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The map label for this gene is hisC [H]

Identifier: 134300193

GI number: 134300193

Start: 2573937

End: 2575052

Strand: Reverse

Name: hisC [H]

Synonym: Dred_2354

Alternate gene names: 134300193

Gene position: 2575052-2573937 (Counterclockwise)

Preceding gene: 134300194

Following gene: 134300192

Centisome position: 71.37

GC content: 45.7

Gene sequence:

>1116_bases
TTGAAGGATGTGAAAAAATTGCGTGATTCTTTTAATGTAACCAAACTCATTCGCCCGGATTTAGAGAAATTGATACCCTA
TGATGCCCACCTCTACCCCGAGGCCATTAAACTGGATGCCAATGAAAACCCCTTTCCCTTTCCTCAAGCAGTGGCCCAAC
AGATGGCTGCCCTCGTTGCCGATGAACTGCTGAGCCGCTATCCTGATAGTGATGCCATTGAACTACGTAAAGACATTGCA
GAATATGCAGGGGTGTTACCGGAACAGGTGATGGCGGGTAATGGTTCTGACGAGCTAATCTTAAATATATTACTAACCTT
TGGCACCGGTGGTCGGGTGCTTATCACCAACCCCACCTTCGGCATGTATAAAATACATGCTCTGATTGCGGGGGCCAGAC
CCATTCCAGTGCCCCGTCGTAGTGATTTCTCTGTTGACGTACCTGCCTTGGTGAGTTATGCTCGGAAACCGGAAGCAAGG
GTAATTTTTCTTTGCTCCCCCAATAACCCCACAGGTAATGCTTCGACCCTAGAGGAAATAGAAGGTGTGCTGCAGCAGGT
AAATTGCCTGGTGGTGGTTGACCAGGCCTATCTGGAGTTTGGTGGAGAAGACTGTACCCCTCTGTTGAACCGTTATCCCA
ACCTGTTAATTCTTCGGACCTTTTCCAAAGCCTTTGCAACGGCAGGCTTGCGGGTTGGCTACATGCTGGCTCACCCAGAT
GTATTACGTCAAATAAAGAAGGTCAAACAACCCTATAATTTAAATTCCTTTTCACAGGCCGCAGCCAGAGTAGTGTTAAA
AAATAAGGAGCACTTTAAACTGCAAATTCAGGAGATTAAAGAGCAACGTGAGAAGGTTTATCAAAATTTACAAAGTTTAG
AAGGAGTAACATCTTACCCTTCAGTTACAAACTATATCCTTTTCCGAACCAATTATGCCAGTAAAACCGTTTACCAGGGT
TTATTGGAAAAAGGAGTGCTCATCCGTCAATTGGGCGGTCCGGAATTGCCCGGTTTCCTGCGCATGTCCATTGGTACCCC
GGAGGAAAATACAAAATTTCTGCAAGCCCTAACAGAAGTTCTTGAGCAATTAAGGGAGGAAAAAGACAATTGCTAA

Upstream 100 bases:

>100_bases
AGGTATTTGCTATCGGTGCGGAGACCGGAGCTAATGGGGATAACTTAAATATTAGATGTGTATATATTCATTGCACCGAA
GAAAAACTGGGACATTCCCT

Downstream 100 bases:

>100_bases
ACCGTCAAGCTAAATTCGAACGCAAAACCTCTGAAACCGACATTTTGGTGGAAGTTTTTCTGGACGGTAATGGCAAATAT
CAGGTGGCAACCGGAGTCGG

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase [H]

Number of amino acids: Translated: 371; Mature: 371

Protein sequence:

>371_residues
MKDVKKLRDSFNVTKLIRPDLEKLIPYDAHLYPEAIKLDANENPFPFPQAVAQQMAALVADELLSRYPDSDAIELRKDIA
EYAGVLPEQVMAGNGSDELILNILLTFGTGGRVLITNPTFGMYKIHALIAGARPIPVPRRSDFSVDVPALVSYARKPEAR
VIFLCSPNNPTGNASTLEEIEGVLQQVNCLVVVDQAYLEFGGEDCTPLLNRYPNLLILRTFSKAFATAGLRVGYMLAHPD
VLRQIKKVKQPYNLNSFSQAAARVVLKNKEHFKLQIQEIKEQREKVYQNLQSLEGVTSYPSVTNYILFRTNYASKTVYQG
LLEKGVLIRQLGGPELPGFLRMSIGTPEENTKFLQALTEVLEQLREEKDNC

Sequences:

>Translated_371_residues
MKDVKKLRDSFNVTKLIRPDLEKLIPYDAHLYPEAIKLDANENPFPFPQAVAQQMAALVADELLSRYPDSDAIELRKDIA
EYAGVLPEQVMAGNGSDELILNILLTFGTGGRVLITNPTFGMYKIHALIAGARPIPVPRRSDFSVDVPALVSYARKPEAR
VIFLCSPNNPTGNASTLEEIEGVLQQVNCLVVVDQAYLEFGGEDCTPLLNRYPNLLILRTFSKAFATAGLRVGYMLAHPD
VLRQIKKVKQPYNLNSFSQAAARVVLKNKEHFKLQIQEIKEQREKVYQNLQSLEGVTSYPSVTNYILFRTNYASKTVYQG
LLEKGVLIRQLGGPELPGFLRMSIGTPEENTKFLQALTEVLEQLREEKDNC
>Mature_371_residues
MKDVKKLRDSFNVTKLIRPDLEKLIPYDAHLYPEAIKLDANENPFPFPQAVAQQMAALVADELLSRYPDSDAIELRKDIA
EYAGVLPEQVMAGNGSDELILNILLTFGTGGRVLITNPTFGMYKIHALIAGARPIPVPRRSDFSVDVPALVSYARKPEAR
VIFLCSPNNPTGNASTLEEIEGVLQQVNCLVVVDQAYLEFGGEDCTPLLNRYPNLLILRTFSKAFATAGLRVGYMLAHPD
VLRQIKKVKQPYNLNSFSQAAARVVLKNKEHFKLQIQEIKEQREKVYQNLQSLEGVTSYPSVTNYILFRTNYASKTVYQG
LLEKGVLIRQLGGPELPGFLRMSIGTPEENTKFLQALTEVLEQLREEKDNC

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=361, Percent_Identity=32.9639889196676, Blast_Score=168, Evalue=6e-43,
Organism=Escherichia coli, GI1788722, Length=229, Percent_Identity=26.2008733624454, Blast_Score=70, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6322075, Length=392, Percent_Identity=30.8673469387755, Blast_Score=157, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 41556; Mature: 41556

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDVKKLRDSFNVTKLIRPDLEKLIPYDAHLYPEAIKLDANENPFPFPQAVAQQMAALVA
CCHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHH
DELLSRYPDSDAIELRKDIAEYAGVLPEQVMAGNGSDELILNILLTFGTGGRVLITNPTF
HHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHHCCCCCEEEEECCCC
GMYKIHALIAGARPIPVPRRSDFSVDVPALVSYARKPEARVIFLCSPNNPTGNASTLEEI
CHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHH
EGVLQQVNCLVVVDQAYLEFGGEDCTPLLNRYPNLLILRTFSKAFATAGLRVGYMLAHPD
HHHHHHCCEEEEEEHHHHHCCCCCCCHHHHCCCCEEEEHHHHHHHHHHCCHHEEEECCHH
VLRQIKKVKQPYNLNSFSQAAARVVLKNKEHFKLQIQEIKEQREKVYQNLQSLEGVTSYP
HHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
SVTNYILFRTNYASKTVYQGLLEKGVLIRQLGGPELPGFLRMSIGTPEENTKFLQALTEV
CHHCEEEEEECCHHHHHHHHHHHHCHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHH
LEQLREEKDNC
HHHHHHHCCCC
>Mature Secondary Structure
MKDVKKLRDSFNVTKLIRPDLEKLIPYDAHLYPEAIKLDANENPFPFPQAVAQQMAALVA
CCHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHH
DELLSRYPDSDAIELRKDIAEYAGVLPEQVMAGNGSDELILNILLTFGTGGRVLITNPTF
HHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHHCCCCCEEEEECCCC
GMYKIHALIAGARPIPVPRRSDFSVDVPALVSYARKPEARVIFLCSPNNPTGNASTLEEI
CHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHH
EGVLQQVNCLVVVDQAYLEFGGEDCTPLLNRYPNLLILRTFSKAFATAGLRVGYMLAHPD
HHHHHHCCEEEEEEHHHHHCCCCCCCHHHHCCCCEEEEHHHHHHHHHHCCHHEEEECCHH
VLRQIKKVKQPYNLNSFSQAAARVVLKNKEHFKLQIQEIKEQREKVYQNLQSLEGVTSYP
HHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
SVTNYILFRTNYASKTVYQGLLEKGVLIRQLGGPELPGFLRMSIGTPEENTKFLQALTEV
CHHCEEEEEECCHHHHHHHHHHHHCHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHH
LEQLREEKDNC
HHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA