPAIISTIDVVFGDVDR
>Mature_416_residues
AEYKNYTLNFGPVHPAAHGVLRLILELDGENVVRADPHVGLLHRGTEKLAEFKPYNQSIGYMDRLDYVSMMCNEHAYVMA
IEKLLQLEVPERAKYIRVMFAEMTRILNHLLWVAACGIDLGAMTVFLYAFRVREDLFDCYEAVSGARMHAAYFRPGGVAR
DLPTQMPQYQKTRFTSKRKAKKLNEPRQGSMLDFLDHFVVDFEKSLDEIDTLLTDNRLWKQRTVDIGTVTAERAKELGFT
GPMLRGSGVAWDLRKTQPYEVYHKLEFDIPIGANGDCYDRYLVRMAEMRESNKLIKQCVDWLRANPGPVLSDNHKVAPPK
RNAMKNNMEELIHHFKLFSEGYCTTEGEVYVGTEHPKGEFGVYIKSDGANKPYRLKMRAPGFAHISAMDELLSGHMLADT
PAIISTIDVVFGDVDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI4758786, Length=413, Percent_Identity=56.4164648910412, Blast_Score=482, Evalue=1e-136,
Organism=Homo sapiens, GI260898743, Length=407, Percent_Identity=55.7739557739558, Blast_Score=468, Evalue=1e-132,
Organism=Escherichia coli, GI145693162, Length=410, Percent_Identity=35.609756097561, Blast_Score=276, Evalue=3e-75,
Organism=Escherichia coli, GI1789076, Length=423, Percent_Identity=28.1323877068558, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1788832, Length=409, Percent_Identity=25.9168704156479, Blast_Score=106, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17555284, Length=413, Percent_Identity=53.7530266343826, Blast_Score=458, Evalue=1e-129,
Organism=Caenorhabditis elegans, GI17568379, Length=413, Percent_Identity=52.5423728813559, Blast_Score=452, Evalue=1e-127,
Organism=Drosophila melanogaster, GI24638644, Length=413, Percent_Identity=56.1743341404358, Blast_Score=492, Evalue=1e-139,
Organism=Drosophila melanogaster, GI221459469, Length=414, Percent_Identity=50.2415458937198, Blast_Score=446, Evalue=1e-125,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010219
- InterPro:   IPR001135
- InterPro:   IPR014029
- InterPro:   IPR022885 [H]

Pfam domain/function: PF00346 Complex1_49kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 47596; Mature: 47465

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEYKNYTLNFGPVHPAAHGVLRLILELDGENVVRADPHVGLLHRGTEKLAEFKPYNQSI
CCCCCCCEEECCCCCHHHHHHHHHHHHCCCCCEEECCCCCCHHHCCHHHHHHCCCCCCCC
GYMDRLDYVSMMCNEHAYVMAIEKLLQLEVPERAKYIRVMFAEMTRILNHLLWVAACGID
CHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
LGAMTVFLYAFRVREDLFDCYEAVSGARMHAAYFRPGGVARDLPTQMPQYQKTRFTSKRK
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHCCCHHHHHHHHHHHH
AKKLNEPRQGSMLDFLDHFVVDFEKSLDEIDTLLTDNRLWKQRTVDIGTVTAERAKELGF
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCEEEHHHHHHHHHCCC
TGPMLRGSGVAWDLRKTQPYEVYHKLEFDIPIGANGDCYDRYLVRMAEMRESNKLIKQCV
CCCCCCCCCCEEECCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
DWLRANPGPVLSDNHKVAPPKRNAMKNNMEELIHHFKLFSEGYCTTEGEVYVGTEHPKGE
HHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCC
FGVYIKSDGANKPYRLKMRAPGFAHISAMDELLSGHMLADTPAIISTIDVVFGDVDR
EEEEEECCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
AEYKNYTLNFGPVHPAAHGVLRLILELDGENVVRADPHVGLLHRGTEKLAEFKPYNQSI
CCCCCCEEECCCCCHHHHHHHHHHHHCCCCCEEECCCCCCHHHCCHHHHHHCCCCCCCC
GYMDRLDYVSMMCNEHAYVMAIEKLLQLEVPERAKYIRVMFAEMTRILNHLLWVAACGID
CHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
LGAMTVFLYAFRVREDLFDCYEAVSGARMHAAYFRPGGVARDLPTQMPQYQKTRFTSKRK
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHCCCHHHHHHHHHHHH
AKKLNEPRQGSMLDFLDHFVVDFEKSLDEIDTLLTDNRLWKQRTVDIGTVTAERAKELGF
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCEEEHHHHHHHHHCCC
TGPMLRGSGVAWDLRKTQPYEVYHKLEFDIPIGANGDCYDRYLVRMAEMRESNKLIKQCV
CCCCCCCCCCEEECCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
DWLRANPGPVLSDNHKVAPPKRNAMKNNMEELIHHFKLFSEGYCTTEGEVYVGTEHPKGE
HHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCC
FGVYIKSDGANKPYRLKMRAPGFAHISAMDELLSGHMLADTPAIISTIDVVFGDVDR
EEEEEECCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA