Click here to switch to the map view.

The map label for this gene is hisB

Identifier: 134300192

GI number: 134300192

Start: 2573353

End: 2573943

Strand: Reverse

Name: hisB

Synonym: Dred_2353

Alternate gene names: 134300192

Gene position: 2573943-2573353 (Counterclockwise)

Preceding gene: 134300193

Following gene: 134300191

Centisome position: 71.34

GC content: 46.19

Gene sequence:

>591_bases
TTGCTAAACCGTCAAGCTAAATTCGAACGCAAAACCTCTGAAACCGACATTTTGGTGGAAGTTTTTCTGGACGGTAATGG
CAAATATCAGGTGGCAACCGGAGTCGGTTTTTTTGATCATATGCTTTGCTTATTTGCCAAACACGGGGCCCTTGATCTAA
CTGTGAAAGCAGCAGGAGATACTCATATTGATGATCATCATACCGTAGAAGATGTGGGGATCACCTTGGGACAGTCCATC
AAGCAGGCCCTGGGGGATAAGCAGGGAATCGTTCGCTATGGCCATGCTTTGGTACCCATGGATGAATCCTTGATTCTAGT
GGCTTTGGATATGAGCGGCAGGGGTCATTTGGAATTAGATTTACCTTTGCCCGCGGCTAAAGTGGGAAATTTCGATACCG
AATTGGTGGAAGAATTTTTTAGAGCACTGGCCCTGAACTGTGGTATGACCCTTCATGTACGAATGTTAAGTGGTCGCAAT
ACCCATCATATTATTGAGGGAGCCTTTAAGGCCCTAGGAAGGGCTTTACGACAGGCGGTGTCCAAGGATCAACGGTTAAC
AGGTATTCCTTCCACTAAGGGAGTGTTGTAA

Upstream 100 bases:

>100_bases
CCGGTTTCCTGCGCATGTCCATTGGTACCCCGGAGGAAAATACAAAATTTCTGCAAGCCCTAACAGAAGTTCTTGAGCAA
TTAAGGGAGGAAAAAGACAA

Downstream 100 bases:

>100_bases
GATGATTGCCATTATTGATTATGGCATGGGCAATTTACGCAGTGTGCAAAAGGGCTTTGCCAGGGCAGGCTACCAGGCAG
AAATAGTCCAACAACCAGAG

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 196; Mature: 196

Protein sequence:

>196_residues
MLNRQAKFERKTSETDILVEVFLDGNGKYQVATGVGFFDHMLCLFAKHGALDLTVKAAGDTHIDDHHTVEDVGITLGQSI
KQALGDKQGIVRYGHALVPMDESLILVALDMSGRGHLELDLPLPAAKVGNFDTELVEEFFRALALNCGMTLHVRMLSGRN
THHIIEGAFKALGRALRQAVSKDQRLTGIPSTKGVL

Sequences:

>Translated_196_residues
MLNRQAKFERKTSETDILVEVFLDGNGKYQVATGVGFFDHMLCLFAKHGALDLTVKAAGDTHIDDHHTVEDVGITLGQSI
KQALGDKQGIVRYGHALVPMDESLILVALDMSGRGHLELDLPLPAAKVGNFDTELVEEFFRALALNCGMTLHVRMLSGRN
THHIIEGAFKALGRALRQAVSKDQRLTGIPSTKGVL
>Mature_196_residues
MLNRQAKFERKTSETDILVEVFLDGNGKYQVATGVGFFDHMLCLFAKHGALDLTVKAAGDTHIDDHHTVEDVGITLGQSI
KQALGDKQGIVRYGHALVPMDESLILVALDMSGRGHLELDLPLPAAKVGNFDTELVEEFFRALALNCGMTLHVRMLSGRN
THHIIEGAFKALGRALRQAVSKDQRLTGIPSTKGVL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=196, Percent_Identity=50.5102040816327, Blast_Score=188, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6324776, Length=220, Percent_Identity=39.0909090909091, Blast_Score=151, Evalue=6e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_DESRM (A4J710)

Other databases:

- EMBL:   CP000612
- RefSeq:   YP_001113688.1
- ProteinModelPortal:   A4J710
- SMR:   A4J710
- STRING:   A4J710
- GeneID:   4956206
- GenomeReviews:   CP000612_GR
- KEGG:   drm:Dred_2353
- eggNOG:   COG0131
- HOGENOM:   HBG289010
- OMA:   TLHVETL
- PhylomeDB:   A4J710
- ProtClustDB:   CLSK2537108
- BioCyc:   DRED349161:DRED_2353-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 21384; Mature: 21384

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNRQAKFERKTSETDILVEVFLDGNGKYQVATGVGFFDHMLCLFAKHGALDLTVKAAGD
CCCCCCHHHHCCCCCEEEEEEEECCCCCEEEEECCCHHHHHHHHHHCCCCEEEEEEECCC
THIDDHHTVEDVGITLGQSIKQALGDKQGIVRYGHALVPMDESLILVALDMSGRGHLELD
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHCCEECCCCCCEEEEEEECCCCCEEEEE
LPLPAAKVGNFDTELVEEFFRALALNCGMTLHVRMLSGRNTHHIIEGAFKALGRALRQAV
CCCCHHHCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHH
SKDQRLTGIPSTKGVL
CCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLNRQAKFERKTSETDILVEVFLDGNGKYQVATGVGFFDHMLCLFAKHGALDLTVKAAGD
CCCCCCHHHHCCCCCEEEEEEEECCCCCEEEEECCCHHHHHHHHHHCCCCEEEEEEECCC
THIDDHHTVEDVGITLGQSIKQALGDKQGIVRYGHALVPMDESLILVALDMSGRGHLELD
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHCCEECCCCCCEEEEEEECCCCCEEEEE
LPLPAAKVGNFDTELVEEFFRALALNCGMTLHVRMLSGRNTHHIIEGAFKALGRALRQAV
CCCCHHHCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHH
SKDQRLTGIPSTKGVL
CCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA