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The map label for this gene is purL [H]

Identifier: 134300205

GI number: 134300205

Start: 2590313

End: 2592538

Strand: Reverse

Name: purL [H]

Synonym: Dred_2366

Alternate gene names: 134300205

Gene position: 2592538-2590313 (Counterclockwise)

Preceding gene: 134300206

Following gene: 134300204

Centisome position: 71.85

GC content: 50.54

Gene sequence:

>2226_bases
ATGATAGTGGAGGAAAAGGTTTGGCGGGAGATGGGCCTGACTGACTCTGAGTATGAAAGGATCGTAGAGATTCTGGGTCG
CCACCCTAACTATGTAGAAGTTGGTATATTTGCCGTTATGTGGTCGGAACACTGCAGTTACAAAACTTCCCGGCCAGCCT
TGAAAACGCTCCCCACCGAGGGACCGGCCATTCTGCAGGGACCCGGCGAAAATGCTGGTATTGTTGACATTGGCGATGGA
CAAGCTGTTGTCTTTAAAATAGAAAGTCATAACCACCCTTCAGCCATTGAGCCCTATCAAGGTGCGGCCACCGGTGTGGG
TGGAATTTTACGGGATATCTTTACCATGGGTGCCAGGCCCATTGCCGTGTTAGACAGTCTGCGTTTTGGTGAACTGGATA
ACCCCCGGGTACGCTACCTTTTTGATGGTGTAGTATCTGGTATCAGCGGCTACGGCAACTGTATCGGTGTGCCTACGGTG
GGTGGTGAAGTATATTTCTCAGATAGCTATGAAGAAAACTGTCTGGTAAATGTCATGTGTGTGGGCTTAATTGACCAGAA
GGATATTAAAAAAGGTCTGGCCGCCGGAGTTGGTAACCCGGTCATGGTGGTTGGTGCCAAAACCGGCCGTGATGGTATAC
ATGGGGCCACCTTTGCCTCGGAAGAATTGTCTGAAGCAGCTGCAGAAAGGCGTCCTGCTGTGCAGGTAGGGGACCCTTTT
ATGGAAAAACTTCTTTTAGAAGCTTGTCTGGAGGTTATTAAAACCGGTTATGTGGTAGGTATTCAGGATATGGGTGCTGC
GGGATTAACCAGTTCTTCCTGTGAAATGGCCAGCCGGGCTGGTACTGGACTGGAGATGGATTTAGCCCTGGTACCCCGCC
GGGAAGAGGGAATGACCCCCTATGAGCTAATGCTGTCGGAATCCCAGGAGCGGATGCTGCTGGTGGTTGAAAAGGGTACC
GAGGATAAAGTAAAAGATATCTTTGCAAAATGGGACCTGGACTGCGTGGTGGTGGGGCAGGTTACAGACGATGGACTGCT
GCGCCTGAAGGAAGGGGATCAGGTGGTGGCAGAGATGCCTGCCAAAGCCCTGACAGACGAAGCACCGCTATATCACCGGC
CCACCGAAGTACCTGCTTATTTAGAAGACATTCATAATTTTCCGCTGGAGCAGCTTAATATGCCCGATGACTATAATGAA
GTGCTGCTAAAGCTGCTGGCGACCCCTAACATTGCCAGCAAAGAATACGTCTACCGACAATATGACCATATGGTGGGTCT
CAATACTGTTGTCCTGCCTGGCTCTGATGCCGCGGTATTACGGGTCAAGGGGACCAAAAAGGGCATTGCCATGACCACCG
ATTGCAACGGTCGCTTTTGCTATCTGGACCCAAAAACCGGCGCAGCCATTGCCGTGGCTGAGGCAGCCCGCAACTTAGTT
TGTTCCGGGGCAAAACCCCTGGCTATTACTAACTGCCTCAATTTTGGTAATCCGGAAAAGCCGGAAGTCATGTGGACCTT
CTGGCGCTGCATCGAAGGAATGGGAGAGGCTTGCCGAGTACTGGAAACTCCCGTGACTGGAGGTAACGTAAGTTTATACA
ATGAAACAAAGGGCAGTGCCGTTTATCCCACCCCTACCATTGGTATGGTGGGCTTGGTGGAAGATTTGGACAAGGTATGT
ACCCAGGATTTTAAGACAGAGGGAGACGCCATTTTCTTGATTGGTGAAAACCTTCCAGAGCTAGGCGGTAGTGAATATCT
AAAGGTGCATCATGGATTGGAAAAGGGTAAGGCACCGGTACTGGACCTGGCATTAGAAAAGAAAATTCAGCAGTTTGTAC
TGAATGAAATAAAGAACGGTTTGATTAAATCTGCCCATGACTGTTCCGAAGGCGGCTTGGCTGTGGCCTTGGCTGAGTGT
TGCATTGCCGGCGGTTTGGGAGCGGATATCACAATGGTACGCAGATTCAGAGGGGACGCTCTACTTTTTGGGGAAAGCCA
GTCCCGCATTGTGATCTCCCTCGACCGCAGCAAAGGTGTGGAATTGGTTAAAAAGCTGGTGGATGCCGGAGTACCCTACA
GCCAGTTGGGAACCGTGGGAGGCAATTCATTGGTCATCAATGTTGTAAATCCTGGTTGCACCGGTTGCGGCGGCAATTTG
ATAAATCTATCCGTGTCCAAGCTGGCAGAAACCTGGCGGGGGGCGATTGAATGTTTAATGAAATAG

Upstream 100 bases:

>100_bases
TGCCCCACCCGGAACGCTGTGCCGAAGAAATACTGGGTAATATTGATGGACAACTGATTTTTAAATCCTTGCTGGAAACC
TGGCAGAGGAGGTGTGGCTA

Downstream 100 bases:

>100_bases
GTACGATCCTTTGGTCCGATAAGCCAGTGGAAGAATGTGGTGTGTTTGGCATTTTTGCTCCTGGGTTGGATGTGGCTCGT
TTAACTTACTACGGGCTTCA

Product: phosphoribosylformylglycinamidine synthase II

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II [H]

Number of amino acids: Translated: 741; Mature: 741

Protein sequence:

>741_residues
MIVEEKVWREMGLTDSEYERIVEILGRHPNYVEVGIFAVMWSEHCSYKTSRPALKTLPTEGPAILQGPGENAGIVDIGDG
QAVVFKIESHNHPSAIEPYQGAATGVGGILRDIFTMGARPIAVLDSLRFGELDNPRVRYLFDGVVSGISGYGNCIGVPTV
GGEVYFSDSYEENCLVNVMCVGLIDQKDIKKGLAAGVGNPVMVVGAKTGRDGIHGATFASEELSEAAAERRPAVQVGDPF
MEKLLLEACLEVIKTGYVVGIQDMGAAGLTSSSCEMASRAGTGLEMDLALVPRREEGMTPYELMLSESQERMLLVVEKGT
EDKVKDIFAKWDLDCVVVGQVTDDGLLRLKEGDQVVAEMPAKALTDEAPLYHRPTEVPAYLEDIHNFPLEQLNMPDDYNE
VLLKLLATPNIASKEYVYRQYDHMVGLNTVVLPGSDAAVLRVKGTKKGIAMTTDCNGRFCYLDPKTGAAIAVAEAARNLV
CSGAKPLAITNCLNFGNPEKPEVMWTFWRCIEGMGEACRVLETPVTGGNVSLYNETKGSAVYPTPTIGMVGLVEDLDKVC
TQDFKTEGDAIFLIGENLPELGGSEYLKVHHGLEKGKAPVLDLALEKKIQQFVLNEIKNGLIKSAHDCSEGGLAVALAEC
CIAGGLGADITMVRRFRGDALLFGESQSRIVISLDRSKGVELVKKLVDAGVPYSQLGTVGGNSLVINVVNPGCTGCGGNL
INLSVSKLAETWRGAIECLMK

Sequences:

>Translated_741_residues
MIVEEKVWREMGLTDSEYERIVEILGRHPNYVEVGIFAVMWSEHCSYKTSRPALKTLPTEGPAILQGPGENAGIVDIGDG
QAVVFKIESHNHPSAIEPYQGAATGVGGILRDIFTMGARPIAVLDSLRFGELDNPRVRYLFDGVVSGISGYGNCIGVPTV
GGEVYFSDSYEENCLVNVMCVGLIDQKDIKKGLAAGVGNPVMVVGAKTGRDGIHGATFASEELSEAAAERRPAVQVGDPF
MEKLLLEACLEVIKTGYVVGIQDMGAAGLTSSSCEMASRAGTGLEMDLALVPRREEGMTPYELMLSESQERMLLVVEKGT
EDKVKDIFAKWDLDCVVVGQVTDDGLLRLKEGDQVVAEMPAKALTDEAPLYHRPTEVPAYLEDIHNFPLEQLNMPDDYNE
VLLKLLATPNIASKEYVYRQYDHMVGLNTVVLPGSDAAVLRVKGTKKGIAMTTDCNGRFCYLDPKTGAAIAVAEAARNLV
CSGAKPLAITNCLNFGNPEKPEVMWTFWRCIEGMGEACRVLETPVTGGNVSLYNETKGSAVYPTPTIGMVGLVEDLDKVC
TQDFKTEGDAIFLIGENLPELGGSEYLKVHHGLEKGKAPVLDLALEKKIQQFVLNEIKNGLIKSAHDCSEGGLAVALAEC
CIAGGLGADITMVRRFRGDALLFGESQSRIVISLDRSKGVELVKKLVDAGVPYSQLGTVGGNSLVINVVNPGCTGCGGNL
INLSVSKLAETWRGAIECLMK
>Mature_741_residues
MIVEEKVWREMGLTDSEYERIVEILGRHPNYVEVGIFAVMWSEHCSYKTSRPALKTLPTEGPAILQGPGENAGIVDIGDG
QAVVFKIESHNHPSAIEPYQGAATGVGGILRDIFTMGARPIAVLDSLRFGELDNPRVRYLFDGVVSGISGYGNCIGVPTV
GGEVYFSDSYEENCLVNVMCVGLIDQKDIKKGLAAGVGNPVMVVGAKTGRDGIHGATFASEELSEAAAERRPAVQVGDPF
MEKLLLEACLEVIKTGYVVGIQDMGAAGLTSSSCEMASRAGTGLEMDLALVPRREEGMTPYELMLSESQERMLLVVEKGT
EDKVKDIFAKWDLDCVVVGQVTDDGLLRLKEGDQVVAEMPAKALTDEAPLYHRPTEVPAYLEDIHNFPLEQLNMPDDYNE
VLLKLLATPNIASKEYVYRQYDHMVGLNTVVLPGSDAAVLRVKGTKKGIAMTTDCNGRFCYLDPKTGAAIAVAEAARNLV
CSGAKPLAITNCLNFGNPEKPEVMWTFWRCIEGMGEACRVLETPVTGGNVSLYNETKGSAVYPTPTIGMVGLVEDLDKVC
TQDFKTEGDAIFLIGENLPELGGSEYLKVHHGLEKGKAPVLDLALEKKIQQFVLNEIKNGLIKSAHDCSEGGLAVALAEC
CIAGGLGADITMVRRFRGDALLFGESQSRIVISLDRSKGVELVKKLVDAGVPYSQLGTVGGNSLVINVVNPGCTGCGGNL
INLSVSKLAETWRGAIECLMK

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family [H]

Homologues:

Organism=Homo sapiens, GI31657129, Length=698, Percent_Identity=25.9312320916905, Blast_Score=114, Evalue=4e-25,
Organism=Escherichia coli, GI48994899, Length=759, Percent_Identity=25.5599472990777, Blast_Score=135, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI17553022, Length=660, Percent_Identity=22.7272727272727, Blast_Score=96, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6321498, Length=737, Percent_Identity=22.9308005427408, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24582111, Length=720, Percent_Identity=25.5555555555556, Blast_Score=110, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24582109, Length=720, Percent_Identity=25.5555555555556, Blast_Score=110, Evalue=3e-24,
Organism=Drosophila melanogaster, GI17137292, Length=720, Percent_Identity=25.5555555555556, Blast_Score=110, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.5.3 [H]

Molecular weight: Translated: 79693; Mature: 79693

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVEEKVWREMGLTDSEYERIVEILGRHPNYVEVGIFAVMWSEHCSYKTSRPALKTLPTE
CCCHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEHHHHEEEHHHHCCCCCCCCHHHCCCCC
GPAILQGPGENAGIVDIGDGQAVVFKIESHNHPSAIEPYQGAATGVGGILRDIFTMGARP
CCEEEECCCCCCCEEEECCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCH
IAVLDSLRFGELDNPRVRYLFDGVVSGISGYGNCIGVPTVGGEVYFSDSYEENCLVNVMC
HHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEECCCCCCEEEECCCCCCCCEEEEEE
VGLIDQKDIKKGLAAGVGNPVMVVGAKTGRDGIHGATFASEELSEAAAERRPAVQVGDPF
EECCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCEECCCHH
MEKLLLEACLEVIKTGYVVGIQDMGAAGLTSSSCEMASRAGTGLEMDLALVPRREEGMTP
HHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCHHHHHHHCCCCCEEEEEECCCCCCCCCH
YELMLSESQERMLLVVEKGTEDKVKDIFAKWDLDCVVVGQVTDDGLLRLKEGDQVVAEMP
HHHHHCCCCCEEEEEEECCCHHHHHHHHHHCCCCEEEEEEECCCCEEEECCCCHHHHHCC
AKALTDEAPLYHRPTEVPAYLEDIHNFPLEQLNMPDDYNEVLLKLLATPNIASKEYVYRQ
HHHHCCCCCCCCCCCCCHHHHHHHHCCCHHHCCCCCCHHHHHHHHHCCCCCCCHHHHHHH
YDHMVGLNTVVLPGSDAAVLRVKGTKKGIAMTTDCNGRFCYLDPKTGAAIAVAEAARNLV
HHHHCCCCEEEECCCCEEEEEEECCCCCEEEEECCCCEEEEECCCCCCEEHHHHHHHHHH
CSGAKPLAITNCLNFGNPEKPEVMWTFWRCIEGMGEACRVLETPVTGGNVSLYNETKGSA
CCCCCCEEEEHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCE
VYPTPTIGMVGLVEDLDKVCTQDFKTEGDAIFLIGENLPELGGSEYLKVHHGLEKGKAPV
ECCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCEEEECCCCCCCCCCH
LDLALEKKIQQFVLNEIKNGLIKSAHDCSEGGLAVALAECCIAGGLGADITMVRRFRGDA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCE
LLFGESQSRIVISLDRSKGVELVKKLVDAGVPYSQLGTVGGNSLVINVVNPGCTGCGGNL
EEEECCCCEEEEEECCCCCHHHHHHHHHCCCCHHHHCCCCCCEEEEEEECCCCCCCCCCE
INLSVSKLAETWRGAIECLMK
EEEEHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIVEEKVWREMGLTDSEYERIVEILGRHPNYVEVGIFAVMWSEHCSYKTSRPALKTLPTE
CCCHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEHHHHEEEHHHHCCCCCCCCHHHCCCCC
GPAILQGPGENAGIVDIGDGQAVVFKIESHNHPSAIEPYQGAATGVGGILRDIFTMGARP
CCEEEECCCCCCCEEEECCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCH
IAVLDSLRFGELDNPRVRYLFDGVVSGISGYGNCIGVPTVGGEVYFSDSYEENCLVNVMC
HHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEECCCCCCEEEECCCCCCCCEEEEEE
VGLIDQKDIKKGLAAGVGNPVMVVGAKTGRDGIHGATFASEELSEAAAERRPAVQVGDPF
EECCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCEECCCHH
MEKLLLEACLEVIKTGYVVGIQDMGAAGLTSSSCEMASRAGTGLEMDLALVPRREEGMTP
HHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCHHHHHHHCCCCCEEEEEECCCCCCCCCH
YELMLSESQERMLLVVEKGTEDKVKDIFAKWDLDCVVVGQVTDDGLLRLKEGDQVVAEMP
HHHHHCCCCCEEEEEEECCCHHHHHHHHHHCCCCEEEEEEECCCCEEEECCCCHHHHHCC
AKALTDEAPLYHRPTEVPAYLEDIHNFPLEQLNMPDDYNEVLLKLLATPNIASKEYVYRQ
HHHHCCCCCCCCCCCCCHHHHHHHHCCCHHHCCCCCCHHHHHHHHHCCCCCCCHHHHHHH
YDHMVGLNTVVLPGSDAAVLRVKGTKKGIAMTTDCNGRFCYLDPKTGAAIAVAEAARNLV
HHHHCCCCEEEECCCCEEEEEEECCCCCEEEEECCCCEEEEECCCCCCEEHHHHHHHHHH
CSGAKPLAITNCLNFGNPEKPEVMWTFWRCIEGMGEACRVLETPVTGGNVSLYNETKGSA
CCCCCCEEEEHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCE
VYPTPTIGMVGLVEDLDKVCTQDFKTEGDAIFLIGENLPELGGSEYLKVHHGLEKGKAPV
ECCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCEEEECCCCCCCCCCH
LDLALEKKIQQFVLNEIKNGLIKSAHDCSEGGLAVALAECCIAGGLGADITMVRRFRGDA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCE
LLFGESQSRIVISLDRSKGVELVKKLVDAGVPYSQLGTVGGNSLVINVVNPGCTGCGGNL
EEEECCCCEEEEEECCCCCHHHHHHHHHCCCCHHHHCCCCCCEEEEEEECCCCCCCCCCE
INLSVSKLAETWRGAIECLMK
EEEEHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA